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Protein

F-box/LRR-repeat protein 15

Gene

FBXL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • bone mineralization Source: UniProtKB
  • dorsal/ventral pattern formation Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: UniProtKB
  • post-translational protein modification Source: Reactome
  • protein polyubiquitination Source: Reactome
  • protein ubiquitination Source: UniProtKB
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 15
Alternative name(s):
F-box only protein 37
Gene namesi
Name:FBXL15
Synonyms:FBXO37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107872.12
HGNCiHGNC:28155 FBXL15
MIMi610287 gene
neXtProtiNX_Q9H469

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107872
PharmGKBiPA134928704

Polymorphism and mutation databases

BioMutaiFBXL15
DMDMi239938631

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199311 – 300F-box/LRR-repeat protein 15Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H469
MaxQBiQ9H469
PaxDbiQ9H469
PeptideAtlasiQ9H469
PRIDEiQ9H469
ProteomicsDBi80789

PTM databases

iPTMnetiQ9H469
PhosphoSitePlusiQ9H469

Expressioni

Gene expression databases

BgeeiENSG00000107872
CleanExiHS_FBXL15
ExpressionAtlasiQ9H469 baseline and differential
GenevisibleiQ9H469 HS

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122593, 21 interactors
IntActiQ9H469, 17 interactors
MINTiQ9H469
STRINGi9606.ENSP00000224862

Structurei

3D structure databases

ProteinModelPortaliQ9H469
SMRiQ9H469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 66F-boxAdd BLAST48
Repeati141 – 162LRR 1Add BLAST22
Repeati167 – 188LRR 2Add BLAST22
Repeati194 – 215LRR 3Add BLAST22
Repeati220 – 241LRR 4Add BLAST22
Repeati246 – 267LRR 5Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 269Interaction with SMURF11 PublicationAdd BLAST157

Sequence similaritiesi

Belongs to the FBXL15 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1W Eukaryota
ENOG4111ZPI LUCA
GeneTreeiENSGT00760000119059
HOVERGENiHBG051578
InParanoidiQ9H469
KOiK10281
OMAiLAHCEWV
OrthoDBiEOG091G0UTZ
PhylomeDBiQ9H469
TreeFamiTF326769

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF13516 LRR_6, 1 hit
SMARTiView protein in SMART
SM00367 LRR_CC, 6 hits
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPMEPSGG EQEPGAVRFL DLPWEDVLLP HVLNRVPLRQ LLRLQRVSRA
60 70 80 90 100
FRSLVQLHLA GLRRFDAAQV GPQIPRAALA RLLRDAEGLQ ELALAPCHEW
110 120 130 140 150
LSDEDLVPVL ARNPQLRSVA LGGCGQLSRR ALGALAEGCP RLQRLSLAHC
160 170 180 190 200
DWVDGLALRG LADRCPALEE LDLTACRQLK DEAIVYLAQR RGAGLRSLSL
210 220 230 240 250
AVNANVGDAA VQELARNCPE LHHLDLTGCL RVGSDGVRTL AEYCPVLRSL
260 270 280 290 300
RVRHCHHVAE SSLSRLRKRG VDIDVEPPLH QALVLLQDMA GFAPFVNLQV
Length:300
Mass (Da):32,998
Last modified:June 16, 2009 - v2
Checksum:i3AF8CAFDDF75D720
GO

Sequence cautioni

The sequence AAH02912 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH36120 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI12517 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12518 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12519 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12520 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12522 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164R → H in AAH36120 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121928 Genomic DNA Translation: CAI12517.1 Sequence problems.
AL121928 Genomic DNA Translation: CAI12518.1 Sequence problems.
AL121928 Genomic DNA Translation: CAI12519.1 Sequence problems.
AL121928 Genomic DNA Translation: CAI12520.1 Sequence problems.
AL121928 Genomic DNA Translation: CAI12522.2 Different initiation.
BC002912 mRNA Translation: AAH02912.1 Different initiation.
BC036120 mRNA Translation: AAH36120.1 Different initiation.
BC130566 mRNA Translation: AAI30567.1
CCDSiCCDS31273.1
RefSeqiNP_077302.3, NM_024326.3
XP_005270207.1, XM_005270150.4
XP_005270208.1, XM_005270151.3
XP_016872120.1, XM_017016631.1
UniGeneiHs.380081

Genome annotation databases

EnsembliENST00000224862; ENSP00000224862; ENSG00000107872
GeneIDi79176
KEGGihsa:79176
UCSCiuc001kvk.2 human

Similar proteinsi

Entry informationi

Entry nameiFXL15_HUMAN
AccessioniPrimary (citable) accession number: Q9H469
Secondary accession number(s): A1L4J8
, B1AKX8, B1AKX9, B1AKY0, B1AKY1, C9JWA4, Q0D2Q3, Q49AL7, Q5JWA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 16, 2009
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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