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UniProtKB - Q9H4A3 (WNK1_HUMAN)

Entry version 213 (25 May 2022)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Serine/threonine-protein kinase WNK1

Gene

WNK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

By similarity2 Publications

Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance.

By similarity

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.1 Publication
HSN2 was originally thought to be an intronless gene lying within a WNK1 gene intron. It has been shown to be a nervous system-specific exon of WNK1 included in isoform 4 and isoform 5 (PubMed:18521183).1 Publication
It is uncertain whether Met-1 or Met-214 is the initiator in isoform 4 and isoform 5.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

By hypertonicity. Activation requires autophosphorylation of Ser-382, that may be regulated by calcium. Phosphorylation of Ser-378 also promotes increased activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei231ATP; via amide nitrogenCombined sources1 Publication1
Binding sitei351ATPCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei368Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi301 – 304ATPCombined sources1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H4A3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2672351, Stimuli-sensing channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H4A3

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H4A3

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q9H4A3, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase WNK1Curated (EC:2.7.11.11 Publication)
Alternative name(s):
Erythrocyte 65 kDa protein
Short name:
p65
Kinase deficient protein
Protein kinase lysine-deficient 1Imported
Protein kinase with no lysine 11 Publication
Short name:
hWNK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK1Imported
Synonyms:HSN21 Publication, KDP, KIAA0344Imported, PRKWNK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14540, WNK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605232, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H4A3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000060237

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pseudohypoaldosteronism 2C (PHA2C)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis in some cases, and correction of physiologic abnormalities by thiazide diuretics.
Related information in OMIM
Neuropathy, hereditary sensory and autonomic, 2A (HSAN2A)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves.
Related information in OMIM

Keywords - Diseasei

Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		65125

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		WNK1

MalaCards human disease database

More...MalaCardsi		WNK1
MIMi201300, phenotype
614492, phenotype

Open Targets

More...OpenTargetsi		ENSG00000060237

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		970, Hereditary sensory and autonomic neuropathy type 2
88940, Pseudohypoaldosteronism type 2C

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33782

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H4A3, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075173

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2280

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WNK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453029

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868191 – 2382Serine/threonine-protein kinase WNK1Add BLAST2382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei378Phosphoserine; by autocatalysisBy similarity1
Modified residuei382Phosphoserine; by autocatalysisBy similarity1
Modified residuei1261PhosphoserineCombined sources1
Modified residuei1978PhosphoserineCombined sources1
Modified residuei2002PhosphoserineCombined sources1
Modified residuei2011PhosphoserineCombined sources1
Modified residuei2012PhosphoserineCombined sources1
Modified residuei2027PhosphoserineCombined sources1
Modified residuei2029PhosphoserineCombined sources1
Modified residuei2032PhosphoserineCombined sources1
Modified residuei2121PhosphoserineCombined sources1
Modified residuei2270PhosphoserineBy similarity1
Modified residuei2286PhosphoserineBy similarity1
Modified residuei2370PhosphoserineCombined sources1
Modified residuei2372PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylation at Ser-382 is inhibited by intracellular calcium.By similarity
May be O-glycosylated.1 Publication
Ubiquitinated in vitro by the BCR(KLHL3) complex and in vivo by a BCR(KLHL2) complex, leading to proteasomal degradation.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H4A3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H4A3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H4A3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H4A3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H4A3

PeptideAtlas

More...PeptideAtlasi		Q9H4A3

PRoteomics IDEntifications database

More...PRIDEi		Q9H4A3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80804 [Q9H4A3-1]
80805 [Q9H4A3-2]
80806 [Q9H4A3-4]
80807 [Q9H4A3-5]
80808 [Q9H4A3-6]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		484, 1 O-Linked glycan

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9H4A3, 39 sites, 2 O-linked glycans (39 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H4A3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H4A3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H4A3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000060237, Expressed in corpus callosum and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H4A3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H4A3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000060237, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYT2 (By similarity).

Interacts with WNK3 and WNK4 (By similarity).

