UniProtKB - Q9H4G1 (CST9L_HUMAN)
Protein
Cystatin-9-like
Gene
CST9L
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Lacks critical consensus sites important for cysteine protease inhibition.Curated
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protease inhibitor, Thiol protease inhibitor |
Names & Taxonomyi
Protein namesi | Recommended name: Cystatin-9-likeAlternative name(s): Testatin1 Publication |
Gene namesi | Name:CST9L Synonyms:CTES7B1 Publication ORF Names:UNQ1835/PRO3543 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16233 CST9L |
MIMi | 616536 gene |
neXtProti | NX_Q9H4G1 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 128821 |
OpenTargetsi | ENSG00000101435 |
PharmGKBi | PA26982 |
Miscellaneous databases
Pharosi | Q9H4G1 |
Polymorphism and mutation databases
BioMutai | CST9L |
DMDMi | 20137970 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | 1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000006656 | 29 – 147 | Cystatin-9-likeAdd BLAST | 119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 98 ↔ 108 | By similarity | ||
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 122 ↔ 142 | By similarity | ||
Glycosylationi | 139 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9H4G1 |
PaxDbi | Q9H4G1 |
PeptideAtlasi | Q9H4G1 |
PRIDEi | Q9H4G1 |
ProteomicsDBi | 80835 |
PTM databases
iPTMneti | Q9H4G1 |
PhosphoSitePlusi | Q9H4G1 |
Expressioni
Tissue specificityi
Specifically espressed in testis.2 Publications
Gene expression databases
Bgeei | ENSG00000101435 Expressed in 18 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9H4G1 baseline and differential |
Genevisiblei | Q9H4G1 HS |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 126159, 48 interactors |
IntActi | Q9H4G1, 8 interactors |
STRINGi | 9606.ENSP00000366178 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cystatin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410J1WW Eukaryota ENOG4111DUC LUCA |
GeneTreei | ENSGT00940000161877 |
HOGENOMi | HOG000231754 |
InParanoidi | Q9H4G1 |
KOi | K13905 |
OMAi | TISTEPW |
OrthoDBi | 1577727at2759 |
PhylomeDBi | Q9H4G1 |
Family and domain databases
CDDi | cd00042 CY, 1 hit |
InterProi | View protein in InterPro IPR000010 Cystatin_dom |
Pfami | View protein in Pfam PF00031 Cystatin, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9H4G1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGLPWKGGL SWALLLLLLG SQILLIYAWH FHEQRDCDEH NVMARYLPAT
60 70 80 90 100
VEFAVHTFNQ QSKDYYAYRL GHILNSWKEQ VESKTVFSME LLLGRTRCGK
110 120 130 140
FEDDIDNCHF QESTELNNTF TCFFTISTRP WMTQFSLLNK TCLEGFH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022079 | 109 | H → P1 PublicationCorresponds to variant dbSNP:rs2295564Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358615 mRNA Translation: AAQ88978.1 AK312112 mRNA Translation: BAG35048.1 AL121894 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10140.1 BC029656 mRNA Translation: AAH29656.1 |
CCDSi | CCDS13157.1 |
RefSeqi | NP_542177.1, NM_080610.2 |
Genome annotation databases
Ensembli | ENST00000376979; ENSP00000366178; ENSG00000101435 |
GeneIDi | 128821 |
KEGGi | hsa:128821 |
UCSCi | uc002wtk.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358615 mRNA Translation: AAQ88978.1 AK312112 mRNA Translation: BAG35048.1 AL121894 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10140.1 BC029656 mRNA Translation: AAH29656.1 |
CCDSi | CCDS13157.1 |
RefSeqi | NP_542177.1, NM_080610.2 |
3D structure databases
SMRi | Q9H4G1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 126159, 48 interactors |
IntActi | Q9H4G1, 8 interactors |
STRINGi | 9606.ENSP00000366178 |
PTM databases
iPTMneti | Q9H4G1 |
PhosphoSitePlusi | Q9H4G1 |
Polymorphism and mutation databases
BioMutai | CST9L |
DMDMi | 20137970 |
Proteomic databases
MassIVEi | Q9H4G1 |
PaxDbi | Q9H4G1 |
PeptideAtlasi | Q9H4G1 |
PRIDEi | Q9H4G1 |
ProteomicsDBi | 80835 |
Protocols and materials databases
DNASUi | 128821 |
Genome annotation databases
Ensembli | ENST00000376979; ENSP00000366178; ENSG00000101435 |
GeneIDi | 128821 |
KEGGi | hsa:128821 |
UCSCi | uc002wtk.5 human |
Organism-specific databases
CTDi | 128821 |
DisGeNETi | 128821 |
GeneCardsi | CST9L |
HGNCi | HGNC:16233 CST9L |
MIMi | 616536 gene |
neXtProti | NX_Q9H4G1 |
OpenTargetsi | ENSG00000101435 |
PharmGKBi | PA26982 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410J1WW Eukaryota ENOG4111DUC LUCA |
GeneTreei | ENSGT00940000161877 |
HOGENOMi | HOG000231754 |
InParanoidi | Q9H4G1 |
KOi | K13905 |
OMAi | TISTEPW |
OrthoDBi | 1577727at2759 |
PhylomeDBi | Q9H4G1 |
Miscellaneous databases
GeneWikii | CST9L |
GenomeRNAii | 128821 |
Pharosi | Q9H4G1 |
PROi | PR:Q9H4G1 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101435 Expressed in 18 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9H4G1 baseline and differential |
Genevisiblei | Q9H4G1 HS |
Family and domain databases
CDDi | cd00042 CY, 1 hit |
InterProi | View protein in InterPro IPR000010 Cystatin_dom |
Pfami | View protein in Pfam PF00031 Cystatin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CST9L_HUMAN | |
Accessioni | Q9H4G1Primary (citable) accession number: Q9H4G1 Secondary accession number(s): B2R5A1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | October 16, 2019 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot