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Protein

Regulator of cell cycle RGCC

Gene

RGCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.4 Publications

GO - Molecular functioni

  • protein kinase activator activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • R-SMAD binding Source: BHF-UCL

GO - Biological processi

  • cellular response to hypoxia Source: BHF-UCL
  • complement activation Source: BHF-UCL
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
  • fibroblast activation Source: UniProtKB
  • mitotic cell cycle arrest Source: BHF-UCL
  • negative regulation of angiogenesis Source: BHF-UCL
  • negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
  • negative regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of cytokine secretion Source: BHF-UCL
  • negative regulation of endothelial cell proliferation Source: BHF-UCL
  • negative regulation of exit from mitosis Source: BHF-UCL
  • negative regulation of fibroblast growth factor production Source: BHF-UCL
  • negative regulation of mitotic cell cycle phase transition Source: BHF-UCL
  • positive regulation of cell cycle arrest Source: BHF-UCL
  • positive regulation of collagen biosynthetic process Source: BHF-UCL
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: BHF-UCL
  • positive regulation of cytokine secretion Source: BHF-UCL
  • positive regulation of DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of DNA biosynthetic process Source: BHF-UCL
  • positive regulation of endothelial cell apoptotic process Source: BHF-UCL
  • positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  • positive regulation of extracellular matrix assembly Source: BHF-UCL
  • positive regulation of extracellular matrix constituent secretion Source: BHF-UCL
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of mitotic nuclear division Source: BHF-UCL
  • positive regulation of stress fiber assembly Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of cell cycle RGCC
Alternative name(s):
Response gene to complement 32 protein
Short name:
RGC-32
Gene namesi
Name:RGCC
Synonyms:C13orf15, RGC32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102760.12
HGNCiHGNC:20369 RGCC
MIMi610077 gene
neXtProtiNX_Q9H4X1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111T → A: Loss of phosphorylation. Reduced stimulation of CDK1 activity. 1 Publication1

Organism-specific databases

DisGeNETi28984
OpenTargetsiENSG00000102760
PharmGKBiPA134895181

Polymorphism and mutation databases

BioMutaiRGCC
DMDMi74752653

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747011 – 137Regulator of cell cycle RGCCAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei69PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei111Phosphothreonine; by CDK1Combined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H4X1
MaxQBiQ9H4X1
PaxDbiQ9H4X1
PeptideAtlasiQ9H4X1
PRIDEiQ9H4X1
ProteomicsDBi80878
80879 [Q9H4X1-2]

PTM databases

iPTMnetiQ9H4X1
PhosphoSitePlusiQ9H4X1

Expressioni

Tissue specificityi

Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues.2 Publications

Inductioni

By Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation.2 Publications

Gene expression databases

BgeeiENSG00000102760
CleanExiHS_C13orf15
GenevisibleiQ9H4X1 HS

Organism-specific databases

HPAiHPA035638
HPA063701

Interactioni

Subunit structurei

Interacts with SMAD3 (By similarity). Interacts with CDK1 and PLK1.By similarity1 Publication

GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL
  • R-SMAD binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi118805, 10 interactors
IntActiQ9H4X1, 2 interactors
STRINGi9606.ENSP00000368664

Structurei

3D structure databases

ProteinModelPortaliQ9H4X1
SMRiQ9H4X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 26Ala-richAdd BLAST16
Compositional biasi64 – 109Ser/Thr-richAdd BLAST46

Phylogenomic databases

eggNOGiENOG410J12H Eukaryota
ENOG4111Y7V LUCA
GeneTreeiENSGT00390000011709
HOGENOMiHOG000294092
HOVERGENiHBG060999
InParanoidiQ9H4X1
OMAiFRYDEHL
OrthoDBiEOG091G1849
PhylomeDBiQ9H4X1
TreeFamiTF336312

Family and domain databases

InterProiView protein in InterPro
IPR029252 RGCC
PANTHERiPTHR32193 PTHR32193, 1 hit
PfamiView protein in Pfam
PF15151 RGCC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H4X1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPPAAQGSP AAAAAAAPAL DSAAAEDLSD ALCEFDAVLA DFASPFHERH
60 70 80 90 100
FHYEEHLERM KRRSSASVSD SSGFSDSESA DSLYRNSFSF SDEKLNSPTD
110 120 130
STPALLSATV TPQKAKLGDT KELEAFIADL DKTLASM
Length:137
Mass (Da):14,559
Last modified:March 1, 2001 - v1
Checksum:i76265677DBCD9525
GO
Isoform 2 (identifier: Q9H4X1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-25: Missing.

Show »
Length:117
Mass (Da):12,924
Checksum:i3F01B45873DE5909
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3P → Q in AAH66334 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0228736 – 25Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036549 mRNA Translation: AAF04336.1
AL354833 Genomic DNA No translation available.
BC066334 mRNA Translation: AAH66334.1
CCDSiCCDS41880.1 [Q9H4X1-1]
RefSeqiNP_054778.2, NM_014059.2 [Q9H4X1-1]
UniGeneiHs.507866

Genome annotation databases

EnsembliENST00000379359; ENSP00000368664; ENSG00000102760 [Q9H4X1-1]
GeneIDi28984
KEGGihsa:28984
UCSCiuc001uyi.3 human [Q9H4X1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRGCC_HUMAN
AccessioniPrimary (citable) accession number: Q9H4X1
Secondary accession number(s): Q6NZ48, Q9UL69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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