Interacts with KLHL3 (PubMed:23387299, PubMed:23576762). Isoform 3:

Interacts with isoform 1 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122403, 101 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H4A3

Database of interacting proteins

More...DIPi		DIP-32648N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9H4A3

Protein interaction database and analysis system

More...IntActi		Q9H4A3, 90 interactors

Molecular INTeraction database

More...MINTi		Q9H4A3

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9H4A3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H4A3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12382
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9H4A3

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9H4A3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H4A3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 479Protein kinasePROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni95 – 203DisorderedSequence analysisAdd BLAST109
Regioni488 – 555Autoinhibitory domainBy similarityAdd BLAST68
Regioni573 – 779DisorderedSequence analysisAdd BLAST207
Regioni1018 – 1041DisorderedSequence analysisAdd BLAST24
Regioni1053 – 1119DisorderedSequence analysisAdd BLAST67
Regioni1457 – 1476DisorderedSequence analysisAdd BLAST20
Regioni1733 – 1790DisorderedSequence analysisAdd BLAST58
Regioni1866 – 1948DisorderedSequence analysisAdd BLAST83
Regioni1994 – 2069DisorderedSequence analysisAdd BLAST76
Regioni2101 – 2196DisorderedSequence analysisAdd BLAST96
Regioni2332 – 2352DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Polar residuesSequence analysisAdd BLAST17
Compositional biasi49 – 65Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi101 – 115Pro residuesSequence analysisAdd BLAST15
Compositional biasi152 – 168Polar residuesSequence analysisAdd BLAST17
Compositional biasi573 – 589Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi590 – 629Polar residuesSequence analysisAdd BLAST40
Compositional biasi636 – 779Polar residuesSequence analysisAdd BLAST144
Compositional biasi1053 – 1092Polar residuesSequence analysisAdd BLAST40
Compositional biasi1096 – 1116Basic residuesSequence analysisAdd BLAST21
Compositional biasi1733 – 1748Polar residuesSequence analysisAdd BLAST16
Compositional biasi1871 – 1885Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1886 – 1906Polar residuesSequence analysisAdd BLAST21
Compositional biasi1922 – 1948Polar residuesSequence analysisAdd BLAST27
Compositional biasi2030 – 2062Polar residuesSequence analysisAdd BLAST33
Compositional biasi2133 – 2196Polar residuesSequence analysisAdd BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0584, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155474

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H4A3

Identification of Orthologs from Complete Genome Data

More...OMAi		PEPNGMT

Database of Orthologous Groups

More...OrthoDBi		27514at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H4A3

TreeFam database of animal gene trees

More...TreeFami		TF315363

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: WNK1 is a complex 33-exons gene, in total 9 WNK1 exons are alternatively spliced, some expressed in a tissue-specific manner. Additional isoforms seems to exist.

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9H4A3-1) [UniParc]FASTAAdd to basket
Also known as: L-WNK1

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGAAEKQS STPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAVTGR 
        60         70         80         90        100
TEEYRRRRHT MDKDSRGAAA TTTTTEHRFF RRSVICDSNA TALELPGLPL 
       110        120        130        140        150
SLPQPSIPAA VPQSAPPEPH REETVTATAT SQVAQQPPAA AAPGEQAVAG 
       160        170        180        190        200
PAPSTVPSST SKDRPVSQPS LVGSKEEPPP ARSGSGGGSA KEPQEERSQQ 
       210        220        230        240        250
QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD TETTVEVAWC 
       260        270        280        290        300
ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 
       310        320        330        340        350
TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL 
       360        370        380        390        400
KCDNIFITGP TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD 
       410        420        430        440        450
ESVDVYAFGM CMLEMATSEY PYSECQNAAQ IYRRVTSGVK PASFDKVAIP 
       460        470        480        490        500
EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ EETGVRVELA EEDDGEKIAI 
       510        520        530        540        550
KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM VESGYVCEGD 
       560        570        580        590        600
HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KKKQEESSLK QQVEQSSASQ 
       610        620        630        640        650
TGIKQLPSAS TGIPTASTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL 
       660        670        680        690        700
SDGTVDSGQG SSVFTESRVS SQQTVSYGSQ HEQAHSTGTV PGHIPSTVQA 
       710        720        730        740        750
QSQPHGVYPP SSVAQGQSQG QPSSSSLTGV SSSQPIQHPQ QQQGIQQTAP 
       760        770        780        790        800
PQQTVQYSLS QTSTSSEATT AQPVSQPQAP QVLPQVSAGK QLPVSQPVPT 
       810        820        830        840        850
IQGEPQIPVA TQPSVVPVHS GAHFLPVGQP LPTPLLPQYP VSQIPISTPH 
       860        870        880        890        900
VSTAQTGFSS LPITMAAGIT QPLLTLASSA TTAAIPGVST VVPSQLPTLL 
       910        920        930        940        950
QPVTQLPSQV HPQLLQPAVQ SMGIPANLGQ AAEVPLSSGD VLYQGFPPRL 
       960        970        980        990       1000
PPQYPGDSNI APSSNVASVC IHSTVLSPPM PTEVLATPGY FPTVVQPYVE 
      1010       1020       1030       1040       1050
SNLLVPMGGV GGQVQVSQPG GSLAQAPTTS SQQAVLESTQ GVSQVAPAEP 
      1060       1070       1080       1090       1100
VAVAQTQATQ PTTLASSVDS AHSDVASGMS DGNENVPSSS GRHEGRTTKR 
      1110       1120       1130       1140       1150
HYRKSVRSRS RHEKTSRPKL RILNVSNKGD RVVECQLETH NRKMVTFKFD 
      1160       1170       1180       1190       1200
LDGDNPEEIA TIMVNNDFIL AIERESFVDQ VREIIEKADE MLSEDVSVEP 
      1210       1220       1230       1240       1250
EGDQGLESLQ GKDDYGFSGS QKLEGEFKQP IPASSMPQQI GIPTSSLTQV 
      1260       1270       1280       1290       1300
VHSAGRRFIV SPVPESRLRE SKVFPSEITD TVAASTAQSP GMNLSHSASS 
      1310       1320       1330       1340       1350
LSLQQAFSEL RRAQMTEGPN TAPPNFSHTG PTFPVVPPFL SSIAGVPTTA 
      1360       1370       1380       1390       1400
AATAPVPATS SPPNDISTSV IQSEVTVPTE EGIAGVATST GVVTSGGLPI 
      1410       1420       1430       1440       1450
PPVSESPVLS SVVSSITIPA VVSISTTSPS LQVPTSTSEI VVSSTALYPS 
      1460       1470       1480       1490       1500
VTVSATSASA GGSTATPGPK PPAVVSQQAA GSTTVGATLT SVSTTTSFPS 
      1510       1520       1530       1540       1550
TASQLCIQLS SSTSTPTLAE TVVVSAHSLD KTSHSSTTGL AFSLSAPSSS 
      1560       1570       1580       1590       1600
SSPGAGVSSY ISQPGGLHPL VIPSVIASTP ILPQAAGPTS TPLLPQVPSI 
      1610       1620       1630       1640       1650
PPLVQPVANV PAVQQTLIHS QPQPALLPNQ PHTHCPEVDS DTQPKAPGID 
      1660       1670       1680       1690       1700
DIKTLEEKLR SLFSEHSSSG AQHASVSLET SLVIESTVTP GIPTTAVAPS 
      1710       1720       1730       1740       1750
KLLTSTTSTC LPPTNLPLGT VALPVTPVVT PGQVSTPVST TTSGVKPGTA 
      1760       1770       1780       1790       1800
PSKPPLTKAP VLPVGTELPA GTLPSEQLPP FPGPSLTQSQ QPLEDLDAQL 
      1810       1820       1830       1840       1850
RRTLSPEMIT VTSAVGPVSM AAPTAITEAG TQPQKGVSQV KEGPVLATSS 
      1860       1870       1880       1890       1900
GAGVFKMGRF QVSVAADGAQ KEGKNKSEDA KSVHFESSTS ESSVLSSSSP 
      1910       1920       1930       1940       1950
ESTLVKPEPN GITIPGISSD VPESAHKTTA SEAKSDTGQP TKVGRFQVTT 
      1960       1970       1980       1990       2000
TANKVGRFSV SKTEDKITDT KKEGPVASPP FMDLEQAVLP AVIPKKEKPE 
      2010       2020       2030       2040       2050
LSEPSHLNGP SSDPEAAFLS RDVDDGSGSP HSPHQLSSKS LPSQNLSQSL 
      2060       2070       2080       2090       2100
SNSFNSSYMS SDNESDIEDE DLKLELRRLR DKHLKEIQDL QSRQKHEIES 
      2110       2120       2130       2140       2150
LYTKLGKVPP AVIIPPAAPL SGRRRRPTKS KGSKSSRSSS LGNKSPQLSG 
      2160       2170       2180       2190       2200
NLSGQSAASV LHPQQTLHPP GNIPESGQNQ LLQPLKPSPS SDNLYSAFTS 
      2210       2220       2230       2240       2250
DGAISVPSLS APGQGTSSTN TVGATVNSQA AQAQPPAMTS SRKGTFTDDL 
      2260       2270       2280       2290       2300
HKLVDNWARD AMNLSGRRGS KGHMNYEGPG MARKFSAPGQ LCISMTSNLG 
      2310       2320       2330       2340       2350
GSAPISAASA TSLGHFTKSM CPPQQYGFPA TPFGAQWSGT GGPAPQPLGQ 
      2360       2370       2380 
FQPVGTASLQ NFNISNLQKS ISNPPGSNLR TT
Note: Strong expression in dorsal root ganglia and spinal cord.
Length:2,382
Mass (Da):250,794
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i426785F98A452A0A
GO
Isoform 21 Publication (identifier: Q9H4A3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     740-740: Missing.
     792-1037: Missing.

