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Protein

Golgi-associated plant pathogenesis-related protein 1

Gene

GLIPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi-associated plant pathogenesis-related protein 1
Short name:
GAPR-1
Short name:
Golgi-associated PR-1 protein
Alternative name(s):
Glioma pathogenesis-related protein 2
Short name:
GliPR 2
Gene namesi
Name:GLIPR2
Synonyms:C9orf19, GAPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122694.15
HGNCiHGNC:18007 GLIPR2
MIMi607141 gene
neXtProtiNX_Q9H4G4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152007
OpenTargetsiENSG00000122694
PharmGKBiPA164720283

Chemistry databases

DrugBankiDB03661 Cysteinesulfonic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002115242 – 154Golgi-associated plant pathogenesis-related protein 1Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ9H4G4
MaxQBiQ9H4G4
PaxDbiQ9H4G4
PeptideAtlasiQ9H4G4
PRIDEiQ9H4G4
ProteomicsDBi80836
TopDownProteomicsiQ9H4G4

PTM databases

iPTMnetiQ9H4G4
PhosphoSitePlusiQ9H4G4
SwissPalmiQ9H4G4

Expressioni

Tissue specificityi

Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000122694 Expressed in 203 organ(s), highest expression level in blood
CleanExiHS_GLIPR2
ExpressionAtlasiQ9H4G4 baseline and differential
GenevisibleiQ9H4G4 HS

Organism-specific databases

HPAiHPA029478

Interactioni

Subunit structurei

Homodimer. Interacts with CAV1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127417, 7 interactors
DIPiDIP-60127N
IntActiQ9H4G4, 5 interactors
MINTiQ9H4G4
STRINGi9606.ENSP00000367196

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H4G4
SMRiQ9H4G4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H4G4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 132SCPAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 98Interaction with CAV11 Publication8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 53Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00390000020276
HOVERGENiHBG051701
InParanoidiQ9H4G4
OMAiRGWFLVC
OrthoDBiEOG091G0QVD
PhylomeDBiQ9H4G4
TreeFamiTF313138

Family and domain databases

CDDicd05382 SCP_GAPR-1_like, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034113 SCP_GAPR1-like
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H4G4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR
60 70 80 90 100
ILKHSPESSR GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG
110 120 130 140 150
TGHFTAMVWK NTKKMGVGKA SASDGSSFVV ARYFPAGNVV NEGFFEENVL

PPKK
Length:154
Mass (Da):17,218
Last modified:January 23, 2007 - v3
Checksum:i5AA9B26A21EF1039
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VZR0Q5VZR0_HUMAN
Golgi-associated plant pathogenesis...
GLIPR2
128Annotation score:
A0A087WUM5A0A087WUM5_HUMAN
Golgi-associated plant pathogenesis...
GLIPR2
72Annotation score:
A0A088AWP7A0A088AWP7_HUMAN
Golgi-associated plant pathogenesis...
GLIPR2
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37R → Q AA sequence (PubMed:11865038).Curated1
Sequence conflicti87 – 90IKNY → VHFM in AAH17918 (PubMed:15489334).Curated4
Sequence conflicti101 – 154TGHFT…LPPKK → IRFFFFNFLLFLSKPLLYFS YF in BAC11019 (PubMed:14702039).CuratedAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011129 mRNA Translation: CAC12812.1
AY039756 mRNA Translation: AAK83460.1
AK074488 mRNA Translation: BAC11019.1
AK075091 mRNA Translation: BAC11395.1
AL158830 Genomic DNA No translation available.
BC017918 mRNA Translation: AAH17918.1
CCDSiCCDS6598.1
RefSeqiNP_071738.1, NM_022343.3
UniGeneiHs.493819

Genome annotation databases

EnsembliENST00000377960; ENSP00000367196; ENSG00000122694
GeneIDi152007
KEGGihsa:152007
UCSCiuc003zyz.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011129 mRNA Translation: CAC12812.1
AY039756 mRNA Translation: AAK83460.1
AK074488 mRNA Translation: BAC11019.1
AK075091 mRNA Translation: BAC11395.1
AL158830 Genomic DNA No translation available.
BC017918 mRNA Translation: AAH17918.1
CCDSiCCDS6598.1
RefSeqiNP_071738.1, NM_022343.3
UniGeneiHs.493819

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SMBX-ray1.55A1-154[»]
4AIWX-ray1.50A1-154[»]
5VHGX-ray1.27A4-153[»]
ProteinModelPortaliQ9H4G4
SMRiQ9H4G4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127417, 7 interactors
DIPiDIP-60127N
IntActiQ9H4G4, 5 interactors
MINTiQ9H4G4
STRINGi9606.ENSP00000367196

Chemistry databases

DrugBankiDB03661 Cysteinesulfonic Acid

PTM databases

iPTMnetiQ9H4G4
PhosphoSitePlusiQ9H4G4
SwissPalmiQ9H4G4

Proteomic databases

EPDiQ9H4G4
MaxQBiQ9H4G4
PaxDbiQ9H4G4
PeptideAtlasiQ9H4G4
PRIDEiQ9H4G4
ProteomicsDBi80836
TopDownProteomicsiQ9H4G4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377960; ENSP00000367196; ENSG00000122694
GeneIDi152007
KEGGihsa:152007
UCSCiuc003zyz.5 human

Organism-specific databases

CTDi152007
DisGeNETi152007
EuPathDBiHostDB:ENSG00000122694.15
GeneCardsiGLIPR2
HGNCiHGNC:18007 GLIPR2
HPAiHPA029478
MIMi607141 gene
neXtProtiNX_Q9H4G4
OpenTargetsiENSG00000122694
PharmGKBiPA164720283
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00390000020276
HOVERGENiHBG051701
InParanoidiQ9H4G4
OMAiRGWFLVC
OrthoDBiEOG091G0QVD
PhylomeDBiQ9H4G4
TreeFamiTF313138

Miscellaneous databases

ChiTaRSiGLIPR2 human
EvolutionaryTraceiQ9H4G4
GenomeRNAii152007
PROiPR:Q9H4G4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122694 Expressed in 203 organ(s), highest expression level in blood
CleanExiHS_GLIPR2
ExpressionAtlasiQ9H4G4 baseline and differential
GenevisibleiQ9H4G4 HS

Family and domain databases

CDDicd05382 SCP_GAPR-1_like, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034113 SCP_GAPR1-like
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAPR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H4G4
Secondary accession number(s): Q5VZR1
, Q8N2S6, Q8WWC9, Q8WX36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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