UniProtKB - Q9H579 (MROH8_HUMAN)

BLAST

>sp|Q9H579|MROH8_HUMAN Protein MROH8 OS=Homo sapiens OX=9606 GN=MROH8 PE=2 SV=2
MSSKHRICSQEEVVIPCAYDSDSESVDLELSNLEIIKKGSSSIELTDLDIPDIPGLHCEP
LSHSPRHLTQQDPLSEAIVEKLIQSIQKVFNGELKGELEKLKFLGDLSSLSQALPYDETA
KSFIHSHIADIVHTLNVLVQEERPHSLSSSMRQEVFVTIADLSYQDVHLLLGSEDRAELF
SLTIKSIITLPSVRTLTQIQEIMPNGTCNTECLYRQTFQAFSEMLQSLVVKDPHLENLDT
IIKLPLRFQRLGHLVALMALLCGDPQEKVAEEAAEGIHSLLHITLRLKYITHDKKDQQNL
KRALTKCREFLELHSSAAKCFYNCPFRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCI
QRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSIISQPRVRQQIINTVSLFISRPKYTD
IVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVA
VSP

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History
Entry version 110 (12 Sep 2018)
Sequence version 2 (01 Feb 2003)
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Protein

Protein MROH8

Gene

MROH8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein MROH8 Alternative name(s): Maestro heat-like repeat-containing protein family member 8
Gene namesⁱ	Name:MROH8 Synonyms:C20orf131, C20orf132
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101353.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16125 MROH8
neXtProtⁱ	NX_Q9H579

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	140699
PharmGKBⁱ	PA25674

Polymorphism and mutation databases

BioMutaⁱ	MROH8
DMDMⁱ	28201794

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079462	1 – 483	Protein MROH8Add BLAST		483

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q9H579
PRIDEⁱ	Q9H579
ProteomicsDBⁱ	80895 80896 [Q9H579-2]

PTM databases

iPTMnetⁱ	Q9H579

iPTMnetⁱ

Q9H579

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101353 Expressed in 125 organ(s), highest expression level in testis
CleanExⁱ	HS_C20orf132
ExpressionAtlasⁱ	Q9H579 baseline and differential
Genevisibleⁱ	Q9H579 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060298

HPAⁱ

HPA060298

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	126660, 2 interactors

BioGridⁱ

126660, 2 interactors

Family & Domainsⁱ

Phylogenomic databases

HOVERGENⁱ	HBG051196
InParanoidⁱ	Q9H579
PhylomeDBⁱ	Q9H579

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H579-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI 
        60         70         80         90        100
PDIPGLHCEP LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK 
       110        120        130        140        150
LKFLGDLSSL SQALPYDETA KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS 
       160        170        180        190        200
MRQEVFVTIA DLSYQDVHLL LGSEDRAELF SLTIKSIITL PSVRTLTQIQ 
       210        220        230        240        250
EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT IIKLPLRFQR 
       260        270        280        290        300
LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL 
       310        320        330        340        350
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD 
       360        370        380        390        400
TLKTLKHPCI QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR 
       410        420        430        440        450
VRQQIINTVS LFISRPKYTD IVLSFLLCHP VPYNRHLAEV WRMLSVELPS 
       460        470        480 
TTWILWRLLR KLQKCHNEPA QEKMAYVAVA VSP

Length:483

Mass (Da):54,816

Last modified:February 1, 2003 - v2

Checksum:ⁱ1B1F8EC547A88352

Isoform 2 (identifier: Q9H579-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
331-381: Missing.
481-483: VSP → ATDALYEVFL...LQKLMGRSSA

« Hide

        10         20         30         40         50
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI 
        60         70         80         90        100
PDIPGLHCEP LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK 
       110        120        130        140        150
LKFLGDLSSL SQALPYDETA KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS 
       160        170        180        190        200
MRQEVFVTIA DLSYQDVHLL LGSEDRAELF SLTIKSIITL PSVRTLTQIQ 
       210        220        230        240        250
EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT IIKLPLRFQR 
       260        270        280        290        300
LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL 
       310        320        330        340        350
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VPEIMGVICA QLSIISQPRV 
       360        370        380        390        400
RQQIINTVSL FISRPKYTDI VLSFLLCHPV PYNRHLAEVW RMLSVELPST 
       410        420        430        440        450
TWILWRLLRK LQKCHNEPAQ EKMAYVAVAA TDALYEVFLG NRLRAATFRL 
       460        470        480        490        500
FPQLLMTLLI QIHHSIGLTM SDVDIPSGLY TEQEVPSEVT PLCFAMQATK 
       510        520        530        540        550
TLLLRTCCLQ EFNIMEKNKG WALLGGKDGH LQGLFLLANA LLERNQLLAQ 
       560        570        580        590        600
KVMYLLVPLL NRGNDKHKLT SAGSFVELLR SPVAKRLPSI YSVARFKDWL 
       610        620        630        640        650
QDGNHLFRIL GLRGLYNLVG HQEMREDIKS LLPYIVDSLR ETDEKIVLSA 
       660        670        680        690        700
IQILLQLVRT MDFTTLAAMM RTLFSLFGDV RSDVHRFSVT LFGAAIKSVK 
       710        720        730        740        750
NPDKKSIENQ VLDSLVPLLL YSQDENDAVA EESRQVLTIC AQFLKWKLPQ 
       760        770        780        790        800
EVYSKDPWHI KPTEAGTICR FFEKKCKGKI NILEQTLMYS KNPKLPIRRS 
       810        820        830        840        850
AVLFVGLLSK YMDHNELRRM GTDWIEDDLR DLLCDPEPSL CIIASQTLLL 
       860        870 
VQMARAEPKP KQRVNWLQKL MGRSSA

Note: No experimental confirmation available.

Show »

Length:876

Mass (Da):99,626

Checksum:ⁱ1B0EF63288B685FD

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y2W4	H0Y2W4_HUMAN	Protein MROH8 Protein MROH8	MROH8	1,069	Annotation score:
E7ETR9	E7ETR9_HUMAN	Protein MROH8 Protein MROH8	MROH8	946	Annotation score:
H0Y7Y5	H0Y7Y5_HUMAN	Protein MROH8 Protein MROH8	MROH8	670	Annotation score:
H0Y3S5	H0Y3S5_HUMAN	Protein MROH8 Protein MROH8	MROH8	629	Annotation score:
Q5JYR0	Q5JYR0_HUMAN	Protein MROH8 Protein MROH8	MROH8	34	Annotation score:
Q5JYQ9	Q5JYQ9_HUMAN	Protein MROH8 Protein MROH8	MROH8	24	Annotation score:

Sequence cautionⁱ

The sequence BAC04162 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	354	T → N in BAC04162 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003821	331 – 381	Missing in isoform 2. 1 PublicationAdd BLAST		51
Alternative sequenceⁱVSP_003822	481 – 483	VSP → ATDALYEVFLGNRLRAATFR LFPQLLMTLLIQIHHSIGLT MSDVDIPSGLYTEQEVPSEV TPLCFAMQATKTLLLRTCCL QEFNIMEKNKGWALLGGKDG HLQGLFLLANALLERNQLLA QKVMYLLVPLLNRGNDKHKL TSAGSFVELLRSPVAKRLPS IYSVARFKDWLQDGNHLFRI LGLRGLYNLVGHQEMREDIK SLLPYIVDSLRETDEKIVLS AIQILLQLVRTMDFTTLAAM MRTLFSLFGDVRSDVHRFSV TLFGAAIKSVKNPDKKSIEN QVLDSLVPLLLYSQDENDAV AEESRQVLTICAQFLKWKLP QEVYSKDPWHIKPTEAGTIC RFFEKKCKGKINILEQTLMY SKNPKLPIRRSAVLFVGLLS KYMDHNELRRMGTDWIEDDL RDLLCDPEPSLCIIASQTLL LVQMARAEPKPKQRVNWLQK LMGRSSA in isoform 2. 1 Publication		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093432 mRNA Translation: BAC04162.1 Different initiation. AL031659 Genomic DNA No translation available. AL136172 Genomic DNA No translation available. AL833864 mRNA Translation: CAD38722.1
NCBI Reference Sequences More...RefSeqⁱ	NP_689716.4, NM_152503.5 NP_998796.1, NM_213631.2 NP_998797.2, NM_213632.2
UniGeneⁱ	Hs.349125

Genome annotation databases

Ensemblⁱ	ENST00000421643; ENSP00000413544; ENSG00000101353
GeneIDⁱ	140699
KEGGⁱ	hsa:140699
UCSC genome browser More...UCSCⁱ	uc061wux.1 human [Q9H579-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9H579	MROH8 isoform 5 (Fragment)		PONAB		603	UniRef90_Q9H579
MROH8 isoform 2 (Fragment)		PANTR		599
UPI00039059D9		HUMAN		573
UPI00020A9E3E		NOMLE		573
UPI0004F082D5		PANPA		573
+2
Q9H579-2	MROH8 isoform 7 (Fragment)		PANTR		669	UniRef90_Q9H579-2
UPI00062A934D		NOMLE		966
UPI000D09B202		PANTR		966

Protein	Similar proteins		Species	Score	Length	Source
Q9H579	MROH8 isoform 5 (Fragment)		PONAB		603	UniRef50_Q9H579
MROH8 isoform 2 (Fragment)		PANTR		599
UPI00039059D9		HUMAN		573
UPI00020A9E3E		NOMLE		573
UPI0004F082D5		PANPA		573
+14
Q9H579-2	MROH8 isoform 7 (Fragment)		PANTR		669	UniRef50_Q9H579-2
protein MROH8 isoform X5		Enhydra lutris kenyoni		1006
Maestro heat like repeat family member 8		MUSPF		1053
protein MROH8		ODORO		1052
LOW QUALITY PROTEIN: protein MROH8		URSMA		963
+240

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093432 mRNA Translation: BAC04162.1 Different initiation. AL031659 Genomic DNA No translation available. AL136172 Genomic DNA No translation available. AL833864 mRNA Translation: CAD38722.1
RefSeqⁱ	NP_689716.4, NM_152503.5 NP_998796.1, NM_213631.2 NP_998797.2, NM_213632.2
UniGeneⁱ	Hs.349125

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126660, 2 interactors

BioGridⁱ

126660, 2 interactors

PTM databases

iPTMnetⁱ	Q9H579

iPTMnetⁱ

Q9H579

Polymorphism and mutation databases

BioMutaⁱ	MROH8
DMDMⁱ	28201794

Proteomic databases

PeptideAtlasⁱ	Q9H579
PRIDEⁱ	Q9H579
ProteomicsDBⁱ	80895 80896 [Q9H579-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	140699
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000421643; ENSP00000413544; ENSG00000101353
GeneIDⁱ	140699
KEGGⁱ	hsa:140699
UCSCⁱ	uc061wux.1 human [Q9H579-1]

Organism-specific databases

CTDⁱ	140699
DisGeNETⁱ	140699
EuPathDBⁱ	HostDB:ENSG00000101353.14
GeneCardsⁱ	MROH8
H-InvDBⁱ	HIX0015790
HGNCⁱ	HGNC:16125 MROH8
HPAⁱ	HPA060298
neXtProtⁱ	NX_Q9H579
PharmGKBⁱ	PA25674
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG051196
InParanoidⁱ	Q9H579
PhylomeDBⁱ	Q9H579

Miscellaneous databases

ChiTaRSⁱ	MROH8 human
GeneWikiⁱ	C20orf132
GenomeRNAiⁱ	140699
Protein Ontology More...PROⁱ	PR:Q9H579

Gene expression databases

Bgeeⁱ	ENSG00000101353 Expressed in 125 organ(s), highest expression level in testis
CleanExⁱ	HS_C20orf132
ExpressionAtlasⁱ	Q9H579 baseline and differential
Genevisibleⁱ	Q9H579 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MROH8_HUMAN
Accessionⁱ	Q9H579Primary (citable) accession number: Q9H579 Secondary accession number(s): Q5JYQ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	February 1, 2003
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H579 (MROH8_HUMAN)

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Protein MROH8

MROH8

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