Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicular inhibitory amino acid transporter

Gene

SLC32A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the uptake of GABA and glycine into the synaptic vesicles.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-888590 GABA synthesis, release, reuptake and degradation

Protein family/group databases

TCDBi2.A.18.5.4 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular inhibitory amino acid transporter
Alternative name(s):
GABA and glycine transporter
Solute carrier family 32 member 1
Vesicular GABA transporter
Short name:
hVIAAT
Gene namesi
Name:SLC32A1
Synonyms:VGAT, VIAAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101438.3
HGNCiHGNC:11018 SLC32A1
MIMi616440 gene
neXtProtiNX_Q9H598

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 133CytoplasmicSequence analysisAdd BLAST133
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 204Lumenal, vesicleSequence analysisAdd BLAST50
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 242CytoplasmicSequence analysisAdd BLAST17
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 265Lumenal, vesicleSequence analysis2
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 305CytoplasmicSequence analysisAdd BLAST19
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 341Lumenal, vesicleSequence analysisAdd BLAST15
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383CytoplasmicSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 438Lumenal, vesicleSequence analysisAdd BLAST34
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 461CytoplasmicSequence analysis2
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 489Lumenal, vesicleSequence analysis7
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 525CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140679
OpenTargetsiENSG00000101438
PharmGKBiPA401

Chemistry databases

DrugBankiDB00145 Glycine
GuidetoPHARMACOLOGYi1133

Polymorphism and mutation databases

BioMutaiSLC32A1
DMDMi29428257

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938201 – 525Vesicular inhibitory amino acid transporterAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186Nitrated tyrosineBy similarity1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Nitration

Proteomic databases

EPDiQ9H598
PaxDbiQ9H598
PeptideAtlasiQ9H598
PRIDEiQ9H598
ProteomicsDBi80902

PTM databases

iPTMnetiQ9H598
PhosphoSitePlusiQ9H598

Expressioni

Tissue specificityi

Retina. Expressed throughout the horizontal cells or more specifically at the terminals.1 Publication

Gene expression databases

BgeeiENSG00000101438
CleanExiHS_SLC32A1
GenevisibleiQ9H598 HS

Organism-specific databases

HPAiCAB037156
HPA058859
HPA059985

Interactioni

Protein-protein interaction databases

BioGridi126644, 3 interactors
IntActiQ9H598, 1 interactor
MINTiQ9H598
STRINGi9606.ENSP00000217420

Structurei

3D structure databases

ProteinModelPortaliQ9H598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4303 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00490000043380
HOGENOMiHOG000220837
HOVERGENiHBG061364
InParanoidiQ9H598
KOiK15015
OMAiNWSHIAA
OrthoDBiEOG091G05MY
PhylomeDBiQ9H598
TreeFamiTF312818

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLLRSKLS NVATSVSNKS QAKMSGMFAR MGFQAATDEE AVGFAHCDDL
60 70 80 90 100
DFEHRQGLQM DILKAEGEPC GDEGAEAPVE GDIHYQRGSG APLPPSGSKD
110 120 130 140 150
QVGGGGEFGG HDKPKITAWE AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF
160 170 180 190 200
LIIFAAVVCC YTGKILIACL YEENEDGEVV RVRDSYVAIA NACCAPRFPT
210 220 230 240 250
LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ KSWSIIATAV
260 270 280 290 300
LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY
310 320 330 340 350
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL
360 370 380 390 400
KGLFALVAYL TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA
410 420 430 440 450
AVEVLEKSLF QEGSRAFFPA CYSGDGRLKS WGLTLRCALV VFTLLMAIYV
460 470 480 490 500
PHFALLMGLT GSLTGAGLCF LLPSLFHLRL LWRKLLWHQV FFDVAIFVIG
510 520
GICSVSGFVH SLEGLIEAYR TNAED
Length:525
Mass (Da):57,415
Last modified:June 1, 2001 - v2
Checksum:iC3C4B0786B8DE745
GO

Sequence cautioni

The sequence AAH36458 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261K → R in AAH36458 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048121423S → G. Corresponds to variant dbSNP:rs34517228Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044836 mRNA Translation: AAK98782.1
AK055051 mRNA Translation: BAB70846.1
AL133519 Genomic DNA No translation available.
BC036458 mRNA Translation: AAH36458.2 Different initiation.
BC053582 mRNA Translation: AAH53582.1
CCDSiCCDS13307.1
RefSeqiNP_542119.1, NM_080552.2
UniGeneiHs.179080

Genome annotation databases

EnsembliENST00000217420; ENSP00000217420; ENSG00000101438
GeneIDi140679
KEGGihsa:140679
UCSCiuc002xjc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVIAAT_HUMAN
AccessioniPrimary (citable) accession number: Q9H598
Secondary accession number(s): Q8N489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health