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Entry version 160 (11 Dec 2019)
Sequence version 2 (07 Dec 2004)
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Protein

Zinc finger protein 644

Gene

ZNF644

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri410 – 432C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 548C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri586 – 609C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri963 – 987C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1038 – 1060C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 644
Alternative name(s):
Zinc finger motif enhancer-binding protein 2
Short name:
Zep-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF644
Synonyms:KIAA1221, ZEP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122482.20

Human Gene Nomenclature Database

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HGNCi
HGNC:29222 ZNF644

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614159 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H582

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopia 21, autosomal dominant (MYP21)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073995242T → M in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143932357Ensembl.1
Natural variantiVAR_073996274E → V in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs774685437Ensembl.1
Natural variantiVAR_073997305E → K in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149597385Ensembl.1
Natural variantiVAR_073999401T → A in MYP21; unknown pathological significance. 1 Publication1
Natural variantiVAR_066389587I → V in MYP21. 1 PublicationCorresponds to variant dbSNP:rs146936371EnsemblClinVar.1
Natural variantiVAR_066390672S → G in MYP21. 2 PublicationsCorresponds to variant dbSNP:rs387907109EnsemblClinVar.1
Natural variantiVAR_066391680R → G in MYP21. 1 Publication1
Natural variantiVAR_074001683R → T in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201546602Ensembl.1
Natural variantiVAR_066392699C → Y in MYP21. 1 Publication1
Natural variantiVAR_074004851D → H in MYP21; unknown pathological significance. 1 Publication1
Natural variantiVAR_074005956T → S in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1050960158Ensembl.1
Natural variantiVAR_0740061089Y → C in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs193167060Ensembl.1
Natural variantiVAR_0740081278E → G in MYP21; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
84146

MalaCards human disease database

More...
MalaCardsi
ZNF644
MIMi614167 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000122482

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134984168

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H582 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF644

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404958

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476981 – 1327Zinc finger protein 644Add BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei199PhosphoserineCombined sources1
Cross-linki213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki263Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei309PhosphoserineCombined sources1
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki344Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki346Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki346Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki390Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki589Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki598Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki603Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki627Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki641Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki712Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki718Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki720Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki727Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki762Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki763Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki795Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki817Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei820PhosphoserineCombined sources1
Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki843Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki962Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1000PhosphoserineCombined sources1
Cross-linki1009Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1031Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1088Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1094Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1189PhosphoserineCombined sources1
Cross-linki1192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H582

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H582

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H582

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H582

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H582

PeptideAtlas

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PeptideAtlasi
Q9H582

PRoteomics IDEntifications database

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PRIDEi
Q9H582

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
80897 [Q9H582-1]
80898 [Q9H582-2]
80899 [Q9H582-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H582

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H582

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, placenta, retina and retinal pigment epithelium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122482 Expressed in 202 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H582 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H582 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123913, 59 interactors

Protein interaction database and analysis system

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IntActi
Q9H582, 53 interactors

Molecular INTeraction database

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MINTi
Q9H582

STRING: functional protein association networks

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STRINGi
9606.ENSP00000337008

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H582 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri410 – 432C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 548C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri586 – 609C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri963 – 987C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1038 – 1060C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158258

