Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase omega-2

Gene

GSTO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.2 Publications
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.2 Publications
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.1 Publication

pH dependencei

Optimum pH is 7.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32Nucleophile1
Binding sitei59Glutathione1 Publication1
Binding sitei72Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Transferase

Enzyme and pathway databases

BRENDAi1.8.5.1 2681
2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-2 (EC:2.5.1.182 Publications)
Short name:
GSTO-2
Alternative name(s):
Glutathione S-transferase omega 2-2
Short name:
GSTO 2-2
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.12 Publications)
Monomethylarsonic acid reductase (EC:1.20.4.21 Publication)
Short name:
MMA(V) reductase
Gene namesi
Name:GSTO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000065621.14
HGNCiHGNC:23064 GSTO2
MIMi612314 gene
neXtProtiNX_Q9H4Y5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34Y → A: Abolishes DHAR activity. 1 Publication1

Organism-specific databases

DisGeNETi119391
OpenTargetsiENSG00000065621
PharmGKBiPA133787053

Chemistry databases

ChEMBLiCHEMBL2161
DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGSTO2
DMDMi34922124

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858881 – 243Glutathione S-transferase omega-2Add BLAST243

Proteomic databases

PaxDbiQ9H4Y5
PeptideAtlasiQ9H4Y5
PRIDEiQ9H4Y5
ProteomicsDBi80881
80882 [Q9H4Y5-2]

PTM databases

iPTMnetiQ9H4Y5
PhosphoSitePlusiQ9H4Y5

Expressioni

Tissue specificityi

Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis.1 Publication

Gene expression databases

BgeeiENSG00000065621 Expressed in 157 organ(s), highest expression level in right testis
CleanExiHS_GSTO2
GenevisibleiQ9H4Y5 HS

Organism-specific databases

HPAiHPA048141

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125638, 16 interactors
IntActiQ9H4Y5, 11 interactors
STRINGi9606.ENSP00000345023

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H4Y5
SMRiQ9H4Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101GST N-terminalAdd BLAST80
Domaini106 – 231GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 86Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00390000005479
HOGENOMiHOG000006560
HOVERGENiHBG051853
InParanoidiQ9H4Y5
KOiK00799
OMAiADHYSHR
OrthoDBiEOG091G0IEA
PhylomeDBiQ9H4Y5
TreeFamiTF105325

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H4Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGDATRTLG KGSQPPGPVP EGLIRIYSMR FCPYSHRTRL VLKAKDIRHE
60 70 80 90 100
VVNINLRNKP EWYYTKHPFG HIPVLETSQC QLIYESVIAC EYLDDAYPGR
110 120 130 140 150
KLFPYDPYER ARQKMLLELF CKVPHLTKEC LVALRCGREC TNLKAALRQE
160 170 180 190 200
FSNLEEILEY QNTTFFGGTC ISMIDYLLWP WFERLDVYGI LDCVSHTPAL
210 220 230 240
RLWISAMKWD PTVCALLMDK SIFQGFLNLY FQNNPNAFDF GLC
Length:243
Mass (Da):28,254
Last modified:March 1, 2001 - v1
Checksum:i45A959432BCF490A
GO
Isoform 2 (identifier: Q9H4Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-156: Missing.

Note: No experimental confirmation available.
Show »
Length:209
Mass (Da):24,399
Checksum:i4FEFB66449685934
GO
Isoform 3 (identifier: Q9H4Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):25,387
Checksum:iA04CD756F6EB962F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215A → V in AAP47743 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049492130C → Y. Corresponds to variant dbSNP:rs45582439Ensembl.1
Natural variantiVAR_016812142N → D1 PublicationCorresponds to variant dbSNP:rs156697Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452671 – 28Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_042567123 – 156Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY350731 mRNA Translation: AAR02452.1
AY209189 mRNA Translation: AAP47743.1
AK291886 mRNA Translation: BAF84575.1
AK296266 mRNA Translation: BAG58978.1
AL139341 Genomic DNA No translation available.
AL162742 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49600.1
BC046194 mRNA No translation available.
BC056918 mRNA Translation: AAH56918.1
AY191318 mRNA Translation: AAO23573.1
CCDSiCCDS53574.1 [Q9H4Y5-2]
CCDS53575.1 [Q9H4Y5-3]
CCDS7556.1 [Q9H4Y5-1]
RefSeqiNP_001177942.1, NM_001191013.1 [Q9H4Y5-2]
NP_001177943.1, NM_001191014.1 [Q9H4Y5-3]
NP_001177944.1, NM_001191015.1
NP_899062.1, NM_183239.1 [Q9H4Y5-1]
XP_011537572.1, XM_011539270.2 [Q9H4Y5-1]
UniGeneiHs.107384
Hs.203634

Genome annotation databases

EnsembliENST00000338595; ENSP00000345023; ENSG00000065621 [Q9H4Y5-1]
ENST00000369707; ENSP00000358721; ENSG00000065621 [Q9H4Y5-3]
ENST00000450629; ENSP00000390986; ENSG00000065621 [Q9H4Y5-2]
GeneIDi119391
KEGGihsa:119391
UCSCiuc001kyb.4 human [Q9H4Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY350731 mRNA Translation: AAR02452.1
AY209189 mRNA Translation: AAP47743.1
AK291886 mRNA Translation: BAF84575.1
AK296266 mRNA Translation: BAG58978.1
AL139341 Genomic DNA No translation available.
AL162742 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49600.1
BC046194 mRNA No translation available.
BC056918 mRNA Translation: AAH56918.1
AY191318 mRNA Translation: AAO23573.1
CCDSiCCDS53574.1 [Q9H4Y5-2]
CCDS53575.1 [Q9H4Y5-3]
CCDS7556.1 [Q9H4Y5-1]
RefSeqiNP_001177942.1, NM_001191013.1 [Q9H4Y5-2]
NP_001177943.1, NM_001191014.1 [Q9H4Y5-3]
NP_001177944.1, NM_001191015.1
NP_899062.1, NM_183239.1 [Q9H4Y5-1]
XP_011537572.1, XM_011539270.2 [Q9H4Y5-1]
UniGeneiHs.107384
Hs.203634

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q18X-ray1.70A/B1-239[»]
3Q19X-ray1.90A/B1-239[»]
3QAGX-ray2.00A1-239[»]
ProteinModelPortaliQ9H4Y5
SMRiQ9H4Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125638, 16 interactors
IntActiQ9H4Y5, 11 interactors
STRINGi9606.ENSP00000345023

Chemistry databases

ChEMBLiCHEMBL2161
DrugBankiDB00143 Glutathione

PTM databases

iPTMnetiQ9H4Y5
PhosphoSitePlusiQ9H4Y5

Polymorphism and mutation databases

BioMutaiGSTO2
DMDMi34922124

Proteomic databases

PaxDbiQ9H4Y5
PeptideAtlasiQ9H4Y5
PRIDEiQ9H4Y5
ProteomicsDBi80881
80882 [Q9H4Y5-2]

Protocols and materials databases

DNASUi119391
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338595; ENSP00000345023; ENSG00000065621 [Q9H4Y5-1]
ENST00000369707; ENSP00000358721; ENSG00000065621 [Q9H4Y5-3]
ENST00000450629; ENSP00000390986; ENSG00000065621 [Q9H4Y5-2]
GeneIDi119391
KEGGihsa:119391
UCSCiuc001kyb.4 human [Q9H4Y5-1]

Organism-specific databases

CTDi119391
DisGeNETi119391
EuPathDBiHostDB:ENSG00000065621.14
GeneCardsiGSTO2
HGNCiHGNC:23064 GSTO2
HPAiHPA048141
MIMi612314 gene
neXtProtiNX_Q9H4Y5
OpenTargetsiENSG00000065621
PharmGKBiPA133787053
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00390000005479
HOGENOMiHOG000006560
HOVERGENiHBG051853
InParanoidiQ9H4Y5
KOiK00799
OMAiADHYSHR
OrthoDBiEOG091G0IEA
PhylomeDBiQ9H4Y5
TreeFamiTF105325

Enzyme and pathway databases

BRENDAi1.8.5.1 2681
2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

ChiTaRSiGSTO2 human
GeneWikiiGSTO2
GenomeRNAii119391
PROiPR:Q9H4Y5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065621 Expressed in 157 organ(s), highest expression level in right testis
CleanExiHS_GSTO2
GenevisibleiQ9H4Y5 HS

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTO2_HUMAN
AccessioniPrimary (citable) accession number: Q9H4Y5
Secondary accession number(s): A8K771
, B4DJW6, E7ESD6, Q49TW5, Q5GM70, Q5JU15, Q86WP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again