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Entry version 156 (16 Oct 2019)
Sequence version 2 (01 Oct 2001)
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Protein

PR domain zinc finger protein 12

Gene

PRDM12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the positive regulation of histone H3-K9 dimethylation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri243 – 265C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 323C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 12 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM12
Synonyms:PFM9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13997 PRDM12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616458 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H4Q4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neuropathy, hereditary sensory and autonomic, 8 (HSAN8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN8 patients manifest congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages. Some patients may also have decreased sweating and tear production.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07461731D → Y in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs879255637EnsemblClinVar.1
Natural variantiVAR_074618102I → N in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs879255636EnsemblClinVar.1
Natural variantiVAR_074619160W → C in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 Publication1
Natural variantiVAR_074620168R → C in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs767397937Ensembl.1
Natural variantiVAR_074621172E → D in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs755205487EnsemblClinVar.1
Natural variantiVAR_074622289H → L in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs879255638EnsemblClinVar.1
Natural variantiVAR_074623352A → AAAAAAAA in HSAN8; reduced protein amount; results in protein aggregation. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
59335

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PRDM12

MalaCards human disease database

More...
MalaCardsi
PRDM12
MIMi616488 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000130711

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
478664 Hereditary sensory and autonomic neuropathy type 8

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33710

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H4Q4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRDM12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25008955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477691 – 367PR domain zinc finger protein 12Add BLAST367

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H4Q4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H4Q4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H4Q4

PeptideAtlas

More...
PeptideAtlasi
Q9H4Q4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H4Q4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80872

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H4Q4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H4Q4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Not found in adult tissues except in dorsal root ganglia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130711 Expressed in 97 organ(s), highest expression level in vastus lateralis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H4Q4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043143

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121878, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253008

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H4Q4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H4Q4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 203SETPROSITE-ProRule annotationAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi344 – 359Poly-AlaAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri243 – 265C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 323C2H2-type 3PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCSB Eukaryota
ENOG410YUJ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161616

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231554

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H4Q4

Identification of Orthologs from Complete Genome Data

More...
OMAi
HHANPKT

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H4Q4

TreeFam database of animal gene trees

More...
TreeFami
TF332260

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017126 Znf_PRDM12

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037163 PRDM12, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H4Q4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGSVLPAEA LVLKTGLKAP GLALAEVITS DILHSFLYGR WRNVLGEQLF
60 70 80 90 100
EDKSHHASPK TAFTAEVLAQ SFSGEVQKLS SLVLPAEVII AQSSIPGEGL
110 120 130 140 150
GIFSKTWIKA GTEMGPFTGR VIAPEHVDIC KNNNLMWEVF NEDGTVRYFI
160 170 180 190 200
DASQEDHRSW MTYIKCARNE QEQNLEVVQI GTSIFYKAIE MIPPDQELLV
210 220 230 240 250
WYGNSHNTFL GIPGVPGLEE DQKKNKHEDF HPADSAAGPA GRMRCVICHR
260 270 280 290 300
GFNSRSNLRS HMRIHTLDKP FVCRFCNRRF SQSSTLRNHV RLHTGERPYK
310 320 330 340 350
CQVCQSAYSQ LAGLRAHQKS ARHRPPSTAL QAHSPALPAP HAHAPALAAA
360
AAAAAAAAAH HLPAMVL
Length:367
Mass (Da):40,403
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2C665E3AE076C76
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-alanine tract is polymorphic in the general population and contains a maximum of 14 alanines.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07461731D → Y in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs879255637EnsemblClinVar.1
Natural variantiVAR_074618102I → N in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs879255636EnsemblClinVar.1
Natural variantiVAR_074619160W → C in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 Publication1
Natural variantiVAR_074620168R → C in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs767397937Ensembl.1
Natural variantiVAR_074621172E → D in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs755205487EnsemblClinVar.1
Natural variantiVAR_074622289H → L in HSAN8; no effect on nuclear localization; not able to induce histone H3-K9 dimethylation. 1 PublicationCorresponds to variant dbSNP:rs879255638EnsemblClinVar.1
Natural variantiVAR_074623352A → AAAAAAAA in HSAN8; reduced protein amount; results in protein aggregation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY004252 mRNA Translation: AAG13447.2
AL359092 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87940.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6934.1

NCBI Reference Sequences

More...
RefSeqi
NP_067632.2, NM_021619.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253008; ENSP00000253008; ENSG00000130711

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:59335

UCSC genome browser

More...
UCSCi
uc004bzt.2 human

Keywords - Coding sequence diversityi

Triplet repeat expansion

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004252 mRNA Translation: AAG13447.2
AL359092 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87940.1
CCDSiCCDS6934.1
RefSeqiNP_067632.2, NM_021619.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EP0X-ray2.10A/B60-229[»]
SMRiQ9H4Q4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121878, 1 interactor
STRINGi9606.ENSP00000253008

PTM databases

iPTMnetiQ9H4Q4
PhosphoSitePlusiQ9H4Q4

Polymorphism and mutation databases

BioMutaiPRDM12
DMDMi25008955

Proteomic databases

EPDiQ9H4Q4
MassIVEiQ9H4Q4
PaxDbiQ9H4Q4
PeptideAtlasiQ9H4Q4
PRIDEiQ9H4Q4
ProteomicsDBi80872

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
59335

Genome annotation databases

EnsembliENST00000253008; ENSP00000253008; ENSG00000130711
GeneIDi59335
KEGGihsa:59335
UCSCiuc004bzt.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
59335
DisGeNETi59335

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRDM12
GeneReviewsiPRDM12
HGNCiHGNC:13997 PRDM12
HPAiHPA043143
MalaCardsiPRDM12
MIMi616458 gene
616488 phenotype
neXtProtiNX_Q9H4Q4
OpenTargetsiENSG00000130711
Orphaneti478664 Hereditary sensory and autonomic neuropathy type 8
PharmGKBiPA33710

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KCSB Eukaryota
ENOG410YUJ3 LUCA
GeneTreeiENSGT00940000161616
HOGENOMiHOG000231554
InParanoidiQ9H4Q4
OMAiHHANPKT
OrthoDBi1318335at2759
PhylomeDBiQ9H4Q4
TreeFamiTF332260

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRDM12 human
EvolutionaryTraceiQ9H4Q4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
59335
PharosiQ9H4Q4

Protein Ontology

More...
PROi
PR:Q9H4Q4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130711 Expressed in 97 organ(s), highest expression level in vastus lateralis
GenevisibleiQ9H4Q4 HS

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017126 Znf_PRDM12
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
PIRSFiPIRSF037163 PRDM12, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRD12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4Q4
Secondary accession number(s): A3KFK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2001
Last modified: October 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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