OSBPL3

Functionⁱ

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).4 Publications

GO - Molecular functionⁱ

cholesterol binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17428193
lipid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sterol binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sterol transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bile acid biosynthetic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid transport, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-192105 Synthesis of bile acids and bile salts

Reactomeⁱ

R-HSA-192105 Synthesis of bile acids and bile salts

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oxysterol-binding protein-related protein 3 Short name: ORP-3 Short name: OSBP-related protein 3
Gene namesⁱ	Name:OSBPL3 Synonyms:KIAA0704, ORP3, OSBP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000070882.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16370 OSBPL3
MIMⁱ	606732 gene
neXtProtⁱ	NX_Q9H4L5

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	60	K → I: Abolishes plasma membrane targeting and nuclear localization. 1 Publication	1
Mutagenesisⁱ	61	K → A: Abolishes plasma membrane targeting and nuclear localization. 1 Publication	1
Mutagenesisⁱ	71	K → A: Abolishes plasma membrane targeting and nuclear localization. 1 Publication	1
Mutagenesisⁱ	72	R → I: Abolishes plasma membrane targeting and nuclear localization. 1 Publication	1
Mutagenesisⁱ	97	G → E: Decreases plasma membrane targeting and nuclear localization. 1 Publication	1
Mutagenesisⁱ	162 – 167	FFSGST → AAAAAA: No effect on interaction with VAPA. 1 Publication	6
Mutagenesisⁱ	451 – 453	FFD → VVV: Reduces VAPA binding. Abolishes association with endoplasmic reticulum. 2 Publications	3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26031
Open Targets More...OpenTargetsⁱ	ENSG00000070882
PharmGKBⁱ	PA32828

Polymorphism and mutation databases

BioMutaⁱ	OSBPL3
DMDMⁱ	20139176

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100371	1 – 887	Oxysterol-binding protein-related protein 3Add BLAST		887

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	34	PhosphoserineCombined sources	1
Modified residueⁱ	200	PhosphoserineCombined sources	1
Modified residueⁱ	251	PhosphoserineCombined sources	1
Modified residueⁱ	265	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	304	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	309	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	323	Phosphoserine1 Publication	1
Modified residueⁱ	371	Phosphoserine1 Publication	1
Modified residueⁱ	372	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	410	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	425	PhosphoserineCombined sources	1
Modified residueⁱ	437	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	440	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187 (PubMed:25447204). Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion (PubMed:18270267).2 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H4L5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H4L5
PaxDbⁱ	Q9H4L5
PeptideAtlas More...PeptideAtlasⁱ	Q9H4L5
PRIDEⁱ	Q9H4L5
ProteomicsDBⁱ	80852 80853 [Q9H4L5-2] 80854 [Q9H4L5-3] 80855 [Q9H4L5-4] 80856 [Q9H4L5-5] 80857 [Q9H4L5-6] 80858 [Q9H4L5-7] 80859 [Q9H4L5-8]

PTM databases

iPTMnetⁱ	Q9H4L5
PhosphoSitePlusⁱ	Q9H4L5

Expressionⁱ

Tissue specificityⁱ

Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland. Expressed at low concentration in whole brain, esophagus, duodenum, ileocecum, colon, skeletal muscle, bone marrow, placenta and mammary gland (PubMed:14593528). Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung (PubMed:12590732).2 Publications

Developmental stageⁱ

Expressed in several fetal tissues including kidney, thymus, spleen and lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000070882 Expressed in 188 organ(s), highest expression level in cortex of kidney
ExpressionAtlasⁱ	Q9H4L5 baseline and differential
Genevisibleⁱ	Q9H4L5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000691 HPA048401

HPAⁱ

HPA000691
HPA048401

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:16143324). Interacts with RRAS (PubMed:18270267). Interacts (phosphorylated form) with VAPA (PubMed:16143324, PubMed:25447204).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ORF	Q9Q2G4	5	EBI-1051317,EBI-6248094	From Human immunodeficiency virus 1.

With

Entry

#Exp.

IntAct

Notes

ORF

Q9Q2G4

5

EBI-1051317,EBI-6248094

From Human immunodeficiency virus 1.

