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Entry version 136 (22 Apr 2020)
Sequence version 2 (11 Jan 2011)
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Protein

Piezo-type mechanosensitive ion channel component 2

Gene

PIEZO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation.By similarity

Miscellaneous

Piezo comes from the Greek 'piesi' meaning pressure.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Sensory transduction, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.75.1.2 the mechanical nociceptor, piezo (piezo) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel component 2
Alternative name(s):
Protein FAM38B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIEZO2
Synonyms:C18orf30, C18orf58, FAM38B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26270 PIEZO2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613629 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H5I5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei581 – 598HelicalSequence analysisAdd BLAST18
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei782 – 802HelicalSequence analysisAdd BLAST21
Transmembranei932 – 952HelicalSequence analysisAdd BLAST21
Transmembranei958 – 978HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1005HelicalSequence analysisAdd BLAST21
Transmembranei1053 – 1073HelicalSequence analysisAdd BLAST21
Transmembranei1134 – 1154HelicalSequence analysisAdd BLAST21
Transmembranei1170 – 1190HelicalSequence analysisAdd BLAST21
Transmembranei1217 – 1237HelicalSequence analysisAdd BLAST21
Transmembranei1291 – 1311HelicalSequence analysisAdd BLAST21
Transmembranei1315 – 1335HelicalSequence analysisAdd BLAST21
Transmembranei1349 – 1371HelicalSequence analysisAdd BLAST23
Transmembranei1404 – 1424HelicalSequence analysisAdd BLAST21
Transmembranei1900 – 1920HelicalSequence analysisAdd BLAST21
Transmembranei1935 – 1955HelicalSequence analysisAdd BLAST21
Transmembranei1967 – 1987HelicalSequence analysisAdd BLAST21
Transmembranei2191 – 2211HelicalSequence analysisAdd BLAST21
Transmembranei2232 – 2252HelicalSequence analysisAdd BLAST21
Transmembranei2260 – 2280HelicalSequence analysisAdd BLAST21
Transmembranei2290 – 2310HelicalSequence analysisAdd BLAST21
Transmembranei2327 – 2344HelicalSequence analysisAdd BLAST18
Transmembranei2358 – 2378HelicalSequence analysisAdd BLAST21
Transmembranei2406 – 2426HelicalSequence analysisAdd BLAST21
Transmembranei2662 – 2682HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Arthrogryposis, distal, 5 (DA5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA5 features include ocular abnormalities, typically ptosis, ophthalmoplegia and/or strabismus, in addition to contractures of the skeletal muscles. Some patients have pulmonary hypertension as a result of restrictive lung disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071817712M → V in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777453EnsemblClinVar.1
Natural variantiVAR_070938802I → F in DA5; recovers faster from inactivation. 1 PublicationCorresponds to variant dbSNP:rs587777076EnsemblClinVar.1
Natural variantiVAR_0713042718R → L in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777452EnsemblClinVar.1
Natural variantiVAR_0713052718R → P in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777452EnsemblClinVar.1
Natural variantiVAR_0718182727Missing in DA5; causes slowing of inactivation of PIEZO2-dependent mechanically activated currents as well as significantly faster recovery from inactivation compared to wild-type. 1 Publication1
Natural variantiVAR_0713062739S → P in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777454EnsemblClinVar.1
Arthrogryposis, distal, 3 (DA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA3 features include short stature and cleft palate.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0713032686R → H in DA3. 1 PublicationCorresponds to variant dbSNP:rs587777450EnsemblClinVar.1
Marden-Walker syndrome (MWKS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by a mask-like face with blepharophimosis, micrognathia, cleft or high-arched palate, low-set ears, congenital joint contractures, kyphoscoliosis, pectus excavatum or carinatum, and arachnodactyly. Additional features include decreased muscular mass, failure to thrive, renal anomalies, hypoplastic corpus callosum, cerebellar vermis hypoplasia, enlarged cisterna magna, and psychomotor retardation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0713022686R → C in MWKS. 1 PublicationCorresponds to variant dbSNP:rs587777451EnsemblClinVar.1
Arthrogryposis, distal, with impaired proprioception and touch (DAIPT)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DAIPT is an autosomal recessive disease characterized by selective loss of discriminative touch perception, ataxia, difficulty walking, dysmetria, and progressive skeletal contractures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0778431685R → P in DAIPT. 1 PublicationCorresponds to variant dbSNP:rs886039823EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
63895

MalaCards human disease database

More...
MalaCardsi
PIEZO2
MIMi108145 phenotype
114300 phenotype
248700 phenotype
617146 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000154864

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1154 Arthrogryposis-oculomotor limitation-electroretinal anomalies syndrome
376 Gordon syndrome
2461 Marden-Walker syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134930761

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H5I5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIEZO2

Domain mapping of disease mutations (DMDM)

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DMDMi
317373264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001868181 – 2752Piezo-type mechanosensitive ion channel component 2Add BLAST2752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei838PhosphoserineBy similarity1
Glycosylationi1013N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1085N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H5I5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H5I5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H5I5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H5I5

PeptideAtlas

More...
PeptideAtlasi
Q9H5I5

PRoteomics IDEntifications database

More...
PRIDEi
Q9H5I5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80910 [Q9H5I5-1]
80911 [Q9H5I5-2]
80912 [Q9H5I5-3]
80913 [Q9H5I5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H5I5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H5I5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000154864 Expressed in lung and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H5I5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H5I5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000154864 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer, most likely homotetramer.

Interacts with STOML3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121975, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000421377

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H5I5 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1458 – 1529Sequence analysisAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi453 – 480Glu-richAdd BLAST28
Compositional biasi609 – 668Glu-richAdd BLAST60
Compositional biasi852 – 901Glu-richAdd BLAST50
Compositional biasi2099 – 2135Ser-richAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1893 Eukaryota
ENOG410YVF6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154456

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_031849_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H5I5

KEGG Orthology (KO)

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KOi
K22128

Identification of Orthologs from Complete Genome Data

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OMAi
YIKAPSD

Database of Orthologous Groups

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OrthoDBi
13738at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H5I5

TreeFam database of animal gene trees

More...
TreeFami
TF314295

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom

The PANTHER Classification System

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PANTHERi
PTHR13167 PTHR13167, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H5I5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT
60 70 80 90 100
TMQGHTGRLL KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE
110 120 130 140 150
KTFRQIGFES LKGADAGNGI RVFVPDIGMF IASLTIWLLC RNIVQKPVTD
160 170 180 190 200
EAAQSNPEFE NEELAEGEKI DSEEALIYEE DFNGGDGVEG ELEESTKLKM
210 220 230 240 250
FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS LTSSVYFFVF
260 270 280 290 300
LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP
310 320 330 340 350
NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT
360 370 380 390 400
LIRIWLQEPL VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK
410 420 430 440 450
LLSMTQDDYK PSDGLLVTVN GNPVDYHTIH PSLPMENGPG KADLYSTPQY
460 470 480 490 500
RWEPSDESSE KREEEEEEKE EFEEERSREE KRSIKVHAMV SVFQFIMKQS
510 520 530 540 550
YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA MISSPFMVVY
560 570 580 590 600
GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH
610 620 630 640 650
LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE
660 670 680 690 700
EKQERKKVEQ EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF
710 720 730 740 750
EGKIVMYKII YMVLFLFCVA LYQVHYEWWR KILKYFWMSV VIYTMLVLIF
760 770 780 790 800
IYTYQFENFP GLWQNMTGLK KEKLEDLGLK QFTVAELFTR IFIPTSFLLV
810 820 830 840 850
CILHLHYFHD RFLELTDLKS IPSKEDNTIY RLAHPEGSLP DLTMMHLTAS
860 870 880 890 900
LEKPEVRKLA EPGEEKLEGY SEKAQKGDLG KDSEESEEDG EEEEESEEEE
910 920 930 940 950
ETSDLRNKWH LVIDRLTVLF LKFLEYFHKL QVFMWWILEL HIIKIVSSYI
960 970 980 990 1000
IWVSVKEVSL FNYVFLISWA FALPYAKLRR LASSVCTVWT CVIIVCKMLY
1010 1020 1030 1040 1050
QLQTIKPENF SVNCSLPNEN QTNIPFNELN KSLLYSAPID PTEWVGLRKS
1060 1070 1080 1090 1100
SPLLVYLRNN LLMLAILAFE VTIYRHQEYY RGRNNLTAPV SRTIFHDITR
1110 1120 1130 1140 1150
LHLDDGLINC AKYFINYFFY KFGLETCFLM SVNVIGQRMD FYAMIHACWL
1160 1170 1180 1190 1200
IAVLYRRRRK AIAEIWPKYC CFLACIITFQ YFICIGIPPA PCRDYPWRFK
1210 1220 1230 1240 1250
GASFNDNIIK WLYFPDFIVR PNPVFLVYDF MLLLCASLQR QIFEDENKAA
1260 1270 1280 1290 1300
VRIMAGDNVE ICMNLDAASF SQHNPVPDFI HCRSYLDMSK VIIFSYLFWF
1310 1320 1330 1340 1350
VLTIIFITGT TRISIFCMGY LVACFYFLLF GGDLLLKPIK SILRYWDWLI
1360 1370 1380 1390 1400
AYNVFVITMK NILSIGACGY IGTLVHNSCW LIQAFSLACT VKGYQMPAAN
1410 1420 1430 1440 1450
SPCTLPSGEA GIIWDSICFA FLLLQRRVFM SYYFLHVVAD IKASQILASR
1460 1470 1480 1490 1500
GAELFQATIV KAVKARIEEE KKSMDQLKRQ MDRIKARQQK YKKGKERMLS
1510 1520 1530 1540 1550
LTQEPGEGQD MQKLSEEDDE READKQKAKG KKKQWWRPWV DHASMVRSGD
1560 1570 1580 1590 1600
YYLFETDSEE EEEEELKKED EEPPRRSAFQ FVYQAWITDP KTALRQRHKE
1610 1620 1630 1640 1650
KKRSAREERK RRRKGSKEGP VEWEDREDEP IKKKSDGPDN IIKRIFNILK
1660 1670 1680 1690 1700
FTWVLFLATV DSFTTWLNSI SREHIDISTV LRIERCMLTR EIKKGNVPTR
1710 1720 1730 1740 1750
ESIHMYYQNH IMNLSRESGL DTIDEHPGAA SGAQTAHRMD SLDSHDSISS
1760 1770 1780 1790 1800
EPTQCTMLYS RQGTTETIEE VEAEQEEEAG STAPEPREAK EYEATGYDVG
1810 1820 1830 1840 1850
AMGAEEASLT PEEELTQFST LDGDVEAPPS YSKAVSFEHL SFGSQDDSAG
1860 1870 1880 1890 1900
KNRMAVSPDD SRTDKLGSSI LPPLTHELTA SELLLKKMFH DDELEESEKF
1910 1920 1930 1940 1950
YVGQPRFLLL FYAMYNTLVA RSEMVCYFVI ILNHMVSASM ITLLLPILIF
1960 1970 1980 1990 2000
LWAMLSVPRP SRRFWMMAIV YTEVAIVVKY FFQFGFFPWN KNVEVNKDKP
2010 2020 2030 2040 2050
YHPPNIIGVE KKEGYVLYDL IQLLALFFHR SILKCHGLWD EDDMTESGMA
2060 2070 2080 2090 2100
REESDDELSL GHGRRDSSDS LKSINLAASV ESVHVTFPEQ QTAVRRKRSG
2110 2120 2130 2140 2150
SSSEPSQRSS FSSNRSQRGS TSTRNSSQKG SSVLSIKQKG KRELYMEKLQ
2160 2170 2180 2190 2200
EHLIKAKAFT IKKTLEIYVP IKQFFYNLIH PEYSAVTDVY VLMFLADTVD
2210 2220 2230 2240 2250
FIIIVFGFWA FGKHSAAADI TSSLSEDQVP GPFLVMVLIQ FGTMVVDRAL
2260 2270 2280 2290 2300
YLRKTVLGKV IFQVILVFGI HFWMFFILPG VTERKFSQNL VAQLWYFVKC
2310 2320 2330 2340 2350
VYFGLSAYQI RCGYPTRVLG NFLTKSYNYV NLFLFQGFRL VPFLTELRAV
2360 2370 2380 2390 2400
MDWVWTDTTL SLSSWICVED IYAHIFILKC WRESEKRYPQ PRGQKKKKVV
2410 2420 2430 2440 2450
KYGMGGMIIV LLICIVWFPL LFMSLIKSVA GVINQPLDVS VTITLGGYQP
2460 2470 2480 2490 2500
IFTMSAQQSQ LKVMDQQSFN KFIQAFSRDT GAMQFLENYE KEDITVAELE
2510 2520 2530 2540 2550
GNSNSLWTIS PPSKQKMIHE LLDPNSSFSV VFSWSIQRNL SLGAKSEIAT
2560 2570 2580 2590 2600
DKLSFPLKNI TRKNIAKMIA GNSTESSKTP VTIEKIYPYY VKAPSDSNSK
2610 2620 2630 2640 2650
PIKQLLSENN FMDITIILSR DNTTKYNSEW WVLNLTGNRI YNPNSQALEL
2660 2670 2680 2690 2700
VVFNDKVSPP SLGFLAGYGI MGLYASVVLV IGKFVREFFS GISHSIMFEE
2710 2720 2730 2740 2750
LPNVDRILKL CTDIFLVRET GELELEEDLY AKLIFLYRSP ETMIKWTREK

