RBKS

Functionⁱ

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.UniRule annotation1 Publication

Catalytic activityⁱ

ATP + D-ribose = ADP + D-ribose 5-phosphate.UniRule annotation1 Publication

Cofactorⁱ

Mg²⁺UniRule annotationNote: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.UniRule annotation

Activity regulationⁱ

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity (By similarity). Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate (PubMed:17585908).UniRule annotation1 Publication

Kineticsⁱ

Pathwayⁱ: D-ribose degradation

This protein is involved in step 2 of the subpathway that synthesizes D-ribose 5-phosphate from beta-D-ribopyranose.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

no protein annotated in this organism
Ribokinase (RBKS), Ribokinase (rbsK), Ribokinase (RBKS), Ribokinase (RBKS), Ribokinase (RBKS)

This subpathway is part of the pathway D-ribose degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from beta-D-ribopyranose, the pathway D-ribose degradation and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	154	SubstrateUniRule annotationBy similarity	1
Binding siteⁱ	199	ATPUniRule annotation1 Publication	1
Binding siteⁱ	256	ATPUniRule annotation1 Publication	1
Metal bindingⁱ	263	PotassiumUniRule annotation1 Publication	1
Metal bindingⁱ	265	Potassium; via carbonyl oxygenUniRule annotationBy similarity	1
Active siteⁱ	269	Proton acceptorUniRule annotationBy similarity	1
Binding siteⁱ	269	SubstrateUniRule annotationBy similarity	1
Binding siteⁱ	295	ATPUniRule annotation1 Publication	1
Metal bindingⁱ	301	Potassium; via carbonyl oxygenUniRule annotation1 Publication	1
Metal bindingⁱ	304	Potassium; via carbonyl oxygenUniRule annotation1 Publication	1
Metal bindingⁱ	306	Potassium; via carbonyl oxygenUniRule annotationBy similarity	1
Metal bindingⁱ	310	PotassiumUniRule annotation1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	235 – 240	ATPUniRule annotation1 Publication		6
Nucleotide bindingⁱ	268 – 269	ATPUniRule annotation1 Publication		2

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
metal ion binding Source: UniProtKB-KW
ribokinase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
D-ribose catabolic process Source: UniProtKB-UniRule
pentose-phosphate shunt Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Carbohydrate metabolism
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-71336 Pentose phosphate pathway
UniPathwayⁱ	UPA00916;UER00889

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribokinase1 PublicationUniRule annotation (EC:2.7.1.15UniRule annotation1 Publication) Short name: RK1 PublicationUniRule annotation
Gene namesⁱ	Name:RBKSUniRule annotation Synonyms:RBSK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171174.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30325 RBKS
MIMⁱ	611132 gene
neXtProtⁱ	NX_Q9H477

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64080
Open Targets More...OpenTargetsⁱ	ENSG00000171174
PharmGKBⁱ	PA134951602

Polymorphism and mutation databases

DMDMⁱ	20139730

DMDMⁱ

20139730

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080092	1 – 322	RibokinaseAdd BLAST		322

Proteomic databases

EPDⁱ	Q9H477
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H477
PaxDbⁱ	Q9H477
PeptideAtlas More...PeptideAtlasⁱ	Q9H477
PRIDEⁱ	Q9H477
ProteomicsDBⁱ	80790

PTM databases

iPTMnetⁱ	Q9H477
PhosphoSitePlusⁱ	Q9H477

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171174 Expressed in 187 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasⁱ	Q9H477 baseline and differential
Genevisibleⁱ	Q9H477 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019725 HPA028285

HPAⁱ

HPA019725
HPA028285

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotationBy similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACD	Q96AP0	2	EBI-10982959,EBI-717666

With

Entry

#Exp.

IntAct

Notes

ACD

Q96AP0

2

EBI-10982959,EBI-717666

Protein-protein interaction databases

BioGridⁱ	122046, 11 interactors
IntActⁱ	Q9H477, 6 interactors
STRINGⁱ	9606.ENSP00000306817

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	17 – 21	Combined sources	5
Beta strandⁱ	25 – 31	Combined sources	7
Beta strandⁱ	41 – 43	Combined sources	3
Beta strandⁱ	45 – 52	Combined sources	8
Helixⁱ	54 – 64	Combined sources	11
Beta strandⁱ	69 – 78	Combined sources	10
Helixⁱ	79 – 90	Combined sources	12
Beta strandⁱ	98 – 101	Combined sources	4
Beta strandⁱ	108 – 113	Combined sources	6
Beta strandⁱ	119 – 124	Combined sources	6
Helixⁱ	126 – 130	Combined sources	5
Helixⁱ	133 – 138	Combined sources	6
Helixⁱ	140 – 145	Combined sources	6
Beta strandⁱ	147 – 151	Combined sources	5
Beta strandⁱ	153 – 155	Combined sources	3
Helixⁱ	157 – 169	Combined sources	13
Beta strandⁱ	173 – 176	Combined sources	4
Helixⁱ	188 – 191	Combined sources	4
Beta strandⁱ	194 – 199	Combined sources	6
Helixⁱ	200 – 207	Combined sources	8
Helixⁱ	214 – 225	Combined sources	12
Turnⁱ	226 – 228	Combined sources	3
Beta strandⁱ	230 – 235	Combined sources	6
Helixⁱ	237 – 239	Combined sources	3
Beta strandⁱ	241 – 247	Combined sources	7
Beta strandⁱ	252 – 254	Combined sources	3
Helixⁱ	267 – 281	Combined sources	15
Helixⁱ	287 – 301	Combined sources	15
Beta strandⁱ	304 – 306	Combined sources	3
Helixⁱ	307 – 310	Combined sources	4
Helixⁱ	314 – 316	Combined sources	3
Helixⁱ	319 – 322	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H477
SMRⁱ	Q9H477
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9H477

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	25 – 27	Substrate bindingUniRule annotationBy similarity		3
Regionⁱ	53 – 57	Substrate bindingUniRule annotationBy similarity		5

Sequence similaritiesⁱ

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2855 Eukaryota COG0524 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005743
HOGENOMⁱ	HOG000235950
HOVERGENⁱ	HBG018350
InParanoidⁱ	Q9H477
KEGG Orthology (KO) More...KOⁱ	K00852
OMAⁱ	DIVLIQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08OZ
PhylomeDBⁱ	Q9H477
TreeFamⁱ	TF105770

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01174 ribokinase, 1 hit
Gene3Dⁱ	3.40.1190.20, 1 hit
HAMAPⁱ	MF_01987 Ribokinase, 1 hit
InterProⁱ	View protein in InterPro IPR002173 Carboh/pur_kinase_PfkB_CS IPR011877 D_ribokin IPR011611 PfkB_dom IPR002139 Ribo/fructo_kinase IPR029056 Ribokinase-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00294 PfkB, 1 hit
PRINTSⁱ	PR00990 RIBOKINASE
SUPFAMⁱ	SSF53613 SSF53613, 1 hit
TIGRFAMsⁱ	TIGR02152 D_ribokin_bact, 1 hit
PROSITEⁱ	View protein in PROSITE PS00584 PFKB_KINASES_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H477-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASGEPQRQ WQEEVAAVVV VGSCMTDLVS LTSRLPKTGE TIHGHKFFIG 
        60         70         80         90        100
FGGKGANQCV QAARLGAMTS MVCKVGKDSF GNDYIENLKQ NDISTEFTYQ 
       110        120        130        140        150
TKDAATGTAS IIVNNEGQNI IVIVAGANLL LNTEDLRAAA NVISRAKVMV 
       160        170        180        190        200
CQLEITPATS LEALTMARRS GVKTLFNPAP AIADLDPQFY TLSDVFCCNE 
       210        220        230        240        250
SEAEILTGLT VGSAADAGEA ALVLLKRGCQ VVIITLGAEG CVVLSQTEPE 
       260        270        280        290        300
PKHIPTEKVK AVDTTGAGDS FVGALAFYLA YYPNLSLEDM LNRSNFIAAV 
       310        320 
SVQAAGTQSS YPYKKDLPLT LF

Length:322

Mass (Da):34,143

Last modified:March 1, 2001 - v1

Checksum:ⁱ50D0E7161F33E94B

GO

Isoform 2 (identifier: Q9H477-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
266-322: GAGDSFVGAL...YKKDLPLTLF → CRPGSRPKSEAASVKKQKHYK

« Hide

        10         20         30         40         50
MAASGEPQRQ WQEEVAAVVV VGSCMTDLVS LTSRLPKTGE TIHGHKFFIG 
        60         70         80         90        100
FGGKGANQCV QAARLGAMTS MVCKVGKDSF GNDYIENLKQ NDISTEFTYQ 
       110        120        130        140        150
TKDAATGTAS IIVNNEGQNI IVIVAGANLL LNTEDLRAAA NVISRAKVMV 
       160        170        180        190        200
CQLEITPATS LEALTMARRS GVKTLFNPAP AIADLDPQFY TLSDVFCCNE 
       210        220        230        240        250
SEAEILTGLT VGSAADAGEA ALVLLKRGCQ VVIITLGAEG CVVLSQTEPE 
       260        270        280 
PKHIPTEKVK AVDTTCRPGS RPKSEAASVK KQKHYK

Note: No experimental confirmation available.

Show »

Length:286

Mass (Da):30,361

Checksum:ⁱ020866FD563F058F

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C091	H7C091_HUMAN	Ribokinase Ribokinase	RBKS	147	Annotation score:
E7EQ18	E7EQ18_HUMAN	Ribokinase Ribokinase	RBKS	63	Annotation score:
E9PBU0	E9PBU0_HUMAN	Ribokinase Ribokinase	RBKS	36	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	101	T → A in AAT64917 (Ref. 2) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054380	266 – 322	GAGDS…PLTLF → CRPGSRPKSEAASVKKQKHY K in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ404857 mRNA Translation: CAC12877.1 AY643715 mRNA Translation: AAT64917.1 AK300989 mRNA Translation: BAG62608.1 AC021171 Genomic DNA No translation available. AC110084 Genomic DNA No translation available. BC017425 mRNA Translation: AAH17425.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1762.1 [Q9H477-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001274509.1, NM_001287580.1 NP_071411.1, NM_022128.2 [Q9H477-1]
UniGeneⁱ	Hs.11916

Genome annotation databases

Ensemblⁱ	ENST00000302188; ENSP00000306817; ENSG00000171174 [Q9H477-1]
GeneIDⁱ	64080
KEGGⁱ	hsa:64080
UCSC genome browser More...UCSCⁱ	uc002rlo.3 human [Q9H477-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H477	Uncharacterized protein RBSK (Fragment)		HUMAN		29	UniRef100_Q9H477
UPI0007E529E2		HUMAN		330

Protein	Similar proteins		Species	Score	Length	Source
Q9H477	Uncharacterized protein RBSK (Fragment)		HUMAN		29	UniRef90_Q9H477
RBKS isoform 4 (Fragment)		PONAB		146
RBKS isoform 5 (Fragment)		PANTR		146
UPI000274641D		PANPA		286
UPI0008F4DADA		GORGO		286
+15

Protein	Similar proteins		Species	Score	Length	Source
Q9H477	Uncharacterized protein RBSK (Fragment)		HUMAN		29	UniRef50_Q9H477
RBKS isoform 4 (Fragment)		PONAB		146
RBKS isoform 5 (Fragment)		PANTR		146
Ribokinase		PHYCD		276
ribokinase isoform X5		URSMA		267
+91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ404857 mRNA Translation: CAC12877.1 AY643715 mRNA Translation: AAT64917.1 AK300989 mRNA Translation: BAG62608.1 AC021171 Genomic DNA No translation available. AC110084 Genomic DNA No translation available. BC017425 mRNA Translation: AAH17425.1
CCDSⁱ	CCDS1762.1 [Q9H477-1]
RefSeqⁱ	NP_001274509.1, NM_001287580.1 NP_071411.1, NM_022128.2 [Q9H477-1]
UniGeneⁱ	Hs.11916

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FV7	X-ray	2.10	A/B	11-322	[»]
	5BYC	X-ray	1.95	A/B	1-322	[»]
	5BYD	X-ray	2.10	A/B	1-322	[»]
	5BYE	X-ray	1.75	A/B	1-322	[»]
	5BYF	X-ray	2.00	A/B	1-322	[»]
	5C3Y	X-ray	2.60	A/B/C/D/E/F/G/H/I/J/K/L	1-322	[»]
	5C3Z	X-ray	1.90	A/B	1-322	[»]
	5C40	X-ray	1.50	A/B	1-322	[»]
	5C41	X-ray	1.95	A/B/C/D	1-322	[»]
ProteinModelPortalⁱ	Q9H477
SMRⁱ	Q9H477
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122046, 11 interactors
IntActⁱ	Q9H477, 6 interactors
STRINGⁱ	9606.ENSP00000306817

PTM databases

iPTMnetⁱ	Q9H477
PhosphoSitePlusⁱ	Q9H477

Polymorphism and mutation databases

DMDMⁱ	20139730

DMDMⁱ

20139730

Proteomic databases

EPDⁱ	Q9H477
MaxQBⁱ	Q9H477
PaxDbⁱ	Q9H477
PeptideAtlasⁱ	Q9H477
PRIDEⁱ	Q9H477
ProteomicsDBⁱ	80790

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64080
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302188; ENSP00000306817; ENSG00000171174 [Q9H477-1]
GeneIDⁱ	64080
KEGGⁱ	hsa:64080
UCSCⁱ	uc002rlo.3 human [Q9H477-1]

Organism-specific databases

CTDⁱ	64080
DisGeNETⁱ	64080
EuPathDBⁱ	HostDB:ENSG00000171174.13
GeneCardsⁱ	RBKS
HGNCⁱ	HGNC:30325 RBKS
HPAⁱ	HPA019725 HPA028285
MIMⁱ	611132 gene
neXtProtⁱ	NX_Q9H477
OpenTargetsⁱ	ENSG00000171174
PharmGKBⁱ	PA134951602
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2855 Eukaryota COG0524 LUCA
GeneTreeⁱ	ENSGT00390000005743
HOGENOMⁱ	HOG000235950
HOVERGENⁱ	HBG018350
InParanoidⁱ	Q9H477
KOⁱ	K00852
OMAⁱ	DIVLIQQ
OrthoDBⁱ	EOG091G08OZ
PhylomeDBⁱ	Q9H477
TreeFamⁱ	TF105770

Enzyme and pathway databases

UniPathwayⁱ	UPA00916;UER00889
Reactomeⁱ	R-HSA-71336 Pentose phosphate pathway

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H477
GenomeRNAiⁱ	64080
Protein Ontology More...PROⁱ	PR:Q9H477
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171174 Expressed in 187 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasⁱ	Q9H477 baseline and differential
Genevisibleⁱ	Q9H477 HS

Family and domain databases

CDDⁱ	cd01174 ribokinase, 1 hit
Gene3Dⁱ	3.40.1190.20, 1 hit
HAMAPⁱ	MF_01987 Ribokinase, 1 hit
InterProⁱ	View protein in InterPro IPR002173 Carboh/pur_kinase_PfkB_CS IPR011877 D_ribokin IPR011611 PfkB_dom IPR002139 Ribo/fructo_kinase IPR029056 Ribokinase-like
Pfamⁱ	View protein in Pfam PF00294 PfkB, 1 hit
PRINTSⁱ	PR00990 RIBOKINASE
SUPFAMⁱ	SSF53613 SSF53613, 1 hit
TIGRFAMsⁱ	TIGR02152 D_ribokin_bact, 1 hit
PROSITEⁱ	View protein in PROSITE PS00584 PFKB_KINASES_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBSK_HUMAN
Accessionⁱ	Q9H477Primary (citable) accession number: Q9H477 Secondary accession number(s): A9UK04, B4DV96
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9H477 (RBSK_HUMAN)

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Ribokinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: D-ribose degradation

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: D-ribose degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