Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-like protein 8

Gene

ACTL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB

Enzyme and pathway databases

SignaLinkiQ9H568

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 8
Alternative name(s):
Cancer/testis antigen 57
Short name:
CT57
Gene namesi
Name:ACTL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117148.7
HGNCiHGNC:24018 ACTL8
neXtProtiNX_Q9H568

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi81569
OpenTargetsiENSG00000117148
PharmGKBiPA142672644

Polymorphism and mutation databases

BioMutaiACTL8
DMDMi74752665

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861711 – 366Actin-like protein 8Add BLAST366

Proteomic databases

EPDiQ9H568
MaxQBiQ9H568
PaxDbiQ9H568
PeptideAtlasiQ9H568
PRIDEiQ9H568
ProteomicsDBi80894

PTM databases

iPTMnetiQ9H568
PhosphoSitePlusiQ9H568

Expressioni

Tissue specificityi

Strongly expressed in testis and pancreas. Weak expression in placenta.1 Publication

Gene expression databases

BgeeiENSG00000117148 Expressed in 32 organ(s), highest expression level in oocyte
CleanExiHS_ACTL8
GenevisibleiQ9H568 HS

Organism-specific databases

HPAiHPA027176

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
COL4A3BPQ9Y5P43EBI-10306917,EBI-739994

Protein-protein interaction databases

BioGridi123530, 23 interactors
IntActiQ9H568, 23 interactors
STRINGi9606.ENSP00000364555

Structurei

3D structure databases

ProteinModelPortaliQ9H568
SMRiQ9H568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00910000144135
HOGENOMiHOG000233340
HOVERGENiHBG094566
InParanoidiQ9H568
OMAiCRENPGP
OrthoDBiEOG091G08US
PhylomeDBiQ9H568
TreeFamiTF340354

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARTVIIDH GSGFLKAGTA GWNEPQMVFP NIVNYLPCKE NPGPSYARRR
60 70 80 90 100
VSLGIDICHP DTFSYPIERG RILNWEGVQY LWSFVLENHR REQEVPPVII
110 120 130 140 150
TETPLREPAD RKKMLEILFE LLHVPSVLLA DQLQMSLYAS GLLTGVVVDS
160 170 180 190 200
GYGLTRVQPF HQGRPLPASG KTLEFAGQDL SAYLLKSLFK EDCDRRCLFQ
210 220 230 240 250
LETVAVTQMN KCYVPQNLGE ALDFRERQQS ALDESNTYQL PDGSRVELTP
260 270 280 290 300
MQRVAPEMFF SPQVFEQPGP SIPRAIVESV ESCEISLRPL LVSHVMACGG
310 320 330 340 350
NTLYPGFTKR LFRELMGDHV SSTKATVWEG SNRNFSVWLG ASVVAHLSTY
360
QSEWMSREEY GEHMRM
Length:366
Mass (Da):41,360
Last modified:March 1, 2001 - v1
Checksum:iBCCFC1E5CDC1C8FB
GO

Sequence cautioni

The sequence AAA62476 differs from that shown. Reason: Frameshift at positions 30, 49, 110, 127, 141, 344, 347 and 354.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0320793A → S2 PublicationsCorresponds to variant dbSNP:rs694214Ensembl.1
Natural variantiVAR_032080245R → C. Corresponds to variant dbSNP:rs3795322Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20582 mRNA Translation: AAA62476.1 Frameshift.
AK057339 mRNA Translation: BAB71434.1
AL136529 Genomic DNA No translation available.
BC028909 mRNA Translation: AAH28909.1
CCDSiCCDS183.1
RefSeqiNP_110439.2, NM_030812.2
XP_011540514.1, XM_011542212.2
UniGeneiHs.2149

Genome annotation databases

EnsembliENST00000375406; ENSP00000364555; ENSG00000117148
ENST00000617065; ENSP00000481590; ENSG00000117148
GeneIDi81569
KEGGihsa:81569
UCSCiuc001bat.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20582 mRNA Translation: AAA62476.1 Frameshift.
AK057339 mRNA Translation: BAB71434.1
AL136529 Genomic DNA No translation available.
BC028909 mRNA Translation: AAH28909.1
CCDSiCCDS183.1
RefSeqiNP_110439.2, NM_030812.2
XP_011540514.1, XM_011542212.2
UniGeneiHs.2149

3D structure databases

ProteinModelPortaliQ9H568
SMRiQ9H568
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123530, 23 interactors
IntActiQ9H568, 23 interactors
STRINGi9606.ENSP00000364555

PTM databases

iPTMnetiQ9H568
PhosphoSitePlusiQ9H568

Polymorphism and mutation databases

BioMutaiACTL8
DMDMi74752665

Proteomic databases

EPDiQ9H568
MaxQBiQ9H568
PaxDbiQ9H568
PeptideAtlasiQ9H568
PRIDEiQ9H568
ProteomicsDBi80894

Protocols and materials databases

DNASUi81569
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375406; ENSP00000364555; ENSG00000117148
ENST00000617065; ENSP00000481590; ENSG00000117148
GeneIDi81569
KEGGihsa:81569
UCSCiuc001bat.3 human

Organism-specific databases

CTDi81569
DisGeNETi81569
EuPathDBiHostDB:ENSG00000117148.7
GeneCardsiACTL8
H-InvDBiHIX0000184
HGNCiHGNC:24018 ACTL8
HPAiHPA027176
neXtProtiNX_Q9H568
OpenTargetsiENSG00000117148
PharmGKBiPA142672644
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00910000144135
HOGENOMiHOG000233340
HOVERGENiHBG094566
InParanoidiQ9H568
OMAiCRENPGP
OrthoDBiEOG091G08US
PhylomeDBiQ9H568
TreeFamiTF340354

Enzyme and pathway databases

SignaLinkiQ9H568

Miscellaneous databases

ChiTaRSiACTL8 human
GeneWikiiACTL8
GenomeRNAii81569
PROiPR:Q9H568

Gene expression databases

BgeeiENSG00000117148 Expressed in 32 organ(s), highest expression level in oocyte
CleanExiHS_ACTL8
GenevisibleiQ9H568 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTL8_HUMAN
AccessioniPrimary (citable) accession number: Q9H568
Secondary accession number(s): Q13104, Q96M75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again