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Protein

CUE domain-containing protein 2

Gene

CUEDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.2 Publications

GO - Biological processi

  • negative regulation of cytokine production involved in inflammatory response Source: MGI
  • negative regulation of macrophage cytokine production Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
CUE domain-containing protein 2
Gene namesi
Name:CUEDC2
Synonyms:C10orf66
ORF Names:HOYS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107874.10
HGNCiHGNC:28352 CUEDC2
MIMi614142 gene
neXtProtiNX_Q9H467

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.

Organism-specific databases

DisGeNETi79004
OpenTargetsiENSG00000107874
PharmGKBiPA134871975

Polymorphism and mutation databases

BioMutaiCUEDC2
DMDMi74752634

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829921 – 287CUE domain-containing protein 2Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H467
MaxQBiQ9H467
PaxDbiQ9H467
PeptideAtlasiQ9H467
PRIDEiQ9H467
ProteomicsDBi80788

PTM databases

iPTMnetiQ9H467
PhosphoSitePlusiQ9H467

Expressioni

Tissue specificityi

Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.

Gene expression databases

BgeeiENSG00000107874
CleanExiHS_CUEDC2
GenevisibleiQ9H467 HS

Organism-specific databases

HPAiHPA036544
HPA041829

Interactioni

Subunit structurei

Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122475, 22 interactors
IntActiQ9H467, 4 interactors
MINTiQ9H467
STRINGi9606.ENSP00000358953

Structurei

3D structure databases

ProteinModelPortaliQ9H467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 187CUEPROSITE-ProRule annotationAdd BLAST44

Domaini

The CUE domain mediates interaction with PGR and ESR1.

Sequence similaritiesi

Belongs to the CUEDC2 family.Curated

Phylogenomic databases

eggNOGiENOG410IJTC Eukaryota
ENOG4111GK5 LUCA
GeneTreeiENSGT00390000014513
HOGENOMiHOG000044753
HOVERGENiHBG106839
InParanoidiQ9H467
OMAiTEMEKNQ
OrthoDBiEOG091G0FYA
PhylomeDBiQ9H467
TreeFamiTF324328

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
PfamiView protein in Pfam
PF02845 CUE, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELERIVSAA LLAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE
60 70 80 90 100
NFDMEAFTEM MEAYVPGFAH IPRGTIGDMM QKLSGQLSDA RNKENLQPQS
110 120 130 140 150
SGVQGQVPIS PEPLQRPEML KEETRSSAAA AADTQDEATG AEEELLPGVD
160 170 180 190 200
VLLEVFPTCS VEQAQWVLAK ARGDLEEAVQ MLVEGKEEGP AAWEGPNQDL
210 220 230 240 250
PRRLRGPQKD ELKSFILQKY MMVDSAEDQK IHRPMAPKEA PKKLIRYIDN
260 270 280
QVVSTKGERF KDVRNPEAEE MKATYINLKP ARKYRFH
Length:287
Mass (Da):32,009
Last modified:March 1, 2001 - v1
Checksum:iD092D9A6168E9C15
GO

Sequence cautioni

The sequence AAH00262 differs from that shown. Reason: Erroneous termination at position 227. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228D → Y in AAH00262 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025425 mRNA Translation: BAB87809.1
AB232358 mRNA Translation: BAE19942.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49696.1
CH471066 Genomic DNA Translation: EAW49697.1
BC000262 mRNA Translation: AAH00262.1 Sequence problems.
CCDSiCCDS41566.1
RefSeqiNP_076945.2, NM_024040.2
UniGeneiHs.500874

Genome annotation databases

EnsembliENST00000369937; ENSP00000358953; ENSG00000107874
GeneIDi79004
KEGGihsa:79004
UCSCiuc001kvn.3 human

Similar proteinsi

Entry informationi

Entry nameiCUED2_HUMAN
AccessioniPrimary (citable) accession number: Q9H467
Secondary accession number(s): D3DR88, Q9BWG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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