Show »
Length:2,135
Mass (Da):225,560
Checksum:i2961D903C013A22C
GO
Isoform 3 (identifier: Q9H4A3-4) [UniParc]FASTAAdd to basket
Also known as: KS-WNK1, Kidney-Specific

The sequence of this isoform differs from the canonical sequence as follows:
     1-407: Missing.
     408-437: FGMCMLEMATSEYPYSECQNAAQIYRRVTS → MDIKKKDFCSVFVIINSHCCCCPQKDCINE

Note: Kinase-defective isoform. Produced by alternative promoter usage and alternative splicing.Curated
Show »
Length:1,975
Mass (Da):206,646
Checksum:iB03B35C0321782D3
GO
Isoform 4 (identifier: Q9H4A3-5) [UniParc]FASTAAdd to basket
Also known as: Brain and spinal cord variant

The sequence of this isoform differs from the canonical sequence as follows:
     714-1037: AQGQSQGQPS...TTSSQQAVLE → PRRGRSMSVC...VLPQVSAGKQ

Note: Contains the nervous system-specific exon HSN2. Produced by alternative splicing.Curated
Show »
Length:2,634
Mass (Da):279,538
Checksum:i2F95DCDA28619B4C
GO
Isoform 5 (identifier: Q9H4A3-6) [UniParc]FASTAAdd to basket
Also known as: Dorsal root ganglia and sciatic nerve variant, DRG and sciatic nerve variant

The sequence of this isoform differs from the canonical sequence as follows:
     713-713: V → VPQSMAHPCG...SSGGSALHPQ
     792-944: Missing.

Note: Contains the nervous system-specific exon HSN2. Produced by alternative splicing.Curated
Show »
Length:2,642
Mass (Da):279,713
Checksum:iD0AB5C95ABFF46A4
GO
Isoform 6 (identifier: Q9H4A3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     713-713: V → VPQSMAHPCG...SSGGSALHPQ
     2215-2215: G → GCAKFNCASEQVTFKPGGRRTRFLRKMVKKVCPCNQLCR

Note: Contains the nervous system-specific exon HSN2. Produced by alternative splicing.Curated
Show »
Length:2,833
Mass (Da):299,725
Checksum:i24CA46FC81669858
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWT4F5GWT4_HUMAN
Non-specific serine/threonine prote...
WNK1
2,134Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UYG0F6UYG0_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFM0A0A6Q8PFM0_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
1,531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH68H0YH68_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF81H0YF81_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH79H0YH79_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L251I3L251_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFP5H0YFP5_HUMAN
Serine/threonine-protein kinase WNK...
WNK1
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF31483 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence AAI30468 differs from that shown. Probable cloning artifact.Curated
The sequence AAI30470 differs from that shown. Probable cloning artifact.Curated
The sequence DAA04494 differs from that shown. Reason: Erroneous gene model prediction. Includes 3' and 3' intronic sequences.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164R → S AA sequence (PubMed:2507249).Curated1
Sequence conflicti1836Missing in BAA20802 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041309141A → T1 PublicationCorresponds to variant dbSNP:rs11554421EnsemblClinVar.1
Natural variantiVAR_041310149A → V1 PublicationCorresponds to variant dbSNP:rs34880640EnsemblClinVar.1
Natural variantiVAR_041311419E → Q in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041312509I → T1 PublicationCorresponds to variant dbSNP:rs34728563EnsemblClinVar.1
Natural variantiVAR_041313527D → G1 PublicationCorresponds to variant dbSNP:rs34408667Ensembl.1
Natural variantiVAR_019992665T → I1 PublicationCorresponds to variant dbSNP:rs2286007EnsemblClinVar.1
Natural variantiVAR_041314674T → A1 PublicationCorresponds to variant dbSNP:rs11833299EnsemblClinVar.1
Natural variantiVAR_041315823H → R1 PublicationCorresponds to variant dbSNP:rs56015776EnsemblClinVar.1
Natural variantiVAR_0590331056T → P3 PublicationsCorresponds to variant dbSNP:rs956868EnsemblClinVar.1
Natural variantiVAR_0356401199E → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0590341506C → S3 PublicationsCorresponds to variant dbSNP:rs7955371EnsemblClinVar.1
Natural variantiVAR_0413161546A → V1 PublicationCorresponds to variant dbSNP:rs56351358EnsemblClinVar.1
Natural variantiVAR_0356411799Q → E in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications1
Natural variantiVAR_0413171808M → I3 PublicationsCorresponds to variant dbSNP:rs12828016EnsemblClinVar.1
Natural variantiVAR_0413181823P → L1 PublicationCorresponds to variant dbSNP:rs17755373EnsemblClinVar.1
Natural variantiVAR_0413191957R → H1 PublicationCorresponds to variant dbSNP:rs36083875Ensembl.1
Natural variantiVAR_0413202190S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0413212362F → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0413222380R → W1 PublicationCorresponds to variant dbSNP:rs56262445EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0506341 – 407Missing in isoform 3. CuratedAdd BLAST407
Alternative sequenceiVSP_050637408 – 437FGMCM…RRVTS → MDIKKKDFCSVFVIINSHCC CCPQKDCINE in isoform 3. CuratedAdd BLAST30
Alternative sequenceiVSP_040267713V → VPQSMAHPCGGTPTYPESQI FFPTIHERPVSFSPPPTCPP KVAISQRRKSTSFLEAQTHH FQPLLRTVGQSLLPPGGSPT NWTPEAVVMLGTTASRVTGE SCEIQVHPMFEPSQVYSDYR PGLVLPEEAHYFIPQEAVYV AGVHYQARVAEQYEGIPYNS SVLSSPMKQIPEQKPVQGGP TSSSVFEFPSGQAFLVGHLQ NLRLDSGLGPGSPLSSISAP ISTDATRLKFHPVFVPHSAP AVLTHNNESRSNCVFEFHVH TPSSSSGEGGGILPQRVYRN RQVAVDLNQEELPPQSVGLH GYLQPVTEEKHNYHAPELTV SVVEPIGQNWPIGSPEYSSD SSQITSSDPSDFQSPPPTGG AAAPFGSDVSMPFIHLPQTV LQESPLFFCFPQGTTSQQVL TASFSSGGSALHPQ in isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_040268714 – 1037AQGQS…QAVLE → PRRGRSMSVCVPIFLLLPLC PASLPVLFHPTASTVCTSFS FPPPDCPEETFAEKLSKALE SVLPMHSASQRKHRRSSLPS LFVSTPQSMAHPCGGTPTYP ESQIFFPTIHERPVSFSPPP TCPPKVAISQRRKSTSFLEA QTHHFQPLLRTVGQSLLPPG GSPTNWTPEAVVMLGTTASR VTGESCEIQVHPMFEPSQVY SDYRPGLVLPEEAHYFIPQE AVYVAGVHYQARVAEQYEGI PYNSSVLSSPMKQIPEQKPV QGGPTSSSVFEFPSGQAFLV GHLQNLRLDSGLGPGSPLSS ISAPISTDATRLKFHPVFVP HSAPAVLTHNNESRSNCVFE FHVHTPSSSSGEGGGILPQR VYRNRQVAVDLNQEELPPQS VGLHGYLQPVTEEKHNYHAP ELTVSVVEPIGQNWPIGSPE YSSDSSQITSSDPSDFQSPP PTGGAAAPFGSDVSMPFIHL PQTVLQESPLFFCFPQGTTS QQVLTASFSSGGSALHPQAQ GQSQGQPSSSSLTGVSSSQP IQHPQQQQGIQQTAPPQQTV QYSLSQTSTSSEATTAQPVS QPQAPQVLPQVSAGKQ in isoform 4. CuratedAdd BLAST324
Alternative sequenceiVSP_040269740Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_050638792 – 1037Missing in isoform 2. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_040270792 – 944Missing in isoform 5. CuratedAdd BLAST153
Alternative sequenceiVSP_0537672215G → GCAKFNCASEQVTFKPGGRR TRFLRKMVKKVCPCNQLCR in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ296290 mRNA Translation: CAC15059.1
JQ358908 mRNA Translation: AEY99342.1
FJ515833 Genomic DNA Translation: ACS13726.1
FJ515833 Genomic DNA Translation: ACS13727.1
FJ515833 Genomic DNA Translation: ACS13728.1
AC004765 Genomic DNA No translation available.
AC004803 Genomic DNA No translation available.
AF061944 mRNA Translation: AAF31483.1 Sequence problems.
AB002342 mRNA Translation: BAA20802.2
AY231477 mRNA Translation: AAO46160.1
BC013629 mRNA Translation: AAH13629.2
BC130467 mRNA Translation: AAI30468.1 Sequence problems.
BC130469 mRNA Translation: AAI30470.1 Sequence problems.
BK004108 Genomic DNA Translation: DAA04494.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73419.1 [Q9H4A3-5]
CCDS8506.1 [Q9H4A3-1]

NCBI Reference Sequences

More...RefSeqi		NP_001171914.1, NM_001184985.1 [Q9H4A3-6]
NP_055638.2, NM_014823.2
NP_061852.3, NM_018979.3 [Q9H4A3-1]
NP_998820.3, NM_213655.4 [Q9H4A3-5]
XP_016875326.1, XM_017019837.1
XP_016875327.1, XM_017019838.1 [Q9H4A3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000315939.11; ENSP00000313059.6; ENSG00000060237.19
ENST00000340908.9; ENSP00000341292.5; ENSG00000060237.19 [Q9H4A3-5]
ENST00000530271.6; ENSP00000433548.3; ENSG00000060237.19 [Q9H4A3-7]
ENST00000537687.5; ENSP00000444465.1; ENSG00000060237.19 [Q9H4A3-6]
ENST00000675631.1; ENSP00000502415.1; ENSG00000060237.19 [Q9H4A3-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		65125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:65125

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000315939.11; ENSP00000313059.6; NM_018979.4; NP_061852.3

UCSC genome browser

More...UCSCi		uc001qio.4, human [Q9H4A3-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296290 mRNA Translation: CAC15059.1
JQ358908 mRNA Translation: AEY99342.1
FJ515833 Genomic DNA Translation: ACS13726.1
FJ515833 Genomic DNA Translation: ACS13727.1
FJ515833 Genomic DNA Translation: ACS13728.1
AC004765 Genomic DNA No translation available.
AC004803 Genomic DNA No translation available.
AF061944 mRNA Translation: AAF31483.1 Sequence problems.
AB002342 mRNA Translation: BAA20802.2
AY231477 mRNA Translation: AAO46160.1
BC013629 mRNA Translation: AAH13629.2
BC130467 mRNA Translation: AAI30468.1 Sequence problems.
BC130469 mRNA Translation: AAI30470.1 Sequence problems.
BK004108 Genomic DNA Translation: DAA04494.1 Sequence problems.
CCDSiCCDS73419.1 [Q9H4A3-5]
CCDS8506.1 [Q9H4A3-1]
RefSeqiNP_001171914.1, NM_001184985.1 [Q9H4A3-6]
NP_055638.2, NM_014823.2
NP_061852.3, NM_018979.3 [Q9H4A3-1]
NP_998820.3, NM_213655.4 [Q9H4A3-5]
XP_016875326.1, XM_017019837.1
XP_016875327.1, XM_017019838.1 [Q9H4A3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PWNX-ray1.84A210-482[»]
5TF9X-ray2.50A/B206-483[»]
5WDYX-ray2.46A/B206-483[»]
5WE8X-ray2.01A/B206-483[»]
6FBKX-ray1.74P1247-1269[»]
AlphaFoldDBiQ9H4A3
BMRBiQ9H4A3
SMRiQ9H4A3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122403, 101 interactors
CORUMiQ9H4A3
DIPiDIP-32648N
ELMiQ9H4A3
IntActiQ9H4A3, 90 interactors
MINTiQ9H4A3

Chemistry databases

BindingDBiQ9H4A3
ChEMBLiCHEMBL1075173
GuidetoPHARMACOLOGYi2280

Protein family/group databases

MoonDBiQ9H4A3, Predicted

PTM databases

GlyConnecti484, 1 O-Linked glycan
GlyGeniQ9H4A3, 39 sites, 2 O-linked glycans (39 sites)
iPTMnetiQ9H4A3
MetOSiteiQ9H4A3
PhosphoSitePlusiQ9H4A3

Genetic variation databases

BioMutaiWNK1
DMDMi296453029

Proteomic databases

EPDiQ9H4A3
jPOSTiQ9H4A3
MassIVEiQ9H4A3
MaxQBiQ9H4A3
PaxDbiQ9H4A3
PeptideAtlasiQ9H4A3
PRIDEiQ9H4A3
ProteomicsDBi80804 [Q9H4A3-1]
80805 [Q9H4A3-2]
80806 [Q9H4A3-4]
80807 [Q9H4A3-5]
80808 [Q9H4A3-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22083, 609 antibodies from 42 providers

The DNASU plasmid repository

More...DNASUi		65125

Genome annotation databases

EnsembliENST00000315939.11; ENSP00000313059.6; ENSG00000060237.19
ENST00000340908.9; ENSP00000341292.5; ENSG00000060237.19 [Q9H4A3-5]
ENST00000530271.6; ENSP00000433548.3; ENSG00000060237.19 [Q9H4A3-7]
ENST00000537687.5; ENSP00000444465.1; ENSG00000060237.19 [Q9H4A3-6]
ENST00000675631.1; ENSP00000502415.1; ENSG00000060237.19 [Q9H4A3-4]
GeneIDi65125
KEGGihsa:65125
MANE-SelectiENST00000315939.11; ENSP00000313059.6; NM_018979.4; NP_061852.3
UCSCiuc001qio.4, human [Q9H4A3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		65125
DisGeNETi65125

GeneCards: human genes, protein and diseases

More...GeneCardsi		WNK1
GeneReviewsiWNK1
HGNCiHGNC:14540, WNK1
HPAiENSG00000060237, Tissue enhanced (brain)
MalaCardsiWNK1
MIMi201300, phenotype
605232, gene
614492, phenotype
neXtProtiNX_Q9H4A3
OpenTargetsiENSG00000060237
Orphaneti970, Hereditary sensory and autonomic neuropathy type 2
88940, Pseudohypoaldosteronism type 2C
PharmGKBiPA33782
VEuPathDBiHostDB:ENSG00000060237

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0584, Eukaryota
GeneTreeiENSGT00940000155474
InParanoidiQ9H4A3
OMAiPEPNGMT
OrthoDBi27514at2759
PhylomeDBiQ9H4A3
TreeFamiTF315363

Enzyme and pathway databases

PathwayCommonsiQ9H4A3
ReactomeiR-HSA-2672351, Stimuli-sensing channels
SignaLinkiQ9H4A3
SIGNORiQ9H4A3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		65125, 563 hits in 1133 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WNK1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WNK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		65125
PharosiQ9H4A3, Tchem

Protein Ontology

More...PROi		PR:Q9H4A3
RNActiQ9H4A3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000060237, Expressed in corpus callosum and 250 other tissues
ExpressionAtlasiQ9H4A3, baseline and differential
GenevisibleiQ9H4A3, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR024678, Kinase_OSR1/WNK_CCT
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202, OSR1_C, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H4A3
Secondary accession number(s): A1L4B0
, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3, O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673, Q96CZ6, Q9P1S9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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