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UniProtKB - Q9H4F8 (SMOC1_HUMAN)

Entry version 174 (10 Feb 2021)
Sequence version 1 (01 Mar 2001)
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Protein

SPARC-related modular calcium-binding protein 1

Gene

SMOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi372 – 3831Sequence analysisAdd BLAST12
Calcium bindingi409 – 4202Sequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H4F8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H4F8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPARC-related modular calcium-binding protein 1
Alternative name(s):
Secreted modular calcium-binding protein 1
Short name:
SMOC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMOC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20318, SMOC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608488, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H4F8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198732.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ophthalmoacromelic syndrome (OAS)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare disorder presenting with ocular anomalies, ranging from mild microphthalmia to true anophthalmia, and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and oligodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069326278R → C in OAS. 1 PublicationCorresponds to variant dbSNP:rs776638586EnsemblClinVar.1
Natural variantiVAR_069327283T → N in OAS. 1 Publication1
Natural variantiVAR_069328286R → H in OAS. 1 PublicationCorresponds to variant dbSNP:rs1365818420EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Microphthalmia

Organism-specific databases

DisGeNET

More...DisGeNETi		64093

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		SMOC1

MalaCards human disease database

More...MalaCardsi		SMOC1
MIMi206920, phenotype

Open Targets

More...OpenTargetsi		ENSG00000198732

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1106, Microphthalmia with limb anomalies

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134942329

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H4F8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SMOC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		38258649

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002031627 – 434SPARC-related modular calcium-binding protein 1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 74PROSITE-ProRule annotation
Disulfide bondi47 ↔ 67PROSITE-ProRule annotation
Disulfide bondi56 ↔ 87PROSITE-ProRule annotation
Disulfide bondi95 ↔ 118By similarity
Disulfide bondi129 ↔ 136By similarity
Disulfide bondi138 ↔ 158By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi227 ↔ 251By similarity
Disulfide bondi262 ↔ 269By similarity
Disulfide bondi271 ↔ 292By similarity
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H4F8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H4F8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H4F8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H4F8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H4F8

PeptideAtlas

More...PeptideAtlasi		Q9H4F8

PRoteomics IDEntifications database

More...PRIDEi		Q9H4F8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80829 [Q9H4F8-1]
80830 [Q9H4F8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9H4F8, 5 sites, 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H4F8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H4F8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in many tissues with a strongest signal in ovary. No expression in spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198732, Expressed in subventricular zone (inner) (primate) and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H4F8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H4F8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198732, Tissue enhanced (brain, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122055, 43 interactors

Protein interaction database and analysis system

More...IntActi		Q9H4F8, 31 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355110

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H4F8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 89Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini92 – 158Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini224 – 292Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
Domaini359 – 394EF-hand 1Add BLAST36
Domaini396 – 431EF-hand 2Add BLAST36

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4578, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018436

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023483_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H4F8

Identification of Orthologs from Complete Genome Data

More...OMAi		WKSEDER

Database of Orthologous Groups

More...OrthoDBi		1057719at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H4F8

TreeFam database of animal gene trees

More...TreeFami		TF320666

Family and domain databases

Conserved Domains Database

More...CDDi		cd16240, EFh_SPARC_SMOC1, 1 hit
cd00191, TY, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.800.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR037639, SMOC1_EC
IPR019577, SPARC/Testican_Ca-bd-dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07648, Kazal_2, 1 hit
PF10591, SPARC_Ca_bdg, 1 hit
PF00086, Thyroglobulin_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00280, KAZAL, 1 hit
SM00211, TY, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF57610, SSF57610, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS51465, KAZAL_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 2 hits
PS51162, THYROGLOBULIN_1_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H4F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPARCARLL TPHLLLVLVQ LSPARGHRTT GPRFLISDRD PQCNLHCSRT 
        60         70         80         90        100
QPKPICASDG RSYESMCEYQ RAKCRDPTLG VVHRGRCKDA GQSKCRLERA 
       110        120        130        140        150
QALEQAKKPQ EAVFVPECGE DGSFTQVQCH TYTGYCWCVT PDGKPISGSS 
       160        170        180        190        200
VQNKTPVCSG SVTDKPLSQG NSGRKDDGSK PTPTMETQPV FDGDEITAPT 
       210        220        230        240        250
LWIKHLVIKD SKLNNTNIRN SEKVYSCDQE RQSALEEAQQ NPREGIVIPE 
       260        270        280        290        300
CAPGGLYKPV QCHQSTGYCW CVLVDTGRPL PGTSTRYVMP SCESDARAKT 
       310        320        330        340        350
TEADDPFKDR ELPGCPEGKK MEFITSLLDA LTTDMVQAIN SAAPTGGGRF 
       360        370        380        390        400
SEPDPSHTLE ERVVHWYFSQ LDSNSSNDIN KREMKPFKRY VKKKAKPKKC 
       410        420        430 
ARRFTDYCDL NKDKVISLPE LKGCLGVSKE GRLV
Length:434
Mass (Da):48,163
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CB639212BA42478
GO
Isoform 2 (identifier: Q9H4F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-430: E → EV

Show »
Length:435
Mass (Da):48,262
Checksum:i3E1945054B9BA424
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03449882V → M. Corresponds to variant dbSNP:rs10150925EnsemblClinVar.1
Natural variantiVAR_069326278R → C in OAS. 1 PublicationCorresponds to variant dbSNP:rs776638586EnsemblClinVar.1
Natural variantiVAR_069327283T → N in OAS. 1 Publication1
Natural variantiVAR_069328286R → H in OAS. 1 PublicationCorresponds to variant dbSNP:rs1365818420EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008720430E → EV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ249900 mRNA Translation: CAC10352.1
AK289988 mRNA Translation: BAF82677.1
AK313063 mRNA Translation: BAG35892.1
AL135747 Genomic DNA No translation available.
AL157789 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81013.1
CH471061 Genomic DNA Translation: EAW81014.1
BC008608 mRNA Translation: AAH08608.1
BC011548 mRNA Translation: AAH11548.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32110.1 [Q9H4F8-2]
CCDS9798.1 [Q9H4F8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001030024.1, NM_001034852.2 [Q9H4F8-2]
NP_071420.1, NM_022137.5 [Q9H4F8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361956; ENSP00000355110; ENSG00000198732 [Q9H4F8-2]
ENST00000381280; ENSP00000370680; ENSG00000198732 [Q9H4F8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64093

UCSC genome browser

More...UCSCi		uc001xls.3, human [Q9H4F8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249900 mRNA Translation: CAC10352.1
AK289988 mRNA Translation: BAF82677.1
AK313063 mRNA Translation: BAG35892.1
AL135747 Genomic DNA No translation available.
AL157789 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81013.1
CH471061 Genomic DNA Translation: EAW81014.1
BC008608 mRNA Translation: AAH08608.1
BC011548 mRNA Translation: AAH11548.1
CCDSiCCDS32110.1 [Q9H4F8-2]
CCDS9798.1 [Q9H4F8-1]
RefSeqiNP_001030024.1, NM_001034852.2 [Q9H4F8-2]
NP_071420.1, NM_022137.5 [Q9H4F8-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122055, 43 interactors
IntActiQ9H4F8, 31 interactors
STRINGi9606.ENSP00000355110

PTM databases

GlyGeniQ9H4F8, 5 sites, 2 O-linked glycans (2 sites)
iPTMnetiQ9H4F8
PhosphoSitePlusiQ9H4F8

Genetic variation databases

BioMutaiSMOC1
DMDMi38258649

Proteomic databases

EPDiQ9H4F8
jPOSTiQ9H4F8
MassIVEiQ9H4F8
MaxQBiQ9H4F8
PaxDbiQ9H4F8
PeptideAtlasiQ9H4F8
PRIDEiQ9H4F8
ProteomicsDBi80829 [Q9H4F8-1]
80830 [Q9H4F8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		125, 121 antibodies

The DNASU plasmid repository

More...DNASUi		64093

Genome annotation databases

EnsembliENST00000361956; ENSP00000355110; ENSG00000198732 [Q9H4F8-2]
ENST00000381280; ENSP00000370680; ENSG00000198732 [Q9H4F8-1]
GeneIDi64093
KEGGihsa:64093
UCSCiuc001xls.3, human [Q9H4F8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64093
DisGeNETi64093

GeneCards: human genes, protein and diseases

More...GeneCardsi		SMOC1
GeneReviewsiSMOC1
HGNCiHGNC:20318, SMOC1
HPAiENSG00000198732, Tissue enhanced (brain, liver)
MalaCardsiSMOC1
MIMi206920, phenotype
608488, gene
neXtProtiNX_Q9H4F8
OpenTargetsiENSG00000198732
Orphaneti1106, Microphthalmia with limb anomalies
PharmGKBiPA134942329
VEuPathDBiHostDB:ENSG00000198732.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4578, Eukaryota
GeneTreeiENSGT00390000018436
HOGENOMiCLU_023483_0_0_1
InParanoidiQ9H4F8
OMAiWKSEDER
OrthoDBi1057719at2759
PhylomeDBiQ9H4F8
TreeFamiTF320666

Enzyme and pathway databases

PathwayCommonsiQ9H4F8
SIGNORiQ9H4F8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64093, 2 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SMOC1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64093
PharosiQ9H4F8, Tbio

Protein Ontology

More...PROi		PR:Q9H4F8
RNActiQ9H4F8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198732, Expressed in subventricular zone (inner) (primate) and 181 other tissues
ExpressionAtlasiQ9H4F8, baseline and differential
GenevisibleiQ9H4F8, HS

Family and domain databases

CDDicd16240, EFh_SPARC_SMOC1, 1 hit
cd00191, TY, 2 hits
Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR037639, SMOC1_EC
IPR019577, SPARC/Testican_Ca-bd-dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
PF10591, SPARC_Ca_bdg, 1 hit
PF00086, Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00280, KAZAL, 1 hit
SM00211, TY, 2 hits
SUPFAMiSSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF57610, SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS51465, KAZAL_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 2 hits
PS51162, THYROGLOBULIN_1_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMOC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4F8
Secondary accession number(s): A8K1S3, B2R7P5, Q96F78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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