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Protein

Dual specificity protein phosphatase 21

Gene

DUSP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 21 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Low molecular weight dual specificity phosphatase 21
Short name:
LMW-DSP21
Gene namesi
Name:DUSP21
Synonyms:LMWDSP21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189037.7
HGNCiHGNC:20476 DUSP21
MIMi300678 gene
neXtProtiNX_Q9H596

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi63904
OpenTargetsiENSG00000189037
PharmGKBiPA134967875

Polymorphism and mutation databases

BioMutaiDUSP21
DMDMi50400652

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948341 – 190Dual specificity protein phosphatase 21Add BLAST190

Proteomic databases

PaxDbiQ9H596
PeptideAtlasiQ9H596
PRIDEiQ9H596
ProteomicsDBi80901

PTM databases

DEPODiQ9H596
iPTMnetiQ9H596
PhosphoSitePlusiQ9H596

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000189037 Expressed in 11 organ(s), highest expression level in testis
CleanExiHS_DUSP21
GenevisibleiQ9H596 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121980, 49 interactors
IntActiQ9H596, 26 interactors
MINTiQ9H596
STRINGi9606.ENSP00000343244

Structurei

3D structure databases

ProteinModelPortaliQ9H596
SMRiQ9H596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 161Tyrosine-protein phosphataseAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 128Sufficient for mitochondrial localizationBy similarityAdd BLAST86

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1718 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233766
HOVERGENiHBG051422
InParanoidiQ9H596
KOiK14165
OMAiRMINSPV
OrthoDBiEOG091G0249
PhylomeDBiQ9H596
TreeFamiTF316009

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASASSFSS SQGVQQPSIY SFSQITRSLF LSNGVAANDK LLLSSNRITA
60 70 80 90 100
IVNASVEVVN VFFEGIQYIK VPVTDARDSR LYDFFDPIAD LIHTIDMRQG
110 120 130 140 150
RTLLHCMAGV SRSASLCLAY LMKYHSMSLL DAHTWTKSRR PIIRPNNGFW
160 170 180 190
EQLINYEFKL FNNNTVRMIN SPVGNIPDIY EKDLRMMISM
Length:190
Mass (Da):21,529
Last modified:March 1, 2001 - v1
Checksum:i3E52BA31A4944EE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190M → I in CAG33440 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035644167R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1372839121Ensembl.1
Natural variantiVAR_019423186M → T2 PublicationsCorresponds to variant dbSNP:rs1045031Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533018 mRNA Translation: AAN59788.1
AY156515 mRNA Translation: AAO17295.1
CR457159 mRNA Translation: CAG33440.1
AL133545 Genomic DNA No translation available.
BC119755 mRNA Translation: AAI19756.1
BC119756 mRNA Translation: AAI19757.1
CCDSiCCDS14264.1
RefSeqiNP_071359.3, NM_022076.3
UniGeneiHs.534478

Genome annotation databases

EnsembliENST00000339042; ENSP00000343244; ENSG00000189037
GeneIDi63904
KEGGihsa:63904
UCSCiuc004dgd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533018 mRNA Translation: AAN59788.1
AY156515 mRNA Translation: AAO17295.1
CR457159 mRNA Translation: CAG33440.1
AL133545 Genomic DNA No translation available.
BC119755 mRNA Translation: AAI19756.1
BC119756 mRNA Translation: AAI19757.1
CCDSiCCDS14264.1
RefSeqiNP_071359.3, NM_022076.3
UniGeneiHs.534478

3D structure databases

ProteinModelPortaliQ9H596
SMRiQ9H596
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121980, 49 interactors
IntActiQ9H596, 26 interactors
MINTiQ9H596
STRINGi9606.ENSP00000343244

PTM databases

DEPODiQ9H596
iPTMnetiQ9H596
PhosphoSitePlusiQ9H596

Polymorphism and mutation databases

BioMutaiDUSP21
DMDMi50400652

Proteomic databases

PaxDbiQ9H596
PeptideAtlasiQ9H596
PRIDEiQ9H596
ProteomicsDBi80901

Protocols and materials databases

DNASUi63904
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339042; ENSP00000343244; ENSG00000189037
GeneIDi63904
KEGGihsa:63904
UCSCiuc004dgd.4 human

Organism-specific databases

CTDi63904
DisGeNETi63904
EuPathDBiHostDB:ENSG00000189037.7
GeneCardsiDUSP21
HGNCiHGNC:20476 DUSP21
MIMi300678 gene
neXtProtiNX_Q9H596
OpenTargetsiENSG00000189037
PharmGKBiPA134967875
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1718 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233766
HOVERGENiHBG051422
InParanoidiQ9H596
KOiK14165
OMAiRMINSPV
OrthoDBiEOG091G0249
PhylomeDBiQ9H596
TreeFamiTF316009

Miscellaneous databases

GenomeRNAii63904
PROiPR:Q9H596
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189037 Expressed in 11 organ(s), highest expression level in testis
CleanExiHS_DUSP21
GenevisibleiQ9H596 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS21_HUMAN
AccessioniPrimary (citable) accession number: Q9H596
Secondary accession number(s): Q0VDA6, Q6IAJ6, Q6YDQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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