UniProtKB - Q9H4L4 (SENP3_HUMAN)
Sentrin-specific protease 3
SENP3
Functioni
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 465 | By similarity | 1 | |
Active sitei | 482 | By similarity | 1 | |
Active sitei | 532 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
GO - Biological processi
- protein desumoylation Source: GO_Central
- rRNA processing Source: Reactome
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
BRENDAi | 3.4.22.B72, 2681 |
PathwayCommonsi | Q9H4L4 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Protein family/group databases
MEROPSi | C48.003 |
Names & Taxonomyi
Protein namesi | Recommended name: Sentrin-specific protease 3 (EC:3.4.22.-)Alternative name(s): SUMO-1-specific protease 3 Sentrin/SUMO-specific protease SENP3 |
Gene namesi | Name:SENP3 Synonyms:SSP3, SUSP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000161956.12 |
HGNCi | HGNC:17862, SENP3 |
MIMi | 612844, gene |
neXtProti | NX_Q9H4L4 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
- nucleoplasm 2 Publications
Other locations
- Cytoplasm By similarity
Note: Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).By similarity1 Publication
Nucleus
- MLL1 complex Source: UniProtKB
- nucleolus Source: LIFEdb
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 532 | C → S: Loss of enzymatic activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 26168 |
OpenTargetsi | ENSG00000161956 |
PharmGKBi | PA134933213 |
Miscellaneous databases
Pharosi | Q9H4L4, Tbio |
Polymorphism and mutation databases
BioMutai | SENP3 |
DMDMi | 119370525 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101721 | 1 – 574 | Sentrin-specific protease 3Add BLAST | 574 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 73 | PhosphoserineBy similarity | 1 | |
Modified residuei | 75 | PhosphoserineBy similarity | 1 | |
Modified residuei | 169 | PhosphoserineBy similarity | 1 | |
Modified residuei | 176 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 181 | PhosphoserineBy similarity | 1 | |
Modified residuei | 188 | PhosphoserineBy similarity | 1 | |
Modified residuei | 212 | PhosphoserineBy similarity | 1 | |
Modified residuei | 232 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H4L4 |
jPOSTi | Q9H4L4 |
MassIVEi | Q9H4L4 |
MaxQBi | Q9H4L4 |
PaxDbi | Q9H4L4 |
PeptideAtlasi | Q9H4L4 |
PRIDEi | Q9H4L4 |
ProteomicsDBi | 80851 |
PTM databases
iPTMneti | Q9H4L4 |
PhosphoSitePlusi | Q9H4L4 |
SwissPalmi | Q9H4L4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000161956, Expressed in anterior cingulate cortex and 234 other tissues |
ExpressionAtlasi | Q9H4L4, baseline and differential |
Genevisiblei | Q9H4L4, HS |
Organism-specific databases
HPAi | ENSG00000161956, Low tissue specificity |
Interactioni
Subunit structurei
Binds to SUMO1 and SUMO3 (By similarity).
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Interacts with EP300, NPM1 and CDCA8.
Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
Interacts with NOL9.
Interacts with CCAR2.
By similarity7 PublicationsBinary interactionsi
Hide detailsQ9H4L4
Protein-protein interaction databases
BioGRIDi | 117594, 139 interactors |
CORUMi | Q9H4L4 |
DIPi | DIP-47511N |
IntActi | Q9H4L4, 43 interactors |
MINTi | Q9H4L4 |
STRINGi | 9606.ENSP00000314029 |
Miscellaneous databases
RNActi | Q9H4L4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 386 – 543 | ProteaseAdd BLAST | 158 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 125 – 128 | Nuclear localization signalSequence analysis | 4 | |
Motifi | 153 – 159 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 68 | Pro-richAdd BLAST | 56 | |
Compositional biasi | 76 – 92 | Glu-richAdd BLAST | 17 | |
Compositional biasi | 192 – 195 | Poly-Pro | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0778, Eukaryota |
GeneTreei | ENSGT00940000156309 |
HOGENOMi | CLU_035238_0_0_1 |
InParanoidi | Q9H4L4 |
OrthoDBi | 1480705at2759 |
PhylomeDBi | Q9H4L4 |
TreeFami | TF316289 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR003653, Peptidase_C48_C IPR037945, SENP3 |
PANTHERi | PTHR12606:SF16, PTHR12606:SF16, 1 hit |
Pfami | View protein in Pfam PF02902, Peptidase_C48, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50600, ULP_PROTEASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKETIQGTGS WGPEPPGPGI PPAYSSPRRE RLRWPPPPKP RLKSGGGFGP
60 70 80 90 100
DPGSGTTVPA RRLPVPRPSF DASASEEEEE EEEEEDEDEE EEVAAWRLPP
110 120 130 140 150
RWSQLGTSQR PRPSRPTHRK TCSQRRRRAM RAFRMLLYSK STSLTFHWKL
160 170 180 190 200
WGRHRGRRRG LAHPKNHLSP QQGGATPQVP SPCCRFDSPR GPPPPRLGLL
210 220 230 240 250
GALMAEDGVR GSPPVPSGPP MEEDGLRWTP KSPLDPDSGL LSCTLPNGFG
260 270 280 290 300
GQSGPEGERS LAPPDASILI SNVCSIGDHV AQELFQGSDL GMAEEAERPG
310 320 330 340 350
EKAGQHSPLR EEHVTCVQSI LDEFLQTYGS LIPLSTDEVV EKLEDIFQQE
360 370 380 390 400
FSTPSRKGLV LQLIQSYQRM PGNAMVRGFR VAYKRHVLTM DDLGTLYGQN
410 420 430 440 450
WLNDQVMNMY GDLVMDTVPE KVHFFNSFFY DKLRTKGYDG VKRWTKNVDI
460 470 480 490 500
FNKELLLIPI HLEVHWSLIS VDVRRRTITY FDSQRTLNRR CPKHIAKYLQ
510 520 530 540 550
AEAVKKDRLD FHQGWKGYFK MNVARQNNDS DCGAFVLQYC KHLALSQPFS
560 570
FTQQDMPKLR RQIYKELCHC KLTV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3QL36 | J3QL36_HUMAN | Sentrin-specific protease 3 | SENP3 | 237 | Annotation score: | ||
J3KSF5 | J3KSF5_HUMAN | Sentrin-specific protease 3 | SENP3 | 82 | Annotation score: | ||
J3QRE4 | J3QRE4_HUMAN | Sentrin-specific protease 3 | SENP3 | 110 | Annotation score: | ||
A0A087WV50 | A0A087WV50_HUMAN | Sentrin-specific protease 3 | SENP3 | 177 | Annotation score: | ||
A0A087WZ63 | A0A087WZ63_HUMAN | Sentrin-specific protease 3 | SENP3 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 – 31 | ER → DG in AAG33252 (PubMed:10806345).Curated | 2 | |
Sequence conflicti | 60 | A → T in AAG33252 (PubMed:10806345).Curated | 1 | |
Sequence conflicti | 65 | V → A in AAG33252 (PubMed:10806345).Curated | 1 | |
Sequence conflicti | 113 – 114 | PS → AL in AAG33252 (PubMed:10806345).Curated | 2 | |
Sequence conflicti | 117 | T → S in AAG33252 (PubMed:10806345).Curated | 1 | |
Sequence conflicti | 134 | R → Q in AAG33252 (PubMed:10806345).Curated | 1 | |
Sequence conflicti | 161 | L → S in AAH48306 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051544 | 515 | W → R. Corresponds to variant dbSNP:rs9972914Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008763 mRNA Translation: AAG33252.1 AF199459 mRNA Translation: AAL25652.1 AL050283 mRNA Translation: CAB43384.2 AL834294 mRNA Translation: CAD38967.1 BC048306 mRNA Translation: AAH48306.1 BC080658 mRNA Translation: AAH80658.1 |
CCDSi | CCDS73958.1 |
PIRi | T08759 |
RefSeqi | NP_056485.2, NM_015670.5 |
Genome annotation databases
Ensembli | ENST00000321337; ENSP00000314029; ENSG00000161956 ENST00000429205; ENSP00000403712; ENSG00000161956 |
GeneIDi | 26168 |
KEGGi | hsa:26168 |
UCSCi | uc032esp.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008763 mRNA Translation: AAG33252.1 AF199459 mRNA Translation: AAL25652.1 AL050283 mRNA Translation: CAB43384.2 AL834294 mRNA Translation: CAD38967.1 BC048306 mRNA Translation: AAH48306.1 BC080658 mRNA Translation: AAH80658.1 |
CCDSi | CCDS73958.1 |
PIRi | T08759 |
RefSeqi | NP_056485.2, NM_015670.5 |
3D structure databases
SMRi | Q9H4L4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117594, 139 interactors |
CORUMi | Q9H4L4 |
DIPi | DIP-47511N |
IntActi | Q9H4L4, 43 interactors |
MINTi | Q9H4L4 |
STRINGi | 9606.ENSP00000314029 |
Protein family/group databases
MEROPSi | C48.003 |
PTM databases
iPTMneti | Q9H4L4 |
PhosphoSitePlusi | Q9H4L4 |
SwissPalmi | Q9H4L4 |
Polymorphism and mutation databases
BioMutai | SENP3 |
DMDMi | 119370525 |
Proteomic databases
EPDi | Q9H4L4 |
jPOSTi | Q9H4L4 |
MassIVEi | Q9H4L4 |
MaxQBi | Q9H4L4 |
PaxDbi | Q9H4L4 |
PeptideAtlasi | Q9H4L4 |
PRIDEi | Q9H4L4 |
ProteomicsDBi | 80851 |
Protocols and materials databases
Antibodypediai | 24161, 228 antibodies |
DNASUi | 26168 |
Genome annotation databases
Ensembli | ENST00000321337; ENSP00000314029; ENSG00000161956 ENST00000429205; ENSP00000403712; ENSG00000161956 |
GeneIDi | 26168 |
KEGGi | hsa:26168 |
UCSCi | uc032esp.2, human |
Organism-specific databases
CTDi | 26168 |
DisGeNETi | 26168 |
EuPathDBi | HostDB:ENSG00000161956.12 |
GeneCardsi | SENP3 |
HGNCi | HGNC:17862, SENP3 |
HPAi | ENSG00000161956, Low tissue specificity |
MIMi | 612844, gene |
neXtProti | NX_Q9H4L4 |
OpenTargetsi | ENSG00000161956 |
PharmGKBi | PA134933213 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0778, Eukaryota |
GeneTreei | ENSGT00940000156309 |
HOGENOMi | CLU_035238_0_0_1 |
InParanoidi | Q9H4L4 |
OrthoDBi | 1480705at2759 |
PhylomeDBi | Q9H4L4 |
TreeFami | TF316289 |
Enzyme and pathway databases
BRENDAi | 3.4.22.B72, 2681 |
PathwayCommonsi | Q9H4L4 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 26168, 5 hits in 101 CRISPR screens |
GeneWikii | SENP3 |
GenomeRNAii | 26168 |
Pharosi | Q9H4L4, Tbio |
PROi | PR:Q9H4L4 |
RNActi | Q9H4L4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161956, Expressed in anterior cingulate cortex and 234 other tissues |
ExpressionAtlasi | Q9H4L4, baseline and differential |
Genevisiblei | Q9H4L4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR003653, Peptidase_C48_C IPR037945, SENP3 |
PANTHERi | PTHR12606:SF16, PTHR12606:SF16, 1 hit |
Pfami | View protein in Pfam PF02902, Peptidase_C48, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50600, ULP_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SENP3_HUMAN | |
Accessioni | Q9H4L4Primary (citable) accession number: Q9H4L4 Secondary accession number(s): Q66K15 Q9Y3W9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | December 12, 2006 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries