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Entry version 170 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Nuclear RNA export factor 3

Gene

NXF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a tissue-specific nuclear mRNA export factor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: InterPro
  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H4D5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 3
Alternative name(s):
TAP-like protein 3
Short name:
TAPL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NXF3
Synonyms:TAPL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8073, NXF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300316, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H4D5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000147206

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi300L → R: Inactivates CRM1 binding; when associated with R-302. 1 Publication1
Mutagenesisi302L → R: Inactivates CRM1 binding; when associated with R-300. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
56000

Open Targets

More...
OpenTargetsi
ENSG00000147206

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31860

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H4D5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NXF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20455187

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205341 – 531Nuclear RNA export factor 3Add BLAST531

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H4D5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H4D5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H4D5

PeptideAtlas

More...
PeptideAtlasi
Q9H4D5

PRoteomics IDEntifications database

More...
PRIDEi
Q9H4D5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80824 [Q9H4D5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H4D5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H4D5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high level in testis and at low level in a small number of tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147206, Expressed in right testis and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H4D5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H4D5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147206, Tissue enhanced (fallopian tube, gallbladder, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121025, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2436, mRNA nuclear export factor complex, NXF3-NXT1
CPX-2612, mRNA nuclear export factor NXF3-NXT2

Protein interaction database and analysis system

More...
IntActi
Q9H4D5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9H4D5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378504

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H4D5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H4D5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 192RRMAdd BLAST80
Domaini344 – 494NTF2PROSITE-ProRule annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 59DisorderedSequence analysisAdd BLAST27
Regioni83 – 106DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 51Polar residuesSequence analysisAdd BLAST19
Compositional biasi83 – 102Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Lacks C-terminal domain that mediates direct interactions with nucleoporins.
Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.
The RNA-binding domain is a non-canonical RNP-type domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011280_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H4D5

Identification of Orthologs from Complete Genome Data

More...
OMAi
MQAHFFV

Database of Orthologous Groups

More...
OrthoDBi
1051093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H4D5

TreeFam database of animal gene trees

More...
TreeFami
TF314566

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00780, NTF2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675, LRR_dom_sf
IPR002075, NTF2
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR030216, NXF3
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR015245, Tap_RNA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10662, PTHR10662, 1 hit
PTHR10662:SF12, PTHR10662:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02136, NTF2, 1 hit
PF09162, Tap-RNA_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50177, NTF2_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H4D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLPSGHTTG HTDQVVQRRA RCWDIYQRRF SSRSEPVNPG MHSSSHQQQD
60 70 80 90 100
GDAAMHGAHM DSPVRYTPYT ISPYNRKGSF RKQDQTHVNM EREQKPPERR
110 120 130 140 150
MEGNMPDGTL GSWFKITVPF GIKYNEKWLL NLIQNECSVP FVPVEFHYEN
160 170 180 190 200
MHASFFVENA SIAYALKNVS GKIWDEDNEK ISIFVNPAGI PHFVHRELKS
210 220 230 240 250
EKVEQIKLAM NQQCDVSQEA LDIQRLPFYP DMVNRDTKMA SNPRKCMAAS
260 270 280 290 300
LDVHEENIPT VMSAGEMDKW KGIEPGEKCA DRSPVCTTFS DTSSNINSIL
310 320 330 340 350
ELFPKLLCLD GQQSPRATLC GTEAHKRLPT CKGSFFGSEM LKNLVLQFLQ
360 370 380 390 400
QYYLIYDSGD RQGLLSAYHD EACFSLSIPF NPEDSAPSSF CKFFKDSRNI
410 420 430 440 450
KILKDPYLRG ELLKHTKLDI VDSLSALPKT QHDLSSFLVD MWYQTEWMLC
460 470 480 490 500
FSVNGVFKEV EGQSQGSVLA FTRTFIATPG SSSSLCIVND KLFVRDTSHQ
510 520 530
GTQSALFTLV PTAFSSSVPA FSQEQQKMLP S
Length:531
Mass (Da):60,102
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A47C7D35FC396B9
GO
Isoform 2 (identifier: Q9H4D5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     297-322: NSILELFPKLLCLDGQQSPRATLCGT → KSVVPSVTTWDPDLCLIAPFCRRRQH
     323-531: Missing.