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H582

Identification of Orthologs from Complete Genome Data

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OMAi
QKFASND

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H582

TreeFam database of animal gene trees

More...
TreeFami
TF333705

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H582-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSFLQQDVN KTKSRLNVLN GLANNMDDLK INTDITGAKE ELLDDNNFIS
60 70 80 90 100
DKESGVHKPK DCQTSFQKNN TLTLPEELSK DKSENALSGG QSSLFIHAGA
110 120 130 140 150
PTVSSENFIL PKGAAVNGPV SHSSLTKTSN MNKGSVSLTT GQPVDQPTTE
160 170 180 190 200
SCSTLKVAAD LQLSTPQKAS QHQVLFLLSD VAHAKNPTHS NKKLPTSASV
210 220 230 240 250
GCDIQNSVGS NIKSDGTLIN QVEVGEDGED LLVKDDCVNT VTGISSGTDG
260 270 280 290 300
FRSENDTNWD PQKEFIQFLM TNEETVDKAP PHSKIGLEKK RKRKMDVSKI
310 320 330 340 350
TRYTEDCFSD SNCVPNKSKM QEVDFLEQNE ELQAVDSQKY ALSKVKPEST
360 370 380 390 400
DEDLESVDAF QHLIYNPDKC GEESSPVHTS TFLSNTLKKK CEESDSESPA
410 420 430 440 450
TFSTEEPSFY PCTKCNVNFR EKKHLHRHMM YHLDGNSHFR HLNVPRPYAC
460 470 480 490 500
RECGRTFRDR NSLLKHMIIH QERRQKLMEE IRELKELQDE GRSARLQCPQ
510 520 530 540 550
CVFGTNCPKT FVQHAKTHEK DKRYYCCEEC NFMAVTENEL ECHRGIAHGA
560 570 580 590 600
VVKCPMVTSD IAQRKTQKKT FMKDSVVGSS KKSATYICKM CPFTTSAKSV
610 620 630 640 650
LKKHTEYLHS SSCVDSFGSP LGLDKRKNDI LEEPVDSDST KTLTKQQSTT
660 670 680 690 700
FPKNSALKQD VKRTFGSTSQ SSSFSKIHKR PHRIQKARKS IAQSGVNMCN
710 720 730 740 750
QNSSPHKNVT IKSSVDQKPK YFHQAAKEKS NAKANSHYLY RHKYENYRMI
760 770 780 790 800
KKSGESYPVH FKKEEASSLN SLHLFSSSSN SHNNFISDPH KPDAKRPESF
810 820 830 840 850
KDHRRVAVKR VIKESKKESS VGGEDLDSYP DFLHKMTVVV LQKLNSAEKK
860 870 880 890 900
DSYETEDESS WDNVELGDYT TQAIEDETYS DINQEHVNLF PLFKSKVEGQ
910 920 930 940 950
EPGENATLSY DQNDGFYFEY YEDTGSNNFL HEIHDPQHLE TADASLSKHS
960 970 980 990 1000
SVFHWTDLSL EKKSCPYCPA TFETGVGLSN HVRGHLHRAG LSYEARHVVS
1010 1020 1030 1040 1050
PEQIATSDKM QHFKRTGTGT PVKRVRKAIE KSETTSEHTC QLCGGWFDTK
1060 1070 1080 1090 1100
IGLSNHVRGH LKRLGKTKWD AHKSPICVLN EMMQNEEKYE KILKALNSRR
1110 1120 1130 1140 1150
IIPRPFVAQK LASSDDFISQ NVIPLEAYRN GLKTEALSVS ASEEEGLNFL
1160 1170 1180 1190 1200
NEYDETKPEL PSGKKNQSLT LIELLKNKRM GEERNSAISP QKIHNQTARK
1210 1220 1230 1240 1250
RFVQKCVLPL NEDSPLMYQP QKMDLTMHSA LDCKQKKSRS RSGSKKKMLT
1260 1270 1280 1290 1300
LPHGADEVYI LRCRFCGLVF RGPLSVQEDW IKHLQRHIVN ANLPRTGAGM
1310 1320
VEVTSLLKKP ASITETSFSL LMAEAAS
Length:1,327
Mass (Da):149,565
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53CE36BE21FC5056
GO
Isoform 2 (identifier: Q9H582-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1230-1232: ALD → GLI
     1233-1327: Missing.

Show »
Length:1,232
Mass (Da):139,012
Checksum:i50D719F07AF12CBA
GO
Isoform 3 (identifier: Q9H582-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1222: Missing.
     1223-1229: MDLTMHS → MLIRQNL

Show »
Length:105
Mass (Da):11,724
Checksum:i237D95A0CC5CAD1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZL9A0A087WZL9_HUMAN
Zinc finger protein 644
ZNF644
650Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti296D → M in BAD32777 (Ref. 1) Curated1
Sequence conflicti1125L → P in BAD32777 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03559353E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_073995242T → M in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs143932357Ensembl.1
Natural variantiVAR_073996274E → V in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs774685437Ensembl.1
Natural variantiVAR_073997305E → K in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149597385Ensembl.1
Natural variantiVAR_073998369K → M Polymorphism. 1 Publication1
Natural variantiVAR_073999401T → A in MYP21; unknown pathological significance. 1 Publication1
Natural variantiVAR_074000550A → T Polymorphism. 1 PublicationCorresponds to variant dbSNP:rs754440728Ensembl.1
Natural variantiVAR_052885556M → V. Corresponds to variant dbSNP:rs17131242Ensembl.1
Natural variantiVAR_066389587I → V in MYP21. 1 PublicationCorresponds to variant dbSNP:rs146936371EnsemblClinVar.1
Natural variantiVAR_066390672S → G in MYP21. 2 PublicationsCorresponds to variant dbSNP:rs387907109EnsemblClinVar.1
Natural variantiVAR_066391680R → G in MYP21. 1 Publication1
Natural variantiVAR_074001683R → T in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201546602Ensembl.1
Natural variantiVAR_066392699C → Y in MYP21. 1 Publication1
Natural variantiVAR_074002706H → Y1 PublicationCorresponds to variant dbSNP:rs908368905Ensembl.1
Natural variantiVAR_074003707K → E1 PublicationCorresponds to variant dbSNP:rs12117237Ensembl.1
Natural variantiVAR_052886794A → V. Corresponds to variant dbSNP:rs10922938Ensembl.1
Natural variantiVAR_074004851D → H in MYP21; unknown pathological significance. 1 Publication1
Natural variantiVAR_074005956T → S in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1050960158Ensembl.1
Natural variantiVAR_0740061089Y → C in MYP21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs193167060Ensembl.1
Natural variantiVAR_0740071100R → H1 PublicationCorresponds to variant dbSNP:rs140271599Ensembl.1
Natural variantiVAR_0740081278E → G in MYP21; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0158551 – 1222Missing in isoform 3. 2 PublicationsAdd BLAST1222
Alternative sequenceiVSP_0158561223 – 1229MDLTMHS → MLIRQNL in isoform 3. 2 Publications7
Alternative sequenceiVSP_0121581230 – 1232ALD → GLI in isoform 2. 1 Publication3
Alternative sequenceiVSP_0121591233 – 1327Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019255 mRNA Translation: BAD32777.1
AK291520 mRNA Translation: BAF84209.1
AL136109 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73118.1
BC050656 mRNA Translation: AAH50656.1
BC063683 mRNA Translation: AAH63683.2
BC110841 mRNA Translation: AAI10842.1
BC132776 mRNA Translation: AAI32777.1
BC132778 mRNA Translation: AAI32779.1
AB033047 mRNA Translation: BAA86535.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS731.1 [Q9H582-1]
CCDS732.1 [Q9H582-3]

NCBI Reference Sequences

More...
RefSeqi
NP_057704.2, NM_016620.3 [Q9H582-3]
NP_115562.3, NM_032186.4 [Q9H582-3]
NP_958357.1, NM_201269.2 [Q9H582-1]
XP_016857977.1, XM_017002488.1 [Q9H582-1]
XP_016857978.1, XM_017002489.1 [Q9H582-1]
XP_016857979.1, XM_017002490.1 [Q9H582-1]
XP_016857980.1, XM_017002491.1 [Q9H582-1]
XP_016857981.1, XM_017002492.1 [Q9H582-3]
XP_016857982.1, XM_017002493.1 [Q9H582-3]
XP_016857983.1, XM_017002494.1 [Q9H582-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337393; ENSP00000337008; ENSG00000122482 [Q9H582-1]
ENST00000347275; ENSP00000340828; ENSG00000122482 [Q9H582-3]
ENST00000361321; ENSP00000354659; ENSG00000122482 [Q9H582-3]
ENST00000370440; ENSP00000359469; ENSG00000122482 [Q9H582-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84146

