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Protein

Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

Gene

ST6GALNAC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • glycolipid metabolic process Source: ProtInc
  • O-glycan processing Source: Reactome

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS06223-MONOMER
BRENDAi2.4.99.7 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism
R-HSA-977068 Termination of O-glycan biosynthesis
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (EC:2.4.99.7)
Alternative name(s):
NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase
ST6GalNAc IV
Short name:
ST6GalNAcIV
Sialyltransferase 3C
Short name:
SIAT3-C
Sialyltransferase 7D
Short name:
SIAT7-D
Gene namesi
Name:ST6GALNAC4
Synonyms:SIAT3C, SIAT7D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136840.18
HGNCiHGNC:17846 ST6GALNAC4
MIMi606378 gene
neXtProtiNX_Q9H4F1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini28 – 302LumenalSequence analysisAdd BLAST275

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27090
OpenTargetsiENSG00000136840
PharmGKBiPA38250

Polymorphism and mutation databases

BioMutaiST6GALNAC4
DMDMi21759443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492781 – 302Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferaseAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 225By similarity
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H4F1
MaxQBiQ9H4F1
PaxDbiQ9H4F1
PeptideAtlasiQ9H4F1
PRIDEiQ9H4F1
ProteomicsDBi80828

PTM databases

iPTMnetiQ9H4F1
PhosphoSitePlusiQ9H4F1

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000136840 Expressed in 186 organ(s), highest expression level in body of pancreas
CleanExiHS_ST6GALNAC4
ExpressionAtlasiQ9H4F1 baseline and differential
GenevisibleiQ9H4F1 HS

Organism-specific databases

HPAiHPA009042

Interactioni

Protein-protein interaction databases

BioGridi117992, 12 interactors
IntActiQ9H4F1, 1 interactor
STRINGi9606.ENSP00000336733

Structurei

3D structure databases

ProteinModelPortaliQ9H4F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074444
HOVERGENiHBG058710
InParanoidiQ9H4F1
KOiK03374
OMAiSYCREES
OrthoDBiEOG091G0H9S
PhylomeDBiQ9H4F1
TreeFamiTF352818

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H4F1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAPGRLVLI ILCSVVFSAV YILLCCWAGL PLCLATCLDH HFPTGSRPTV
60 70 80 90 100
PGPLHFSGYS SVPDGKPLVR EPCRSCAVVS SSGQMLGSGL GAEIDSAECV
110 120 130 140 150
FRMNQAPTVG FEADVGQRST LRVVSHTSVP LLLRNYSHYF QKARDTLYMV
160 170 180 190 200
WGQGRHMDRV LGGRTYRTLL QLTRMYPGLQ VYTFTERMMA YCDQIFQDET
210 220 230 240 250
GKNRRQSGSF LSTGWFTMIL ALELCEEIVV YGMVSDSYCR EKSHPSVPYH
260 270 280 290 300
YFEKGRLDEC QMYLAHEQAP RSAHRFITEK AVFSRWAKKR PIVFAHPSWR

TE
Length:302
Mass (Da):34,201
Last modified:July 11, 2002 - v2
Checksum:i08A4CDC749A6D783
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NJX0A6NJX0_HUMAN
Alpha-N-acetyl-neuraminyl-2,3-beta-...
ST6GALNAC4
200Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119 – 120ST → QA in AAF00102 (Ref. 2) Curated2
Sequence conflicti119S → T in CAC07404 (PubMed:11062056).Curated1
Sequence conflicti140F → L in BAA91281 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271734 mRNA Translation: CAC07404.1
AF127142 mRNA Translation: AAF00102.1
AB035172 mRNA Translation: BAA87034.1
AK000600 mRNA Translation: BAA91281.1
AL157935 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87717.1
BC036705 mRNA Translation: AAH36705.1
Y17460 Genomic DNA Translation: CAB44353.1
Y17461 Genomic DNA Translation: CAB44354.1
CCDSiCCDS6883.1
RefSeqiNP_778204.1, NM_175039.3
NP_778205.1, NM_175040.3
UniGeneiHs.3972
Hs.709827

Genome annotation databases

EnsembliENST00000335791; ENSP00000336733; ENSG00000136840
GeneIDi27090
KEGGihsa:27090
UCSCiuc004bss.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST6GalNAc IV

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271734 mRNA Translation: CAC07404.1
AF127142 mRNA Translation: AAF00102.1
AB035172 mRNA Translation: BAA87034.1
AK000600 mRNA Translation: BAA91281.1
AL157935 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87717.1
BC036705 mRNA Translation: AAH36705.1
Y17460 Genomic DNA Translation: CAB44353.1
Y17461 Genomic DNA Translation: CAB44354.1
CCDSiCCDS6883.1
RefSeqiNP_778204.1, NM_175039.3
NP_778205.1, NM_175040.3
UniGeneiHs.3972
Hs.709827

3D structure databases

ProteinModelPortaliQ9H4F1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117992, 12 interactors
IntActiQ9H4F1, 1 interactor
STRINGi9606.ENSP00000336733

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

PTM databases

iPTMnetiQ9H4F1
PhosphoSitePlusiQ9H4F1

Polymorphism and mutation databases

BioMutaiST6GALNAC4
DMDMi21759443

Proteomic databases

EPDiQ9H4F1
MaxQBiQ9H4F1
PaxDbiQ9H4F1
PeptideAtlasiQ9H4F1
PRIDEiQ9H4F1
ProteomicsDBi80828

Protocols and materials databases

DNASUi27090
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335791; ENSP00000336733; ENSG00000136840
GeneIDi27090
KEGGihsa:27090
UCSCiuc004bss.3 human

Organism-specific databases

CTDi27090
DisGeNETi27090
EuPathDBiHostDB:ENSG00000136840.18
GeneCardsiST6GALNAC4
HGNCiHGNC:17846 ST6GALNAC4
HPAiHPA009042
MIMi606378 gene
neXtProtiNX_Q9H4F1
OpenTargetsiENSG00000136840
PharmGKBiPA38250
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074444
HOVERGENiHBG058710
InParanoidiQ9H4F1
KOiK03374
OMAiSYCREES
OrthoDBiEOG091G0H9S
PhylomeDBiQ9H4F1
TreeFamiTF352818

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS06223-MONOMER
BRENDAi2.4.99.7 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

GeneWikiiST6GALNAC4
GenomeRNAii27090
PROiPR:Q9H4F1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136840 Expressed in 186 organ(s), highest expression level in body of pancreas
CleanExiHS_ST6GALNAC4
ExpressionAtlasiQ9H4F1 baseline and differential
GenevisibleiQ9H4F1 HS

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIA7D_HUMAN
AccessioniPrimary (citable) accession number: Q9H4F1
Secondary accession number(s): Q5T9D0
, Q9NWU6, Q9UKU1, Q9ULB9, Q9Y3G3, Q9Y3G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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