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UniProtKB - Q9H4L5 (OSBL3_HUMAN)

Entry version 164 (07 Apr 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Oxysterol-binding protein-related protein 3

Gene

OSBPL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H4L5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-192105, Synthesis of bile acids and bile salts

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 3
Short name:
ORP-3
Short name:
OSBP-related protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSBPL3
Synonyms:KIAA0704, ORP3, OSBP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16370, OSBPL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606732, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H4L5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000070882.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60K → I: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi61K → A: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi71K → A: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi72R → I: Abolishes plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi97G → E: Decreases plasma membrane targeting and nuclear localization. 1 Publication1
Mutagenesisi162 – 167FFSGST → AAAAAA: No effect on interaction with VAPA. 1 Publication6
Mutagenesisi451 – 453FFD → VVV: Reduces VAPA binding. Abolishes association with endoplasmic reticulum. 2 Publications3

Organism-specific databases

DisGeNET

More...DisGeNETi		26031

Open Targets

More...OpenTargetsi		ENSG00000070882

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32828

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H4L5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OSBPL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		20139176

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003711 – 887Oxysterol-binding protein-related protein 3Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1 Publication1
Modified residuei304PhosphoserineCombined sources1 Publication1
Modified residuei309PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1 Publication1
Modified residuei323Phosphoserine1 Publication1
Modified residuei371Phosphoserine1 Publication1
Modified residuei372PhosphoserineCombined sources1 Publication1
Modified residuei410PhosphoserineCombined sources1 Publication1
Modified residuei425PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1 Publication1
Modified residuei440PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187 (PubMed:25447204). Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion (PubMed:18270267).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H4L5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H4L5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H4L5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H4L5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H4L5

PeptideAtlas

More...PeptideAtlasi		Q9H4L5

PRoteomics IDEntifications database

More...PRIDEi		Q9H4L5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80852 [Q9H4L5-1]
80853 [Q9H4L5-2]
80854 [Q9H4L5-3]
80855 [Q9H4L5-4]
80856 [Q9H4L5-5]
80857 [Q9H4L5-6]
80858 [Q9H4L5-7]
80859 [Q9H4L5-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H4L5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H4L5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland. Expressed at low concentration in whole brain, esophagus, duodenum, ileocecum, colon, skeletal muscle, bone marrow, placenta and mammary gland (PubMed:14593528). Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung (PubMed:12590732).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in several fetal tissues including kidney, thymus, spleen and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000070882, Expressed in cortex of kidney and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H4L5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H4L5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000070882, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:16143324).

Interacts with RRAS (PubMed:18270267).

Interacts (phosphorylated form) with VAPA (PubMed:16143324, PubMed:25447204).

Interacts with OSBPL6 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117497, 79 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9H4L5

Protein interaction database and analysis system

More...IntActi		Q9H4L5, 56 interactors

Molecular INTeraction database

More...MINTi		Q9H4L5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315410

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H4L5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H4L5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 146PHPROSITE-ProRule annotationAdd BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi161 – 167FFAT 11 Publication7
Motifi450 – 454FFAT 21 Publication5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FFAT 2 motif is required for interaction with VAPA and regulation of the endoplasmic reticulum targeting of ORP3. The FFAT 1 motif may contribute to VAPA binding.2 Publications
The PH domain binds phosphoinositides, with a preference for PI(3,4)P2 and PI(3,4,5)P3. The PH domain mediates targeting to the plasma membrane (PubMed:18270267).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1737, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007105_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H4L5

Identification of Orthologs from Complete Genome Data

More...OMAi		XAKYWST

Database of Orthologous Groups

More...OrthoDBi		542090at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H4L5

