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Protein

Protein MROH8

Gene

MROH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MROH8
Alternative name(s):
Maestro heat-like repeat-containing protein family member 8
Gene namesi
Name:MROH8
Synonyms:C20orf131, C20orf132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101353.14
HGNCiHGNC:16125 MROH8
neXtProtiNX_Q9H579

Pathology & Biotechi

Organism-specific databases

DisGeNETi140699
PharmGKBiPA25674

Polymorphism and mutation databases

BioMutaiMROH8
DMDMi28201794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794621 – 483Protein MROH8Add BLAST483

Proteomic databases

PeptideAtlasiQ9H579
PRIDEiQ9H579
ProteomicsDBi80895
80896 [Q9H579-2]

PTM databases

iPTMnetiQ9H579

Expressioni

Gene expression databases

BgeeiENSG00000101353 Expressed in 125 organ(s), highest expression level in testis
CleanExiHS_C20orf132
ExpressionAtlasiQ9H579 baseline and differential
GenevisibleiQ9H579 HS

Organism-specific databases

HPAiHPA060298

Interactioni

Protein-protein interaction databases

BioGridi126660, 2 interactors

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG051196
InParanoidiQ9H579
PhylomeDBiQ9H579

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI
60 70 80 90 100
PDIPGLHCEP LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK
110 120 130 140 150
LKFLGDLSSL SQALPYDETA KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS
160 170 180 190 200
MRQEVFVTIA DLSYQDVHLL LGSEDRAELF SLTIKSIITL PSVRTLTQIQ
210 220 230 240 250
EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT IIKLPLRFQR
260 270 280 290 300
LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL
310 320 330 340 350
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD
360 370 380 390 400
TLKTLKHPCI QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR
410 420 430 440 450
VRQQIINTVS LFISRPKYTD IVLSFLLCHP VPYNRHLAEV WRMLSVELPS
460 470 480
TTWILWRLLR KLQKCHNEPA QEKMAYVAVA VSP
Length:483
Mass (Da):54,816
Last modified:February 1, 2003 - v2
Checksum:i1B1F8EC547A88352
GO
Isoform 2 (identifier: Q9H579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-381: Missing.
     481-483: VSP → ATDALYEVFL...LQKLMGRSSA

Note: No experimental confirmation available.
Show »
Length:876
Mass (Da):99,626
Checksum:i1B0EF63288B685FD
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y2W4H0Y2W4_HUMAN
Protein MROH8
MROH8
1,069Annotation score:
E7ETR9E7ETR9_HUMAN
Protein MROH8
MROH8
946Annotation score:
H0Y7Y5H0Y7Y5_HUMAN
Protein MROH8
MROH8
670Annotation score:
H0Y3S5H0Y3S5_HUMAN
Protein MROH8
MROH8
629Annotation score:
Q5JYR0Q5JYR0_HUMAN
Protein MROH8
MROH8
34Annotation score:
Q5JYQ9Q5JYQ9_HUMAN
Protein MROH8
MROH8
24Annotation score:

Sequence cautioni

The sequence BAC04162 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354T → N in BAC04162 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003821331 – 381Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_003822481 – 483VSP → ATDALYEVFLGNRLRAATFR LFPQLLMTLLIQIHHSIGLT MSDVDIPSGLYTEQEVPSEV TPLCFAMQATKTLLLRTCCL QEFNIMEKNKGWALLGGKDG HLQGLFLLANALLERNQLLA QKVMYLLVPLLNRGNDKHKL TSAGSFVELLRSPVAKRLPS IYSVARFKDWLQDGNHLFRI LGLRGLYNLVGHQEMREDIK SLLPYIVDSLRETDEKIVLS AIQILLQLVRTMDFTTLAAM MRTLFSLFGDVRSDVHRFSV TLFGAAIKSVKNPDKKSIEN QVLDSLVPLLLYSQDENDAV AEESRQVLTICAQFLKWKLP QEVYSKDPWHIKPTEAGTIC RFFEKKCKGKINILEQTLMY SKNPKLPIRRSAVLFVGLLS KYMDHNELRRMGTDWIEDDL RDLLCDPEPSLCIIASQTLL LVQMARAEPKPKQRVNWLQK LMGRSSA in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093432 mRNA Translation: BAC04162.1 Different initiation.
AL031659 Genomic DNA No translation available.
AL136172 Genomic DNA No translation available.
AL833864 mRNA Translation: CAD38722.1
RefSeqiNP_689716.4, NM_152503.5
NP_998796.1, NM_213631.2
NP_998797.2, NM_213632.2
UniGeneiHs.349125

Genome annotation databases

EnsembliENST00000421643; ENSP00000413544; ENSG00000101353
GeneIDi140699
KEGGihsa:140699
UCSCiuc061wux.1 human [Q9H579-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093432 mRNA Translation: BAC04162.1 Different initiation.
AL031659 Genomic DNA No translation available.
AL136172 Genomic DNA No translation available.
AL833864 mRNA Translation: CAD38722.1
RefSeqiNP_689716.4, NM_152503.5
NP_998796.1, NM_213631.2
NP_998797.2, NM_213632.2
UniGeneiHs.349125

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126660, 2 interactors

PTM databases

iPTMnetiQ9H579

Polymorphism and mutation databases

BioMutaiMROH8
DMDMi28201794

Proteomic databases

PeptideAtlasiQ9H579
PRIDEiQ9H579
ProteomicsDBi80895
80896 [Q9H579-2]

Protocols and materials databases

DNASUi140699
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421643; ENSP00000413544; ENSG00000101353
GeneIDi140699
KEGGihsa:140699
UCSCiuc061wux.1 human [Q9H579-1]

Organism-specific databases

CTDi140699
DisGeNETi140699
EuPathDBiHostDB:ENSG00000101353.14
GeneCardsiMROH8
H-InvDBiHIX0015790
HGNCiHGNC:16125 MROH8
HPAiHPA060298
neXtProtiNX_Q9H579
PharmGKBiPA25674
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG051196
InParanoidiQ9H579
PhylomeDBiQ9H579

Miscellaneous databases

ChiTaRSiMROH8 human
GeneWikiiC20orf132
GenomeRNAii140699
PROiPR:Q9H579

Gene expression databases

BgeeiENSG00000101353 Expressed in 125 organ(s), highest expression level in testis
CleanExiHS_C20orf132
ExpressionAtlasiQ9H579 baseline and differential
GenevisibleiQ9H579 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMROH8_HUMAN
AccessioniPrimary (citable) accession number: Q9H579
Secondary accession number(s): Q5JYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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