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Protein

ESF1 homolog

Gene

ESF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ESF1 homolog
Alternative name(s):
ABT1-associated protein
Gene namesi
Name:ESF1
Synonyms:ABTAP, C20orf6
ORF Names:HDCMC28P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000089048.14
HGNCiHGNC:15898 ESF1
neXtProtiNX_Q9H501

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089048
PharmGKBiPA162385420

Polymorphism and mutation databases

BioMutaiESF1
DMDMi25452905

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000794102 – 851ESF1 homologAdd BLAST850

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei311PhosphothreonineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei663PhosphoserineCombined sources1
Modified residuei693PhosphothreonineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei823PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H501
MaxQBiQ9H501
PaxDbiQ9H501
PeptideAtlasiQ9H501
PRIDEiQ9H501
ProteomicsDBi80886

PTM databases

iPTMnetiQ9H501
PhosphoSitePlusiQ9H501

Expressioni

Gene expression databases

BgeeiENSG00000089048 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExiHS_ESF1
ExpressionAtlasiQ9H501 baseline and differential
GenevisibleiQ9H501 HS

Organism-specific databases

HPAiHPA047083
HPA050396

Interactioni

Subunit structurei

Interacts with ABT1. Forms a complex with ABT1 and suppresses the ABT1-induced activation of polymerase II-directed transcription in mammalian cells (By similarity).By similarity

Protein-protein interaction databases

BioGridi119620, 31 interactors
IntActiQ9H501, 21 interactors
MINTiQ9H501
STRINGi9606.ENSP00000202816

Structurei

3D structure databases

ProteinModelPortaliQ9H501
SMRiQ9H501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili730 – 824Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 170Lys-richAdd BLAST84
Compositional biasi268 – 321Asp-richAdd BLAST54
Compositional biasi567 – 851Lys-richAdd BLAST285

Sequence similaritiesi

Belongs to the ESF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2318 Eukaryota
COG5638 LUCA
GeneTreeiENSGT00390000004881
HOGENOMiHOG000182523
HOVERGENiHBG051149
InParanoidiQ9H501
OMAiLTWDETA
OrthoDBiEOG091G0A19
PhylomeDBiQ9H501
TreeFamiTF105822

Family and domain databases

InterProiView protein in InterPro
IPR039754 Esf1
IPR012580 NUC153
PANTHERiPTHR12202 PTHR12202, 2 hits
PfamiView protein in Pfam
PF08159 NUC153, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H501-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKQEIMSD QRFRRVAKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN
60 70 80 90 100
YAVDKRGRPI SHSTTEDLKR FYDLSDSDSN LSGEDSKALS QKKIKKKKTQ
110 120 130 140 150
TKKEIDSKNL VEKKKETKKA NHKGSENKTD LDNSIGIKKM KTSCKFKIDS
160 170 180 190 200
NISPKKDSKE FTQKNKKEKK NIVQHTTDSS LEEKQRTLDS GTSEIVKSPR
210 220 230 240 250
IECSKTRREM QSVVQLIMTR DSDGYENSTD GEMCDKDALE EDSESVSEIG
260 270 280 290 300
SDEESENEIT SVGRASGDDD GSEDDEEEDE DEEEDEDEDS EDDDKSDSGP
310 320 330 340 350
DLARGKGNIE TSSEDEDDTA DLFPEESGFE HAWRELDKDA PRADEITRRL
360 370 380 390 400
AVCNMDWDRL KAKDLLALFN SFKPKGGVIF SVKIYPSEFG KERMKEEQVQ
410 420 430 440 450
GPVELLSIPE DAPEKDWTSR EKLRDYQFKR LKYYYAVVDC DSPETASKIY
460 470 480 490 500
EDCDGLEFES SCSFIDLRFI PDDITFDDEP KDVASEVNLT AYKPKYFTSA
510 520 530 540 550
AMGTSTVEIT WDETDHERIT MLNRKFKKEE LLDMDFQAYL ASSSEDEEEI
560 570 580 590 600
EEELQGDDGV NVEEDGKTKK SQKDDEEQIA KYRQLLQVIQ EKEKKGKEND
610 620 630 640 650
MEMEIKWVPG LKESAEEMVK NKLEGKDKLT PWEQFLEKKK EKKRLKRKQK
660 670 680 690 700
ALAEEASEEE LPSDVDLNDP YFAEEVKQIG INKKSVKSAK DGTSPEEEIE
710 720 730 740 750
IERQKAEMAL LMMDEDEDSK KHFNYNKIVE HQNLSKKKKK QLMKKKELIE
760 770 780 790 800
DDFEVNVNDA RFQAMYTSHL FNLDPSDPNF KKTKAMEKIL EEKARQRERK
810 820 830 840 850
EQELTQAIKK KESEIEKESQ RKSIDPALSM LIKSIKTKTE QFQARKKQKV

K
Length:851
Mass (Da):98,796
Last modified:March 1, 2001 - v1
Checksum:i1BA283E7A0A65432
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX71A0A087WX71_HUMAN
ESF1 homolog
ESF1
456Annotation score:

Sequence cautioni

The sequence AAF65504 differs from that shown. Reason: Frameshift at position 664.Curated
The sequence BAA91123 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14167 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186R → K in AAF65504 (Ref. 4) Curated1
Sequence conflicti198S → T in BAB14023 (PubMed:14702039).Curated1
Sequence conflicti228S → P in BAA91123 (PubMed:14702039).Curated1
Sequence conflicti298S → G in AAF65504 (Ref. 4) Curated1
Sequence conflicti336L → S in BAA91123 (PubMed:14702039).Curated1
Sequence conflicti351A → V in AAF65504 (Ref. 4) Curated1
Sequence conflicti390G → R in AAF65504 (Ref. 4) Curated1
Sequence conflicti469F → Y in AAF65504 (Ref. 4) Curated1
Sequence conflicti474I → V in BAA91123 (PubMed:14702039).Curated1
Sequence conflicti483V → A in AAF65504 (Ref. 4) Curated1
Sequence conflicti514T → S in BAB14023 (PubMed:14702039).Curated1
Sequence conflicti593E → K in AAH46107 (PubMed:15489334).Curated1
Sequence conflicti829S → P in BAB14167 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053082386P → L. Corresponds to variant dbSNP:rs6079171Ensembl.1
Natural variantiVAR_024331550I → T2 PublicationsCorresponds to variant dbSNP:rs3180370Ensembl.1
Natural variantiVAR_053083824I → L. Corresponds to variant dbSNP:rs34414644Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161659 Genomic DNA No translation available.
AK000375 mRNA Translation: BAA91123.1 Sequence problems.
AK022369 mRNA Translation: BAB14023.1
AK022670 mRNA Translation: BAB14167.1 Different initiation.
BC046107 mRNA Translation: AAH46107.1
AF068285 mRNA Translation: AAF65504.1 Frameshift.
CCDSiCCDS13117.1
RefSeqiNP_001263309.1, NM_001276380.1
NP_057733.2, NM_016649.3
XP_016883363.1, XM_017027874.1
UniGeneiHs.369284

Genome annotation databases

EnsembliENST00000202816; ENSP00000202816; ENSG00000089048
GeneIDi51575
KEGGihsa:51575
UCSCiuc002woj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161659 Genomic DNA No translation available.
AK000375 mRNA Translation: BAA91123.1 Sequence problems.
AK022369 mRNA Translation: BAB14023.1
AK022670 mRNA Translation: BAB14167.1 Different initiation.
BC046107 mRNA Translation: AAH46107.1
AF068285 mRNA Translation: AAF65504.1 Frameshift.
CCDSiCCDS13117.1
RefSeqiNP_001263309.1, NM_001276380.1
NP_057733.2, NM_016649.3
XP_016883363.1, XM_017027874.1
UniGeneiHs.369284

3D structure databases

ProteinModelPortaliQ9H501
SMRiQ9H501
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119620, 31 interactors
IntActiQ9H501, 21 interactors
MINTiQ9H501
STRINGi9606.ENSP00000202816

PTM databases

iPTMnetiQ9H501
PhosphoSitePlusiQ9H501

Polymorphism and mutation databases

BioMutaiESF1
DMDMi25452905

Proteomic databases

EPDiQ9H501
MaxQBiQ9H501
PaxDbiQ9H501
PeptideAtlasiQ9H501
PRIDEiQ9H501
ProteomicsDBi80886

Protocols and materials databases

DNASUi51575
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202816; ENSP00000202816; ENSG00000089048
GeneIDi51575
KEGGihsa:51575
UCSCiuc002woj.3 human

Organism-specific databases

CTDi51575
EuPathDBiHostDB:ENSG00000089048.14
GeneCardsiESF1
H-InvDBiHIX0015649
HGNCiHGNC:15898 ESF1
HPAiHPA047083
HPA050396
neXtProtiNX_Q9H501
OpenTargetsiENSG00000089048
PharmGKBiPA162385420
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2318 Eukaryota
COG5638 LUCA
GeneTreeiENSGT00390000004881
HOGENOMiHOG000182523
HOVERGENiHBG051149
InParanoidiQ9H501
OMAiLTWDETA
OrthoDBiEOG091G0A19
PhylomeDBiQ9H501
TreeFamiTF105822

Miscellaneous databases

ChiTaRSiESF1 human
GeneWikiiESF1
GenomeRNAii51575
PROiPR:Q9H501

Gene expression databases

BgeeiENSG00000089048 Expressed in 235 organ(s), highest expression level in secondary oocyte
CleanExiHS_ESF1
ExpressionAtlasiQ9H501 baseline and differential
GenevisibleiQ9H501 HS

Family and domain databases

InterProiView protein in InterPro
IPR039754 Esf1
IPR012580 NUC153
PANTHERiPTHR12202 PTHR12202, 2 hits
PfamiView protein in Pfam
PF08159 NUC153, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H501
Secondary accession number(s): Q86X92
, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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