TreeFam database of animal gene trees

More...TreeFami		TF320922

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037239, OSBP_sf
IPR000648, Oxysterol-bd
IPR018494, Oxysterol-bd_CS
IPR011993, PH-like_dom_sf
IPR041680, PH_8
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR10972, PTHR10972, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01237, Oxysterol_BP, 1 hit
PF15409, PH_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF144000, SSF144000, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01013, OSBP, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1a (identifier: Q9H4L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 
       310        320        330        340        350
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 
       360        370        380        390        400
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR 
       410        420        430        440        450
IHAESLLLDS PAVAKSGDNL AEENSRDENR ALVHQLSNES RLSITDSLSE 
       460        470        480        490        500
FFDAQEVLLS PSSSENEISD DDSYVSDISD NLSLDNLSND LDNERQTLGP 
       510        520        530        540        550
VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL SKVAMPVELN 
       560        570        580        590        600
EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 
       610        620        630        640        650
GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD 
       660        670        680        690        700
VRWKNKFWGK SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI 
       710        720        730        740        750
EHYGEIVIKN LHDDSCYCKV NFIKAKYWST NAHEIEGTVF DRSGKAVHRL 
       760        770        780        790        800
FGKWHESIYC GGGSSSACVW RANPMPKGYE QYYSFTQFAL ELNEMDPSSK 
       810        820        830        840        850
SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR RVLEENHVEH 
       860        870        880 
QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW
Length:887
Mass (Da):101,224
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12E16912BD3F2E99
GO
Isoform 1b (identifier: Q9H4L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.

Show »
Length:856
Mass (Da):97,687
Checksum:i1D56185E3FB98744
GO
Isoform 1c (identifier: Q9H4L5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.

Show »
Length:851
Mass (Da):97,325
Checksum:iDA08C319F2BAEDCE
GO
Isoform 1d (identifier: Q9H4L5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.

Show »
Length:820
Mass (Da):93,788
Checksum:i3D0A8947F6EE4DC5
GO
Isoform 2a (identifier: Q9H4L5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:642
Mass (Da):72,211
Checksum:i7AC19EA7AE07E5E4
GO
Isoform 2b (identifier: Q9H4L5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:611
Mass (Da):68,674
Checksum:i1A92347357A219CE
GO
Isoform 2c (identifier: Q9H4L5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:606
Mass (Da):68,313
Checksum:iEA72B4600CF3C1B8
GO
Isoform 2d (identifier: Q9H4L5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:575
Mass (Da):64,776
Checksum:iCD8F92033643E963
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JEF2C9JEF2_HUMAN
Oxysterol-binding protein-related p...
OSBPL3
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ19C9JZ19_HUMAN
Oxysterol-binding protein-related p...
OSBPL3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8P4C9J8P4_HUMAN
Oxysterol-binding protein-related p...
OSBPL3
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31679 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053548354M → V. Corresponds to variant dbSNP:rs11768296Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008219259 – 289Missing in isoform 1b, isoform 1d, isoform 2b and isoform 2d. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_008220387 – 422Missing in isoform 1c, isoform 1d, isoform 2c and isoform 2d. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_008221584 – 631YVAAF…EQVSH → RSQPSLATVQPRSPSHEAIH GAHQRDSPCSLRFHFDCSVN RFITQSCLASSAWLFPVTL in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_008222632 – 887Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST256

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY008372 mRNA Translation: AAG23400.1
AF392444 mRNA Translation: AAL40657.1
AF491781 mRNA Translation: AAM27386.1
AF491782 mRNA Translation: AAM27387.1
AF491783 mRNA Translation: AAM27388.1
AF491784 mRNA Translation: AAM27389.1
AF491785 mRNA Translation: AAM27390.1
AF491786 mRNA Translation: AAM27391.1
AF515639 mRNA Translation: AAM74165.1
AF515640 mRNA Translation: AAM74166.1
AB014604 mRNA Translation: BAA31679.2 Different initiation.
AC003093 Genomic DNA Translation: AAB83939.1
AC004008 Genomic DNA No translation available.
AC004016 Genomic DNA Translation: AAC26986.2
AC004239 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24240.1
CH236948 Genomic DNA Translation: EAL24241.1
CH236948 Genomic DNA Translation: EAL24242.1
CH236948 Genomic DNA Translation: EAL24243.1
CH236948 Genomic DNA Translation: EAL24244.1
CH236948 Genomic DNA Translation: EAL24245.1
CH471073 Genomic DNA Translation: EAW93816.1
CH471073 Genomic DNA Translation: EAW93817.1
CH471073 Genomic DNA Translation: EAW93818.1
CH471073 Genomic DNA Translation: EAW93819.1
CH471073 Genomic DNA Translation: EAW93820.1
CH471073 Genomic DNA Translation: EAW93821.1
BC017731 mRNA Translation: AAH17731.1
AF323727 mRNA Translation: AAG53408.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47564.1 [Q9H4L5-4]
CCDS5390.1 [Q9H4L5-1]
CCDS5391.1 [Q9H4L5-2]
CCDS5392.1 [Q9H4L5-3]

NCBI Reference Sequences

More...RefSeqi		NP_056365.1, NM_015550.3 [Q9H4L5-1]
NP_663160.1, NM_145320.2 [Q9H4L5-2]
NP_663161.1, NM_145321.2 [Q9H4L5-3]
NP_663162.1, NM_145322.2 [Q9H4L5-4]
XP_005249755.1, XM_005249698.3 [Q9H4L5-1]
XP_006715744.1, XM_006715681.3 [Q9H4L5-2]
XP_006715745.1, XM_006715682.3 [Q9H4L5-3]
XP_006715746.1, XM_006715683.3 [Q9H4L5-4]
XP_011513560.1, XM_011515258.2 [Q9H4L5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313367; ENSP00000315410; ENSG00000070882 [Q9H4L5-1]
ENST00000396429; ENSP00000379706; ENSG00000070882 [Q9H4L5-3]
ENST00000396431; ENSP00000379708; ENSG00000070882 [Q9H4L5-2]
ENST00000409069; ENSP00000386953; ENSG00000070882 [Q9H4L5-4]
ENST00000409452; ENSP00000386801; ENSG00000070882 [Q9H4L5-5]
ENST00000409555; ENSP00000386990; ENSG00000070882 [Q9H4L5-8]
ENST00000409759; ENSP00000386325; ENSG00000070882 [Q9H4L5-7]
ENST00000409863; ENSP00000386429; ENSG00000070882 [Q9H4L5-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26031

UCSC genome browser

More...UCSCi		uc003sxf.5, human [Q9H4L5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008372 mRNA Translation: AAG23400.1
AF392444 mRNA Translation: AAL40657.1
AF491781 mRNA Translation: AAM27386.1
AF491782 mRNA Translation: AAM27387.1
AF491783 mRNA Translation: AAM27388.1
AF491784 mRNA Translation: AAM27389.1
AF491785 mRNA Translation: AAM27390.1
AF491786 mRNA Translation: AAM27391.1
AF515639 mRNA Translation: AAM74165.1
AF515640 mRNA Translation: AAM74166.1
AB014604 mRNA Translation: BAA31679.2 Different initiation.
AC003093 Genomic DNA Translation: AAB83939.1
AC004008 Genomic DNA No translation available.
AC004016 Genomic DNA Translation: AAC26986.2
AC004239 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24240.1
CH236948 Genomic DNA Translation: EAL24241.1
CH236948 Genomic DNA Translation: EAL24242.1
CH236948 Genomic DNA Translation: EAL24243.1
CH236948 Genomic DNA Translation: EAL24244.1
CH236948 Genomic DNA Translation: EAL24245.1
CH471073 Genomic DNA Translation: EAW93816.1
CH471073 Genomic DNA Translation: EAW93817.1
CH471073 Genomic DNA Translation: EAW93818.1
CH471073 Genomic DNA Translation: EAW93819.1
CH471073 Genomic DNA Translation: EAW93820.1
CH471073 Genomic DNA Translation: EAW93821.1
BC017731 mRNA Translation: AAH17731.1
AF323727 mRNA Translation: AAG53408.1
CCDSiCCDS47564.1 [Q9H4L5-4]
CCDS5390.1 [Q9H4L5-1]
CCDS5391.1 [Q9H4L5-2]
CCDS5392.1 [Q9H4L5-3]
RefSeqiNP_056365.1, NM_015550.3 [Q9H4L5-1]
NP_663160.1, NM_145320.2 [Q9H4L5-2]
NP_663161.1, NM_145321.2 [Q9H4L5-3]
NP_663162.1, NM_145322.2 [Q9H4L5-4]
XP_005249755.1, XM_005249698.3 [Q9H4L5-1]
XP_006715744.1, XM_006715681.3 [Q9H4L5-2]
XP_006715745.1, XM_006715682.3 [Q9H4L5-3]
XP_006715746.1, XM_006715683.3 [Q9H4L5-4]
XP_011513560.1, XM_011515258.2 [Q9H4L5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7CYZX-ray2.10A/B511-887[»]
SMRiQ9H4L5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117497, 79 interactors
ELMiQ9H4L5
IntActiQ9H4L5, 56 interactors
MINTiQ9H4L5
STRINGi9606.ENSP00000315410

PTM databases

iPTMnetiQ9H4L5
PhosphoSitePlusiQ9H4L5

Genetic variation databases

BioMutaiOSBPL3
DMDMi20139176

Proteomic databases

EPDiQ9H4L5
jPOSTiQ9H4L5
MassIVEiQ9H4L5
MaxQBiQ9H4L5
PaxDbiQ9H4L5
PeptideAtlasiQ9H4L5
PRIDEiQ9H4L5
ProteomicsDBi80852 [Q9H4L5-1]
80853 [Q9H4L5-2]
80854 [Q9H4L5-3]
80855 [Q9H4L5-4]
80856 [Q9H4L5-5]
80857 [Q9H4L5-6]
80858 [Q9H4L5-7]
80859 [Q9H4L5-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12224, 110 antibodies

Genome annotation databases

EnsembliENST00000313367; ENSP00000315410; ENSG00000070882 [Q9H4L5-1]
ENST00000396429; ENSP00000379706; ENSG00000070882 [Q9H4L5-3]
ENST00000396431; ENSP00000379708; ENSG00000070882 [Q9H4L5-2]
ENST00000409069; ENSP00000386953; ENSG00000070882 [Q9H4L5-4]
ENST00000409452; ENSP00000386801; ENSG00000070882 [Q9H4L5-5]
ENST00000409555; ENSP00000386990; ENSG00000070882 [Q9H4L5-8]
ENST00000409759; ENSP00000386325; ENSG00000070882 [Q9H4L5-7]
ENST00000409863; ENSP00000386429; ENSG00000070882 [Q9H4L5-6]
GeneIDi26031
KEGGihsa:26031
UCSCiuc003sxf.5, human [Q9H4L5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26031
DisGeNETi26031

GeneCards: human genes, protein and diseases

More...GeneCardsi		OSBPL3
HGNCiHGNC:16370, OSBPL3
HPAiENSG00000070882, Low tissue specificity
MIMi606732, gene
neXtProtiNX_Q9H4L5
OpenTargetsiENSG00000070882
PharmGKBiPA32828
VEuPathDBiHostDB:ENSG00000070882.12

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1737, Eukaryota
GeneTreeiENSGT00940000155957
HOGENOMiCLU_007105_4_1_1
InParanoidiQ9H4L5
OMAiXAKYWST
OrthoDBi542090at2759
PhylomeDBiQ9H4L5
TreeFamiTF320922

Enzyme and pathway databases

PathwayCommonsiQ9H4L5
ReactomeiR-HSA-192105, Synthesis of bile acids and bile salts

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26031, 8 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OSBPL3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		OSBPL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26031
PharosiQ9H4L5, Tbio

Protein Ontology

More...PROi		PR:Q9H4L5
RNActiQ9H4L5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000070882, Expressed in cortex of kidney and 199 other tissues
ExpressionAtlasiQ9H4L5, baseline and differential
GenevisibleiQ9H4L5, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239, OSBP_sf
IPR000648, Oxysterol-bd
IPR018494, Oxysterol-bd_CS
IPR011993, PH-like_dom_sf
IPR041680, PH_8
IPR001849, PH_domain
PANTHERiPTHR10972, PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237, Oxysterol_BP, 1 hit
PF15409, PH_8, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF144000, SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013, OSBP, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4L5
Secondary accession number(s): A4D167
, A4D168, A4D169, A4D170, A4D171, A4D172, B8ZZ79, B8ZZP0, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: April 7, 2021
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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