Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box only protein 44

Gene

FBXO44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Miscellaneous

In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 44
Alternative name(s):
F-box protein FBX30
F-box/G-domain protein 3
Gene namesi
Name:FBXO44
Synonyms:FBG3, FBX30, FBX44, FBX6A, FBXO6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132879.13
HGNCiHGNC:24847 FBXO44
MIMi609111 gene
neXtProtiNX_Q9H4M3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi93611
OpenTargetsiENSG00000132879
PharmGKBiPA134863106

Polymorphism and mutation databases

BioMutaiFBXO44
DMDMi61252661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199451 – 255F-box only protein 44Add BLAST255

Proteomic databases

EPDiQ9H4M3
MaxQBiQ9H4M3
PaxDbiQ9H4M3
PeptideAtlasiQ9H4M3
PRIDEiQ9H4M3
ProteomicsDBi80863
80864 [Q9H4M3-2]

PTM databases

iPTMnetiQ9H4M3

Expressioni

Tissue specificityi

Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver.1 Publication

Gene expression databases

BgeeiENSG00000132879 Expressed in 183 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FBXO44
ExpressionAtlasiQ9H4M3 baseline and differential
GenevisibleiQ9H4M3 HS

Organism-specific databases

HPAiHPA003363

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi125038, 16 interactors
IntActiQ9H4M3, 10 interactors
STRINGi9606.ENSP00000251547

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H4M3
SMRiQ9H4M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 50F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini71 – 252FBAPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOVERGENiHBG003593
InParanoidiQ9H4M3
KOiK10103
PhylomeDBiQ9H4M3
TreeFamiTF320527

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H4M3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVGNINELP ENILLELFTH VPARQLLLNC RLVCSLWRDL IDLVTLWKRK
60 70 80 90 100
CLREGFITED WDQPVADWKI FYFLRSLHRN LLHNPCAEEG FEFWSLDVNG
110 120 130 140 150
GDEWKVEDLS RDQRKEFPND QVKKYFVTSY YTCLKSQVVD LKAEGYWEEL
160 170 180 190 200
MDTTRPDIEV KDWFAARPDC GSKYQLCVQL LSSAHAPLGT FQPDPATIQQ
210 220 230 240 250
KSDAKWREVS HTFSNYPPGV RYIWFQHGGV DTHYWAGWYG PRVTNSSITI

GPPLP
Length:255
Mass (Da):29,747
Last modified:March 15, 2005 - v3
Checksum:i3DA167B70E22A7E8
GO
Isoform 2 (identifier: Q9H4M3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-224: KKYFVTSYYT...NYPPGVRYIW → RSQARLRVQV...TPPEPPSAEP
     225-255: Missing.

Show »
Length:224
Mass (Da):25,698
Checksum:i7016A8750CB6FB71
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1P2B7Z1P2_HUMAN
F-box only protein 44
FBXO44
256Annotation score:
A0A0A0MSI6A0A0A0MSI6_HUMAN
F-box only protein 44
FBXO44
165Annotation score:
R4GMZ8R4GMZ8_HUMAN
F-box only protein 44
FBXO44
148Annotation score:
R4GNH4R4GNH4_HUMAN
F-box only protein 44
FBXO44
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101G → D in CAH18221 (PubMed:17974005).Curated1
Sequence conflicti251G → R in AAK77940 (PubMed:12383498).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011346123 – 224KKYFV…VRYIW → RSQARLRVQVPAVRSAPVVR ARASGDLPARPGDHPAEERC QVEGGLPHILQLPARRPLHL VSARRRGHSLLGRLVRPEGH QQQHHHRAPAALTPPEPPSA EP in isoform 2. 3 PublicationsAdd BLAST102
Alternative sequenceiVSP_011347225 – 255Missing in isoform 2. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007380 mRNA Translation: AAG09623.1
AY040878 mRNA Translation: AAK77940.1
AK301418 mRNA Translation: BAH13479.1
AK055344 mRNA Translation: BAG51504.1
CR749368 mRNA Translation: CAH18221.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71690.1
CH471130 Genomic DNA Translation: EAW71691.1
BC007832 mRNA Translation: AAH07832.1
CCDSiCCDS131.1 [Q9H4M3-2]
CCDS132.1 [Q9H4M3-1]
RefSeqiNP_001014765.1, NM_001014765.1 [Q9H4M3-1]
NP_001291719.1, NM_001304790.1 [Q9H4M3-2]
NP_001291720.1, NM_001304791.1 [Q9H4M3-1]
NP_149438.2, NM_033182.5 [Q9H4M3-1]
NP_904319.1, NM_183412.2 [Q9H4M3-2]
NP_904320.1, NM_183413.2 [Q9H4M3-2]
XP_006711108.1, XM_006711045.2 [Q9H4M3-1]
XP_016858332.1, XM_017002843.1 [Q9H4M3-1]
XP_016858333.1, XM_017002844.1 [Q9H4M3-2]
UniGeneiHs.556006

Genome annotation databases

EnsembliENST00000251546; ENSP00000251546; ENSG00000132879 [Q9H4M3-2]
ENST00000251547; ENSP00000251547; ENSG00000132879 [Q9H4M3-1]
ENST00000376760; ENSP00000365951; ENSG00000132879 [Q9H4M3-2]
ENST00000376762; ENSP00000365953; ENSG00000132879 [Q9H4M3-2]
ENST00000376770; ENSP00000365961; ENSG00000132879 [Q9H4M3-1]
GeneIDi93611
KEGGihsa:93611
UCSCiuc001ask.4 human [Q9H4M3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

FLAG-FBG3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007380 mRNA Translation: AAG09623.1
AY040878 mRNA Translation: AAK77940.1
AK301418 mRNA Translation: BAH13479.1
AK055344 mRNA Translation: BAG51504.1
CR749368 mRNA Translation: CAH18221.1
AL031731 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71690.1
CH471130 Genomic DNA Translation: EAW71691.1
BC007832 mRNA Translation: AAH07832.1
CCDSiCCDS131.1 [Q9H4M3-2]
CCDS132.1 [Q9H4M3-1]
RefSeqiNP_001014765.1, NM_001014765.1 [Q9H4M3-1]
NP_001291719.1, NM_001304790.1 [Q9H4M3-2]
NP_001291720.1, NM_001304791.1 [Q9H4M3-1]
NP_149438.2, NM_033182.5 [Q9H4M3-1]
NP_904319.1, NM_183412.2 [Q9H4M3-2]
NP_904320.1, NM_183413.2 [Q9H4M3-2]
XP_006711108.1, XM_006711045.2 [Q9H4M3-1]
XP_016858332.1, XM_017002843.1 [Q9H4M3-1]
XP_016858333.1, XM_017002844.1 [Q9H4M3-2]
UniGeneiHs.556006

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WSOX-ray2.60A1-255[»]
5B4NX-ray2.30A/B94-191[»]
A/B194-247[»]
ProteinModelPortaliQ9H4M3
SMRiQ9H4M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125038, 16 interactors
IntActiQ9H4M3, 10 interactors
STRINGi9606.ENSP00000251547

PTM databases

iPTMnetiQ9H4M3

Polymorphism and mutation databases

BioMutaiFBXO44
DMDMi61252661

Proteomic databases

EPDiQ9H4M3
MaxQBiQ9H4M3
PaxDbiQ9H4M3
PeptideAtlasiQ9H4M3
PRIDEiQ9H4M3
ProteomicsDBi80863
80864 [Q9H4M3-2]

Protocols and materials databases

DNASUi93611
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251546; ENSP00000251546; ENSG00000132879 [Q9H4M3-2]
ENST00000251547; ENSP00000251547; ENSG00000132879 [Q9H4M3-1]
ENST00000376760; ENSP00000365951; ENSG00000132879 [Q9H4M3-2]
ENST00000376762; ENSP00000365953; ENSG00000132879 [Q9H4M3-2]
ENST00000376770; ENSP00000365961; ENSG00000132879 [Q9H4M3-1]
GeneIDi93611
KEGGihsa:93611
UCSCiuc001ask.4 human [Q9H4M3-1]

Organism-specific databases

CTDi93611
DisGeNETi93611
EuPathDBiHostDB:ENSG00000132879.13
GeneCardsiFBXO44
HGNCiHGNC:24847 FBXO44
HPAiHPA003363
MIMi609111 gene
neXtProtiNX_Q9H4M3
OpenTargetsiENSG00000132879
PharmGKBiPA134863106
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6V Eukaryota
ENOG4111MF5 LUCA
GeneTreeiENSGT00390000003865
HOVERGENiHBG003593
InParanoidiQ9H4M3
KOiK10103
PhylomeDBiQ9H4M3
TreeFamiTF320527

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXO44 human
GenomeRNAii93611
PROiPR:Q9H4M3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132879 Expressed in 183 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FBXO44
ExpressionAtlasiQ9H4M3 baseline and differential
GenevisibleiQ9H4M3 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR007397 F-box-assoc_dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR008979 Galactose-bd-like_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF04300 FBA, 1 hit
SMARTiView protein in SMART
SM01198 FBA, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51114 FBA, 1 hit
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX44_HUMAN
AccessioniPrimary (citable) accession number: Q9H4M3
Secondary accession number(s): B3KNZ2
, B7Z743, Q5TGX2, Q5TGX4, Q5TGX5, Q68DJ9, Q8WWY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 15, 2005
Last modified: October 10, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again