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Entry version 170 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Zinc finger protein 335

Gene

ZNF335

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri245 – 268C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri465 – 487C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 672C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri678 – 701C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1075 – 1097C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1103 – 1126C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H4Z2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 335
Alternative name(s):
NRC-interacting factor 1
Short name:
NIF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF335
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198026.7

Human Gene Nomenclature Database

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HGNCi
HGNC:15807, ZNF335

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610827, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H4Z2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly 10, primary, autosomal recessive (MCPH10)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0694691111R → H in MCPH10; hypomorphic mutation; may cause altered transcript but some full-length protein is still formed. 1 PublicationCorresponds to variant dbSNP:rs397514642EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

More...
DisGeNETi
63925

MalaCards human disease database

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MalaCardsi
ZNF335
MIMi615095, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198026

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
329228, Microcephalic primordial dwarfism due to ZNF335 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38041

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9H4Z2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF335

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475381 – 1342Zinc finger protein 335Add BLAST1342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei976PhosphoserineBy similarity1
Modified residuei992PhosphoserineCombined sources1
Modified residuei1007PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1022Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1153PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H4Z2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H4Z2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H4Z2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H4Z2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H4Z2

PeptideAtlas

More...
PeptideAtlasi
Q9H4Z2

PRoteomics IDEntifications database

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PRIDEi
Q9H4Z2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
80883 [Q9H4Z2-1]
80884 [Q9H4Z2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H4Z2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H4Z2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed in fetal tissues including fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198026, Expressed in granulocyte and 177 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H4Z2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198026, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545).

Interacts with CNOT6 (PubMed:18180299).

Interacts with CNOT9; the interaction is direct (PubMed:18180299).

Component of a nuclear receptor-mediated transcription complex composed of at least ZNF335, CCAR2 and EMSY; the complex stimulates the transcription of nuclear receptor target genes such as SOX9 and HOXA1 (PubMed:19131338). Within the complex interacts with EMSY and interacts (via C-terminus) with CCAR2 (PubMed:19131338).

Interacts with members of histone H3'Lys4'(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5 (PubMed:23178126).

Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (PubMed:19131338).

Interacts with RBBP5 and WDR5 (PubMed:19131338).

Interacts with ASHL2 (PubMed:19131338). Components of this complex may associate with components of the ZNF335-CCAR2-EMSY nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (PubMed:19131338). Within this complex also interacts with HCFC1 and MKI67 (PubMed:19131338).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121994, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9H4Z2

Protein interaction database and analysis system

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IntActi
Q9H4Z2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325326

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H4Z2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H4Z2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1041 – 1342Involved in the interaction with CCAR21 PublicationAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1178 – 1330Gln-richAdd BLAST153

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 268C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri465 – 487C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 672C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri678 – 701C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1019 – 1041C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1075 – 1097C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1103 – 1126C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006340_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H4Z2

Identification of Orthologs from Complete Genome Data

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OMAi
FTSTSWP

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H4Z2

TreeFam database of animal gene trees

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TreeFami
TF332472

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H4Z2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEENEVESSS DAAPGPGRPE EPSESGLGVG TSEAVSADSS DAAAAPGQAE
60 70 80 90 100
ADDSGVGQSS DRGSRSQEEV SESSSSADPL PNSYLPDSSS VSHGPVAGVT
110 120 130 140 150
GGPPALVHSS ALPDPNMLVS DCTASSSDLG SAIDKIIEST IGPDLIQNCI
160 170 180 190 200
TVTSAEDGGA ETTRYLILQG PDDGAPMTSP MSSSTLAHSL AAIEALADGP
210 220 230 240 250
TSTSTCLEAQ GGPSSPVQLP PASGAEEPDL QSLEAMMEVV VVQQFKCKMC
260 270 280 290 300
QYRSSTKATL LRHMRERHFR PVAAAAAAAG KKGRLRKWST STKSQEEEGP
310 320 330 340 350
EEEDDDDIVD AGAIDDLEED SDYNPAEDEP RGRQLRLQRP TPSTPRPRRR
360 370 380 390 400
PGRPRKLPRL EISDLPDGVE GEPLVSSQSG QSPPEPQDPE APSSSGPGHL
410 420 430 440 450
VAMGKVSRTP VEAGVSQSDA ENAAPSCPDE HDTLPRRRGR PSRRFLGKKY
460 470 480 490 500
RKYYYKSPKP LLRPFLCRIC GSRFLSHEDL RFHVNSHEAG DPQLFKCLQC
510 520 530 540 550
SYRSRRWSSL KEHMFNHVGS KPYKCDECSY TSVYRKDVIR HAAVHSRDRK
560 570 580 590 600
KRPDPTPKLS SFPCPVCGRV YPMQKRLTQH MKTHSTEKPH MCDKCGKSFK
610 620 630 640 650
KRYTFKMHLL THIQAVANRR FKCEFCEFVC EDKKALLNHQ LSHVSDKPFK
660 670 680 690 700
CSFCPYRTFR EDFLLSHVAV KHTGAKPFAC EYCHFSTRHK KNLRLHVRCR
710 720 730 740 750
HASSFEEWGR RHPEEPPSRR RPFFSLQQIE ELKQQHSAAP GPPPSSPGPP
760 770 780 790 800
EIPPEATTFQ SSEAPSLLCS DTLGGATIIY QQGAEESTAM ATQTALDLLL
810 820 830 840 850
NMSAQRELGG TALQVAVVKS EDVEAGLASP GGQPSPEGAT PQVVTLHVAE
860 870 880 890 900
PGGGAAAESQ LGPPDLPQIT LAPGPFGGTG YSVITAPPME EGTSAPGTPY
910 920 930 940 950
SEEPAGEAAQ AVVVSDTLKE AGTHYIMATD GTQLHHIELT ADGSISFPSP
960 970 980 990 1000
DALASGAKWP LLQCGGLPRD GPEPPSPAKT HCVGDSQSSA SSPPATSKAL
1010 1020 1030 1040 1050
GLAVPPSPPS AATAASKKFS CKICAEAFPG RAEMESHKRA HAGPGAFKCP
1060 1070 1080 1090 1100
DCPFSARQWP EVRAHMAQHS SLRPHQCSQC SFASKNKKDL RRHMLTHTKE
1110 1120 1130 1140 1150
KPFACHLCGQ RFNRNGHLKF HIQRLHSPDG RKSGTPTARA PTQTPTQTII
1160 1170 1180 1190 1200
LNSDDETLAT LHTALQSSHG VLGPERLQQA LSQEHIIVAQ EQTVTNQEEA
1210 1220 1230 1240 1250
AYIQEITTAD GQTVQHLVTS DNQVQYIISQ DGVQHLLPQE YVVVPEGHHI
1260 1270 1280 1290 1300
QVQEGQITHI QYEQGAPFLQ ESQIQYVPVS PGQQLVTQAQ LEAAAHSAVT
1310 1320 1330 1340
AVADAAMAQA QGLFGTDETV PEHIQQLQHQ GIEYDVITLA DD
Length:1,342
Mass (Da):144,893
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D230DEE0B3AE670
GO
Isoform 2 (identifier: Q9H4Z2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.
     156-173: EDGGAETTRYLILQGPDD → MATSSMPESERNVATKAS

