UniProtKB - Q9H4K1 (RIBC2_HUMAN)
Protein
RIB43A-like with coiled-coils protein 2
Gene
RIBC2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: RIB43A-like with coiled-coils protein 2Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13241, RIBC2 |
neXtProti | NX_Q9H4K1 |
VEuPathDBi | HostDB:ENSG00000128408.8 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 26150 |
OpenTargetsi | ENSG00000128408 |
PharmGKBi | PA134967342 |
Miscellaneous databases
Pharosi | Q9H4K1, Tdark |
Genetic variation databases
BioMutai | RIBC2 |
DMDMi | 74752644 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254098 | 1 – 382 | RIB43A-like with coiled-coils protein 2Add BLAST | 382 |
Proteomic databases
EPDi | Q9H4K1 |
MassIVEi | Q9H4K1 |
PaxDbi | Q9H4K1 |
PeptideAtlasi | Q9H4K1 |
PRIDEi | Q9H4K1 |
ProteomicsDBi | 80849 |
PTM databases
PhosphoSitePlusi | Q9H4K1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128408, Expressed in testis and 124 other tissues |
Interactioni
Binary interactionsi
Q9H4K1
With | #Exp. | IntAct |
---|---|---|
tax [P14079] from Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A). | 3 | EBI-740128,EBI-9675698 |
Protein-protein interaction databases
BioGRIDi | 117581, 27 interactors |
IntActi | Q9H4K1, 29 interactors |
MINTi | Q9H4K1 |
STRINGi | 9606.ENSP00000483356 |
Miscellaneous databases
RNActi | Q9H4K1, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 222 – 255 | Sequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the RIB43A family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QWST, Eukaryota |
GeneTreei | ENSGT00390000010825 |
HOGENOMi | CLU_061822_0_1_1 |
InParanoidi | Q9H4K1 |
OMAi | TTRKAVC |
OrthoDBi | 1276305at2759 |
PhylomeDBi | Q9H4K1 |
Family and domain databases
InterProi | View protein in InterPro IPR008805, RIB43A |
PANTHERi | PTHR14517, PTHR14517, 1 hit |
Pfami | View protein in Pfam PF05914, RIB43A, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H4K1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSQTMAVAL PRDLRQDANL AKRRHAELCR QKRVFNARNR IIGGDTEAWD
60 70 80 90 100
VQVHDQKIKE ATEKARHETF AAEMRQNDKI MCILENRKKR DRKNLCRAIN
110 120 130 140 150
DFQQSFQKPE TRREFDLSDP LALKKDLPAR QSDNDVRNTI SGMQKFMGED
160 170 180 190 200
LNFHERKKFQ EEQNREWSLQ QQREWKNARA EQKCAEALYT ETRLQFDETA
210 220 230 240 250
KHLQKLESTT RKAVCASVKD FNKSQAIESV ERKKQEKKQE QEDNLAEITN
260 270 280 290 300
LLRGDLLSEN PQQAASSFGP HRVVPDRWKG MTQEQLEQIR LVQKQQIQEK
310 320 330 340 350
LRLQEEKRQR DLDWDRRRIQ GARATLLFER QQWRRQRDLR RALDSSNLSL
360 370 380
AKEQHLQKKY MNEVYTNQPT GDYFTQFNTG SR
Sequence cautioni
The sequence AAH03024 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH09904 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAC09526 differs from that shown. Reason: Frameshift.Curated
The sequence CAC09526 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAG30324 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028812 | 253 | R → C. Corresponds to variant dbSNP:rs2142661Ensembl. | 1 | |
Natural variantiVAR_028813 | 268 | F → L2 PublicationsCorresponds to variant dbSNP:rs1022478Ensembl. | 1 | |