TN
Length:2,752
Mass (Da):318,064
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD11A1FCEB6D0079
GO
Isoform 2 (identifier: Q9H5I5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2387-2449: Missing.

Show »
Length:2,689
Mass (Da):311,074
Checksum:iAABB4B9D00BD9A7B
GO
Isoform 3 (identifier: Q9H5I5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2043: Missing.

Show »
Length:709
Mass (Da):80,795
Checksum:iDBD498DC75245E19
GO
Isoform 4 (identifier: Q9H5I5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     831-831: R → SHAKVNGRVYLIINSIKKKLPIHQNE

Show »
Length:2,777
Mass (Da):320,890
Checksum:i466021E614EDCFFC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVM7E7EVM7_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
2,703Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRQ5J3KRQ5_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
1,473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ18V9GZ18_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y3N5A0A2R8Y3N5_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLJ9J3QLJ9_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRW1J3KRW1_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YG64A0A2R8YG64_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15556 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15556 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAB15641 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03832 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated
The sequence BAC05412 differs from that shown. Contaminating sequence at the 3'end. Probable cloning artifact.Curated
The sequence BAC05412 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti455S → F in BAC03832 (PubMed:14702039).Curated1
Sequence conflicti758N → D in BAC05412 (PubMed:14702039).Curated1
Sequence conflicti980R → C in BAC87063 (PubMed:14702039).Curated1
Sequence conflicti999L → S in BAC05412 (PubMed:14702039).Curated1
Sequence conflicti1175C → G in BAC87063 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071817712M → V in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777453EnsemblClinVar.1
Natural variantiVAR_070938802I → F in DA5; recovers faster from inactivation. 1 PublicationCorresponds to variant dbSNP:rs587777076EnsemblClinVar.1
Natural variantiVAR_0710391354V → I2 PublicationsCorresponds to variant dbSNP:rs7234309EnsemblClinVar.1
Natural variantiVAR_0778431685R → P in DAIPT. 1 PublicationCorresponds to variant dbSNP:rs886039823EnsemblClinVar.1
Natural variantiVAR_0339252463V → I1 PublicationCorresponds to variant dbSNP:rs3748428EnsemblClinVar.1
Natural variantiVAR_0713022686R → C in MWKS. 1 PublicationCorresponds to variant dbSNP:rs587777451EnsemblClinVar.1
Natural variantiVAR_0713032686R → H in DA3. 1 PublicationCorresponds to variant dbSNP:rs587777450EnsemblClinVar.1
Natural variantiVAR_0713042718R → L in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777452EnsemblClinVar.1
Natural variantiVAR_0713052718R → P in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777452EnsemblClinVar.1
Natural variantiVAR_0718182727Missing in DA5; causes slowing of inactivation of PIEZO2-dependent mechanically activated currents as well as significantly faster recovery from inactivation compared to wild-type. 1 Publication1
Natural variantiVAR_0713062739S → P in DA5. 1 PublicationCorresponds to variant dbSNP:rs587777454EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0404711 – 2043Missing in isoform 3. 1 PublicationAdd BLAST2043
Alternative sequenceiVSP_040630831R → SHAKVNGRVYLIINSIKKKL PIHQNE in isoform 4. 1 Publication1
Alternative sequenceiVSP_0404722387 – 2449Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JN790819 mRNA Translation: AFC88283.1
AK026797 mRNA Translation: BAB15556.1 Sequence problems.
AK027056 mRNA Translation: BAB15641.1 Different initiation.
AK092226 mRNA Translation: BAC03832.1 Sequence problems.
AK098782 mRNA Translation: BAC05412.1 Sequence problems.
AK127627 mRNA Translation: BAC87063.1
AK302764 mRNA Translation: BAH13798.1
AP001180 Genomic DNA No translation available.
AP005117 Genomic DNA No translation available.
AP005120 Genomic DNA No translation available.
AP005404 Genomic DNA No translation available.
AP005793 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11850.2 [Q9H5I5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_071351.2, NM_022068.3 [Q9H5I5-1]
XP_011524026.1, XM_011525724.2 [Q9H5I5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302079; ENSP00000303316; ENSG00000154864 [Q9H5I5-2]
ENST00000503781; ENSP00000421377; ENSG00000154864 [Q9H5I5-1]
ENST00000580640; ENSP00000463094; ENSG00000154864 [Q9H5I5-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63895

UCSC genome browser

More...
UCSCi
uc002koq.4 human [Q9H5I5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN790819 mRNA Translation: AFC88283.1
AK026797 mRNA Translation: BAB15556.1 Sequence problems.
AK027056 mRNA Translation: BAB15641.1 Different initiation.
AK092226 mRNA Translation: BAC03832.1 Sequence problems.
AK098782 mRNA Translation: BAC05412.1 Sequence problems.
AK127627 mRNA Translation: BAC87063.1
AK302764 mRNA Translation: BAH13798.1
AP001180 Genomic DNA No translation available.
AP005117 Genomic DNA No translation available.
AP005120 Genomic DNA No translation available.
AP005404 Genomic DNA No translation available.
AP005793 Genomic DNA No translation available.
CCDSiCCDS11850.2 [Q9H5I5-1]
RefSeqiNP_071351.2, NM_022068.3 [Q9H5I5-1]
XP_011524026.1, XM_011525724.2 [Q9H5I5-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121975, 1 interactor
STRINGi9606.ENSP00000421377

Protein family/group databases

TCDBi1.A.75.1.2 the mechanical nociceptor, piezo (piezo) family

PTM databases

iPTMnetiQ9H5I5
PhosphoSitePlusiQ9H5I5

Polymorphism and mutation databases

BioMutaiPIEZO2
DMDMi317373264

Proteomic databases

jPOSTiQ9H5I5
MassIVEiQ9H5I5
MaxQBiQ9H5I5
PaxDbiQ9H5I5
PeptideAtlasiQ9H5I5
PRIDEiQ9H5I5
ProteomicsDBi80910 [Q9H5I5-1]
80911 [Q9H5I5-2]
80912 [Q9H5I5-3]
80913 [Q9H5I5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2900 202 antibodies

The DNASU plasmid repository

More...
DNASUi
63895

Genome annotation databases

EnsembliENST00000302079; ENSP00000303316; ENSG00000154864 [Q9H5I5-2]
ENST00000503781; ENSP00000421377; ENSG00000154864 [Q9H5I5-1]
ENST00000580640; ENSP00000463094; ENSG00000154864 [Q9H5I5-4]
GeneIDi63895
KEGGihsa:63895
UCSCiuc002koq.4 human [Q9H5I5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63895
DisGeNETi63895

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PIEZO2
HGNCiHGNC:26270 PIEZO2
HPAiENSG00000154864 Tissue enhanced (brain)
MalaCardsiPIEZO2
MIMi108145 phenotype
114300 phenotype
248700 phenotype
613629 gene
617146 phenotype
neXtProtiNX_Q9H5I5
OpenTargetsiENSG00000154864
Orphaneti1154 Arthrogryposis-oculomotor limitation-electroretinal anomalies syndrome
376 Gordon syndrome
2461 Marden-Walker syndrome
PharmGKBiPA134930761

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00940000154456
HOGENOMiCLU_031849_0_0_1
InParanoidiQ9H5I5
KOiK22128
OMAiYIKAPSD
OrthoDBi13738at2759
PhylomeDBiQ9H5I5
TreeFamiTF314295

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIEZO2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63895
PharosiQ9H5I5 Tbio

Protein Ontology

More...
PROi
PR:Q9H5I5
RNActiQ9H5I5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154864 Expressed in lung and 188 other tissues
ExpressionAtlasiQ9H5I5 baseline and differential
GenevisibleiQ9H5I5 HS

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIEZ2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H5I5
Secondary accession number(s): B7Z812
, M4GPJ9, Q6ZS91, Q8N787, Q8NAR6, Q9H5R4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 11, 2011
Last modified: April 22, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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