Protein-protein interaction databases

BioGridⁱ	117497, 40 interactors
ELMⁱ	Q9H4L5
IntActⁱ	Q9H4L5, 39 interactors
Molecular INTeraction database More...MINTⁱ	Q9H4L5
STRINGⁱ	9606.ENSP00000315410

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H4L5
SMRⁱ	Q9H4L5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 146	PHPROSITE-ProRule annotationAdd BLAST		96

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	161 – 167	FFAT 11 Publication		7
Motifⁱ	450 – 454	FFAT 21 Publication		5

Domainⁱ

The FFAT 2 motif is required for interaction with VAPA and regulation of the endoplasmic reticulum targeting of ORP3. The FFAT 1 motif may contribute to VAPA binding.2 Publications

The PH domain binds phosphoinositides, with a preference for PI(3,4)P2 and PI(3,4,5)P3. The PH domain mediates targeting to the plasma membrane (PubMed:18270267).2 Publications

Sequence similaritiesⁱ

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1737 Eukaryota ENOG410XP9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119155
HOVERGENⁱ	HBG058934
InParanoidⁱ	Q9H4L5
KEGG Orthology (KO) More...KOⁱ	K20463
OMAⁱ	YTQEPPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DJB
PhylomeDBⁱ	Q9H4L5
TreeFamⁱ	TF320922

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR037239 OSBP_sf IPR000648 Oxysterol-bd IPR018494 Oxysterol-bd_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR10972 PTHR10972, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01237 Oxysterol_BP, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
SUPFAMⁱ	SSF144000 SSF144000, 1 hit
PROSITEⁱ	View protein in PROSITE PS01013 OSBP, 1 hit PS50003 PH_DOMAIN, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1a (identifier: Q9H4L5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 
       310        320        330        340        350
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 
       360        370        380        390        400
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR 
       410        420        430        440        450
IHAESLLLDS PAVAKSGDNL AEENSRDENR ALVHQLSNES RLSITDSLSE 
       460        470        480        490        500
FFDAQEVLLS PSSSENEISD DDSYVSDISD NLSLDNLSND LDNERQTLGP 
       510        520        530        540        550
VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL SKVAMPVELN 
       560        570        580        590        600
EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 
       610        620        630        640        650
GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD 
       660        670        680        690        700
VRWKNKFWGK SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI 
       710        720        730        740        750
EHYGEIVIKN LHDDSCYCKV NFIKAKYWST NAHEIEGTVF DRSGKAVHRL 
       760        770        780        790        800
FGKWHESIYC GGGSSSACVW RANPMPKGYE QYYSFTQFAL ELNEMDPSSK 
       810        820        830        840        850
SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR RVLEENHVEH 
       860        870        880 
QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW

Length:887

Mass (Da):101,224

Last modified:March 1, 2001 - v1

Checksum:ⁱ12E16912BD3F2E99

GO

Isoform 1b (identifier: Q9H4L5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-289: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 
       310        320        330        340        350
MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK 
       360        370        380        390        400
NALSSALAQN TDLKERLRRI HAESLLLDSP AVAKSGDNLA EENSRDENRA 
       410        420        430        440        450
LVHQLSNESR LSITDSLSEF FDAQEVLLSP SSSENEISDD DSYVSDISDN 
       460        470        480        490        500
LSLDNLSNDL DNERQTLGPV LDSGREAKSR RRTCLPAPCP SSSNISLWNI 
       510        520        530        540        550
LRNNIGKDLS KVAMPVELNE PLNTLQRLCE ELEYSELLDK AAQIPSPLER 
       560        570        580        590        600
MVYVAAFAIS AYASSYYRAG SKPFNPVLGE TYECIREDKG FQFFSEQVSH 
       610        620        630        640        650
HPPISACHAE SRNFVFWQDV RWKNKFWGKS MEIVPIGTTH VTLPVFGDHF 
       660        670        680        690        700
EWNKVTSCIH NILSGQRWIE HYGEIVIKNL HDDSCYCKVN FIKAKYWSTN 
       710        720        730        740        750
AHEIEGTVFD RSGKAVHRLF GKWHESIYCG GGSSSACVWR ANPMPKGYEQ 
       760        770        780        790        800
YYSFTQFALE LNEMDPSSKS LLPPTDTRFR PDQRFLEEGN LEEAEIQKQR 
       810        820        830        840        850
IEQLQRERRR VLEENHVEHQ PRFFRKSDDD SWVSNGTYLE LRKDLGFSKL 

DHPVLW

Show »

Length:856

Mass (Da):97,687

Checksum:ⁱ1D56185E3FB98744

GO

Isoform 1c (identifier: Q9H4L5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
387-422: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 
       310        320        330        340        350
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 
       360        370        380        390        400
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSENSR DENRALVHQL 
       410        420        430        440        450
SNESRLSITD SLSEFFDAQE VLLSPSSSEN EISDDDSYVS DISDNLSLDN 
       460        470        480        490        500
LSNDLDNERQ TLGPVLDSGR EAKSRRRTCL PAPCPSSSNI SLWNILRNNI 
       510        520        530        540        550
GKDLSKVAMP VELNEPLNTL QRLCEELEYS ELLDKAAQIP SPLERMVYVA 
       560        570        580        590        600
AFAISAYASS YYRAGSKPFN PVLGETYECI REDKGFQFFS EQVSHHPPIS 
       610        620        630        640        650
ACHAESRNFV FWQDVRWKNK FWGKSMEIVP IGTTHVTLPV FGDHFEWNKV 
       660        670        680        690        700
TSCIHNILSG QRWIEHYGEI VIKNLHDDSC YCKVNFIKAK YWSTNAHEIE 
       710        720        730        740        750
GTVFDRSGKA VHRLFGKWHE SIYCGGGSSS ACVWRANPMP KGYEQYYSFT 
       760        770        780        790        800
QFALELNEMD PSSKSLLPPT DTRFRPDQRF LEEGNLEEAE IQKQRIEQLQ 
       810        820        830        840        850
RERRRVLEEN HVEHQPRFFR KSDDDSWVSN GTYLELRKDL GFSKLDHPVL 

W

Show »

Length:851

Mass (Da):97,325

Checksum:ⁱDA08C319F2BAEDCE

GO

Isoform 1d (identifier: Q9H4L5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-289: Missing.
387-422: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 
       310        320        330        340        350
MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK 
       360        370        380        390        400
NALSSENSRD ENRALVHQLS NESRLSITDS LSEFFDAQEV LLSPSSSENE 
       410        420        430        440        450
ISDDDSYVSD ISDNLSLDNL SNDLDNERQT LGPVLDSGRE AKSRRRTCLP 
       460        470        480        490        500
APCPSSSNIS LWNILRNNIG KDLSKVAMPV ELNEPLNTLQ RLCEELEYSE 
       510        520        530        540        550
LLDKAAQIPS PLERMVYVAA FAISAYASSY YRAGSKPFNP VLGETYECIR 
       560        570        580        590        600
EDKGFQFFSE QVSHHPPISA CHAESRNFVF WQDVRWKNKF WGKSMEIVPI 
       610        620        630        640        650
GTTHVTLPVF GDHFEWNKVT SCIHNILSGQ RWIEHYGEIV IKNLHDDSCY 
       660        670        680        690        700
CKVNFIKAKY WSTNAHEIEG TVFDRSGKAV HRLFGKWHES IYCGGGSSSA 
       710        720        730        740        750
CVWRANPMPK GYEQYYSFTQ FALELNEMDP SSKSLLPPTD TRFRPDQRFL 
       760        770        780        790        800
EEGNLEEAEI QKQRIEQLQR ERRRVLEENH VEHQPRFFRK SDDDSWVSNG 
       810        820
TYLELRKDLG FSKLDHPVLW

Show »

