UniProtKB - Q9H446 (RWDD1_HUMAN)
Protein
RWD domain-containing protein 1
Gene
RWDD1
Organism
Homo sapiens (Human)
Status
Functioni
Protects DRG2 from proteolytic degradation.By similarity
GO - Biological processi
- androgen receptor signaling pathway Source: Ensembl
- cell aging Source: Ensembl
- cellular response to oxidative stress Source: Ensembl
- cellular response to testosterone stimulus Source: Ensembl
- cytoplasmic translation Source: GO_Central
- positive regulation of androgen receptor activity Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9H446 |
Names & Taxonomyi
Protein namesi | Recommended name: RWD domain-containing protein 1Alternative name(s): DRG family-regulatory protein 2 |
Gene namesi | Name:RWDD1 Synonyms:DFRP2 ORF Names:CGI-24, PTD013 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20993, RWDD1 |
neXtProti | NX_Q9H446 |
VEuPathDBi | HostDB:ENSG00000111832.12 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51389 |
OpenTargetsi | ENSG00000111832 |
PharmGKBi | PA134967923 |
Miscellaneous databases
Pharosi | Q9H446, Tdark |
Genetic variation databases
BioMutai | RWDD1 |
DMDMi | 34098713 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000097540 | 2 – 243 | RWD domain-containing protein 1Add BLAST | 242 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 | |
Modified residuei | 144 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H446 |
jPOSTi | Q9H446 |
MassIVEi | Q9H446 |
MaxQBi | Q9H446 |
PaxDbi | Q9H446 |
PeptideAtlasi | Q9H446 |
PRIDEi | Q9H446 |
ProteomicsDBi | 1990 80786 [Q9H446-1] |
PTM databases
iPTMneti | Q9H446 |
MetOSitei | Q9H446 |
PhosphoSitePlusi | Q9H446 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111832, Expressed in calcaneal tendon and 243 other tissues |
ExpressionAtlasi | Q9H446, baseline and differential |
Genevisiblei | Q9H446, HS |
Organism-specific databases
HPAi | ENSG00000111832, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DRG2.
Interacts with androgen receptor (By similarity).
By similarityBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 119518, 8 interactors |
DIPi | DIP-34520N |
IntActi | Q9H446, 9 interactors |
STRINGi | 9606.ENSP00000420357 |
Miscellaneous databases
RNActi | Q9H446, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9H446 |
SMRi | Q9H446 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9H446 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 114 | RWDPROSITE-ProRule annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 197 | Interaction with DRG2By similarityAdd BLAST | 56 |
Sequence similaritiesi
Belongs to the RWDD1/GIR2 family.Curated
Phylogenomic databases
eggNOGi | KOG4018, Eukaryota |
GeneTreei | ENSGT00390000009168 |
HOGENOMi | CLU_084528_2_0_1 |
InParanoidi | Q9H446 |
OMAi | IYCGELE |
OrthoDBi | 1269244at2759 |
PhylomeDBi | Q9H446 |
TreeFami | TF313662 |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR040213, GIR2-like IPR006575, RWD-domain IPR016135, UBQ-conjugating_enzyme/RWD IPR032378, ZC3H15/TMA46_C |
PANTHERi | PTHR12292, PTHR12292, 1 hit |
Pfami | View protein in Pfam PF16543, DFRP_C, 1 hit PF05773, RWD, 1 hit |
SMARTi | View protein in SMART SM00591, RWD, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS50908, RWD, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H446-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT
60 70 80 90 100
TLKFTYSEKY PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI
110 120 130 140 150
FTLVTAVQEK LNEIVDQIKT RREEEKKQKE KEAEEAEKQL FHGTPVTIEN
160 170 180 190 200
FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK LSGKQLFETD HNLDTSDIQF
210 220 230 240
LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD SAD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RJE3 | E5RJE3_HUMAN | RWD domain-containing protein 1 | RWDD1 | 51 | Annotation score: | ||
E5RGQ3 | E5RGQ3_HUMAN | RWD domain-containing protein 1 | RWDD1 | 72 | Annotation score: | ||
E5RGS5 | E5RGS5_HUMAN | RWD domain-containing protein 1 | RWDD1 | 67 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 – 130 | TRREEEKKQKE → LEERRKNKR in AAD27733 (PubMed:10810093).CuratedAdd BLAST | 11 | |
Sequence conflicti | 139 | Q → R in AAD40376 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044500 | 1 – 96 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132958 mRNA Translation: AAD27733.1 AF092134 mRNA Translation: AAD40376.1 AK290727 mRNA Translation: BAF83416.1 AK301089 mRNA Translation: BAG62691.1 AL121953 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48221.1 CH471051 Genomic DNA Translation: EAW48222.1 BC015802 mRNA Translation: AAH15802.1 |
CCDSi | CCDS34520.1 [Q9H446-1] CCDS43496.1 [Q9H446-2] |
RefSeqi | NP_001007465.1, NM_001007464.2 [Q9H446-2] NP_057036.2, NM_015952.3 [Q9H446-1] NP_057188.2, NM_016104.3 [Q9H446-2] |
Genome annotation databases
Ensembli | ENST00000466444; ENSP00000420357; ENSG00000111832 [Q9H446-1] ENST00000487832; ENSP00000428778; ENSG00000111832 [Q9H446-2] |
GeneIDi | 51389 |
KEGGi | hsa:51389 |
UCSCi | uc003pxc.5, human [Q9H446-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132958 mRNA Translation: AAD27733.1 AF092134 mRNA Translation: AAD40376.1 AK290727 mRNA Translation: BAF83416.1 AK301089 mRNA Translation: BAG62691.1 AL121953 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48221.1 CH471051 Genomic DNA Translation: EAW48222.1 BC015802 mRNA Translation: AAH15802.1 |
CCDSi | CCDS34520.1 [Q9H446-1] CCDS43496.1 [Q9H446-2] |
RefSeqi | NP_001007465.1, NM_001007464.2 [Q9H446-2] NP_057036.2, NM_015952.3 [Q9H446-1] NP_057188.2, NM_016104.3 [Q9H446-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EBM | NMR | - | A | 1-121 | [»] | |
BMRBi | Q9H446 | |||||
SMRi | Q9H446 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119518, 8 interactors |
DIPi | DIP-34520N |
IntActi | Q9H446, 9 interactors |
STRINGi | 9606.ENSP00000420357 |
PTM databases
iPTMneti | Q9H446 |
MetOSitei | Q9H446 |
PhosphoSitePlusi | Q9H446 |
Genetic variation databases
BioMutai | RWDD1 |
DMDMi | 34098713 |
Proteomic databases
EPDi | Q9H446 |
jPOSTi | Q9H446 |
MassIVEi | Q9H446 |
MaxQBi | Q9H446 |
PaxDbi | Q9H446 |
PeptideAtlasi | Q9H446 |
PRIDEi | Q9H446 |
ProteomicsDBi | 1990 80786 [Q9H446-1] |
Protocols and materials databases
Antibodypediai | 32499, 115 antibodies |
DNASUi | 51389 |
Genome annotation databases
Ensembli | ENST00000466444; ENSP00000420357; ENSG00000111832 [Q9H446-1] ENST00000487832; ENSP00000428778; ENSG00000111832 [Q9H446-2] |
GeneIDi | 51389 |
KEGGi | hsa:51389 |
UCSCi | uc003pxc.5, human [Q9H446-1] |
Organism-specific databases
CTDi | 51389 |
DisGeNETi | 51389 |
GeneCardsi | RWDD1 |
HGNCi | HGNC:20993, RWDD1 |
HPAi | ENSG00000111832, Low tissue specificity |
neXtProti | NX_Q9H446 |
OpenTargetsi | ENSG00000111832 |
PharmGKBi | PA134967923 |
VEuPathDBi | HostDB:ENSG00000111832.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4018, Eukaryota |
GeneTreei | ENSGT00390000009168 |
HOGENOMi | CLU_084528_2_0_1 |
InParanoidi | Q9H446 |
OMAi | IYCGELE |
OrthoDBi | 1269244at2759 |
PhylomeDBi | Q9H446 |
TreeFami | TF313662 |
Enzyme and pathway databases
PathwayCommonsi | Q9H446 |
Miscellaneous databases
BioGRID-ORCSi | 51389, 10 hits in 877 CRISPR screens |
ChiTaRSi | RWDD1, human |
EvolutionaryTracei | Q9H446 |
GenomeRNAii | 51389 |
Pharosi | Q9H446, Tdark |
PROi | PR:Q9H446 |
RNActi | Q9H446, protein |
Gene expression databases
Bgeei | ENSG00000111832, Expressed in calcaneal tendon and 243 other tissues |
ExpressionAtlasi | Q9H446, baseline and differential |
Genevisiblei | Q9H446, HS |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR040213, GIR2-like IPR006575, RWD-domain IPR016135, UBQ-conjugating_enzyme/RWD IPR032378, ZC3H15/TMA46_C |
PANTHERi | PTHR12292, PTHR12292, 1 hit |
Pfami | View protein in Pfam PF16543, DFRP_C, 1 hit PF05773, RWD, 1 hit |
SMARTi | View protein in SMART SM00591, RWD, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS50908, RWD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RWDD1_HUMAN | |
Accessioni | Q9H446Primary (citable) accession number: Q9H446 Secondary accession number(s): A8K3W2 Q9Y6B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM