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Entry version 154 (07 Oct 2020)
Sequence version 1 (01 Mar 2001)
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Protein

mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

Gene

PCIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cap-specific adenosine methyltransferase that catalyzes formation of N6,2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).4 Publications

Caution

The role of N6,2'-O-dimethyladenosine cap (m6A(m)) on transcripts is unclear and subject to discussion (PubMed:31279658, PubMed:31279659, PubMed:30467178). According to a report, m6A(m) promotes translation of capped mRNAs (PubMed:30467178). In contrast, another study did not observe a clear effect on mRNA translation, but reported an increased stability of a subset of m6A(m) transcripts (PubMed:31279658). According to a third report, m6A(m) inhibits mRNA translation without affecting mRNA stability (PubMed:31279659).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kcat is 0.036 min(-1) for m7GpppAm capped mRNA (PubMed:31279659). Kcat is 0.34 min(-1) for m7GpppAm dinucleotide (PubMed:31279659).1 Publication
  1. KM=3.5 µM for m7GpppAm1 Publication
  2. KM=82 nM for m7GpppAm oligonucleotide1 Publication
  3. KM=33.4 nM for m7GpppAm capped mRNA1 Publication
  4. KM=28 µM for m7GpppA1 Publication
  5. KM=630 µM for m7GpppA oligonucleotide1 Publication
  6. KM=208 nM for m7GpppAm dinucleotide1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei235SubstrateBy similarity1
    Binding sitei265SubstrateBy similarity1
    Binding sitei558SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q9H4Z3

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    Q9H4Z3

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC:2.1.1.624 Publications)
    Alternative name(s):
    Cap-specific adenosine methyltransferase1 Publication
    Short name:
    CAPAM1 Publication
    Short name:
    hCAPAM1 Publication
    Phosphorylated CTD-interacting factor 11 Publication
    Short name:
    hPCIF11 Publication
    Protein phosphatase 1 regulatory subunit 121
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PCIF11 PublicationImported
    Synonyms:C20orf67Imported, CAPAM1 Publication, PPP1R121
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000100982.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16200, PCIF1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    618626, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H4Z3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi553 – 556NPPF → APPA or SPPG: Abolishes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)). 2 Publications4
    Mutagenesisi553N → A: Strongly reduced formation of N(6),2'-O-dimethyladenosine cap (m6A(m)). 2 Publications1
    Mutagenesisi556F → G: Strongly reduced formation of N(6),2'-O-dimethyladenosine cap (m6A(m)). 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    63935

    Open Targets

    More...
    OpenTargetsi
    ENSG00000100982

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162398977

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9H4Z3, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PCIF1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    26392546

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760871 – 704mRNA (2'-O-methyladenosine-N(6)-)-methyltransferaseAdd BLAST704

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineCombined sources1
    Modified residuei116PhosphoserineCombined sources1
    Modified residuei152PhosphothreonineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9H4Z3

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9H4Z3

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9H4Z3

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9H4Z3

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H4Z3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H4Z3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H4Z3

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    80885

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H4Z3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H4Z3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000100982, Expressed in bone marrow and 207 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9H4Z3, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H4Z3, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000100982, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with POLR2A; interacts with the phosphorylated C-terminal domain (CTD) of POLR2A.

    3 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    122003, 13 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H4Z3, 12 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9H4Z3

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000361486

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q9H4Z3, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1704
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Biological Magnetic Resonance Data Bank

    More...
    BMRBi
    Q9H4Z3

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9H4Z3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9H4Z3

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 77WWPROSITE-ProRule annotationAdd BLAST35

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni553 – 556S-adenosyl-L-methionine bindingCombined sources1 Publication4
    Regioni588 – 592Substrate bindingBy similarity5
    Regioni614 – 616S-adenosyl-L-methionine bindingCombined sources1 Publication3

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi109 – 113Nuclear localization signalSequence analysis5
    Motifi669 – 684Nuclear localization signalSequence analysisAdd BLAST16

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi673 – 684Poly-SerAdd BLAST12

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.1 Publication

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the CAPAM family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QVT7, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000016206

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_014369_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H4Z3

    KEGG Orthology (KO)

    More...
    KOi
    K17584

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KVWCYPI

    Database of Orthologous Groups

    More...
    OrthoDBi
    1523233at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H4Z3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF350163

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00201, WW, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR039881, PCIF1-like
    IPR022035, PCIF1_WW
    IPR001202, WW_dom
    IPR036020, WW_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR21727, PTHR21727, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF12237, PCIF1_WW, 1 hit
    PF00397, WW, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00456, WW, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51045, SSF51045, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50020, WW_DOMAIN_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9H4Z3-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MANENHGSPR EEASLLSHSP GTSNQSQPCS PKPIRLVQDL PEELVHAGWE
    60 70 80 90 100
    KCWSRRENRP YYFNRFTNQS LWEMPVLGQH DVISDPLGLN ATPLPQDSSL
    110 120 130 140 150
    VETPPAENKP RKRQLSEEQP SGNGVKKPKI EIPVTPTGQS VPSSPSIPGT
    160 170 180 190 200
    PTLKMWGTSP EDKQQAALLR PTEVYWDLDI QTNAVIKHRG PSEVLPPHPE
    210 220 230 240 250
    VELLRSQLIL KLRQHYRELC QQREGIEPPR ESFNRWMLER KVVDKGSDPL
    260 270 280 290 300
    LPSNCEPVVS PSMFREIMND IPIRLSRIKF REEAKRLLFK YAEAARRLIE
    310 320 330 340 350
    SRSASPDSRK VVKWNVEDTF SWLRKDHSAS KEDYMDRLEH LRRQCGPHVS
    360 370 380 390 400
    AAAKDSVEGI CSKIYHISLE YVKRIREKHL AILKENNISE EVEAPEVEPR
    410 420 430 440 450
    LVYCYPVRLA VSAPPMPSVE MHMENNVVCI RYKGEMVKVS RNYFSKLWLL
    460 470 480 490 500
    YRYSCIDDSA FERFLPRVWC LLRRYQMMFG VGLYEGTGLQ GSLPVHVFEA
    510 520 530 540 550
    LHRLFGVSFE CFASPLNCYF RQYCSAFPDT DGYFGSRGPC LDFAPLSGSF
    560 570 580 590 600
    EANPPFCEEL MDAMVSHFER LLESSPEPLS FIVFIPEWRE PPTPALTRME
    610 620 630 640 650
    QSRFKRHQLI LPAFEHEYRS GSQHICKKEE MHYKAVHNTA VLFLQNDPGF
    660 670 680 690 700
    AKWAPTPERL QELSAAYRQS GRSHSSGSSS SSSSEAKDRD SGREQGPSRE

    PHPT
    Length:704
    Mass (Da):80,670
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83647BC8408BA9E9
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A087WWZ2A0A087WWZ2_HUMAN
    mRNA (2'-O-methyladenosine-N(6)-)-m...
    PCIF1
    304Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB050014 mRNA Translation: BAC45238.1
    AL162458 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW75778.1
    CH471077 Genomic DNA Translation: EAW75780.1
    BC013365 mRNA Translation: AAH13365.1
    BC010005 mRNA Translation: AAH10005.1
    AL137473 mRNA Translation: CAB70757.2

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13388.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_071387.1, NM_022104.3
    XP_011527282.1, XM_011528980.2
    XP_011527283.1, XM_011528981.2
    XP_016883502.1, XM_017028013.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000372409; ENSP00000361486; ENSG00000100982

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    63935

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:63935

    UCSC genome browser

    More...
    UCSCi
    uc002xqs.4, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB050014 mRNA Translation: BAC45238.1
    AL162458 Genomic DNA No translation available.
    CH471077 Genomic DNA Translation: EAW75778.1
    CH471077 Genomic DNA Translation: EAW75780.1
    BC013365 mRNA Translation: AAH13365.1
    BC010005 mRNA Translation: AAH10005.1
    AL137473 mRNA Translation: CAB70757.2
    CCDSiCCDS13388.1
    RefSeqiNP_071387.1, NM_022104.3
    XP_011527282.1, XM_011528980.2
    XP_011527283.1, XM_011528981.2
    XP_016883502.1, XM_017028013.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2JX8NMR-A40-86[»]
    6IRVX-ray2.70A/B174-672[»]
    6IRWX-ray2.90A/B174-672[»]
    BMRBiQ9H4Z3
    SMRiQ9H4Z3
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi122003, 13 interactors
    IntActiQ9H4Z3, 12 interactors
    MINTiQ9H4Z3
    STRINGi9606.ENSP00000361486

    PTM databases

    iPTMnetiQ9H4Z3
    PhosphoSitePlusiQ9H4Z3

    Polymorphism and mutation databases

    BioMutaiPCIF1
    DMDMi26392546

    Proteomic databases

    EPDiQ9H4Z3
    jPOSTiQ9H4Z3
    MassIVEiQ9H4Z3
    MaxQBiQ9H4Z3
    PaxDbiQ9H4Z3
    PeptideAtlasiQ9H4Z3
    PRIDEiQ9H4Z3
    ProteomicsDBi80885

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    27891, 72 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    63935

    Genome annotation databases

    EnsembliENST00000372409; ENSP00000361486; ENSG00000100982
    GeneIDi63935
    KEGGihsa:63935
    UCSCiuc002xqs.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    63935
    DisGeNETi63935
    EuPathDBiHostDB:ENSG00000100982.11

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PCIF1
    HGNCiHGNC:16200, PCIF1
    HPAiENSG00000100982, Low tissue specificity
    MIMi618626, gene
    neXtProtiNX_Q9H4Z3
    OpenTargetsiENSG00000100982
    PharmGKBiPA162398977

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG502QVT7, Eukaryota
    GeneTreeiENSGT00390000016206
    HOGENOMiCLU_014369_0_0_1
    InParanoidiQ9H4Z3
    KOiK17584
    OMAiKVWCYPI
    OrthoDBi1523233at2759
    PhylomeDBiQ9H4Z3
    TreeFamiTF350163

    Enzyme and pathway databases

    PathwayCommonsiQ9H4Z3
    SignaLinkiQ9H4Z3

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    63935, 15 hits in 886 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PCIF1, human
    EvolutionaryTraceiQ9H4Z3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    63935
    PharosiQ9H4Z3, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q9H4Z3
    RNActiQ9H4Z3, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000100982, Expressed in bone marrow and 207 other tissues
    ExpressionAtlasiQ9H4Z3, baseline and differential
    GenevisibleiQ9H4Z3, HS

    Family and domain databases

    CDDicd00201, WW, 1 hit
    InterProiView protein in InterPro
    IPR039881, PCIF1-like
    IPR022035, PCIF1_WW
    IPR001202, WW_dom
    IPR036020, WW_dom_sf
    PANTHERiPTHR21727, PTHR21727, 1 hit
    PfamiView protein in Pfam
    PF12237, PCIF1_WW, 1 hit
    PF00397, WW, 1 hit
    SMARTiView protein in SMART
    SM00456, WW, 1 hit
    SUPFAMiSSF51045, SSF51045, 1 hit
    PROSITEiView protein in PROSITE
    PS50020, WW_DOMAIN_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPAM_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4Z3
    Secondary accession number(s): E1P5P1, Q54AB9, Q9NT85
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: March 1, 2001
    Last modified: October 7, 2020
    This is version 154 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
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