UniProtKB - Q9H4L4 (SENP3_HUMAN)

BLAST

>sp|Q9H4L4|SENP3_HUMAN Sentrin-specific protease 3 OS=Homo sapiens OX=9606 GN=SENP3 PE=1 SV=2
MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPA
RRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWSQLGTSQRPRPSRPTHRK
TCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRGLAHPKNHLSPQQGGATPQVP
SPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGL
LSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPG
EKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKGLV
LQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPE
KVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITY
FDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYC
KHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV

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History
Entry version 149 (12 Sep 2018)
Sequence version 2 (12 Dec 2006)
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Protein

Sentrin-specific protease 3

Gene

SENP3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.7 Publications

Activity regulationⁱ

On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	465	By similarity	1
Active siteⁱ	482	By similarity	1
Active siteⁱ	532	By similarity	1

GO - Molecular functionⁱ

cysteine-type peptidase activity Source: UniProtKB-KW
endopeptidase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein desumoylation Source: GO_Central
rRNA processing Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease
Biological process	Ubl conjugation pathway

Enzyme and pathway databases

BRENDAⁱ	3.4.22.B72 2681
Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C48.003

MEROPSⁱ

C48.003

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sentrin-specific protease 3 (EC:3.4.22.-) Alternative name(s): SUMO-1-specific protease 3 Sentrin/SUMO-specific protease SENP3
Gene namesⁱ	Name:SENP3 Synonyms:SSP3, SUSP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161956.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17862 SENP3
MIMⁱ	612844 gene
neXtProtⁱ	NX_Q9H4L4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	532	C → S: Loss of enzymatic activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26168
Open Targets More...OpenTargetsⁱ	ENSG00000161956
PharmGKBⁱ	PA134933213

Polymorphism and mutation databases

BioMutaⁱ	SENP3
DMDMⁱ	119370525

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000101721	1 – 574	Sentrin-specific protease 3Add BLAST		574

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	54	PhosphoserineCombined sources	1
Modified residueⁱ	73	PhosphoserineBy similarity	1
Modified residueⁱ	75	PhosphoserineBy similarity	1
Modified residueⁱ	169	PhosphoserineBy similarity	1
Modified residueⁱ	176	PhosphothreonineBy similarity	1
Modified residueⁱ	181	PhosphoserineBy similarity	1
Modified residueⁱ	188	PhosphoserineBy similarity	1
Modified residueⁱ	212	PhosphoserineBy similarity	1
Modified residueⁱ	232	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H4L4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H4L4
PaxDbⁱ	Q9H4L4
PeptideAtlas More...PeptideAtlasⁱ	Q9H4L4
PRIDEⁱ	Q9H4L4
ProteomicsDBⁱ	80851

PTM databases

iPTMnetⁱ	Q9H4L4
PhosphoSitePlusⁱ	Q9H4L4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000161956 Expressed in 223 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_SENP3
ExpressionAtlasⁱ	Q9H4L4 baseline and differential
Genevisibleⁱ	Q9H4L4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060290

HPAⁱ

HPA060290

Interactionⁱ

Subunit structureⁱ

Binds to SUMO1 and SUMO3 (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with CCAR2.By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
NPM1	P06748	6	EBI-2880236,EBI-78579
PELP1	Q8IZL8	5	EBI-2880236,EBI-716449
TEX10	Q9NXF1	2	EBI-2880236,EBI-2371062
UBC	P0CG48	2	EBI-2880236,EBI-3390054
WDR18	Q9BV38	3	EBI-2880236,EBI-727429

Protein-protein interaction databases

BioGridⁱ	117594, 121 interactors
CORUMⁱ	Q9H4L4
Database of interacting proteins More...DIPⁱ	DIP-47511N
IntActⁱ	Q9H4L4, 32 interactors
Molecular INTeraction database More...MINTⁱ	Q9H4L4
STRINGⁱ	9606.ENSP00000403712

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H4L4
SMRⁱ	Q9H4L4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	386 – 543	ProteaseAdd BLAST		158

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	125 – 128	Nuclear localization signalSequence analysis		4
Motifⁱ	153 – 159	Nuclear localization signalSequence analysis		7

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	13 – 68	Pro-richAdd BLAST	56
Compositional biasⁱ	76 – 92	Glu-richAdd BLAST	17
Compositional biasⁱ	192 – 195	Poly-Pro	4

Sequence similaritiesⁱ

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0778 Eukaryota COG5160 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062941
HOGENOMⁱ	HOG000154287
HOVERGENⁱ	HBG059450
InParanoidⁱ	Q9H4L4
KEGG Orthology (KO) More...KOⁱ	K08593
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G092N
PhylomeDBⁱ	Q9H4L4
TreeFamⁱ	TF316289

Family and domain databases

InterProⁱ	View protein in InterPro IPR038765 Papain_like_cys_pep_sf IPR003653 Peptidase_C48_C IPR037945 SENP3
PANTHERⁱ	PTHR12606:SF16 PTHR12606:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02902 Peptidase_C48, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS50600 ULP_PROTEASE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.ⁱShow all

Q9H4L4-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKETIQGTGS WGPEPPGPGI PPAYSSPRRE RLRWPPPPKP RLKSGGGFGP 
        60         70         80         90        100
DPGSGTTVPA RRLPVPRPSF DASASEEEEE EEEEEDEDEE EEVAAWRLPP 
       110        120        130        140        150
RWSQLGTSQR PRPSRPTHRK TCSQRRRRAM RAFRMLLYSK STSLTFHWKL 
       160        170        180        190        200
WGRHRGRRRG LAHPKNHLSP QQGGATPQVP SPCCRFDSPR GPPPPRLGLL 
       210        220        230        240        250
GALMAEDGVR GSPPVPSGPP MEEDGLRWTP KSPLDPDSGL LSCTLPNGFG 
       260        270        280        290        300
GQSGPEGERS LAPPDASILI SNVCSIGDHV AQELFQGSDL GMAEEAERPG 
       310        320        330        340        350
EKAGQHSPLR EEHVTCVQSI LDEFLQTYGS LIPLSTDEVV EKLEDIFQQE 
       360        370        380        390        400
FSTPSRKGLV LQLIQSYQRM PGNAMVRGFR VAYKRHVLTM DDLGTLYGQN 
       410        420        430        440        450
WLNDQVMNMY GDLVMDTVPE KVHFFNSFFY DKLRTKGYDG VKRWTKNVDI 
       460        470        480        490        500
FNKELLLIPI HLEVHWSLIS VDVRRRTITY FDSQRTLNRR CPKHIAKYLQ 
       510        520        530        540        550
AEAVKKDRLD FHQGWKGYFK MNVARQNNDS DCGAFVLQYC KHLALSQPFS 
       560        570 
FTQQDMPKLR RQIYKELCHC KLTV

Length:574

Mass (Da):65,010

Last modified:December 12, 2006 - v2

Checksum:ⁱE495137EE7500741

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
J3QL36	J3QL36_HUMAN	Sentrin-specific protease 3 Sentrin-specific protease 3	SENP3	237	Annotation score:
A0A087WV50	A0A087WV50_HUMAN	Sentrin-specific protease 3 Sentrin-specific protease 3	SENP3	177	Annotation score:
J3KSF5	J3KSF5_HUMAN	Sentrin-specific protease 3 Sentrin-specific protease 3	SENP3	82	Annotation score:
J3QRE4	J3QRE4_HUMAN	Sentrin-specific protease 3 Sentrin-specific protease 3	SENP3	110	Annotation score:
A0A087WZ63	A0A087WZ63_HUMAN	Sentrin-specific protease 3 Sentrin-specific protease 3	SENP3	63	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30 – 31	ER → DG in AAG33252 (PubMed:10806345).Curated	2
Sequence conflictⁱ	60	A → T in AAG33252 (PubMed:10806345).Curated	1
Sequence conflictⁱ	65	V → A in AAG33252 (PubMed:10806345).Curated	1
Sequence conflictⁱ	113 – 114	PS → AL in AAG33252 (PubMed:10806345).Curated	2
Sequence conflictⁱ	117	T → S in AAG33252 (PubMed:10806345).Curated	1
Sequence conflictⁱ	134	R → Q in AAG33252 (PubMed:10806345).Curated	1
Sequence conflictⁱ	161	L → S in AAH48306 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051544	515	W → R. Corresponds to variant dbSNP:rs9972914Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY008763 mRNA Translation: AAG33252.1 AF199459 mRNA Translation: AAL25652.1 AL050283 mRNA Translation: CAB43384.2 AL834294 mRNA Translation: CAD38967.1 BC048306 mRNA Translation: AAH48306.1 BC080658 mRNA Translation: AAH80658.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73958.1
PIRⁱ	T08759
NCBI Reference Sequences More...RefSeqⁱ	NP_056485.2, NM_015670.5
UniGeneⁱ	Hs.513926 Hs.733104

Genome annotation databases

Ensemblⁱ	ENST00000321337; ENSP00000314029; ENSG00000161956 ENST00000429205; ENSP00000403712; ENSG00000161956
GeneIDⁱ	26168
KEGGⁱ	hsa:26168
UCSC genome browser More...UCSCⁱ	uc032esp.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H4L4	Sentrin-specific protease 3		MOUSE		568	UniRef90_Q9H4L4
Uncharacterized protein		RHIRO		580
Uncharacterized protein		RHIBE		580
sentrin-specific protease 3		TARSY		574
Uncharacterized protein		FELCA		574
+120

Protein	Similar proteins		Species	Score	Length	Source
Q9H4L4	Sentrin-specific protease 3		MOUSE		568	UniRef50_Q9H4L4
Uncharacterized protein		RHIRO		580
Uncharacterized protein		RHIBE		580
Uncharacterized protein		Cebus capucinus imitator		574
Sentrin-specific protease 3		CALJA		574
+142

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY008763 mRNA Translation: AAG33252.1 AF199459 mRNA Translation: AAL25652.1 AL050283 mRNA Translation: CAB43384.2 AL834294 mRNA Translation: CAD38967.1 BC048306 mRNA Translation: AAH48306.1 BC080658 mRNA Translation: AAH80658.1
CCDSⁱ	CCDS73958.1
PIRⁱ	T08759
RefSeqⁱ	NP_056485.2, NM_015670.5
UniGeneⁱ	Hs.513926 Hs.733104

3D structure databases

ProteinModelPortalⁱ	Q9H4L4
SMRⁱ	Q9H4L4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117594, 121 interactors
CORUMⁱ	Q9H4L4
DIPⁱ	DIP-47511N
IntActⁱ	Q9H4L4, 32 interactors
MINTⁱ	Q9H4L4
STRINGⁱ	9606.ENSP00000403712

Protein family/group databases

MEROPSⁱ	C48.003

MEROPSⁱ

C48.003

PTM databases

iPTMnetⁱ	Q9H4L4
PhosphoSitePlusⁱ	Q9H4L4

Polymorphism and mutation databases

BioMutaⁱ	SENP3
DMDMⁱ	119370525

Proteomic databases

EPDⁱ	Q9H4L4
MaxQBⁱ	Q9H4L4
PaxDbⁱ	Q9H4L4
PeptideAtlasⁱ	Q9H4L4
PRIDEⁱ	Q9H4L4
ProteomicsDBⁱ	80851

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26168
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000321337; ENSP00000314029; ENSG00000161956 ENST00000429205; ENSP00000403712; ENSG00000161956
GeneIDⁱ	26168
KEGGⁱ	hsa:26168
UCSCⁱ	uc032esp.2 human

Organism-specific databases

CTDⁱ	26168
DisGeNETⁱ	26168
EuPathDBⁱ	HostDB:ENSG00000161956.12
GeneCardsⁱ	SENP3
H-InvDBⁱ	HIX0013501
HGNCⁱ	HGNC:17862 SENP3
HPAⁱ	HPA060290
MIMⁱ	612844 gene
neXtProtⁱ	NX_Q9H4L4
OpenTargetsⁱ	ENSG00000161956
PharmGKBⁱ	PA134933213
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0778 Eukaryota COG5160 LUCA
GeneTreeⁱ	ENSGT00530000062941
HOGENOMⁱ	HOG000154287
HOVERGENⁱ	HBG059450
InParanoidⁱ	Q9H4L4
KOⁱ	K08593
OrthoDBⁱ	EOG091G092N
PhylomeDBⁱ	Q9H4L4
TreeFamⁱ	TF316289

Enzyme and pathway databases

BRENDAⁱ	3.4.22.B72 2681
Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	SENP3 human
GeneWikiⁱ	SENP3
GenomeRNAiⁱ	26168
Protein Ontology More...PROⁱ	PR:Q9H4L4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161956 Expressed in 223 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_SENP3
ExpressionAtlasⁱ	Q9H4L4 baseline and differential
Genevisibleⁱ	Q9H4L4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038765 Papain_like_cys_pep_sf IPR003653 Peptidase_C48_C IPR037945 SENP3
PANTHERⁱ	PTHR12606:SF16 PTHR12606:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF02902 Peptidase_C48, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS50600 ULP_PROTEASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SENP3_HUMAN
Accessionⁱ	Q9H4L4Primary (citable) accession number: Q9H4L4 Secondary accession number(s): Q66K15 , Q86VS7, Q96PS4, Q9Y3W9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
	Last sequence update:	December 12, 2006
	Last modified:	September 12, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9H4L4 (SENP3_HUMAN)

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Sentrin-specific protease 3

SENP3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