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Protein

Glutathione S-transferase omega-2

Gene

GSTO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei32Nucleophile1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei59Glutathione1 Publication1
Binding sitei72Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.8.5.1 2681
2.5.1.18 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156590 Glutathione conjugation
R-HSA-196836 Vitamin C (ascorbate) metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione S-transferase omega-2 (EC:2.5.1.182 Publications)
Short name:
GSTO-2
Alternative name(s):
Glutathione S-transferase omega 2-2
Short name:
GSTO 2-2
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.12 Publications)
Monomethylarsonic acid reductase (EC:1.20.4.21 Publication)
Short name:
MMA(V) reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSTO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000065621.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23064 GSTO2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612314 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H4Y5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi34Y → A: Abolishes DHAR activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
119391

Open Targets

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OpenTargetsi
ENSG00000065621

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA133787053

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2161

Drug and drug target database

More...
DrugBanki
DB00143 Glutathione

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSTO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34922124

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001858881 – 243Glutathione S-transferase omega-2Add BLAST243

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H4Y5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H4Y5

PeptideAtlas

More...
PeptideAtlasi
Q9H4Y5

PRoteomics IDEntifications database

More...
PRIDEi
Q9H4Y5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80881
80882 [Q9H4Y5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H4Y5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H4Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000065621 Expressed in 157 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_GSTO2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H4Y5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048141

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125638, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H4Y5, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345023

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q18X-ray1.70A/B1-239[»]
3Q19X-ray1.90A/B1-239[»]
3QAGX-ray2.00A1-239[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H4Y5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H4Y5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 101GST N-terminalAdd BLAST80
Domaini106 – 231GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 86Glutathione binding1 Publication2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0406 Eukaryota
ENOG410XSIX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006560

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051853

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H4Y5

KEGG Orthology (KO)

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KOi
K00799

Identification of Orthologs from Complete Genome Data

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OMAi
ADHYSHR

Database of Orthologous Groups

More...
OrthoDBi
1225872at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H4Y5

TreeFam database of animal gene trees

More...
TreeFami
TF105325

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13417 GST_N_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01625 GSTRNSFRASEO

Structure-Function Linkage Database

More...
SFLDi
SFLDS00019 Glutathione_Transferase_(cytos, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H4Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGDATRTLG KGSQPPGPVP EGLIRIYSMR FCPYSHRTRL VLKAKDIRHE
60 70 80 90 100
VVNINLRNKP EWYYTKHPFG HIPVLETSQC QLIYESVIAC EYLDDAYPGR
110 120 130 140 150
KLFPYDPYER ARQKMLLELF CKVPHLTKEC LVALRCGREC TNLKAALRQE
160 170 180 190 200
FSNLEEILEY QNTTFFGGTC ISMIDYLLWP WFERLDVYGI LDCVSHTPAL
210 220 230 240
RLWISAMKWD PTVCALLMDK SIFQGFLNLY FQNNPNAFDF GLC
Length:243
Mass (Da):28,254
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45A959432BCF490A
GO
Isoform 2 (identifier: Q9H4Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-156: Missing.

Note: No experimental confirmation available.
Show »
Length:209
Mass (Da):24,399
Checksum:i4FEFB66449685934
GO
Isoform 3 (identifier: Q9H4Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):25,387
Checksum:iA04CD756F6EB962F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti215A → V in AAP47743 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049492130C → Y. Corresponds to variant dbSNP:rs45582439Ensembl.1
Natural variantiVAR_016812142N → D1 PublicationCorresponds to variant dbSNP:rs156697Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452671 – 28Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_042567123 – 156Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY350731 mRNA Translation: AAR02452.1
AY209189 mRNA Translation: AAP47743.1
AK291886 mRNA Translation: BAF84575.1
AK296266 mRNA Translation: BAG58978.1
AL139341 Genomic DNA No translation available.
AL162742 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49600.1
BC046194 mRNA No translation available.
BC056918 mRNA Translation: AAH56918.1
AY191318 mRNA Translation: AAO23573.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53574.1 [Q9H4Y5-2]
CCDS53575.1 [Q9H4Y5-3]
CCDS7556.1 [Q9H4Y5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001177942.1, NM_001191013.1 [Q9H4Y5-2]
NP_001177943.1, NM_001191014.1 [Q9H4Y5-3]
NP_001177944.1, NM_001191015.1
NP_899062.1, NM_183239.1 [Q9H4Y5-1]
XP_011537572.1, XM_011539270.2 [Q9H4Y5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.107384
Hs.203634

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338595; ENSP00000345023; ENSG00000065621 [Q9H4Y5-1]
ENST00000369707; ENSP00000358721; ENSG00000065621 [Q9H4Y5-3]
ENST00000450629; ENSP00000390986; ENSG00000065621 [Q9H4Y5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
119391

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:119391

UCSC genome browser

More...
UCSCi
uc001kyb.4 human [Q9H4Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY350731 mRNA Translation: AAR02452.1
AY209189 mRNA Translation: AAP47743.1
AK291886 mRNA Translation: BAF84575.1
AK296266 mRNA Translation: BAG58978.1
AL139341 Genomic DNA No translation available.
AL162742 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49600.1
BC046194 mRNA No translation available.
BC056918 mRNA Translation: AAH56918.1
AY191318 mRNA Translation: AAO23573.1
CCDSiCCDS53574.1 [Q9H4Y5-2]
CCDS53575.1 [Q9H4Y5-3]
CCDS7556.1 [Q9H4Y5-1]
RefSeqiNP_001177942.1, NM_001191013.1 [Q9H4Y5-2]
NP_001177943.1, NM_001191014.1 [Q9H4Y5-3]
NP_001177944.1, NM_001191015.1
NP_899062.1, NM_183239.1 [Q9H4Y5-1]
XP_011537572.1, XM_011539270.2 [Q9H4Y5-1]
UniGeneiHs.107384
Hs.203634

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q18X-ray1.70A/B1-239[»]
3Q19X-ray1.90A/B1-239[»]
3QAGX-ray2.00A1-239[»]
ProteinModelPortaliQ9H4Y5
SMRiQ9H4Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125638, 16 interactors
IntActiQ9H4Y5, 11 interactors
STRINGi9606.ENSP00000345023

Chemistry databases

ChEMBLiCHEMBL2161
DrugBankiDB00143 Glutathione

PTM databases

iPTMnetiQ9H4Y5
PhosphoSitePlusiQ9H4Y5

Polymorphism and mutation databases

BioMutaiGSTO2
DMDMi34922124

Proteomic databases

jPOSTiQ9H4Y5
PaxDbiQ9H4Y5
PeptideAtlasiQ9H4Y5
PRIDEiQ9H4Y5
ProteomicsDBi80881
80882 [Q9H4Y5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
119391
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338595; ENSP00000345023; ENSG00000065621 [Q9H4Y5-1]
ENST00000369707; ENSP00000358721; ENSG00000065621 [Q9H4Y5-3]
ENST00000450629; ENSP00000390986; ENSG00000065621 [Q9H4Y5-2]
GeneIDi119391
KEGGihsa:119391
UCSCiuc001kyb.4 human [Q9H4Y5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
119391
DisGeNETi119391
EuPathDBiHostDB:ENSG00000065621.14

GeneCards: human genes, protein and diseases

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GeneCardsi
GSTO2
HGNCiHGNC:23064 GSTO2
HPAiHPA048141
MIMi612314 gene
neXtProtiNX_Q9H4Y5
OpenTargetsiENSG00000065621
PharmGKBiPA133787053

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00940000162030
HOGENOMiHOG000006560
HOVERGENiHBG051853
InParanoidiQ9H4Y5
KOiK00799
OMAiADHYSHR
OrthoDBi1225872at2759
PhylomeDBiQ9H4Y5
TreeFamiTF105325

Enzyme and pathway databases

BRENDAi1.8.5.1 2681
2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GSTO2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GSTO2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
119391

Protein Ontology

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PROi
PR:Q9H4Y5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000065621 Expressed in 157 organ(s), highest expression level in right testis
CleanExiHS_GSTO2
GenevisibleiQ9H4Y5 HS

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSTO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4Y5
Secondary accession number(s): A8K771
, B4DJW6, E7ESD6, Q49TW5, Q5GM70, Q5JU15, Q86WP3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: January 16, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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