Length:820

Mass (Da):93,788

Checksum:ⁱ3D0A8947F6EE4DC5

GO

Isoform 2a (identifier: Q9H4L5-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
632-887: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 
       310        320        330        340        350
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 
       360        370        380        390        400
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR 
       410        420        430        440        450
IHAESLLLDS PAVAKSGDNL AEENSRDENR ALVHQLSNES RLSITDSLSE 
       460        470        480        490        500
FFDAQEVLLS PSSSENEISD DDSYVSDISD NLSLDNLSND LDNERQTLGP 
       510        520        530        540        550
VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL SKVAMPVELN 
       560        570        580        590        600
EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVRSQPSLA TVQPRSPSHE 
       610        620        630        640 
AIHGAHQRDS PCSLRFHFDC SVNRFITQSC LASSAWLFPV TL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:642

Mass (Da):72,211

Checksum:ⁱ7AC19EA7AE07E5E4

GO

Isoform 2b (identifier: Q9H4L5-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 
       310        320        330        340        350
MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK 
       360        370        380        390        400
NALSSALAQN TDLKERLRRI HAESLLLDSP AVAKSGDNLA EENSRDENRA 
       410        420        430        440        450
LVHQLSNESR LSITDSLSEF FDAQEVLLSP SSSENEISDD DSYVSDISDN 
       460        470        480        490        500
LSLDNLSNDL DNERQTLGPV LDSGREAKSR RRTCLPAPCP SSSNISLWNI 
       510        520        530        540        550
LRNNIGKDLS KVAMPVELNE PLNTLQRLCE ELEYSELLDK AAQIPSPLER 
       560        570        580        590        600
MVRSQPSLAT VQPRSPSHEA IHGAHQRDSP CSLRFHFDCS VNRFITQSCL 
       610 
ASSAWLFPVT L

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:611

Mass (Da):68,674

Checksum:ⁱ1A92347357A219CE

GO

Isoform 2c (identifier: Q9H4L5-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 
       310        320        330        340        350
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA 
       360        370        380        390        400
FNIMSAEREK LKQLMEQDAS SSPSAQVIGL KNALSSENSR DENRALVHQL 
       410        420        430        440        450
SNESRLSITD SLSEFFDAQE VLLSPSSSEN EISDDDSYVS DISDNLSLDN 
       460        470        480        490        500
LSNDLDNERQ TLGPVLDSGR EAKSRRRTCL PAPCPSSSNI SLWNILRNNI 
       510        520        530        540        550
GKDLSKVAMP VELNEPLNTL QRLCEELEYS ELLDKAAQIP SPLERMVRSQ 
       560        570        580        590        600
PSLATVQPRS PSHEAIHGAH QRDSPCSLRF HFDCSVNRFI TQSCLASSAW 

LFPVTL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:606

Mass (Da):68,313

Checksum:ⁱEA72B4600CF3C1B8

GO

Isoform 2d (identifier: Q9H4L5-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-289: Missing.
     387-422: Missing.
     584-631: YVAAFAISAY...FQFFSEQVSH → RSQPSLATVQ...SSAWLFPVTL
     632-887: Missing.

« Hide

        10         20         30         40         50
MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE 
        60         70         80         90        100
PPVQKGFLLK KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID 
       110        120        130        140        150
VGLSVMSVKK SSKCIDLDTE EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN 
       160        170        180        190        200
EIAMFPHEVN HFFSGSTITD SSSGVFDSIS SRKRSSISKQ NLFQTGSNVS 
       210        220        230        240        250
FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL QSMDVLHRTY 
       260        270        280        290        300
SAPAINAIQV PKPFSGPVRL HSSNPNLSTL DFGEEKNYSD GSETSSEFSK 
       310        320        330        340        350
MQEDLCHIAH KVYFTLRSAF NIMSAEREKL KQLMEQDASS SPSAQVIGLK 
       360        370        380        390        400
NALSSENSRD ENRALVHQLS NESRLSITDS LSEFFDAQEV LLSPSSSENE 
       410        420        430        440        450
ISDDDSYVSD ISDNLSLDNL SNDLDNERQT LGPVLDSGRE AKSRRRTCLP 
       460        470        480        490        500
APCPSSSNIS LWNILRNNIG KDLSKVAMPV ELNEPLNTLQ RLCEELEYSE 
       510        520        530        540        550
LLDKAAQIPS PLERMVRSQP SLATVQPRSP SHEAIHGAHQ RDSPCSLRFH 
       560        570 
FDCSVNRFIT QSCLASSAWL FPVTL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:575

