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Entry version 167 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

SPARC-related modular calcium-binding protein 1

Gene

SMOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi372 – 3831Sequence analysisAdd BLAST12
Calcium bindingi409 – 4202Sequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPARC-related modular calcium-binding protein 1
Alternative name(s):
Secreted modular calcium-binding protein 1
Short name:
SMOC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMOC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198732.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20318 SMOC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608488 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H4F8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ophthalmoacromelic syndrome (OAS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder presenting with ocular anomalies, ranging from mild microphthalmia to true anophthalmia, and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and oligodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069326278R → C in OAS. 1 PublicationCorresponds to variant dbSNP:rs776638586EnsemblClinVar.1
Natural variantiVAR_069327283T → N in OAS. 1 Publication1
Natural variantiVAR_069328286R → H in OAS. 1 PublicationCorresponds to variant dbSNP:rs1365818420Ensembl.1

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNET

More...
DisGeNETi
64093

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SMOC1

MalaCards human disease database

More...
MalaCardsi
SMOC1
MIMi206920 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198732

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1106 Microphthalmia with limb anomalies

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134942329

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H4F8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMOC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258649

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002031627 – 434SPARC-related modular calcium-binding protein 1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 74PROSITE-ProRule annotation
Disulfide bondi47 ↔ 67PROSITE-ProRule annotation
Disulfide bondi56 ↔ 87PROSITE-ProRule annotation
Disulfide bondi95 ↔ 118By similarity
Disulfide bondi129 ↔ 136By similarity
Disulfide bondi138 ↔ 158By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi227 ↔ 251By similarity
Disulfide bondi262 ↔ 269By similarity
Disulfide bondi271 ↔ 292By similarity
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H4F8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H4F8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H4F8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H4F8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H4F8

PeptideAtlas

More...
PeptideAtlasi
Q9H4F8

PRoteomics IDEntifications database

More...
PRIDEi
Q9H4F8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80829 [Q9H4F8-1]
80830 [Q9H4F8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H4F8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H4F8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in many tissues with a strongest signal in ovary. No expression in spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198732 Expressed in 164 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H4F8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H4F8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034427
HPA004153

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122055, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H4F8, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355110

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H4F8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H4F8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 89Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini92 – 158Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini224 – 292Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
Domaini359 – 394EF-hand 1Add BLAST36
Domaini396 – 431EF-hand 2Add BLAST36

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4578 Eukaryota
ENOG410YP7C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018436

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234328

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H4F8

Identification of Orthologs from Complete Genome Data

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OMAi
WKSEDER

Database of Orthologous Groups

More...
OrthoDBi
1057719at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H4F8

TreeFam database of animal gene trees

More...
TreeFami
TF320666

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16240 EFh_SPARC_SMOC1, 1 hit
cd00191 TY, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.800.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR037639 SMOC1_EC
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H4F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPARCARLL TPHLLLVLVQ LSPARGHRTT GPRFLISDRD PQCNLHCSRT
60 70 80 90 100
QPKPICASDG RSYESMCEYQ RAKCRDPTLG VVHRGRCKDA GQSKCRLERA
110 120 130 140 150
QALEQAKKPQ EAVFVPECGE DGSFTQVQCH TYTGYCWCVT PDGKPISGSS
160 170 180 190 200
VQNKTPVCSG SVTDKPLSQG NSGRKDDGSK PTPTMETQPV FDGDEITAPT
210 220 230 240 250
LWIKHLVIKD SKLNNTNIRN SEKVYSCDQE RQSALEEAQQ NPREGIVIPE
260 270 280 290 300
CAPGGLYKPV QCHQSTGYCW CVLVDTGRPL PGTSTRYVMP SCESDARAKT
310 320 330 340 350
TEADDPFKDR ELPGCPEGKK MEFITSLLDA LTTDMVQAIN SAAPTGGGRF
360 370 380 390 400
SEPDPSHTLE ERVVHWYFSQ LDSNSSNDIN KREMKPFKRY VKKKAKPKKC
410 420 430
ARRFTDYCDL NKDKVISLPE LKGCLGVSKE GRLV
Length:434
Mass (Da):48,163
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CB639212BA42478
GO
Isoform 2 (identifier: Q9H4F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-430: E → EV

Show »
Length:435
Mass (Da):48,262
Checksum:i3E1945054B9BA424
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03449882V → M. Corresponds to variant dbSNP:rs10150925Ensembl.1
Natural variantiVAR_069326278R → C in OAS. 1 PublicationCorresponds to variant dbSNP:rs776638586EnsemblClinVar.1
Natural variantiVAR_069327283T → N in OAS. 1 Publication1
Natural variantiVAR_069328286R → H in OAS. 1 PublicationCorresponds to variant dbSNP:rs1365818420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008720430E → EV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ249900 mRNA Translation: CAC10352.1
AK289988 mRNA Translation: BAF82677.1
AK313063 mRNA Translation: BAG35892.1
AL135747 Genomic DNA No translation available.
AL157789 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81013.1
CH471061 Genomic DNA Translation: EAW81014.1
BC008608 mRNA Translation: AAH08608.1
BC011548 mRNA Translation: AAH11548.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32110.1 [Q9H4F8-2]
CCDS9798.1 [Q9H4F8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001030024.1, NM_001034852.2 [Q9H4F8-2]
NP_071420.1, NM_022137.5 [Q9H4F8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361956; ENSP00000355110; ENSG00000198732 [Q9H4F8-2]
ENST00000381280; ENSP00000370680; ENSG00000198732 [Q9H4F8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64093

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64093

UCSC genome browser

More...
UCSCi
uc001xls.3 human [Q9H4F8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249900 mRNA Translation: CAC10352.1
AK289988 mRNA Translation: BAF82677.1
AK313063 mRNA Translation: BAG35892.1
AL135747 Genomic DNA No translation available.
AL157789 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81013.1
CH471061 Genomic DNA Translation: EAW81014.1
BC008608 mRNA Translation: AAH08608.1
BC011548 mRNA Translation: AAH11548.1
CCDSiCCDS32110.1 [Q9H4F8-2]
CCDS9798.1 [Q9H4F8-1]
RefSeqiNP_001030024.1, NM_001034852.2 [Q9H4F8-2]
NP_071420.1, NM_022137.5 [Q9H4F8-1]

3D structure databases

SMRiQ9H4F8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122055, 33 interactors
IntActiQ9H4F8, 29 interactors
STRINGi9606.ENSP00000355110

PTM databases

iPTMnetiQ9H4F8
PhosphoSitePlusiQ9H4F8

Polymorphism and mutation databases

BioMutaiSMOC1
DMDMi38258649

Proteomic databases

EPDiQ9H4F8
jPOSTiQ9H4F8
MassIVEiQ9H4F8
MaxQBiQ9H4F8
PaxDbiQ9H4F8
PeptideAtlasiQ9H4F8
PRIDEiQ9H4F8
ProteomicsDBi80829 [Q9H4F8-1]
80830 [Q9H4F8-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64093

Genome annotation databases

EnsembliENST00000361956; ENSP00000355110; ENSG00000198732 [Q9H4F8-2]
ENST00000381280; ENSP00000370680; ENSG00000198732 [Q9H4F8-1]
GeneIDi64093
KEGGihsa:64093
UCSCiuc001xls.3 human [Q9H4F8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64093
DisGeNETi64093
EuPathDBiHostDB:ENSG00000198732.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SMOC1
GeneReviewsiSMOC1
HGNCiHGNC:20318 SMOC1
HPAiCAB034427
HPA004153
MalaCardsiSMOC1
MIMi206920 phenotype
608488 gene
neXtProtiNX_Q9H4F8
OpenTargetsiENSG00000198732
Orphaneti1106 Microphthalmia with limb anomalies
PharmGKBiPA134942329

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4578 Eukaryota
ENOG410YP7C LUCA
GeneTreeiENSGT00390000018436
HOGENOMiHOG000234328
InParanoidiQ9H4F8
OMAiWKSEDER
OrthoDBi1057719at2759
PhylomeDBiQ9H4F8
TreeFamiTF320666

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SMOC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64093
PharosiQ9H4F8 Tbio

Protein Ontology

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PROi
PR:Q9H4F8
RNActiQ9H4F8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198732 Expressed in 164 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ9H4F8 baseline and differential
GenevisibleiQ9H4F8 HS

Family and domain databases

CDDicd16240 EFh_SPARC_SMOC1, 1 hit
cd00191 TY, 2 hits
Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR037639 SMOC1_EC
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 2 hits
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMOC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4F8
Secondary accession number(s): A8K1S3, B2R7P5, Q96F78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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