Show »
Length:233
Mass (Da):26,653
Checksum:i98A4095DE20120F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6A1H0Y6A1_HUMAN
Nuclear RNA export factor 3
NXF3
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC20434 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050419186N → I. Corresponds to variant dbSNP:rs2301387Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570681 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_057069297 – 322NSILE…TLCGT → KSVVPSVTTWDPDLCLIAPF CRRRQH in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_057070323 – 531Missing in isoform 2. 1 PublicationAdd BLAST209

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ277527 mRNA Translation: CAC16589.1
AF346619 mRNA Translation: AAL07564.1
AK302586 mRNA Translation: BAG63839.1
Z75746 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54722.1
BC031616 mRNA Translation: AAH31616.1
AJ277660 mRNA Translation: CAC20434.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14503.1 [Q9H4D5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_071335.1, NM_022052.1 [Q9H4D5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395065; ENSP00000378504; ENSG00000147206 [Q9H4D5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56000

UCSC genome browser

More...
UCSCi
uc004eju.5, human [Q9H4D5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277527 mRNA Translation: CAC16589.1
AF346619 mRNA Translation: AAL07564.1
AK302586 mRNA Translation: BAG63839.1
Z75746 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54722.1
BC031616 mRNA Translation: AAH31616.1
AJ277660 mRNA Translation: CAC20434.1 Frameshift.
CCDSiCCDS14503.1 [Q9H4D5-1]
RefSeqiNP_071335.1, NM_022052.1 [Q9H4D5-1]

3D structure databases

SMRiQ9H4D5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121025, 7 interactors
ComplexPortaliCPX-2436, mRNA nuclear export factor complex, NXF3-NXT1
CPX-2612, mRNA nuclear export factor NXF3-NXT2
IntActiQ9H4D5, 3 interactors
MINTiQ9H4D5
STRINGi9606.ENSP00000378504

PTM databases

iPTMnetiQ9H4D5
PhosphoSitePlusiQ9H4D5

Genetic variation databases

BioMutaiNXF3
DMDMi20455187

Proteomic databases

EPDiQ9H4D5
MassIVEiQ9H4D5
PaxDbiQ9H4D5
PeptideAtlasiQ9H4D5
PRIDEiQ9H4D5
ProteomicsDBi80824 [Q9H4D5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
526, 187 antibodies

The DNASU plasmid repository

More...
DNASUi
56000

Genome annotation databases

EnsembliENST00000395065; ENSP00000378504; ENSG00000147206 [Q9H4D5-1]
GeneIDi56000
KEGGihsa:56000
UCSCiuc004eju.5, human [Q9H4D5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56000
DisGeNETi56000

GeneCards: human genes, protein and diseases

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GeneCardsi
NXF3
HGNCiHGNC:8073, NXF3
HPAiENSG00000147206, Tissue enhanced (fallopian tube, gallbladder, testis)
MIMi300316, gene
neXtProtiNX_Q9H4D5
OpenTargetsiENSG00000147206
PharmGKBiPA31860
VEuPathDBiHostDB:ENSG00000147206

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3763, Eukaryota
GeneTreeiENSGT00390000007539
HOGENOMiCLU_011280_2_1_1
InParanoidiQ9H4D5
OMAiMQAHFFV
OrthoDBi1051093at2759
PhylomeDBiQ9H4D5
TreeFamiTF314566

Enzyme and pathway databases

PathwayCommonsiQ9H4D5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56000, 12 hits in 639 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NXF3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56000
PharosiQ9H4D5, Tbio

Protein Ontology

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PROi
PR:Q9H4D5
RNActiQ9H4D5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000147206, Expressed in right testis and 125 other tissues
ExpressionAtlasiQ9H4D5, baseline and differential
GenevisibleiQ9H4D5, HS

Family and domain databases

CDDicd00780, NTF2, 1 hit
Gene3Di3.30.70.330, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR002075, NTF2
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR030216, NXF3
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR015245, Tap_RNA-bd
PANTHERiPTHR10662, PTHR10662, 1 hit
PTHR10662:SF12, PTHR10662:SF12, 1 hit
PfamiView protein in Pfam
PF02136, NTF2, 1 hit
PF09162, Tap-RNA_bind, 1 hit
SUPFAMiSSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50177, NTF2_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4D5
Secondary accession number(s): B4DYS7, Q5H9I1, Q9H1A9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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