Mass (Da):64,776

Checksum:ⁱCD8F92033643E963

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JZ19	C9JZ19_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 3	OSBPL3	112	Annotation score:
C9JEF2	C9JEF2_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 3	OSBPL3	89	Annotation score:
C9J8P4	C9J8P4_HUMAN	Oxysterol-binding protein-related p... Oxysterol-binding protein-related protein 3	OSBPL3	61	Annotation score:

Sequence cautionⁱ

The sequence BAA31679 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053548	354	M → V. Corresponds to variant dbSNP:rs11768296Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_008219	259 – 289	Missing in isoform 1b, isoform 1d, isoform 2b and isoform 2d. 1 PublicationAdd BLAST	31
Alternative sequenceⁱVSP_008220	387 – 422	Missing in isoform 1c, isoform 1d, isoform 2c and isoform 2d. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_008221	584 – 631	YVAAF…EQVSH → RSQPSLATVQPRSPSHEAIH GAHQRDSPCSLRFHFDCSVN RFITQSCLASSAWLFPVTL in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST	48
Alternative sequenceⁱVSP_008222	632 – 887	Missing in isoform 2a, isoform 2b, isoform 2c and isoform 2d. 1 PublicationAdd BLAST	256

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY008372 mRNA Translation: AAG23400.1 AF392444 mRNA Translation: AAL40657.1 AF491781 mRNA Translation: AAM27386.1 AF491782 mRNA Translation: AAM27387.1 AF491783 mRNA Translation: AAM27388.1 AF491784 mRNA Translation: AAM27389.1 AF491785 mRNA Translation: AAM27390.1 AF491786 mRNA Translation: AAM27391.1 AF515639 mRNA Translation: AAM74165.1 AF515640 mRNA Translation: AAM74166.1 AB014604 mRNA Translation: BAA31679.2 Different initiation. AC003093 Genomic DNA Translation: AAB83939.1 AC004008 Genomic DNA No translation available. AC004016 Genomic DNA Translation: AAC26986.2 AC004239 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24240.1 CH236948 Genomic DNA Translation: EAL24241.1 CH236948 Genomic DNA Translation: EAL24242.1 CH236948 Genomic DNA Translation: EAL24243.1 CH236948 Genomic DNA Translation: EAL24244.1 CH236948 Genomic DNA Translation: EAL24245.1 CH471073 Genomic DNA Translation: EAW93816.1 CH471073 Genomic DNA Translation: EAW93817.1 CH471073 Genomic DNA Translation: EAW93818.1 CH471073 Genomic DNA Translation: EAW93819.1 CH471073 Genomic DNA Translation: EAW93820.1 CH471073 Genomic DNA Translation: EAW93821.1 BC017731 mRNA Translation: AAH17731.1 AF323727 mRNA Translation: AAG53408.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47564.1 [Q9H4L5-4] CCDS5390.1 [Q9H4L5-1] CCDS5391.1 [Q9H4L5-2] CCDS5392.1 [Q9H4L5-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_056365.1, NM_015550.3 [Q9H4L5-1] NP_663160.1, NM_145320.2 [Q9H4L5-2] NP_663161.1, NM_145321.2 [Q9H4L5-3] NP_663162.1, NM_145322.2 [Q9H4L5-4] XP_005249755.1, XM_005249698.3 [Q9H4L5-1] XP_006715744.1, XM_006715681.3 [Q9H4L5-2] XP_006715745.1, XM_006715682.3 [Q9H4L5-3] XP_006715746.1, XM_006715683.3 [Q9H4L5-4] XP_011513560.1, XM_011515258.2 [Q9H4L5-1]
UniGeneⁱ	Hs.520259

Genome annotation databases

Ensemblⁱ	ENST00000313367; ENSP00000315410; ENSG00000070882 [Q9H4L5-1] ENST00000396429; ENSP00000379706; ENSG00000070882 [Q9H4L5-3] ENST00000396431; ENSP00000379708; ENSG00000070882 [Q9H4L5-2] ENST00000409069; ENSP00000386953; ENSG00000070882 [Q9H4L5-4] ENST00000409452; ENSP00000386801; ENSG00000070882 [Q9H4L5-5] ENST00000409555; ENSP00000386990; ENSG00000070882 [Q9H4L5-8] ENST00000409759; ENSP00000386325; ENSG00000070882 [Q9H4L5-7] ENST00000409863; ENSP00000386429; ENSG00000070882 [Q9H4L5-6]
GeneIDⁱ	26031
KEGGⁱ	hsa:26031
UCSC genome browser More...UCSCⁱ	uc003sxf.5 human [Q9H4L5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H4L5	Oxysterol-binding protein		PANTR		887	UniRef100_Q9H4L5
Oxysterol-binding protein		PANPA		887
Q9H4L5-2	Oxysterol-binding protein		PANTR		856	UniRef100_Q9H4L5-2
Oxysterol-binding protein		PANPA		856
Q9H4L5-4	Oxysterol-binding protein		PANTR		820	UniRef100_Q9H4L5-4

Protein	Similar proteins		Species	Score	Length	Source
Q9H4L5	Oxysterol-binding protein		PANTR		887	UniRef90_Q9H4L5
Oxysterol-binding protein		PANPA		887
Oxysterol-binding protein		DELLE		947
Oxysterol-binding protein (Fragment)		MUSPF		911
Oxysterol-binding protein (Fragment)		CANLF		911
+107
Q9H4L5-2	Oxysterol-binding protein-related protein 3		MOUSE		855	UniRef90_Q9H4L5-2
Oxysterol-binding protein		PANTR		856
Oxysterol-binding protein		PANPA		856
Oxysterol-binding protein		Florida manatee		861
Oxysterol-binding protein		CALJA		859
+70
Q9H4L5-3	Oxysterol-binding protein		Florida manatee		856	UniRef90_Q9H4L5-3
Oxysterol-binding protein		CALJA		854
Oxysterol-binding protein		PANTR		851
oxysterol-binding protein-related protein 3 isoform X3		BALAS		851
Oxysterol-binding protein		MACMU		851
+75
Q9H4L5-4	Oxysterol-binding protein		PANTR		820	UniRef90_Q9H4L5-4
Oxysterol-binding protein		Cebus capucinus imitator		820
Oxysterol-binding protein		CALJA		820
Oxysterol-binding protein		PONAB		820
Oxysterol-binding protein		ODORO		820
+62
Q9H4L5-5	OSBPL3 isoform 6 (Fragment)		PONAB		643	UniRef90_Q9H4L5-5
OSBPL3 isoform 6		PANTR		642
Q9H4L5-6	OSBPL3 isoform 9 (Fragment)		PONAB		612	UniRef90_Q9H4L5-6
OSBPL3 isoform 9		PANTR		611
Q9H4L5-7	OSBPL3 isoform 11 (Fragment)		PONAB		607	UniRef90_Q9H4L5-7
OSBPL3 isoform 11		PANTR		606
Q9H4L5-8	OSBPL3 isoform 10 (Fragment)		PONAB		576	UniRef90_Q9H4L5-8
OSBPL3 isoform 7		PANTR		575

Protein	Similar proteins		Species	Score	Length	Source
Q9H4L5	Oxysterol-binding protein-related protein 3		MOUSE		855	UniRef50_Q9H4L5
Oxysterol-binding protein		PANTR		887
Oxysterol-binding protein		PANPA		887
Oxysterol-binding protein		DELLE		947
Oxysterol-binding protein (Fragment)		MUSPF		911
+902
Q9H4L5-3	Oxysterol-binding protein		Florida manatee		856	UniRef50_Q9H4L5-3
Oxysterol-binding protein		CALJA		854
Oxysterol-binding protein		RHIBE		851
Oxysterol-binding protein		MACMU		851
Oxysterol-binding protein		COLAP		851
+316
Q9H4L5-4	Isoform 1c of Oxysterol-binding protein-related protein 3		HUMAN		851	UniRef50_Q9H4L5-3
Oxysterol-binding protein		Florida manatee		856
Oxysterol-binding protein		CALJA		854
Oxysterol-binding protein		RHIBE		851
Oxysterol-binding protein		MACMU		851
+316
Q9H4L5-5	OSBPL3 isoform 6 (Fragment)		PONAB		643	UniRef50_Q9H4L5-5
OSBPL3 isoform 6		PANTR		642
Oxysterol-binding protein-related protein 3 (Fragment)		brown roatelo		621
Oxysterol-binding protein-related protein 3 (Fragment)		EURHL		601
Oxysterol-binding protein-related protein 3 (Fragment)		HALAL		555
+14
Q9H4L5-6	Isoform 2a of Oxysterol-binding protein-related protein 3		HUMAN		642	UniRef50_Q9H4L5-5
OSBPL3 isoform 6 (Fragment)		PONAB		643
OSBPL3 isoform 6		PANTR		642
Oxysterol-binding protein-related protein 3 (Fragment)		brown roatelo		621
Oxysterol-binding protein-related protein 3 (Fragment)		EURHL		601
+14
Q9H4L5-7	OSBPL3 isoform 11 (Fragment)		PONAB		607	UniRef50_Q9H4L5-7
OSBPL3 isoform 11		PANTR		606
Oxysterol-binding protein		Nothobranchius pienaari		637
Uncharacterized protein		COLVI		631
Oxysterol-binding protein (Fragment)		COLLI		614
+3
Q9H4L5-8	OSBPL3 isoform 10 (Fragment)		PONAB		576	UniRef50_Q9H4L5-8
OSBPL3 isoform 7		PANTR		575

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY008372 mRNA Translation: AAG23400.1 AF392444 mRNA Translation: AAL40657.1 AF491781 mRNA Translation: AAM27386.1 AF491782 mRNA Translation: AAM27387.1 AF491783 mRNA Translation: AAM27388.1 AF491784 mRNA Translation: AAM27389.1 AF491785 mRNA Translation: AAM27390.1 AF491786 mRNA Translation: AAM27391.1 AF515639 mRNA Translation: AAM74165.1 AF515640 mRNA Translation: AAM74166.1 AB014604 mRNA Translation: BAA31679.2 Different initiation. AC003093 Genomic DNA Translation: AAB83939.1 AC004008 Genomic DNA No translation available. AC004016 Genomic DNA Translation: AAC26986.2 AC004239 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24240.1 CH236948 Genomic DNA Translation: EAL24241.1 CH236948 Genomic DNA Translation: EAL24242.1 CH236948 Genomic DNA Translation: EAL24243.1 CH236948 Genomic DNA Translation: EAL24244.1 CH236948 Genomic DNA Translation: EAL24245.1 CH471073 Genomic DNA Translation: EAW93816.1 CH471073 Genomic DNA Translation: EAW93817.1 CH471073 Genomic DNA Translation: EAW93818.1 CH471073 Genomic DNA Translation: EAW93819.1 CH471073 Genomic DNA Translation: EAW93820.1 CH471073 Genomic DNA Translation: EAW93821.1 BC017731 mRNA Translation: AAH17731.1 AF323727 mRNA Translation: AAG53408.1
CCDSⁱ	CCDS47564.1 [Q9H4L5-4] CCDS5390.1 [Q9H4L5-1] CCDS5391.1 [Q9H4L5-2] CCDS5392.1 [Q9H4L5-3]
RefSeqⁱ	NP_056365.1, NM_015550.3 [Q9H4L5-1] NP_663160.1, NM_145320.2 [Q9H4L5-2] NP_663161.1, NM_145321.2 [Q9H4L5-3] NP_663162.1, NM_145322.2 [Q9H4L5-4] XP_005249755.1, XM_005249698.3 [Q9H4L5-1] XP_006715744.1, XM_006715681.3 [Q9H4L5-2] XP_006715745.1, XM_006715682.3 [Q9H4L5-3] XP_006715746.1, XM_006715683.3 [Q9H4L5-4] XP_011513560.1, XM_011515258.2 [Q9H4L5-1]
UniGeneⁱ	Hs.520259

3D structure databases

ProteinModelPortalⁱ	Q9H4L5
SMRⁱ	Q9H4L5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117497, 40 interactors
ELMⁱ	Q9H4L5
IntActⁱ	Q9H4L5, 39 interactors
MINTⁱ	Q9H4L5
STRINGⁱ	9606.ENSP00000315410

