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UniProtKB - Q9H4K1 (RIBC2_HUMAN)

Entry version 117 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

RIB43A-like with coiled-coils protein 2

Gene

RIBC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RIB43A-like with coiled-coils protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIBC2
Synonyms:C22orf11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13241 RIBC2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H4K1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26150

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134967342

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RIBC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752644

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002540981 – 309RIB43A-like with coiled-coils protein 2Add BLAST309

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H4K1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H4K1

PeptideAtlas

More...PeptideAtlasi		Q9H4K1

PRoteomics IDEntifications database

More...PRIDEi		Q9H4K1

ProteomicsDB human proteome resource

More...ProteomicsDBi		80849

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H4K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H4K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA003210

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
taxP140793EBI-740128,EBI-9675698From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117581, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q9H4K1, 27 interactors

Molecular INTeraction database

More...MINTi		Q9H4K1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483356

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili149 – 182Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIB43A family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IE6I Eukaryota
ENOG410YKAG LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231390

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H4K1

Database of Orthologous Groups

More...OrthoDBi		1276305at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H4K1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008805 RIB43A

The PANTHER Classification System

More...PANTHERi		PTHR14517 PTHR14517, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05914 RIB43A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H4K1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQNDKIMCI LENRKKRDRK NLCRAINDFQ QSFQKPETRR EFDLSDPLAL 
        60         70         80         90        100
KKDLPARQSD NDVRNTISGM QKFMGEDLNF HERKKFQEEQ NREWSLQQQR 
       110        120        130        140        150
EWKNARAEQK CAEALYTETR LQFDETAKHL QKLESTTRKA VCASVKDFNK 
       160        170        180        190        200
SQAIESVERK KQEKKQEQED NLAEITNLLR GDLLSENPQQ AASSFGPHRV 
       210        220        230        240        250
VPDRWKGMTQ EQLEQIRLVQ KQQIQEKLRL QEEKRQRDLD WDRRRIQGAR 
       260        270        280        290        300
ATLLFERQQW RRQRDLRRAL DSSNLSLAKE QHLQKKYMNE VYTNQPTGDY 

FTQFNTGSR
Length:309
Mass (Da):37,060
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD7EB2293C8027AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0F7A0A087X0F7_HUMAN
RIB43A domain with coiled-coils 2
RIBC2 hCG_16863
382Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028812180R → C. Corresponds to variant dbSNP:rs2142661Ensembl.1
Natural variantiVAR_028813195F → L2 PublicationsCorresponds to variant dbSNP:rs1022478Ensembl.1
Natural variantiVAR_028814262R → Q2 PublicationsCorresponds to variant dbSNP:rs2072770Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR457398 mRNA Translation: CAG33679.1
AL442116 mRNA Translation: CAC09526.1
CR456438 mRNA Translation: CAG30324.1
AL021391 Genomic DNA No translation available.
BC003024 mRNA Translation: AAH03024.1
BC009904 mRNA Translation: AAH09904.1
AL050075 mRNA Translation: CAB43258.1

Protein sequence database of the Protein Information Resource

More...PIRi		T08734

NCBI Reference Sequences

More...RefSeqi		NP_056468.3, NM_015653.4
XP_005261581.1, XM_005261524.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342894; ENSP00000342529; ENSG00000128408

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26150

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR457398 mRNA Translation: CAG33679.1
AL442116 mRNA Translation: CAC09526.1
CR456438 mRNA Translation: CAG30324.1
AL021391 Genomic DNA No translation available.
BC003024 mRNA Translation: AAH03024.1
BC009904 mRNA Translation: AAH09904.1
AL050075 mRNA Translation: CAB43258.1
PIRiT08734
RefSeqiNP_056468.3, NM_015653.4
XP_005261581.1, XM_005261524.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi117581, 25 interactors
IntActiQ9H4K1, 27 interactors
MINTiQ9H4K1
STRINGi9606.ENSP00000483356

PTM databases

iPTMnetiQ9H4K1
PhosphoSitePlusiQ9H4K1

Polymorphism and mutation databases

BioMutaiRIBC2
DMDMi74752644

Proteomic databases

EPDiQ9H4K1
PaxDbiQ9H4K1
PeptideAtlasiQ9H4K1
PRIDEiQ9H4K1
ProteomicsDBi80849

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		26150
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342894; ENSP00000342529; ENSG00000128408
GeneIDi26150
KEGGihsa:26150

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26150
DisGeNETi26150

GeneCards: human genes, protein and diseases

More...GeneCardsi		RIBC2
HGNCiHGNC:13241 RIBC2
HPAiHPA003210
neXtProtiNX_Q9H4K1
PharmGKBiPA134967342

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IE6I Eukaryota
ENOG410YKAG LUCA
HOGENOMiHOG000231390
InParanoidiQ9H4K1
OrthoDBi1276305at2759
PhylomeDBiQ9H4K1

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26150

Protein Ontology

More...PROi		PR:Q9H4K1

Family and domain databases

InterProiView protein in InterPro
IPR008805 RIB43A
PANTHERiPTHR14517 PTHR14517, 1 hit
PfamiView protein in Pfam
PF05914 RIB43A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIBC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4K1
Secondary accession number(s): Q6ICD0, Q9Y413
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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