Show »
Length:1,187
Mass (Da):129,615
Checksum:i28690A43DE88A4AF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15379 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227E → G in BAG59529 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04756065R → C. Corresponds to variant dbSNP:rs6130982Ensembl.1
Natural variantiVAR_047561101G → S. Corresponds to variant dbSNP:rs6094231Ensembl.1
Natural variantiVAR_024211294S → T1 PublicationCorresponds to variant dbSNP:rs6032606EnsemblClinVar.1
Natural variantiVAR_047562603Y → H. Corresponds to variant dbSNP:rs16990961Ensembl.1
Natural variantiVAR_0694691111R → H in MCPH10; hypomorphic mutation; may cause altered transcript but some full-length protein is still formed. 1 PublicationCorresponds to variant dbSNP:rs397514642EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357911 – 155Missing in isoform 2. 1 PublicationAdd BLAST155
Alternative sequenceiVSP_035792156 – 173EDGGA…QGPDD → MATSSMPESERNVATKAS in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF395833 mRNA Translation: AAN09900.1
AK026157 mRNA Translation: BAB15379.1 Different initiation.
AK296989 mRNA Translation: BAG59529.1
AL162458 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13389.1 [Q9H4Z2-1]

NCBI Reference Sequences

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RefSeqi
NP_071378.1, NM_022095.3 [Q9H4Z2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000322927; ENSP00000325326; ENSG00000198026 [Q9H4Z2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
63925

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:63925

UCSC genome browser

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UCSCi
uc002xqw.4, human [Q9H4Z2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395833 mRNA Translation: AAN09900.1
AK026157 mRNA Translation: BAB15379.1 Different initiation.
AK296989 mRNA Translation: BAG59529.1
AL162458 Genomic DNA No translation available.
CCDSiCCDS13389.1 [Q9H4Z2-1]
RefSeqiNP_071378.1, NM_022095.3 [Q9H4Z2-1]

3D structure databases

SMRiQ9H4Z2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121994, 16 interactors
CORUMiQ9H4Z2
IntActiQ9H4Z2, 4 interactors
STRINGi9606.ENSP00000325326

PTM databases

iPTMnetiQ9H4Z2
PhosphoSitePlusiQ9H4Z2

Polymorphism and mutation databases

BioMutaiZNF335
DMDMi20141037

Proteomic databases

EPDiQ9H4Z2
jPOSTiQ9H4Z2
MassIVEiQ9H4Z2
MaxQBiQ9H4Z2
PaxDbiQ9H4Z2
PeptideAtlasiQ9H4Z2
PRIDEiQ9H4Z2
ProteomicsDBi80883 [Q9H4Z2-1]
80884 [Q9H4Z2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27906, 113 antibodies

The DNASU plasmid repository

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DNASUi
63925

Genome annotation databases

EnsembliENST00000322927; ENSP00000325326; ENSG00000198026 [Q9H4Z2-1]
GeneIDi63925
KEGGihsa:63925
UCSCiuc002xqw.4, human [Q9H4Z2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63925
DisGeNETi63925
EuPathDBiHostDB:ENSG00000198026.7

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF335
HGNCiHGNC:15807, ZNF335
HPAiENSG00000198026, Low tissue specificity
MalaCardsiZNF335
MIMi610827, gene
615095, phenotype
neXtProtiNX_Q9H4Z2
OpenTargetsiENSG00000198026
Orphaneti329228, Microcephalic primordial dwarfism due to ZNF335 deficiency
PharmGKBiPA38041

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158508
HOGENOMiCLU_006340_0_0_1
InParanoidiQ9H4Z2
OMAiFTSTSWP
PhylomeDBiQ9H4Z2
TreeFamiTF332472

Enzyme and pathway databases

PathwayCommonsiQ9H4Z2
ReactomeiR-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
63925, 481 hits in 897 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF335, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63925
PharosiQ9H4Z2, Tbio

Protein Ontology

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PROi
PR:Q9H4Z2
RNActiQ9H4Z2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198026, Expressed in granulocyte and 177 other tissues
GenevisibleiQ9H4Z2, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN335_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4Z2
Secondary accession number(s): B4DLG7, Q548D0, Q9H684
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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