CST9L

Functionⁱ

Miscellaneous

Lacks critical consensus sites important for cysteine protease inhibition.Curated

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Thiol protease inhibitor

Molecular function

Protease inhibitor, Thiol protease inhibitor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cystatin-9-like Alternative name(s): Testatin1 Publication
Gene namesⁱ	Name:CST9L Synonyms:CTES7B1 Publication ORF Names:UNQ1835/PRO3543
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101435.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16233 CST9L
MIMⁱ	616536 gene
neXtProtⁱ	NX_Q9H4G1

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	128821
Open Targets More...OpenTargetsⁱ	ENSG00000101435
PharmGKBⁱ	PA26982

Polymorphism and mutation databases

BioMutaⁱ	CST9L
DMDMⁱ	20137970

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	1 PublicationAdd BLAST		28
ChainⁱPRO_0000006656	29 – 147	Cystatin-9-likeAdd BLAST		119

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	98 ↔ 108	By similarity
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	122 ↔ 142	By similarity
Glycosylationⁱ	139	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9H4G1
PeptideAtlas More...PeptideAtlasⁱ	Q9H4G1
PRIDEⁱ	Q9H4G1
ProteomicsDBⁱ	80835

PTM databases

iPTMnetⁱ	Q9H4G1
PhosphoSitePlusⁱ	Q9H4G1

Expressionⁱ

Tissue specificityⁱ

Specifically espressed in testis.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000101435 Expressed in 18 organ(s), highest expression level in testis
CleanExⁱ	HS_CST9L
ExpressionAtlasⁱ	Q9H4G1 baseline and differential
Genevisibleⁱ	Q9H4G1 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KRTAP10-9	P60411	3	EBI-3923092,EBI-10172052
NOTCH2NL	Q7Z3S9	5	EBI-3923092,EBI-945833

Protein-protein interaction databases

BioGridⁱ	126159, 48 interactors
IntActⁱ	Q9H4G1, 8 interactors
STRINGⁱ	9606.ENSP00000366178

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H4G1
SMRⁱ	Q9H4G1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cystatin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1WW Eukaryota ENOG4111DUC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00430000031103
HOGENOMⁱ	HOG000231754
HOVERGENⁱ	HBG096568
InParanoidⁱ	Q9H4G1
KEGG Orthology (KO) More...KOⁱ	K13905
OMAⁱ	TISTRPW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YM0
PhylomeDBⁱ	Q9H4G1

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00042 CY, 1 hit
InterProⁱ	View protein in InterPro IPR027214 Cystatin IPR000010 Cystatin_dom
PANTHERⁱ	PTHR11413 PTHR11413, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00031 Cystatin, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9H4G1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGLPWKGGL SWALLLLLLG SQILLIYAWH FHEQRDCDEH NVMARYLPAT 
        60         70         80         90        100
VEFAVHTFNQ QSKDYYAYRL GHILNSWKEQ VESKTVFSME LLLGRTRCGK 
       110        120        130        140 
FEDDIDNCHF QESTELNNTF TCFFTISTRP WMTQFSLLNK TCLEGFH

Length:147

Mass (Da):17,276

Last modified:March 1, 2001 - v1

Checksum:ⁱ3A3286FFADCA4FD6

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022079	109	H → P1 PublicationCorresponds to variant dbSNP:rs2295564Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358615 mRNA Translation: AAQ88978.1 AK312112 mRNA Translation: BAG35048.1 AL121894 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10140.1 BC029656 mRNA Translation: AAH29656.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13157.1
NCBI Reference Sequences More...RefSeqⁱ	NP_542177.1, NM_080610.2
UniGeneⁱ	Hs.121554

Genome annotation databases

Ensemblⁱ	ENST00000376979; ENSP00000366178; ENSG00000101435
GeneIDⁱ	128821
KEGGⁱ	hsa:128821
UCSC genome browser More...UCSCⁱ	uc002wtk.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H4G1	Cystatin		HUMAN		147	UniRef100_Q9H4G1

Protein	Similar proteins		Species	Score	Length	Source
Q9H4G1	Cystatin		HUMAN		147	UniRef90_Q9H4G1
Cystatin		PONAB		147
Cystatin		PANTR		146
Cystatin		PANPA		146
Cystatin		GORGO		146
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9H4G1	Putative cystatin-9-like protein CST9LP1		HUMAN		147	UniRef50_Q9H4G1
Cystatin-9		BOVIN		153
Cystatin		PONAB		147
Cystatin		GORGO		146
Cystatin		PANPA		146
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358615 mRNA Translation: AAQ88978.1 AK312112 mRNA Translation: BAG35048.1 AL121894 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10140.1 BC029656 mRNA Translation: AAH29656.1
CCDSⁱ	CCDS13157.1
RefSeqⁱ	NP_542177.1, NM_080610.2
UniGeneⁱ	Hs.121554

3D structure databases

ProteinModelPortalⁱ	Q9H4G1
SMRⁱ	Q9H4G1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126159, 48 interactors
IntActⁱ	Q9H4G1, 8 interactors
STRINGⁱ	9606.ENSP00000366178

PTM databases

iPTMnetⁱ	Q9H4G1
PhosphoSitePlusⁱ	Q9H4G1

Polymorphism and mutation databases

BioMutaⁱ	CST9L
DMDMⁱ	20137970

Proteomic databases

PaxDbⁱ	Q9H4G1
PeptideAtlasⁱ	Q9H4G1
PRIDEⁱ	Q9H4G1
ProteomicsDBⁱ	80835

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	128821
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376979; ENSP00000366178; ENSG00000101435
GeneIDⁱ	128821
KEGGⁱ	hsa:128821
UCSCⁱ	uc002wtk.5 human

Organism-specific databases

CTDⁱ	128821
DisGeNETⁱ	128821
EuPathDBⁱ	HostDB:ENSG00000101435.4
GeneCardsⁱ	CST9L
HGNCⁱ	HGNC:16233 CST9L
MIMⁱ	616536 gene
neXtProtⁱ	NX_Q9H4G1
OpenTargetsⁱ	ENSG00000101435
PharmGKBⁱ	PA26982
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1WW Eukaryota ENOG4111DUC LUCA
GeneTreeⁱ	ENSGT00430000031103
HOGENOMⁱ	HOG000231754
HOVERGENⁱ	HBG096568
InParanoidⁱ	Q9H4G1
KOⁱ	K13905
OMAⁱ	TISTRPW
OrthoDBⁱ	EOG091G0YM0
PhylomeDBⁱ	Q9H4G1

Miscellaneous databases

ChiTaRSⁱ	CST9L human
GeneWikiⁱ	CST9L
GenomeRNAiⁱ	128821
Protein Ontology More...PROⁱ	PR:Q9H4G1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101435 Expressed in 18 organ(s), highest expression level in testis
CleanExⁱ	HS_CST9L
ExpressionAtlasⁱ	Q9H4G1 baseline and differential
Genevisibleⁱ	Q9H4G1 HS

Family and domain databases

CDDⁱ	cd00042 CY, 1 hit
InterProⁱ	View protein in InterPro IPR027214 Cystatin IPR000010 Cystatin_dom
PANTHERⁱ	PTHR11413 PTHR11413, 1 hit
Pfamⁱ	View protein in Pfam PF00031 Cystatin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CST9L_HUMAN
Accessionⁱ	Q9H4G1Primary (citable) accession number: Q9H4G1 Secondary accession number(s): B2R5A1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - Q9H4G1 (CST9L_HUMAN)

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Cystatin-9-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