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Entry version 131 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Essential MCU regulator, mitochondrial

Gene

SMDT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988).

Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807).

Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988).

Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).

3 Publications

Caution

A publication reports an opposite topology (PubMed:26774479). However, 3 different articles, 2 in human and one in mouse, confirm the topology shown in this entry (PubMed:27099988, PubMed:27642048).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H4I9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8949215, Mitochondrial calcium ion transport
R-HSA-8949664, Processing of SMDT1

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.45.1.1, the essential mcu regulator emre (emre) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Essential MCU regulator, mitochondrial1 Publication
Alternative name(s):
Single-pass membrane protein with aspartate-rich tail 1, mitochondrialImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMDT1Imported
Synonyms:C22orf32Imported, EMRE1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25055, SMDT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615588, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H4I9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000183172.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini53 – 64Mitochondrial matrix2 PublicationsAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei65 – 84HelicalSequence analysisAdd BLAST20
Topological domaini85 – 107Mitochondrial intermembrane2 PublicationsAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi81G → W: Abolishes calcium uptake into mitochondria. 1 Publication1
Mutagenesisi85S → W: Abolishes calcium uptake into mitochondria. 1 Publication1
Mutagenesisi101 – 107EDDDDDD → QNNNNNN: Abolishes regulation of calcium uptake into mitochondria. 1 Publication7

Organism-specific databases

DisGeNET

More...
DisGeNETi
91689

Open Targets

More...
OpenTargetsi
ENSG00000183172

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149451

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H4I9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMDT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761431

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 52Mitochondrion1 PublicationAdd BLAST52
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029632053 – 107Essential MCU regulator, mitochondrialAdd BLAST55

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic degradation in neurons: degraded by AFG3L2 before SMDT1/EMRE assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048).1 Publication

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H4I9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H4I9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H4I9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H4I9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H4I9

PeptideAtlas

More...
PeptideAtlasi
Q9H4I9

PRoteomics IDEntifications database

More...
PRIDEi
Q9H4I9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80848

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9H4I9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183172, Expressed in parotid gland and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H4I9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H4I9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183172, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed:24231807).

Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct (PubMed:27099988).

Interacts (via the poly-Asp region) with MICU1 (via polybasic region); the interaction is direct (PubMed:27099988).

Interacts (via its C-terminal poly-Asp tail) with MCUR1; the interaction is direct (PubMed:27184846). Unprocessed form interacts (via transit peptide) with MAIP1 (PubMed:27642048).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124866, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5961, Mitochondrial calcium uniporter complex, MICU1-MICU2 variant
CPX-5963, Mitochondrial calcium uniporter complex, MICU1 variant
CPX-5965, Mitochondrial calcium uniporter complex, MICU1-MICU3 variant
CPX-5966, Mitochondrial calcium uniporter complex, MICUB variant

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H4I9

Protein interaction database and analysis system

More...
IntActi
Q9H4I9, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327467

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H4I9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H4I9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52Interaction with MAIP11 PublicationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi81 – 85GXXXX[G/A/S]1 Publication5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GXXXX[G/A/S] motif at the C-terminal part of the transmembrane region mediates interaction with MCU and is required to activate the calcium-conducting pore in the uniporter complex.1 Publication
The poly-Asp region at the C-terminus mediates interaction with the polybasic region of MICU1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMDT1/EMRE family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4542, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_172921_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H4I9

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALAPVRC

Database of Orthologous Groups

More...
OrthoDBi
1586309at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H4I9

TreeFam database of animal gene trees

More...
TreeFami
TF314649

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018782, MCU_reg

The PANTHER Classification System

More...
PANTHERi
PTHR33904, PTHR33904, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10161, DDDD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H4I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGAARWLV LAPVRSGALR SGPSLRKDGD VSAAWSGSGR SLVPSRSVIV
60 70 80 90 100
TRSGAILPKP VKMSFGLLRV FSIVIPFLYV GTLISKNFAA LLEEHDIFVP

EDDDDDD
Length:107
Mass (Da):11,441
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E00824D322AE99D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDX6F8WDX6_HUMAN
Essential MCU regulator, mitochondr...
SMDT1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03462846R → G1 PublicationCorresponds to variant dbSNP:rs17852210Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL449243 mRNA Translation: CAC15000.1
CR456453 mRNA Translation: CAG30339.1
AK312142 mRNA Translation: BAG35078.1
AL021878 Genomic DNA No translation available.
Z82192 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60488.1
BC024237 mRNA Translation: AAH24237.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14031.1

NCBI Reference Sequences

More...
RefSeqi
NP_201575.3, NM_033318.4
XP_011528811.1, XM_011530509.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331479; ENSP00000327467; ENSG00000183172
ENST00000571525; ENSP00000459368; ENSG00000272901
ENST00000607293; ENSP00000475471; ENSG00000272835
ENST00000615504; ENSP00000485029; ENSG00000274112

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91689

UCSC genome browser

More...
UCSCi
uc003bca.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL449243 mRNA Translation: CAC15000.1
CR456453 mRNA Translation: CAG30339.1
AK312142 mRNA Translation: BAG35078.1
AL021878 Genomic DNA No translation available.
Z82192 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60488.1
BC024237 mRNA Translation: AAH24237.1
CCDSiCCDS14031.1
RefSeqiNP_201575.3, NM_033318.4
XP_011528811.1, XM_011530509.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6K7Xelectron microscopy3.27E/F/G/H/O/P/Q/R48-101[»]
6K7Yelectron microscopy3.60E/F/G/H/R/S/T/U48-101[»]
6O58electron microscopy3.80B/D/F/H/J/L/N/P1-107[»]
6O5Belectron microscopy3.60B/D/F/H1-107[»]
6WDNelectron microscopy3.20D/F/H/J48-98[»]
6WDOelectron microscopy3.60B/D/F/H/J/L/N/P48-100[»]
6XJVelectron microscopy4.17B/D/F/H/J/L/N/P1-107[»]
6XJXelectron microscopy4.60B/D/F/H1-107[»]
SMRiQ9H4I9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124866, 20 interactors
ComplexPortaliCPX-5961, Mitochondrial calcium uniporter complex, MICU1-MICU2 variant
CPX-5963, Mitochondrial calcium uniporter complex, MICU1 variant
CPX-5965, Mitochondrial calcium uniporter complex, MICU1-MICU3 variant
CPX-5966, Mitochondrial calcium uniporter complex, MICUB variant
CORUMiQ9H4I9
IntActiQ9H4I9, 8 interactors
STRINGi9606.ENSP00000327467

Protein family/group databases

TCDBi8.A.45.1.1, the essential mcu regulator emre (emre) family

Genetic variation databases

BioMutaiSMDT1
DMDMi74761431

Proteomic databases

EPDiQ9H4I9
jPOSTiQ9H4I9
MassIVEiQ9H4I9
MaxQBiQ9H4I9
PaxDbiQ9H4I9
PeptideAtlasiQ9H4I9
PRIDEiQ9H4I9
ProteomicsDBi80848
TopDownProteomicsiQ9H4I9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27229, 19 antibodies

The DNASU plasmid repository

More...
DNASUi
91689

Genome annotation databases

EnsembliENST00000331479; ENSP00000327467; ENSG00000183172
ENST00000571525; ENSP00000459368; ENSG00000272901
ENST00000607293; ENSP00000475471; ENSG00000272835
ENST00000615504; ENSP00000485029; ENSG00000274112
GeneIDi91689
KEGGihsa:91689
UCSCiuc003bca.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91689
DisGeNETi91689

GeneCards: human genes, protein and diseases

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GeneCardsi
SMDT1
HGNCiHGNC:25055, SMDT1
HPAiENSG00000183172, Low tissue specificity
MIMi615588, gene
neXtProtiNX_Q9H4I9
OpenTargetsiENSG00000183172
PharmGKBiPA145149451
VEuPathDBiHostDB:ENSG00000183172.8

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4542, Eukaryota
GeneTreeiENSGT00390000017489
HOGENOMiCLU_172921_1_0_1
InParanoidiQ9H4I9
OMAiALAPVRC
OrthoDBi1586309at2759
PhylomeDBiQ9H4I9
TreeFamiTF314649

Enzyme and pathway databases

PathwayCommonsiQ9H4I9
ReactomeiR-HSA-8949215, Mitochondrial calcium ion transport
R-HSA-8949664, Processing of SMDT1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
91689, 7 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SMDT1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91689
PharosiQ9H4I9, Tbio

Protein Ontology

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PROi
PR:Q9H4I9
RNActiQ9H4I9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000183172, Expressed in parotid gland and 219 other tissues
ExpressionAtlasiQ9H4I9, baseline and differential
GenevisibleiQ9H4I9, HS

Family and domain databases

InterProiView protein in InterPro
IPR018782, MCU_reg
PANTHERiPTHR33904, PTHR33904, 1 hit
PfamiView protein in Pfam
PF10161, DDDD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMRE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4I9
Secondary accession number(s): B2R5D1, Q8TAB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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