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UniProtKB - Q9H4H8 (FA83D_HUMAN)

Entry version 155 (07 Apr 2021)
Sequence version 3 (25 Nov 2002)
Previous versions | rss
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Protein

Protein FAM83D

Gene

FAM83D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.3 Publications

Miscellaneous

Was named CHICA (girl in Spanish) because it interacts with KID.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H4H8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM83DCurated
Alternative name(s):
Spindle protein CHICA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM83DImported
Synonyms:C20orf129Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16122, FAM83D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618380, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H4H8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101447.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		81610

Open Targets

More...OpenTargetsi		ENSG00000101447

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25670

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H4H8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM83D

Domain mapping of disease mutations (DMDM)

More...DMDMi		25452904

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794601 – 585Protein FAM83DAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei298PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Modified residuei568PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H4H8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H4H8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H4H8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H4H8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H4H8

PeptideAtlas

More...PeptideAtlasi		Q9H4H8

PRoteomics IDEntifications database

More...PRIDEi		Q9H4H8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80838 [Q9H4H8-1]
80839 [Q9H4H8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H4H8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H4H8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during mitosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101447, Expressed in lower esophagus muscularis layer and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H4H8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H4H8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101447, Tissue enhanced (esophagus, smooth muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBXW7; promotes FBXW7 degradation (PubMed:24344117). May interact with RAF1 (PubMed:24736947).

Interacts with KIF22; recruits KIF22 to mitotic spindle microtubules (PubMed:18485706).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123547, 47 interactors

Protein interaction database and analysis system

More...IntActi		Q9H4H8, 32 interactors

Molecular INTeraction database

More...MINTi		Q9H4H8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000481110

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H4H8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H4H8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni340 – 585Required for interaction with KIF22 and function in chromosome congression1 PublicationAdd BLAST246

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 86Poly-Ala7
Compositional biasi458 – 496Ser-richAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RC3Z, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158405

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040298_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H4H8

Database of Orthologous Groups

More...OrthoDBi		433035at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H4H8

TreeFam database of animal gene trees

More...TreeFami		TF330777

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012461, FAM83_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07894, FAM83, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H4H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLSEGLDE VPAACLSPCG PPNPTELFSE SRRLALEELV AGGPEAFAAF 
        60         70         80         90        100
LRRERLARFL NPDEVHAILR AAERPGEEGA AAAAAAEDSF GSSHDCSSGT 
       110        120        130        140        150
YFPEQSDLEP PLLELGWPAF YQGAYRGATR VETHFQPRGA GEGGPYGCKD 
       160        170        180        190        200
ALRQQLRSAR EVIAVVMDVF TDIDIFRDLQ EICRKQGVAV YILLDQALLS 
       210        220        230        240        250
QFLDMCMDLK VHPEQEKLMT VRTITGNIYY ARSGTKIIGK VHEKFTLIDG 
       260        270        280        290        300
IRVATGSYSF TWTDGKLNSS NLVILSGQVV EHFDLEFRIL YAQSKPISPK 
       310        320        330        340        350
LLSHFQSSNK FDHLTNRKPQ SKELTLGNLL RMRLARLSST PRKADLDPEM 
       360        370        380        390        400
PAEGKAERKP HDCESSTVSE EDYFSSHRDE LQSRKAIDAA TQTEPGEEMP 
       410        420        430        440        450
GLSVSEVGTQ TSITTACAGT QTAVITRIAS SQTTIWSRST TTQTDMDENI 
       460        470        480        490        500
LFPRGTQSTE GSPVSKMSVS RSSSLKSSSS VSSQGSVASS TGSPASIRTT 
       510        520        530        540        550
DFHNPGYPKY LGTPHLELYL SDSLRNLNKE RQFHFAGIRS RLNHMLAMLS 
       560        570        580 
RRTLFTENHL GLHSGNFSRV NLLAVRDVAL YPSYQ
Length:585
Mass (Da):64,424
Last modified:November 25, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D1C86F0BFE47B10
GO
Isoform 2 (identifier: Q9H4H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-138: Missing.

Show »
Length:569
Mass (Da):62,596
Checksum:i3DA40464D119B56D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXK8A0A087WXK8_HUMAN
Chromosome 20 open reading frame 12...
FAM83D C20orf129, hCG_38062
615Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01068 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH06553 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH53683 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH63661 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH80188 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB71016 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB71016 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11V → L in AAH01068 (PubMed:15489334).Curated1
Sequence conflicti11V → L in AAH06553 (PubMed:15489334).Curated1
Sequence conflicti11V → L in AAH63661 (PubMed:15489334).Curated1
Sequence conflicti79G → GA in AAH53683 (PubMed:15489334).Curated1
Sequence conflicti242H → R in BAG64799 (PubMed:11780052).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036446123 – 138Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK055793 mRNA Translation: BAB71016.1 Sequence problems.
AK303860 mRNA Translation: BAG64799.1
AL023803 Genomic DNA No translation available.
BC001068 mRNA Translation: AAH01068.2 Different initiation.
BC006553 mRNA Translation: AAH06553.3 Different initiation.
BC053683 mRNA Translation: AAH53683.1 Different initiation.
BC063661 mRNA Translation: AAH63661.1 Different initiation.
BC080188 mRNA Translation: AAH80188.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42872.2 [Q9H4H8-1]

NCBI Reference Sequences

More...RefSeqi		NP_112181.3, NM_030919.2 [Q9H4H8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000619850; ENSP00000481465; ENSG00000101447 [Q9H4H8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81610

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81610

UCSC genome browser

More...UCSCi		uc061wzh.1, human [Q9H4H8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055793 mRNA Translation: BAB71016.1 Sequence problems.
AK303860 mRNA Translation: BAG64799.1
AL023803 Genomic DNA No translation available.
BC001068 mRNA Translation: AAH01068.2 Different initiation.
BC006553 mRNA Translation: AAH06553.3 Different initiation.
BC053683 mRNA Translation: AAH53683.1 Different initiation.
BC063661 mRNA Translation: AAH63661.1 Different initiation.
BC080188 mRNA Translation: AAH80188.1 Different initiation.
CCDSiCCDS42872.2 [Q9H4H8-1]
RefSeqiNP_112181.3, NM_030919.2 [Q9H4H8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E0LX-ray1.31C384-394[»]
5E0MX-ray1.65C436-446[»]
SMRiQ9H4H8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123547, 47 interactors
IntActiQ9H4H8, 32 interactors
MINTiQ9H4H8
STRINGi9606.ENSP00000481110

PTM databases

iPTMnetiQ9H4H8
PhosphoSitePlusiQ9H4H8

Genetic variation databases

BioMutaiFAM83D
DMDMi25452904

Proteomic databases

EPDiQ9H4H8
jPOSTiQ9H4H8
MassIVEiQ9H4H8
MaxQBiQ9H4H8
PaxDbiQ9H4H8
PeptideAtlasiQ9H4H8
PRIDEiQ9H4H8
ProteomicsDBi80838 [Q9H4H8-1]
80839 [Q9H4H8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		57303, 79 antibodies

Genome annotation databases

EnsembliENST00000619850; ENSP00000481465; ENSG00000101447 [Q9H4H8-1]
GeneIDi81610
KEGGihsa:81610
UCSCiuc061wzh.1, human [Q9H4H8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81610
DisGeNETi81610

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM83D
HGNCiHGNC:16122, FAM83D
HPAiENSG00000101447, Tissue enhanced (esophagus, smooth muscle)
MIMi618380, gene
neXtProtiNX_Q9H4H8
OpenTargetsiENSG00000101447
PharmGKBiPA25670
VEuPathDBiHostDB:ENSG00000101447.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RC3Z, Eukaryota
GeneTreeiENSGT00940000158405
HOGENOMiCLU_040298_0_0_1
InParanoidiQ9H4H8
OrthoDBi433035at2759
PhylomeDBiQ9H4H8
TreeFamiTF330777

Enzyme and pathway databases

PathwayCommonsiQ9H4H8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81610, 32 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM83D, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81610
PharosiQ9H4H8, Tbio

Protein Ontology

More...PROi		PR:Q9H4H8
RNActiQ9H4H8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101447, Expressed in lower esophagus muscularis layer and 158 other tissues
ExpressionAtlasiQ9H4H8, baseline and differential
GenevisibleiQ9H4H8, HS

Family and domain databases

InterProiView protein in InterPro
IPR012461, FAM83_N
PfamiView protein in Pfam
PF07894, FAM83, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA83D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4H8
Secondary accession number(s): B4E1I7
, Q5THR2, Q68EN1, Q6P457, Q7Z6H0, Q96DF5, Q96N89, Q9BVM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: April 7, 2021
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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