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Entry version 125 (07 Apr 2021)
Sequence version 2 (01 Feb 2003)
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Protein

Protein MROH8

Gene

MROH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H579

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MROH8
Alternative name(s):
Maestro heat-like repeat-containing protein family member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MROH8
Synonyms:C20orf131, C20orf132
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16125, MROH8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H579

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000101353.14

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H579, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MROH8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
28201794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794621 – 483Protein MROH8Add BLAST483

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H579

PeptideAtlas

More...
PeptideAtlasi
Q9H579

PRoteomics IDEntifications database

More...
PRIDEi
Q9H579

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80895 [Q9H579-1]
80896 [Q9H579-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H579

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101353, Expressed in testis and 149 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H579, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H579, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000101353, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126660, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339971

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H579, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2032, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H579

Identification of Orthologs from Complete Genome Data

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OMAi
RMKGTDW

Database of Orthologous Groups

More...
OrthoDBi
31329at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H579

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI
60 70 80 90 100
PDIPGLHCEP LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK
110 120 130 140 150
LKFLGDLSSL SQALPYDETA KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS
160 170 180 190 200
MRQEVFVTIA DLSYQDVHLL LGSEDRAELF SLTIKSIITL PSVRTLTQIQ
210 220 230 240 250
EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT IIKLPLRFQR
260 270 280 290 300
LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL
310 320 330 340 350
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD
360 370 380 390 400
TLKTLKHPCI QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR
410 420 430 440 450
VRQQIINTVS LFISRPKYTD IVLSFLLCHP VPYNRHLAEV WRMLSVELPS
460 470 480
TTWILWRLLR KLQKCHNEPA QEKMAYVAVA VSP
Length:483
Mass (Da):54,816
Last modified:February 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B1F8EC547A88352
GO
Isoform 2 (identifier: Q9H579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-381: Missing.
     481-483: VSP → ATDALYEVFL...LQKLMGRSSA

Show »
Length:876
Mass (Da):99,626
Checksum:i1B0EF63288B685FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7Y5H0Y7Y5_HUMAN
Protein MROH8
MROH8
670Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JYQ9Q5JYQ9_HUMAN
Protein MROH8
MROH8
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04162 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti354T → N in BAC04162 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003821331 – 381Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_003822481 – 483VSP → ATDALYEVFLGNRLRAATFR LFPQLLMTLLIQIHHSIGLT MSDVDIPSGLYTEQEVPSEV TPLCFAMQATKTLLLRTCCL QEFNIMEKNKGWALLGGKDG HLQGLFLLANALLERNQLLA QKVMYLLVPLLNRGNDKHKL TSAGSFVELLRSPVAKRLPS IYSVARFKDWLQDGNHLFRI LGLRGLYNLVGHQEMREDIK SLLPYIVDSLRETDEKIVLS AIQILLQLVRTMDFTTLAAM MRTLFSLFGDVRSDVHRFSV TLFGAAIKSVKNPDKKSIEN QVLDSLVPLLLYSQDENDAV AEESRQVLTICAQFLKWKLP QEVYSKDPWHIKPTEAGTIC RFFEKKCKGKINILEQTLMY SKNPKLPIRRSAVLFVGLLS KYMDHNELRRMGTDWIEDDL RDLLCDPEPSLCIIASQTLL LVQMARAEPKPKQRVNWLQK LMGRSSA in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK093432 mRNA Translation: BAC04162.1 Different initiation.
AL031659 Genomic DNA No translation available.
AL136172 Genomic DNA No translation available.
AL833864 mRNA Translation: CAD38722.1

NCBI Reference Sequences

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RefSeqi
NP_689716.4, NM_152503.5
NP_998796.1, NM_213631.2
NP_998797.2, NM_213632.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
140699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140699

UCSC genome browser

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UCSCi
uc061wux.1, human [Q9H579-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093432 mRNA Translation: BAC04162.1 Different initiation.
AL031659 Genomic DNA No translation available.
AL136172 Genomic DNA No translation available.
AL833864 mRNA Translation: CAD38722.1
RefSeqiNP_689716.4, NM_152503.5
NP_998796.1, NM_213631.2
NP_998797.2, NM_213632.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126660, 4 interactors
STRINGi9606.ENSP00000339971

PTM databases

iPTMnetiQ9H579

Genetic variation databases

BioMutaiMROH8
DMDMi28201794

Proteomic databases

MassIVEiQ9H579
PeptideAtlasiQ9H579
PRIDEiQ9H579
ProteomicsDBi80895 [Q9H579-1]
80896 [Q9H579-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26648, 83 antibodies

The DNASU plasmid repository

More...
DNASUi
140699

Genome annotation databases

GeneIDi140699
KEGGihsa:140699
UCSCiuc061wux.1, human [Q9H579-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140699
DisGeNETi140699

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MROH8
HGNCiHGNC:16125, MROH8
HPAiENSG00000101353, Tissue enhanced (testis)
neXtProtiNX_Q9H579
PharmGKBiPA25674
VEuPathDBiHostDB:ENSG00000101353.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2032, Eukaryota
InParanoidiQ9H579
OMAiRMKGTDW
OrthoDBi31329at2759
PhylomeDBiQ9H579

Enzyme and pathway databases

PathwayCommonsiQ9H579

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
140699, 6 hits in 188 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MROH8, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C20orf132

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140699
PharosiQ9H579, Tdark

Protein Ontology

More...
PROi
PR:Q9H579
RNActiQ9H579, protein

Gene expression databases

BgeeiENSG00000101353, Expressed in testis and 149 other tissues
ExpressionAtlasiQ9H579, baseline and differential
GenevisibleiQ9H579, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMROH8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H579
Secondary accession number(s): Q5JYQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: April 7, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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