UCSC genome browser

More...
UCSCi
uc001dnv.4 human [Q9H582-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019255 mRNA Translation: BAD32777.1
AK291520 mRNA Translation: BAF84209.1
AL136109 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73118.1
BC050656 mRNA Translation: AAH50656.1
BC063683 mRNA Translation: AAH63683.2
BC110841 mRNA Translation: AAI10842.1
BC132776 mRNA Translation: AAI32777.1
BC132778 mRNA Translation: AAI32779.1
AB033047 mRNA Translation: BAA86535.1
CCDSiCCDS731.1 [Q9H582-1]
CCDS732.1 [Q9H582-3]
RefSeqiNP_057704.2, NM_016620.3 [Q9H582-3]
NP_115562.3, NM_032186.4 [Q9H582-3]
NP_958357.1, NM_201269.2 [Q9H582-1]
XP_016857977.1, XM_017002488.1 [Q9H582-1]
XP_016857978.1, XM_017002489.1 [Q9H582-1]
XP_016857979.1, XM_017002490.1 [Q9H582-1]
XP_016857980.1, XM_017002491.1 [Q9H582-1]
XP_016857981.1, XM_017002492.1 [Q9H582-3]
XP_016857982.1, XM_017002493.1 [Q9H582-3]
XP_016857983.1, XM_017002494.1 [Q9H582-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123913, 59 interactors
IntActiQ9H582, 53 interactors
MINTiQ9H582
STRINGi9606.ENSP00000337008

PTM databases

iPTMnetiQ9H582
PhosphoSitePlusiQ9H582

Polymorphism and mutation databases

BioMutaiZNF644
DMDMi56404958

Proteomic databases

EPDiQ9H582
jPOSTiQ9H582
MassIVEiQ9H582
MaxQBiQ9H582
PaxDbiQ9H582
PeptideAtlasiQ9H582
PRIDEiQ9H582
ProteomicsDBi80897 [Q9H582-1]
80898 [Q9H582-2]
80899 [Q9H582-3]

Genome annotation databases

EnsembliENST00000337393; ENSP00000337008; ENSG00000122482 [Q9H582-1]
ENST00000347275; ENSP00000340828; ENSG00000122482 [Q9H582-3]
ENST00000361321; ENSP00000354659; ENSG00000122482 [Q9H582-3]
ENST00000370440; ENSP00000359469; ENSG00000122482 [Q9H582-1]
GeneIDi84146
KEGGihsa:84146
UCSCiuc001dnv.4 human [Q9H582-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84146
DisGeNETi84146
EuPathDBiHostDB:ENSG00000122482.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF644
HGNCiHGNC:29222 ZNF644
HPAiHPA057795
MalaCardsiZNF644
MIMi614159 gene
614167 phenotype
neXtProtiNX_Q9H582
OpenTargetsiENSG00000122482
PharmGKBiPA134984168

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158258
InParanoidiQ9H582
OMAiQKFASND
OrthoDBi1318335at2759
PhylomeDBiQ9H582
TreeFamiTF333705

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF644 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZNF644

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84146
PharosiQ9H582 Tbio

Protein Ontology

More...
PROi
PR:Q9H582
RNActiQ9H582 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122482 Expressed in 202 organ(s), highest expression level in intestine
ExpressionAtlasiQ9H582 baseline and differential
GenevisibleiQ9H582 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN644_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H582
Secondary accession number(s): A2RU71
, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9ULJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: December 11, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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