PTM databases

iPTMnetⁱ	Q9H4L5
PhosphoSitePlusⁱ	Q9H4L5

Polymorphism and mutation databases

BioMutaⁱ	OSBPL3
DMDMⁱ	20139176

Proteomic databases

EPDⁱ	Q9H4L5
MaxQBⁱ	Q9H4L5
PaxDbⁱ	Q9H4L5
PeptideAtlasⁱ	Q9H4L5
PRIDEⁱ	Q9H4L5
ProteomicsDBⁱ	80852 80853 [Q9H4L5-2] 80854 [Q9H4L5-3] 80855 [Q9H4L5-4] 80856 [Q9H4L5-5] 80857 [Q9H4L5-6] 80858 [Q9H4L5-7] 80859 [Q9H4L5-8]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000313367; ENSP00000315410; ENSG00000070882 [Q9H4L5-1] ENST00000396429; ENSP00000379706; ENSG00000070882 [Q9H4L5-3] ENST00000396431; ENSP00000379708; ENSG00000070882 [Q9H4L5-2] ENST00000409069; ENSP00000386953; ENSG00000070882 [Q9H4L5-4] ENST00000409452; ENSP00000386801; ENSG00000070882 [Q9H4L5-5] ENST00000409555; ENSP00000386990; ENSG00000070882 [Q9H4L5-8] ENST00000409759; ENSP00000386325; ENSG00000070882 [Q9H4L5-7] ENST00000409863; ENSP00000386429; ENSG00000070882 [Q9H4L5-6]
GeneIDⁱ	26031
KEGGⁱ	hsa:26031
UCSCⁱ	uc003sxf.5 human [Q9H4L5-1]

Organism-specific databases

CTDⁱ	26031
DisGeNETⁱ	26031
EuPathDBⁱ	HostDB:ENSG00000070882.12
GeneCardsⁱ	OSBPL3
HGNCⁱ	HGNC:16370 OSBPL3
HPAⁱ	HPA000691 HPA048401
MIMⁱ	606732 gene
neXtProtⁱ	NX_Q9H4L5
OpenTargetsⁱ	ENSG00000070882
PharmGKBⁱ	PA32828
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1737 Eukaryota ENOG410XP9E LUCA
GeneTreeⁱ	ENSGT00760000119155
HOVERGENⁱ	HBG058934
InParanoidⁱ	Q9H4L5
KOⁱ	K20463
OMAⁱ	YTQEPPI
OrthoDBⁱ	EOG091G0DJB
PhylomeDBⁱ	Q9H4L5
TreeFamⁱ	TF320922

Enzyme and pathway databases

Reactomeⁱ	R-HSA-192105 Synthesis of bile acids and bile salts

Reactomeⁱ

R-HSA-192105 Synthesis of bile acids and bile salts

Miscellaneous databases

ChiTaRSⁱ	OSBPL3 human
GeneWikiⁱ	OSBPL3
GenomeRNAiⁱ	26031
Protein Ontology More...PROⁱ	PR:Q9H4L5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000070882 Expressed in 188 organ(s), highest expression level in cortex of kidney
ExpressionAtlasⁱ	Q9H4L5 baseline and differential
Genevisibleⁱ	Q9H4L5 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR037239 OSBP_sf IPR000648 Oxysterol-bd IPR018494 Oxysterol-bd_CS IPR011993 PH-like_dom_sf IPR001849 PH_domain
PANTHERⁱ	PTHR10972 PTHR10972, 1 hit
Pfamⁱ	View protein in Pfam PF01237 Oxysterol_BP, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
SUPFAMⁱ	SSF144000 SSF144000, 1 hit
PROSITEⁱ	View protein in PROSITE PS01013 OSBP, 1 hit PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OSBL3_HUMAN
Accessionⁱ	Q9H4L5Primary (citable) accession number: Q9H4L5 Secondary accession number(s): A4D167 Q9UED6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H4L5 (OSBL3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Oxysterol-binding protein-related protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Nucleus

Plasma membrane

Cytosol

Other locations

Cytosol

Endoplasmic reticulum

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