UniProtKB - Q9H5H4 (ZN768_HUMAN)
Protein
Zinc finger protein 768
Gene
ZNF768
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 261 – 283 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 289 – 311 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 339 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 429 – 451 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 457 – 479 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 513 – 535 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H5H4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 768 |
Gene namesi | Name:ZNF768 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26273, ZNF768 |
MIMi | 618032, gene |
neXtProti | NX_Q9H5H4 |
VEuPathDBi | HostDB:ENSG00000169957.9 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000169957 |
PharmGKBi | PA162410327 |
Miscellaneous databases
Pharosi | Q9H5H4, Tdark |
Genetic variation databases
BioMutai | ZNF768 |
DMDMi | 158564024 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304408 | 1 – 540 | Zinc finger protein 768Add BLAST | 540 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33 | PhosphoserineBy similarity | 1 | |
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 104 | PhosphoserineBy similarity | 1 | |
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 | |
Modified residuei | 160 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H5H4 |
jPOSTi | Q9H5H4 |
MassIVEi | Q9H5H4 |
MaxQBi | Q9H5H4 |
PaxDbi | Q9H5H4 |
PeptideAtlasi | Q9H5H4 |
PRIDEi | Q9H5H4 |
ProteomicsDBi | 80905 |
PTM databases
iPTMneti | Q9H5H4 |
PhosphoSitePlusi | Q9H5H4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169957, Expressed in apex of heart and 239 other tissues |
ExpressionAtlasi | Q9H5H4, baseline and differential |
Genevisiblei | Q9H5H4, HS |
Organism-specific databases
HPAi | ENSG00000169957, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9H5H4
Protein-protein interaction databases
BioGRIDi | 122839, 58 interactors |
IntActi | Q9H5H4, 29 interactors |
MINTi | Q9H5H4 |
STRINGi | 9606.ENSP00000369777 |
Miscellaneous databases
RNActi | Q9H5H4, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 39 | Poly-Glu | 6 | |
Compositional biasi | 55 – 140 | Pro-richAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 261 – 283 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 289 – 311 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 339 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 429 – 451 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 457 – 479 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 513 – 535 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162267 |
InParanoidi | Q9H5H4 |
OMAi | FEPQNPE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9H5H4 |
TreeFami | TF350793 |
Family and domain databases
InterProi | View protein in InterPro IPR000684, RNA_pol_II_repeat_euk IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF05001, RNA_pol_Rpb1_R, 4 hits PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9H5H4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE
60 70 80 90 100
VEEIPFGLEP QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF
110 120 130 140 150
APRSPESDSQ SPEFESQSPR YEPQSPGYEP RSPGYEPRSP GYESESSRYE
160 170 180 190 200
SQNTELKTQS PEFEAQSSKF QEGAEMLLNP EEKSPLNISV GVHPLDSFTQ
210 220 230 240 250
GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG ALRGPGRRGG
260 270 280 290 300
RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ
310 320 330 340 350
SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC
360 370 380 390 400
GKAFGDSSYL LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP
410 420 430 440 450
FSCGICGKSF SQRSALIPHA RSHAREKPFK CPECGKRFGQ SSVLAIHART
460 470 480 490 500
HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT GERPYRCAVC GKGFCRSSTL
510 520 530 540
LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BS42 | H3BS42_HUMAN | Zinc finger protein 768 | ZNF768 | 509 | Annotation score: |
Sequence cautioni
The sequence AAH13760 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH92403 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15652 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035024 | 181 | E → D1 PublicationCorresponds to variant dbSNP:rs10871453Ensembl. | 1 | |
Natural variantiVAR_052900 | 488 | A → S. Corresponds to variant dbSNP:rs3751848Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC013760 mRNA Translation: AAH13760.1 Different initiation. BC092403 mRNA Translation: AAH92403.2 Different initiation. AK027089 mRNA Translation: BAB15652.1 Different initiation. |
CCDSi | CCDS10681.2 |
RefSeqi | NP_078947.3, NM_024671.3 |
Genome annotation databases
Ensembli | ENST00000380412; ENSP00000369777; ENSG00000169957 |
GeneIDi | 79724 |
KEGGi | hsa:79724 |
UCSCi | uc002dyk.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC013760 mRNA Translation: AAH13760.1 Different initiation. BC092403 mRNA Translation: AAH92403.2 Different initiation. AK027089 mRNA Translation: BAB15652.1 Different initiation. |
CCDSi | CCDS10681.2 |
RefSeqi | NP_078947.3, NM_024671.3 |
3D structure databases
SMRi | Q9H5H4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122839, 58 interactors |
IntActi | Q9H5H4, 29 interactors |
MINTi | Q9H5H4 |
STRINGi | 9606.ENSP00000369777 |
PTM databases
iPTMneti | Q9H5H4 |
PhosphoSitePlusi | Q9H5H4 |
Genetic variation databases
BioMutai | ZNF768 |
DMDMi | 158564024 |
Proteomic databases
EPDi | Q9H5H4 |
jPOSTi | Q9H5H4 |
MassIVEi | Q9H5H4 |
MaxQBi | Q9H5H4 |
PaxDbi | Q9H5H4 |
PeptideAtlasi | Q9H5H4 |
PRIDEi | Q9H5H4 |
ProteomicsDBi | 80905 |
Protocols and materials databases
Antibodypediai | 13715, 131 antibodies |
Genome annotation databases
Ensembli | ENST00000380412; ENSP00000369777; ENSG00000169957 |
GeneIDi | 79724 |
KEGGi | hsa:79724 |
UCSCi | uc002dyk.4, human |
Organism-specific databases
CTDi | 79724 |
GeneCardsi | ZNF768 |
HGNCi | HGNC:26273, ZNF768 |
HPAi | ENSG00000169957, Low tissue specificity |
MIMi | 618032, gene |
neXtProti | NX_Q9H5H4 |
OpenTargetsi | ENSG00000169957 |
PharmGKBi | PA162410327 |
VEuPathDBi | HostDB:ENSG00000169957.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162267 |
InParanoidi | Q9H5H4 |
OMAi | FEPQNPE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9H5H4 |
TreeFami | TF350793 |
Enzyme and pathway databases
PathwayCommonsi | Q9H5H4 |
Miscellaneous databases
BioGRID-ORCSi | 79724, 4 hits in 1018 CRISPR screens |
ChiTaRSi | ZNF768, human |
GenomeRNAii | 79724 |
Pharosi | Q9H5H4, Tdark |
PROi | PR:Q9H5H4 |
RNActi | Q9H5H4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169957, Expressed in apex of heart and 239 other tissues |
ExpressionAtlasi | Q9H5H4, baseline and differential |
Genevisiblei | Q9H5H4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000684, RNA_pol_II_repeat_euk IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF05001, RNA_pol_Rpb1_R, 4 hits PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN768_HUMAN | |
Accessioni | Q9H5H4Primary (citable) accession number: Q9H5H4 Secondary accession number(s): Q569L7, Q96CX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families