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Protein

Cystatin-9-like

Gene

CST9L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Lacks critical consensus sites important for cysteine protease inhibition.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-9-like
Alternative name(s):
Testatin1 Publication
Gene namesi
Name:CST9L
Synonyms:CTES7B1 Publication
ORF Names:UNQ1835/PRO3543
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101435.4
HGNCiHGNC:16233 CST9L
MIMi616536 gene
neXtProtiNX_Q9H4G1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi128821
OpenTargetsiENSG00000101435
PharmGKBiPA26982

Polymorphism and mutation databases

BioMutaiCST9L
DMDMi20137970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000000665629 – 147Cystatin-9-likeAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 108By similarity
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 142By similarity
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H4G1
PeptideAtlasiQ9H4G1
PRIDEiQ9H4G1
ProteomicsDBi80835

PTM databases

iPTMnetiQ9H4G1
PhosphoSitePlusiQ9H4G1

Expressioni

Tissue specificityi

Specifically espressed in testis.2 Publications

Gene expression databases

BgeeiENSG00000101435 Expressed in 18 organ(s), highest expression level in testis
CleanExiHS_CST9L
ExpressionAtlasiQ9H4G1 baseline and differential
GenevisibleiQ9H4G1 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126159, 48 interactors
IntActiQ9H4G1, 8 interactors
STRINGi9606.ENSP00000366178

Structurei

3D structure databases

ProteinModelPortaliQ9H4G1
SMRiQ9H4G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1WW Eukaryota
ENOG4111DUC LUCA
GeneTreeiENSGT00430000031103
HOGENOMiHOG000231754
HOVERGENiHBG096568
InParanoidiQ9H4G1
KOiK13905
OMAiTISTRPW
OrthoDBiEOG091G0YM0
PhylomeDBiQ9H4G1

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H4G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLPWKGGL SWALLLLLLG SQILLIYAWH FHEQRDCDEH NVMARYLPAT
60 70 80 90 100
VEFAVHTFNQ QSKDYYAYRL GHILNSWKEQ VESKTVFSME LLLGRTRCGK
110 120 130 140
FEDDIDNCHF QESTELNNTF TCFFTISTRP WMTQFSLLNK TCLEGFH
Length:147
Mass (Da):17,276
Last modified:March 1, 2001 - v1
Checksum:i3A3286FFADCA4FD6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022079109H → P1 PublicationCorresponds to variant dbSNP:rs2295564Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358615 mRNA Translation: AAQ88978.1
AK312112 mRNA Translation: BAG35048.1
AL121894 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10140.1
BC029656 mRNA Translation: AAH29656.1
CCDSiCCDS13157.1
RefSeqiNP_542177.1, NM_080610.2
UniGeneiHs.121554

Genome annotation databases

EnsembliENST00000376979; ENSP00000366178; ENSG00000101435
GeneIDi128821
KEGGihsa:128821
UCSCiuc002wtk.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCST9L_HUMAN
AccessioniPrimary (citable) accession number: Q9H4G1
Secondary accession number(s): B2R5A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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