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Entry version 174 (11 Dec 2019)
Sequence version 2 (15 Nov 2002)
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Protein

Histone-lysine N-methyltransferase SUV39H2

Gene

SUV39H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi191Zinc 1Combined sources1 Publication1
Metal bindingi191Zinc 2Combined sources1 Publication1
Metal bindingi193Zinc 1Combined sources1 Publication1
Metal bindingi196Zinc 1Combined sources1 Publication1
Metal bindingi196Zinc 3Combined sources1 Publication1
Metal bindingi201Zinc 1Combined sources1 Publication1
Metal bindingi202Zinc 2Combined sources1 Publication1
Metal bindingi229Zinc 2Combined sources1 Publication1
Metal bindingi229Zinc 3Combined sources1 Publication1
Metal bindingi233Zinc 2Combined sources1 Publication1
Metal bindingi235Zinc 3Combined sources1 Publication1
Metal bindingi239Zinc 3Combined sources1 Publication1
Metal bindingi333Zinc 4Combined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei372S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi398Zinc 4Combined sources1 Publication1
Binding sitei399S-adenosyl-L-methionine; via amide nitrogenCombined sources1 Publication1
Metal bindingi400Zinc 4Combined sources1 Publication1
Metal bindingi405Zinc 4Combined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processBiological rhythms, Cell cycle, Differentiation, Transcription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214841 PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.355)
Alternative name(s):
Histone H3-K9 methyltransferase 2
Short name:
H3-K9-HMTase 2
Lysine N-methyltransferase 1B
Suppressor of variegation 3-9 homolog 2
Short name:
Su(var)3-9 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUV39H2
Synonyms:KMT1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152455.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17287 SUV39H2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606503 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H5I1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79723

Open Targets

More...
OpenTargetsi
ENSG00000152455

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868807

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H5I1 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795177

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUV39H2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25091325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001860591 – 410Histone-lysine N-methyltransferase SUV39H2Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei381PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H5I1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H5I1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H5I1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H5I1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H5I1

PeptideAtlas

More...
PeptideAtlasi
Q9H5I1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H5I1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80906 [Q9H5I1-1]
80907 [Q9H5I1-2]
80908 [Q9H5I1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H5I1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H5I1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152455 Expressed in 150 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H5I1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H5I1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045901
HPA057554

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122838, 62 interactors

Protein interaction database and analysis system

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IntActi
Q9H5I1, 67 interactors

Molecular INTeraction database

More...
MINTi
Q9H5I1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346997

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9H5I1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H5I1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H5I1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H5I1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 105ChromoPROSITE-ProRule annotationAdd BLAST59
Domaini189 – 247Pre-SETPROSITE-ProRule annotationAdd BLAST59
Domaini250 – 373SETPROSITE-ProRule annotationAdd BLAST124
Domaini394 – 410Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni261 – 263S-adenosyl-L-methionine bindingCombined sources1 Publication3
Regioni330 – 331S-adenosyl-L-methionine bindingCombined sources1 Publication2

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).By similarity
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1082 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156788

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231244

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H5I1

KEGG Orthology (KO)

More...
KOi
K11419

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYSLCIF

Database of Orthologous Groups

More...
OrthoDBi
753093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H5I1

TreeFam database of animal gene trees

More...
TreeFami
TF106452

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR011381 Histone_H3-K9_MeTrfase
IPR003616 Post-SET_dom
IPR007728 Pre-SET_dom
IPR001214 SET_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00385 Chromo, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF009343 SUV39_SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00298 CHROMO, 1 hit
SM00508 PostSET, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54160 SSF54160, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit
PS50868 POST_SET, 1 hit
PS50867 PRE_SET, 1 hit
PS51579 SAM_MT43_SUVAR39_3, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9H5I1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVGAEARG AWCVPCLVSL DTLQELCRKE KLTCKSIGIT KRNLNNYEVE
60 70 80 90 100
YLCDYKVVKD MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFSNDKHNY
110 120 130 140 150
LSQVKKGKAI TPKDNNKTLK PAIAEYIVKK AKQRIALQRW QDELNRRKNH
160 170 180 190 200
KGMIFVENTV DLEGPPSDFY YINEYKPAPG ISLVNEATFG CSCTDCFFQK
210 220 230 240 250
CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY
260 270 280 290 300
SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK
310 320 330 340 350
GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR
360 370 380 390 400
LPRIALFSTR TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC
410
GAVTCRGYLN
Length:410
Mass (Da):46,682
Last modified:November 15, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED8BBF80AE838C69
GO
Isoform 1 (identifier: Q9H5I1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Show »
Length:350
Mass (Da):39,946
Checksum:iF435E9C5EBEA8BAD
GO
Isoform 2 (identifier: Q9H5I1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-283: Missing.

Show »
Length:230
Mass (Da):26,350
Checksum:iBB9EF88E02C4D74A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y306H0Y306_HUMAN
Histone-lysine N-methyltransferase ...
SUV39H2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JSS2Q5JSS2_HUMAN
Histone-lysine N-methyltransferase ...
SUV39H2
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYH9C9IYH9_HUMAN
Histone-lysine N-methyltransferase ...
SUV39H2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMB4C9JMB4_HUMAN
Histone-lysine N-methyltransferase ...
SUV39H2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9A8G5E9A8_HUMAN
Histone-lysine N-methyltransferase ...
SUV39H2
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036344383D → H in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0022091 – 60Missing in isoform 1. 3 PublicationsAdd BLAST60
Alternative sequenceiVSP_002210104 – 283Missing in isoform 2. 1 PublicationAdd BLAST180

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK027067 mRNA Translation: BAB15645.1
CR457372 mRNA Translation: CAG33653.1
AC069544 Genomic DNA No translation available.
AL360083 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86254.1
CH471072 Genomic DNA Translation: EAW86253.1
CH471072 Genomic DNA Translation: EAW86255.1
CH471072 Genomic DNA Translation: EAW86256.1
BC007754 mRNA Translation: AAH07754.1
BC029360 mRNA Translation: AAH29360.1
AL834488 mRNA Translation: CAD39146.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53493.1 [Q9H5I1-3]
CCDS53494.1 [Q9H5I1-1]
CCDS7104.1 [Q9H5I1-2]

NCBI Reference Sequences

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RefSeqi
NP_001180353.1, NM_001193424.1 [Q9H5I1-1]
NP_001180354.1, NM_001193425.1 [Q9H5I1-2]
NP_001180355.1, NM_001193426.1 [Q9H5I1-3]
NP_001180356.1, NM_001193427.1
NP_078946.1, NM_024670.3 [Q9H5I1-2]
XP_006717566.1, XM_006717503.3 [Q9H5I1-2]
XP_011517964.1, XM_011519662.2 [Q9H5I1-2]
XP_016872126.1, XM_017016637.1 [Q9H5I1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000313519; ENSP00000319208; ENSG00000152455 [Q9H5I1-2]
ENST00000354919; ENSP00000346997; ENSG00000152455 [Q9H5I1-1]
ENST00000378325; ENSP00000367576; ENSG00000152455 [Q9H5I1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79723

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79723

UCSC genome browser

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UCSCi
uc001ing.4 human [Q9H5I1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027067 mRNA Translation: BAB15645.1
CR457372 mRNA Translation: CAG33653.1
AC069544 Genomic DNA No translation available.
AL360083 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86254.1
CH471072 Genomic DNA Translation: EAW86253.1
CH471072 Genomic DNA Translation: EAW86255.1
CH471072 Genomic DNA Translation: EAW86256.1
BC007754 mRNA Translation: AAH07754.1
BC029360 mRNA Translation: AAH29360.1
AL834488 mRNA Translation: CAD39146.1
CCDSiCCDS53493.1 [Q9H5I1-3]
CCDS53494.1 [Q9H5I1-1]
CCDS7104.1 [Q9H5I1-2]
RefSeqiNP_001180353.1, NM_001193424.1 [Q9H5I1-1]
NP_001180354.1, NM_001193425.1 [Q9H5I1-2]
NP_001180355.1, NM_001193426.1 [Q9H5I1-3]
NP_001180356.1, NM_001193427.1
NP_078946.1, NM_024670.3 [Q9H5I1-2]
XP_006717566.1, XM_006717503.3 [Q9H5I1-2]
XP_011517964.1, XM_011519662.2 [Q9H5I1-2]
XP_016872126.1, XM_017016637.1 [Q9H5I1-2]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R3AX-ray2.00A112-410[»]
6P0RX-ray2.40A/B112-410[»]
SMRiQ9H5I1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122838, 62 interactors
IntActiQ9H5I1, 67 interactors
MINTiQ9H5I1
STRINGi9606.ENSP00000346997

Chemistry databases

BindingDBiQ9H5I1
ChEMBLiCHEMBL1795177

PTM databases

iPTMnetiQ9H5I1
PhosphoSitePlusiQ9H5I1

Polymorphism and mutation databases

BioMutaiSUV39H2
DMDMi25091325

Proteomic databases

EPDiQ9H5I1
jPOSTiQ9H5I1
MassIVEiQ9H5I1
MaxQBiQ9H5I1
PaxDbiQ9H5I1
PeptideAtlasiQ9H5I1
PRIDEiQ9H5I1
ProteomicsDBi80906 [Q9H5I1-1]
80907 [Q9H5I1-2]
80908 [Q9H5I1-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79723

Genome annotation databases

EnsembliENST00000313519; ENSP00000319208; ENSG00000152455 [Q9H5I1-2]
ENST00000354919; ENSP00000346997; ENSG00000152455 [Q9H5I1-1]
ENST00000378325; ENSP00000367576; ENSG00000152455 [Q9H5I1-3]
GeneIDi79723
KEGGihsa:79723
UCSCiuc001ing.4 human [Q9H5I1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79723
DisGeNETi79723
EuPathDBiHostDB:ENSG00000152455.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SUV39H2
HGNCiHGNC:17287 SUV39H2
HPAiHPA045901
HPA057554
MIMi606503 gene
neXtProtiNX_Q9H5I1
OpenTargetsiENSG00000152455
PharmGKBiPA134868807

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000156788
HOGENOMiHOG000231244
InParanoidiQ9H5I1
KOiK11419
OMAiPYSLCIF
OrthoDBi753093at2759
PhylomeDBiQ9H5I1
TreeFamiTF106452

Enzyme and pathway databases

ReactomeiR-HSA-3214841 PKMTs methylate histone lysines

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SUV39H2 human
EvolutionaryTraceiQ9H5I1

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SUV39H2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79723
PharosiQ9H5I1 Tbio

Protein Ontology

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PROi
PR:Q9H5I1
RNActiQ9H5I1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152455 Expressed in 150 organ(s), highest expression level in sperm
ExpressionAtlasiQ9H5I1 baseline and differential
GenevisibleiQ9H5I1 HS

Family and domain databases

InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR011381 Histone_H3-K9_MeTrfase
IPR003616 Post-SET_dom
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PIRSFiPIRSF009343 SUV39_SET, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SM00508 PostSET, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit
PS50868 POST_SET, 1 hit
PS50867 PRE_SET, 1 hit
PS51579 SAM_MT43_SUVAR39_3, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUV92_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H5I1
Secondary accession number(s): D3DRT4
, Q5JSS4, Q5JSS5, Q6I9Y3, Q8ND06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: December 11, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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