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Protein

Zinc finger and SCAN domain-containing protein 16

Gene

ZSCAN16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri236 – 258C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 16
Alternative name(s):
Zinc finger protein 392
Zinc finger protein 435
Gene namesi
Name:ZSCAN16
Synonyms:ZNF392, ZNF435
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196812.4
HGNCiHGNC:20813 ZSCAN16
neXtProtiNX_Q9H4T2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196812
PharmGKBiPA162410958

Polymorphism and mutation databases

BioMutaiZSCAN16
DMDMi20178228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475831 – 348Zinc finger and SCAN domain-containing protein 16Add BLAST348

Proteomic databases

MaxQBiQ9H4T2
PaxDbiQ9H4T2
PeptideAtlasiQ9H4T2
PRIDEiQ9H4T2
ProteomicsDBi80875

PTM databases

iPTMnetiQ9H4T2
PhosphoSitePlusiQ9H4T2

Expressioni

Gene expression databases

BgeeiENSG00000196812 Expressed in 169 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_ZSCAN16
GenevisibleiQ9H4T2 HS

Organism-specific databases

HPAiHPA007290

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF446Q9NWS9-28EBI-723596,EBI-740232

Protein-protein interaction databases

BioGridi123252, 4 interactors
IntActiQ9H4T2, 8 interactors
STRINGi9606.ENSP00000366527

Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H4T2
SMRiQ9H4T2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4T2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri236 – 258C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9H4T2
KOiK09230
OMAiKAEDHYW
OrthoDBiEOG091G09O3
PhylomeDBiQ9H4T2
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9H4T2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTALEPEDQ KGLLIIKAED HYWGQDSSSQ KCSPHRRELY RQHFRKLCYQ
60 70 80 90 100
DAPGPREALT QLWELCRQWL RPECHTKEQI LDLLVLEQFL SILPKDLQAW
110 120 130 140 150
VRAHHPETGE EAVTVLEDLE RELDEPGKQV PGNSERRDIL MDKLAPLGRP
160 170 180 190 200
YESLTVQLHP KKTQLEQEAG KPQRNGDKTR TKNEELFQKE DMPKDKEFLG
210 220 230 240 250
EINDRLNKDT PQHPKSKDII ENEGRSEWQQ RERRRYKCDE CGKSFSHSSD
260 270 280 290 300
LSKHRRTHTG EKPYKCDECG KAFIQRSHLI GHHRVHTGVK PYKCKECGKD
310 320 330 340
FSGRTGLIQH QRIHTGEKPY ECDECGRPFR VSSALIRHQR IHTANKLY
Length:348
Mass (Da):40,792
Last modified:October 1, 2001 - v2
Checksum:iEEF71FB077F93BCA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035604137R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs750071607Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025844 mRNA Translation: BAB15257.1
AL358933 Genomic DNA No translation available.
BC004255 mRNA Translation: AAH04255.1
CCDSiCCDS4644.1
RefSeqiNP_001307484.1, NM_001320555.1
NP_001307485.1, NM_001320556.1
NP_001307486.1, NM_001320557.1
NP_079507.1, NM_025231.2
XP_016866813.1, XM_017011324.1
UniGeneiHs.656641

Genome annotation databases

EnsembliENST00000340487; ENSP00000366527; ENSG00000196812
GeneIDi80345
KEGGihsa:80345
UCSCiuc003nkm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025844 mRNA Translation: BAB15257.1
AL358933 Genomic DNA No translation available.
BC004255 mRNA Translation: AAH04255.1
CCDSiCCDS4644.1
RefSeqiNP_001307484.1, NM_001320555.1
NP_001307485.1, NM_001320556.1
NP_001307486.1, NM_001320557.1
NP_079507.1, NM_025231.2
XP_016866813.1, XM_017011324.1
UniGeneiHs.656641

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COTNMR-A225-288[»]
ProteinModelPortaliQ9H4T2
SMRiQ9H4T2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123252, 4 interactors
IntActiQ9H4T2, 8 interactors
STRINGi9606.ENSP00000366527

PTM databases

iPTMnetiQ9H4T2
PhosphoSitePlusiQ9H4T2

Polymorphism and mutation databases

BioMutaiZSCAN16
DMDMi20178228

Proteomic databases

MaxQBiQ9H4T2
PaxDbiQ9H4T2
PeptideAtlasiQ9H4T2
PRIDEiQ9H4T2
ProteomicsDBi80875

Protocols and materials databases

DNASUi80345
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340487; ENSP00000366527; ENSG00000196812
GeneIDi80345
KEGGihsa:80345
UCSCiuc003nkm.4 human

Organism-specific databases

CTDi80345
EuPathDBiHostDB:ENSG00000196812.4
GeneCardsiZSCAN16
HGNCiHGNC:20813 ZSCAN16
HPAiHPA007290
neXtProtiNX_Q9H4T2
OpenTargetsiENSG00000196812
PharmGKBiPA162410958
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9H4T2
KOiK09230
OMAiKAEDHYW
OrthoDBiEOG091G09O3
PhylomeDBiQ9H4T2
TreeFamiTF338304

Miscellaneous databases

EvolutionaryTraceiQ9H4T2
GenomeRNAii80345
PROiPR:Q9H4T2

Gene expression databases

BgeeiENSG00000196812 Expressed in 169 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_ZSCAN16
GenevisibleiQ9H4T2 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZSC16_HUMAN
AccessioniPrimary (citable) accession number: Q9H4T2
Secondary accession number(s): Q9H6K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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