UniProtKB - Q9H4L7 (SMRCD_HUMAN)
Protein
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Gene
SMARCAD1
Organism
Homo sapiens (Human)
Status
Functioni
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.2 Publications
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 521 – 529 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 897 – 904 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: GO_Central
- DNA binding Source: UniProtKB
- DNA-dependent ATPase activity Source: GO_Central
- DNA helicase activity Source: UniProtKB-EC
- ubiquitin binding Source: InterPro
GO - Biological processi
- ATP-dependent chromatin remodeling Source: UniProtKB
- chromatin remodeling Source: UniProtKB
- chromosome separation Source: UniProtKB
- DNA double-strand break processing Source: UniProtKB
- histone H3 deacetylation Source: UniProtKB
- histone H4 deacetylation Source: UniProtKB
- regulation of DNA recombination Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | DNA damage, DNA repair |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H4L7 |
SIGNORi | Q9H4L7 |
Names & Taxonomyi
Protein namesi | Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC:3.6.4.12)Alternative name(s): ATP-dependent helicase 1 Short name: hHEL1 |
Gene namesi | Name:SMARCAD1 Synonyms:KIAA1122 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18398, SMARCAD1 |
MIMi | 612761, gene |
neXtProti | NX_Q9H4L7 |
VEuPathDBi | HostDB:ENSG00000163104.17 |
Subcellular locationi
Nucleus
Other locations
Note: Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage.
Nucleus
- nuclear replication fork Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- heterochromatin Source: UniProtKB
- site of double-strand break Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Adermatoglyphia (ADERM)2 Publications
The disease is caused by variants affecting the gene represented in this entry. Splice site mutations causing aberrant splicing of skin-specific isoform 3 are likely to exert a loss-of-function effect and are involved in ADERM.2 Publications
Disease descriptionAn autosomal dominant condition characterized by the lack of epidermal ridges on the palms and soles, which results in the absence of fingerprints, and is associated with a reduced number of sweat gland openings and reduced sweating of palms and soles.
Related information in OMIMBasan syndrome (BSNS)2 Publications
The disease is caused by variants affecting the gene represented in this entry. Splice site mutations causing aberrant splicing of skin-specific isoform 3 are likely to exert a loss-of-function effect and are involved in BSNS.2 Publications
Disease descriptionAn autosomal dominant form of adermatoglyphia associated with congenital facial milia, acral blistering, digital contractures, and nail abnormalities. Adermatoglyphia is defined by the lack of epidermal ridges on the palms and soles, which results in the absence of fingerprints.
Related information in OMIMHuriez syndrome (HRZ)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized by atrophic fibrosis of the skin of the limbs, nail hypoplasia, and palmoplantar keratoderma. Malignant degeneration of affected skin resulting in aggressive squamous cell carcinoma and early metastasis formation is a distinctive feature of the syndrome.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 528 | K → R: No effect on subcellular localization and on histone deacetylation. 1 Publication | 1 |
Keywords - Diseasei
Ectodermal dysplasia, Palmoplantar keratodermaOrganism-specific databases
DisGeNETi | 56916 |
MalaCardsi | SMARCAD1 |
MIMi | 129200, phenotype 136000, phenotype 181600, phenotype |
OpenTargetsi | ENSG00000163104 |
Orphaneti | 1658, Absence of fingerprints-congenital milia syndrome 384, Huriez syndrome 289465, Isolated congenital adermatoglyphia |
PharmGKBi | PA134954731 |
Miscellaneous databases
Pharosi | Q9H4L7, Tbio |
Genetic variation databases
BioMutai | SMARCAD1 |
DMDMi | 306526240 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074356 | 1 – 1026 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1Add BLAST | 1026 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 54 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 71 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 77 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 79 | PhosphoserineCombined sources | 1 | |
Cross-linki | 84 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 124 | PhosphoserineCombined sources | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 211 | PhosphoserineCombined sources | 1 | |
Modified residuei | 214 | PhosphoserineCombined sources | 1 | |
Modified residuei | 217 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 239 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | PhosphoserineCombined sources | 1 | |
Modified residuei | 302 | PhosphoserineCombined sources | 1 | |
Cross-linki | 335 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 471 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 724 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 996 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9H4L7 |
jPOSTi | Q9H4L7 |
MassIVEi | Q9H4L7 |
MaxQBi | Q9H4L7 |
PaxDbi | Q9H4L7 |
PeptideAtlasi | Q9H4L7 |
PRIDEi | Q9H4L7 |
ProteomicsDBi | 80860 [Q9H4L7-1] 80861 [Q9H4L7-2] 80862 [Q9H4L7-3] |
PTM databases
iPTMneti | Q9H4L7 |
MetOSitei | Q9H4L7 |
PhosphoSitePlusi | Q9H4L7 |
Expressioni
Tissue specificityi
Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin and esophagus. Expressed in fibroblasts and keratinocytes (at protein level) (PubMed:29409814).3 Publications
Gene expression databases
Bgeei | ENSG00000163104, Expressed in intestine and 205 other tissues |
ExpressionAtlasi | Q9H4L7, baseline and differential |
Genevisiblei | Q9H4L7, HS |
Organism-specific databases
HPAi | ENSG00000163104, Low tissue specificity |
Interactioni
Subunit structurei
Binds to DNA preferentially in the vicinity of transcriptional start sites.
Interacts with MSH2 and TRIM28.
Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2.
Interacts with PCNA.
2 PublicationsGO - Molecular functioni
- ubiquitin binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 121244, 147 interactors |
IntActi | Q9H4L7, 19 interactors |
MINTi | Q9H4L7 |
STRINGi | 9606.ENSP00000351947 |
Miscellaneous databases
RNActi | Q9H4L7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 157 – 199 | CUE 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 251 – 294 | CUE 2PROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 509 – 677 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 169 | |
Domaini | 858 – 1010 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 153 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 628 – 631 | DEGH box | 4 | |
Motifi | 721 – 738 | Nuclear localization signalSequence analysisAdd BLAST | 18 | |
Motifi | 1005 – 1008 | DEGD box | 4 |
Sequence similaritiesi
Belongs to the SNF2/RAD54 helicase family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0389, Eukaryota |
GeneTreei | ENSGT00910000144252 |
HOGENOMi | CLU_000315_16_3_1 |
InParanoidi | Q9H4L7 |
OMAi | HAKLIMK |
OrthoDBi | 61251at2759 |
PhylomeDBi | Q9H4L7 |
TreeFami | TF105768 |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR003892, CUE IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51140, CUE, 2 hits PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H4L7-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNLFNLDRFR FEKRNKIEEA PEATPQPSQP GPSSPISLSA EEENAEGEVS
60 70 80 90 100
RANTPDSDIT EKTEDSSVPE TPDNERKASI SYFKNQRGIQ YIDLSSDSED
110 120 130 140 150
VVSPNCSNTV QEKTFNKDTV IIVSEPSEDE ESQGLPTMAR RNDDISELED
160 170 180 190 200
LSELEDLKDA KLQTLKELFP QRSDNDLLKL IESTSTMDGA IAAALLMFGD
210 220 230 240 250
AGGGPRKRKL SSSSEPYEED EFNDDQSIKK TRLDHGEESN ESAESSSNWE
260 270 280 290 300
KQESIVLKLQ KEFPNFDKQE LREVLKEHEW MYTEALESLK VFAEDQDMQY
310 320 330 340 350
VSQSEVPNGK EVSSRSQNYP KNATKTKLKQ KFSMKAQNGF NKKRKKNVFN
360 370 380 390 400
PKRVVEDSEY DSGSDVGSSL DEDYSSGEEV MEDGYKGKIL HFLQDASIGE
410 420 430 440 450
LTLIPQCSQK KAQKITELRP FNSWEALFTK MSKTNGLSED LIWHCKTLIQ
460 470 480 490 500
ERDVVIRLMN KCEDISNKLT KQVTMLTGNG GGWNIEQPSI LNQSLSLKPY
510 520 530 540 550
QKVGLNWLAL VHKHGLNGIL ADEMGLGKTI QAIAFLAYLY QEGNNGPHLI
560 570 580 590 600
VVPASTIDNW LREVNLWCPT LKVLCYYGSQ EERKQIRFNI HSRYEDYNVI
610 620 630 640 650
VTTYNCAISS SDDRSLFRRL KLNYAIFDEG HMLKNMGSIR YQHLMTINAN
660 670 680 690 700
NRLLLTGTPV QNNLLELMSL LNFVMPHMFS SSTSEIRRMF SSKTKSADEQ
710 720 730 740 750
SIYEKERIAH AKQIIKPFIL RRVKEEVLKQ LPPKKDRIEL CAMSEKQEQL
760 770 780 790 800
YLGLFNRLKK SINNLEKNTE MCNVMMQLRK MANHPLLHRQ YYTAEKLKEM
810 820 830 840 850
SQLMLKEPTH CEANPDLIFE DMEVMTDFEL HVLCKQYRHI NNFQLDMDLI
860 870 880 890 900
LDSGKFRVLG CILSELKQKG DRVVLFSQFT MMLDILEVLL KHHQHRYLRL
910 920 930 940 950
DGKTQISERI HLIDEFNTDM DIFVFLLSTK AGGLGINLTS ANVVILHDID
960 970 980 990 1000
CNPYNDKQAE DRCHRVGQTK EVLVIKLISQ GTIEESMLKI NQQKLKLEQD
1010 1020
MTTVDEGDEG SMPADIATLL KTSMGL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RAY8 | D6RAY8_HUMAN | SWI/SNF-related matrix-associated a... | SMARCAD1 | 244 | Annotation score: | ||