Natural variantiVAR_028814 | 335 | R → Q2 PublicationsCorresponds to variant dbSNP:rs2072770Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL442116 mRNA Translation: CAC09526.1 Sequence problems. AL021391 Genomic DNA No translation available. CH471138 Genomic DNA Translation: EAW73384.1 BC003024 mRNA Translation: AAH03024.1 Different initiation. BC009904 mRNA Translation: AAH09904.1 Different initiation. CR456438 mRNA Translation: CAG30324.1 Different initiation. CR457398 mRNA Translation: CAG33679.1 AL050075 mRNA Translation: CAB43258.1 |
CCDSi | CCDS14066.2 |
PIRi | T08734 |
RefSeqi | NP_056468.3, NM_015653.4 XP_005261581.1, XM_005261524.4 |
Genome annotation databases
Ensembli | ENST00000614167; ENSP00000483356; ENSG00000128408 |
GeneIDi | 26150 |
KEGGi | hsa:26150 |
UCSCi | uc032qrc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL442116 mRNA Translation: CAC09526.1 Sequence problems. AL021391 Genomic DNA No translation available. CH471138 Genomic DNA Translation: EAW73384.1 BC003024 mRNA Translation: AAH03024.1 Different initiation. BC009904 mRNA Translation: AAH09904.1 Different initiation. CR456438 mRNA Translation: CAG30324.1 Different initiation. CR457398 mRNA Translation: CAG33679.1 AL050075 mRNA Translation: CAB43258.1 |
CCDSi | CCDS14066.2 |
PIRi | T08734 |
RefSeqi | NP_056468.3, NM_015653.4 XP_005261581.1, XM_005261524.4 |
3D structure databases
SMRi | Q9H4K1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117581, 27 interactors |
IntActi | Q9H4K1, 29 interactors |
MINTi | Q9H4K1 |
STRINGi | 9606.ENSP00000483356 |
PTM databases
PhosphoSitePlusi | Q9H4K1 |
Genetic variation databases
BioMutai | RIBC2 |
DMDMi | 74752644 |
Proteomic databases
EPDi | Q9H4K1 |
MassIVEi | Q9H4K1 |
PaxDbi | Q9H4K1 |
PeptideAtlasi | Q9H4K1 |
PRIDEi | Q9H4K1 |
ProteomicsDBi | 80849 |
Protocols and materials databases
Antibodypediai | 303, 97 antibodies |
DNASUi | 26150 |
Genome annotation databases
Ensembli | ENST00000614167; ENSP00000483356; ENSG00000128408 |
GeneIDi | 26150 |
KEGGi | hsa:26150 |
UCSCi | uc032qrc.2, human |
Organism-specific databases
CTDi | 26150 |
DisGeNETi | 26150 |
GeneCardsi | RIBC2 |
HGNCi | HGNC:13241, RIBC2 |
neXtProti | NX_Q9H4K1 |
OpenTargetsi | ENSG00000128408 |
PharmGKBi | PA134967342 |
VEuPathDBi | HostDB:ENSG00000128408.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWST, Eukaryota |
GeneTreei | ENSGT00390000010825 |
HOGENOMi | CLU_061822_0_1_1 |
InParanoidi | Q9H4K1 |
OMAi | TTRKAVC |
OrthoDBi | 1276305at2759 |
PhylomeDBi | Q9H4K1 |
Enzyme and pathway databases
PathwayCommonsi | Q9H4K1 |
Miscellaneous databases
BioGRID-ORCSi | 26150, 0 hits in 104 CRISPR screens |
ChiTaRSi | RIBC2, human |
GenomeRNAii | 26150 |
Pharosi | Q9H4K1, Tdark |
PROi | PR:Q9H4K1 |
RNActi | Q9H4K1, protein |
Gene expression databases
Bgeei | ENSG00000128408, Expressed in testis and 124 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR008805, RIB43A |
PANTHERi | PTHR14517, PTHR14517, 1 hit |
Pfami | View protein in Pfam PF05914, RIB43A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIBC2_HUMAN | |
Accessioni | Q9H4K1Primary (citable) accession number: Q9H4K1 Secondary accession number(s): A0A087X0F7, Q6ICD0, Q9Y413 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | November 13, 2019 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants