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Protein

Phosphatidylinositol glycan anchor biosynthesis class U protein

Gene

PIGU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.1 Publication

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

  • attachment of GPI anchor to protein Source: UniProtKB
  • GPI anchor biosynthetic process Source: HGNC
  • regulation of JAK-STAT cascade Source: HGNC

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-162791 Attachment of GPI anchor to uPAR
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol glycan anchor biosynthesis class U protein
Alternative name(s):
Cell division cycle protein 91-like 1
Short name:
Protein CDC91-like 1
GPI transamidase component PIG-U
Gene namesi
Name:PIGU
Synonyms:CDC91L1
ORF Names:PSEC0205, UNQ3055/PRO9875
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101464.10
HGNCiHGNC:15791 PIGU
MIMi608528 gene
neXtProtiNX_Q9H490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi128869
OpenTargetsiENSG00000101464
PharmGKBiPA162399506

Polymorphism and mutation databases

BioMutaiPIGU
DMDMi29336947

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001213942 – 435Phosphatidylinositol glycan anchor biosynthesis class U proteinAdd BLAST434

Proteomic databases

EPDiQ9H490
MaxQBiQ9H490
PaxDbiQ9H490
PeptideAtlasiQ9H490
PRIDEiQ9H490
ProteomicsDBi80796
80797 [Q9H490-2]

PTM databases

iPTMnetiQ9H490
PhosphoSitePlusiQ9H490

Expressioni

Gene expression databases

BgeeiENSG00000101464
CleanExiHS_PIGU
ExpressionAtlasiQ9H490 baseline and differential
GenevisibleiQ9H490 HS

Organism-specific databases

HPAiHPA041706
HPA046766

Interactioni

Subunit structurei

Forms a complex with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1.1 Publication

Protein-protein interaction databases

BioGridi126171, 34 interactors
CORUMiQ9H490
IntActiQ9H490, 9 interactors
MINTiQ9H490
STRINGi9606.ENSP00000217446

Structurei

3D structure databases

ProteinModelPortaliQ9H490
SMRiQ9H490
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni269 – 289May be involved in recognition of long-chain fatty acids in GPIAdd BLAST21

Sequence similaritiesi

Belongs to the PIGU family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2552 Eukaryota
ENOG410XST9 LUCA
GeneTreeiENSGT00390000014941
HOGENOMiHOG000189223
HOVERGENiHBG082139
InParanoidiQ9H490
KOiK05293
OMAiWIYAGSG
OrthoDBiEOG091G0F0I
PhylomeDBiQ9H490
TreeFamiTF101063

Family and domain databases

InterProiView protein in InterPro
IPR009600 PIG-U
PANTHERiPTHR13121 PTHR13121, 1 hit
PfamiView protein in Pfam
PF06728 PIG-U, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H490-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLVLVLV VAVTVRAALF RSSLAEFISE RVEVVSPLSS WKRVVEGLSL
60 70 80 90 100
LDLGVSPYSG AVFHETPLII YLFHFLIDYA ELVFMITDAL TAIALYFAIQ
110 120 130 140 150
DFNKVVFKKQ KLLLELDQYA PDVAELIRTP MEMRYIPLKV ALFYLLNPYT
160 170 180 190 200
ILSCVAKSTC AINNTLIAFF ILTTIKGSAF LSAIFLALAT YQSLYPLTLF
210 220 230 240 250
VPGLLYLLQR QYIPVKMKSK AFWIFSWEYA MMYVGSLVVI ICLSFFLLSS
260 270 280 290 300
WDFIPAVYGF ILSVPDLTPN IGLFWYFFAE MFEHFSLFFV CVFQINVFFY
310 320 330 340 350
TIPLAIKLKE HPIFFMFIQI AVIAIFKSYP TVGDVALYMA FFPVWNHLYR
360 370 380 390 400
FLRNIFVLTC IIIVCSLLFP VLWHLWIYAG SANSNFFYAI TLTFNVGQIL
410 420 430
LISDYFYAFL RREYYLTHGL YLTAKDGTEA MLVLK
Length:435
Mass (Da):50,052
Last modified:January 23, 2007 - v3
Checksum:i65FDD796AB533027
GO
Isoform 2 (identifier: Q9H490-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-85: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):47,611
Checksum:i45BA0934D0273E71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407Y → N in BAC11660 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00954366 – 85Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086842 mRNA Translation: BAC53626.1
AY422169 mRNA Translation: AAR23798.1
AY339061 mRNA Translation: AAQ18022.1
AY358816 mRNA Translation: AAQ89175.1
AK075507 mRNA Translation: BAC11660.1
AL118520 Genomic DNA No translation available.
BC030512 mRNA Translation: AAH30512.1
CCDSiCCDS13239.1 [Q9H490-1]
RefSeqiNP_536724.1, NM_080476.4 [Q9H490-1]
UniGeneiHs.253319

Genome annotation databases

EnsembliENST00000217446; ENSP00000217446; ENSG00000101464 [Q9H490-1]
ENST00000374820; ENSP00000363953; ENSG00000101464 [Q9H490-2]
GeneIDi128869
KEGGihsa:128869
UCSCiuc002xas.4 human [Q9H490-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPIGU_HUMAN
AccessioniPrimary (citable) accession number: Q9H490
Secondary accession number(s): Q7Z489, Q8N2F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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