F8W9M2 | F8W9M2_HUMAN | SWI/SNF-related matrix-associated a... | SMARCAD1 | 70 | Annotation score: |
Sequence cautioni
The sequence AAH17953 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA86436 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14759 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 215 | E → D in AAH17953 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 937 | N → D in BAB14759 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028037 | 66 | S → F. Corresponds to variant dbSNP:rs11723410Ensembl. | 1 | |
Natural variantiVAR_028038 | 135 | L → F. Corresponds to variant dbSNP:rs2664891Ensembl. | 1 | |
Natural variantiVAR_028039 | 140 | R → C. Corresponds to variant dbSNP:rs2632398Ensembl. | 1 | |
Natural variantiVAR_028040 | 245 | S → Y. Corresponds to variant dbSNP:rs3103117Ensembl. | 1 | |
Natural variantiVAR_028041 | 247 | S → NCombined sources1 PublicationCorresponds to variant dbSNP:rs11722476Ensembl. | 1 | |
Natural variantiVAR_028042 | 301 | V → ACombined sources2 PublicationsCorresponds to variant dbSNP:rs7439869Ensembl. | 1 | |
Natural variantiVAR_028043 | 351 | P → Q1 PublicationCorresponds to variant dbSNP:rs17854344Ensembl. | 1 | |
Natural variantiVAR_028044 | 972 | V → A1 PublicationCorresponds to variant dbSNP:rs17857297Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043110 | 1 – 430 | Missing in isoform 3. 1 PublicationAdd BLAST | 430 | |
Alternative sequenceiVSP_007104 | 765 | L → LVT in isoform 2. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008271 mRNA Translation: AAG16639.1 AB032948 mRNA Translation: BAA86436.2 Different initiation. AK023990 mRNA Translation: BAB14759.1 Different initiation. AK027490 mRNA Translation: BAB55150.1 AK301668 mRNA Translation: BAH13535.1 AC096746 Genomic DNA No translation available. BC017953 mRNA Translation: AAH17953.1 Sequence problems. BC045534 mRNA Translation: AAH45534.1 AL359929 mRNA Translation: CAB95769.1 AL512768 mRNA Translation: CAC21685.1 |
CCDSi | CCDS3639.1 [Q9H4L7-1] CCDS47101.1 [Q9H4L7-2] CCDS58914.1 [Q9H4L7-3] |
RefSeqi | NP_001121901.1, NM_001128429.2 [Q9H4L7-2] NP_001121902.1, NM_001128430.1 [Q9H4L7-2] NP_001241878.1, NM_001254949.1 [Q9H4L7-3] NP_064544.2, NM_020159.4 [Q9H4L7-1] XP_016863952.1, XM_017008463.1 |
Genome annotation databases
Ensembli | ENST00000354268; ENSP00000346217; ENSG00000163104 [Q9H4L7-1] ENST00000359052; ENSP00000351947; ENSG00000163104 [Q9H4L7-2] ENST00000457823; ENSP00000415576; ENSG00000163104 [Q9H4L7-2] ENST00000509418; ENSP00000423286; ENSG00000163104 [Q9H4L7-3] |
GeneIDi | 56916 |
KEGGi | hsa:56916 |
UCSCi | uc003htb.5, human [Q9H4L7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight The ends of our fingers - Issue 136 of March 2012 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008271 mRNA Translation: AAG16639.1 AB032948 mRNA Translation: BAA86436.2 Different initiation. AK023990 mRNA Translation: BAB14759.1 Different initiation. AK027490 mRNA Translation: BAB55150.1 AK301668 mRNA Translation: BAH13535.1 AC096746 Genomic DNA No translation available. BC017953 mRNA Translation: AAH17953.1 Sequence problems. BC045534 mRNA Translation: AAH45534.1 AL359929 mRNA Translation: CAB95769.1 AL512768 mRNA Translation: CAC21685.1 |
CCDSi | CCDS3639.1 [Q9H4L7-1] CCDS47101.1 [Q9H4L7-2] CCDS58914.1 [Q9H4L7-3] |
RefSeqi | NP_001121901.1, NM_001128429.2 [Q9H4L7-2] NP_001121902.1, NM_001128430.1 [Q9H4L7-2] NP_001241878.1, NM_001254949.1 [Q9H4L7-3] NP_064544.2, NM_020159.4 [Q9H4L7-1] XP_016863952.1, XM_017008463.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6H3A | X-ray | 5.50 | B/D | 95-347 | [»] | |
6QU1 | X-ray | 3.70 | D | 151-198 | [»] | |
SMRi | Q9H4L7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121244, 147 interactors |
IntActi | Q9H4L7, 19 interactors |
MINTi | Q9H4L7 |
STRINGi | 9606.ENSP00000351947 |
PTM databases
iPTMneti | Q9H4L7 |
MetOSitei | Q9H4L7 |
PhosphoSitePlusi | Q9H4L7 |
Genetic variation databases
BioMutai | SMARCAD1 |
DMDMi | 306526240 |
Proteomic databases
EPDi | Q9H4L7 |
jPOSTi | Q9H4L7 |
MassIVEi | Q9H4L7 |
MaxQBi | Q9H4L7 |
PaxDbi | Q9H4L7 |
PeptideAtlasi | Q9H4L7 |
PRIDEi | Q9H4L7 |
ProteomicsDBi | 80860 [Q9H4L7-1] 80861 [Q9H4L7-2] 80862 [Q9H4L7-3] |
Protocols and materials databases
Antibodypediai | 14709, 131 antibodies |
DNASUi | 56916 |
Genome annotation databases
Ensembli | ENST00000354268; ENSP00000346217; ENSG00000163104 [Q9H4L7-1] ENST00000359052; ENSP00000351947; ENSG00000163104 [Q9H4L7-2] ENST00000457823; ENSP00000415576; ENSG00000163104 [Q9H4L7-2] ENST00000509418; ENSP00000423286; ENSG00000163104 [Q9H4L7-3] |
GeneIDi | 56916 |
KEGGi | hsa:56916 |
UCSCi | uc003htb.5, human [Q9H4L7-1] |
Organism-specific databases
CTDi | 56916 |
DisGeNETi | 56916 |
GeneCardsi | SMARCAD1 |
HGNCi | HGNC:18398, SMARCAD1 |
HPAi | ENSG00000163104, Low tissue specificity |
MalaCardsi | SMARCAD1 |
MIMi | 129200, phenotype 136000, phenotype 181600, phenotype 612761, gene |
neXtProti | NX_Q9H4L7 |
OpenTargetsi | ENSG00000163104 |
Orphaneti | 1658, Absence of fingerprints-congenital milia syndrome 384, Huriez syndrome 289465, Isolated congenital adermatoglyphia |
PharmGKBi | PA134954731 |
VEuPathDBi | HostDB:ENSG00000163104.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0389, Eukaryota |
GeneTreei | ENSGT00910000144252 |
HOGENOMi | CLU_000315_16_3_1 |
InParanoidi | Q9H4L7 |
OMAi | HAKLIMK |
OrthoDBi | 61251at2759 |
PhylomeDBi | Q9H4L7 |
TreeFami | TF105768 |
Enzyme and pathway databases
PathwayCommonsi | Q9H4L7 |
SIGNORi | Q9H4L7 |
Miscellaneous databases
BioGRID-ORCSi | 56916, 3 hits in 876 CRISPR screens |
ChiTaRSi | SMARCAD1, human |
GeneWikii | SMARCAD1 |
GenomeRNAii | 56916 |
Pharosi | Q9H4L7, Tbio |
PROi | PR:Q9H4L7 |
RNActi | Q9H4L7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163104, Expressed in intestine and 205 other tissues |
ExpressionAtlasi | Q9H4L7, baseline and differential |
Genevisiblei | Q9H4L7, HS |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR003892, CUE IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51140, CUE, 2 hits PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMRCD_HUMAN | |
Accessioni | Q9H4L7Primary (citable) accession number: Q9H4L7 Secondary accession number(s): B7Z799 Q9ULU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries