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UniProtKB - Q9H4K1 (RIBC2_HUMAN)

Entry version 127 (10 Feb 2021)
Sequence version 2 (13 Nov 2019)
Previous versions | rss
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Protein

RIB43A-like with coiled-coils protein 2

Gene

RIBC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H4K1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RIB43A-like with coiled-coils protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIBC2Imported
Synonyms:C22orf11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13241, RIBC2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H4K1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128408.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26150

Open Targets

More...OpenTargetsi		ENSG00000128408

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134967342

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H4K1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RIBC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752644

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002540981 – 382RIB43A-like with coiled-coils protein 2Add BLAST382

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H4K1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H4K1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H4K1

PeptideAtlas

More...PeptideAtlasi		Q9H4K1

PRoteomics IDEntifications database

More...PRIDEi		Q9H4K1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80849

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H4K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128408, Expressed in testis and 124 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117581, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q9H4K1, 29 interactors

Molecular INTeraction database

More...MINTi		Q9H4K1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483356

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H4K1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H4K1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili222 – 255Sequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIB43A family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWST, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010825

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061822_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H4K1

Identification of Orthologs from Complete Genome Data

More...OMAi		TTRKAVC

Database of Orthologous Groups

More...OrthoDBi		1276305at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H4K1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008805, RIB43A

The PANTHER Classification System

More...PANTHERi		PTHR14517, PTHR14517, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05914, RIB43A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H4K1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSQTMAVAL PRDLRQDANL AKRRHAELCR QKRVFNARNR IIGGDTEAWD 
        60         70         80         90        100
VQVHDQKIKE ATEKARHETF AAEMRQNDKI MCILENRKKR DRKNLCRAIN 
       110        120        130        140        150
DFQQSFQKPE TRREFDLSDP LALKKDLPAR QSDNDVRNTI SGMQKFMGED 
       160        170        180        190        200
LNFHERKKFQ EEQNREWSLQ QQREWKNARA EQKCAEALYT ETRLQFDETA 
       210        220        230        240        250
KHLQKLESTT RKAVCASVKD FNKSQAIESV ERKKQEKKQE QEDNLAEITN 
       260        270        280        290        300
LLRGDLLSEN PQQAASSFGP HRVVPDRWKG MTQEQLEQIR LVQKQQIQEK 
       310        320        330        340        350
LRLQEEKRQR DLDWDRRRIQ GARATLLFER QQWRRQRDLR RALDSSNLSL 
       360        370        380 
AKEQHLQKKY MNEVYTNQPT GDYFTQFNTG SR
Length:382
Mass (Da):45,427
Last modified:November 13, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB39EC19E335B97D4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03024 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH09904 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAC09526 differs from that shown. Reason: Frameshift.Curated
The sequence CAC09526 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAG30324 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028812253R → C. Corresponds to variant dbSNP:rs2142661Ensembl.1
Natural variantiVAR_028813268F → L2 PublicationsCorresponds to variant dbSNP:rs1022478Ensembl.1
Natural variantiVAR_028814335R → Q2 PublicationsCorresponds to variant dbSNP:rs2072770Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL442116 mRNA Translation: CAC09526.1 Sequence problems.
AL021391 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73384.1
BC003024 mRNA Translation: AAH03024.1 Different initiation.
BC009904 mRNA Translation: AAH09904.1 Different initiation.
CR456438 mRNA Translation: CAG30324.1 Different initiation.
CR457398 mRNA Translation: CAG33679.1
AL050075 mRNA Translation: CAB43258.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14066.2

Protein sequence database of the Protein Information Resource

More...PIRi		T08734

NCBI Reference Sequences

More...RefSeqi		NP_056468.3, NM_015653.4
XP_005261581.1, XM_005261524.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000614167; ENSP00000483356; ENSG00000128408

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26150

UCSC genome browser

More...UCSCi		uc032qrc.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL442116 mRNA Translation: CAC09526.1 Sequence problems.
AL021391 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73384.1
BC003024 mRNA Translation: AAH03024.1 Different initiation.
BC009904 mRNA Translation: AAH09904.1 Different initiation.
CR456438 mRNA Translation: CAG30324.1 Different initiation.
CR457398 mRNA Translation: CAG33679.1
AL050075 mRNA Translation: CAB43258.1
CCDSiCCDS14066.2
PIRiT08734
RefSeqiNP_056468.3, NM_015653.4
XP_005261581.1, XM_005261524.4

3D structure databases

SMRiQ9H4K1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117581, 27 interactors
IntActiQ9H4K1, 29 interactors
MINTiQ9H4K1
STRINGi9606.ENSP00000483356

PTM databases

PhosphoSitePlusiQ9H4K1

Genetic variation databases

BioMutaiRIBC2
DMDMi74752644

Proteomic databases

EPDiQ9H4K1
MassIVEiQ9H4K1
PaxDbiQ9H4K1
PeptideAtlasiQ9H4K1
PRIDEiQ9H4K1
ProteomicsDBi80849

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		303, 97 antibodies

The DNASU plasmid repository

More...DNASUi		26150

Genome annotation databases

EnsembliENST00000614167; ENSP00000483356; ENSG00000128408
GeneIDi26150
KEGGihsa:26150
UCSCiuc032qrc.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26150
DisGeNETi26150

GeneCards: human genes, protein and diseases

More...GeneCardsi		RIBC2
HGNCiHGNC:13241, RIBC2
neXtProtiNX_Q9H4K1
OpenTargetsiENSG00000128408
PharmGKBiPA134967342
VEuPathDBiHostDB:ENSG00000128408.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWST, Eukaryota
GeneTreeiENSGT00390000010825
HOGENOMiCLU_061822_0_1_1
InParanoidiQ9H4K1
OMAiTTRKAVC
OrthoDBi1276305at2759
PhylomeDBiQ9H4K1

Enzyme and pathway databases

PathwayCommonsiQ9H4K1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26150, 0 hits in 104 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RIBC2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26150
PharosiQ9H4K1, Tdark

Protein Ontology

More...PROi		PR:Q9H4K1
RNActiQ9H4K1, protein

Gene expression databases

BgeeiENSG00000128408, Expressed in testis and 124 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008805, RIB43A
PANTHERiPTHR14517, PTHR14517, 1 hit
PfamiView protein in Pfam
PF05914, RIB43A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIBC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4K1
Secondary accession number(s): A0A087X0F7, Q6ICD0, Q9Y413
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 13, 2019
Last modified: February 10, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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