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Protein

RWD domain-containing protein 1

Gene

RWDD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects DRG2 from proteolytic degradation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RWD domain-containing protein 1
Alternative name(s):
DRG family-regulatory protein 2
Gene namesi
Name:RWDD1
Synonyms:DFRP2
ORF Names:CGI-24, PTD013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111832.12
HGNCiHGNC:20993 RWDD1
neXtProtiNX_Q9H446

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111832
PharmGKBiPA134967923

Polymorphism and mutation databases

DMDMi34098713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000975402 – 243RWD domain-containing protein 1Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei144PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H446
MaxQBiQ9H446
PaxDbiQ9H446
PeptideAtlasiQ9H446
PRIDEiQ9H446
ProteomicsDBi80786

PTM databases

iPTMnetiQ9H446
PhosphoSitePlusiQ9H446

Expressioni

Gene expression databases

BgeeiENSG00000111832
CleanExiHS_RWDD1
ExpressionAtlasiQ9H446 baseline and differential
GenevisibleiQ9H446 HS

Organism-specific databases

HPAiHPA028712
HPA028713

Interactioni

Subunit structurei

Interacts with DRG2. Interacts with androgen receptor (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119518, 5 interactors
DIPiDIP-34520N
IntActiQ9H446, 6 interactors
STRINGi9606.ENSP00000420357

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 18Combined sources15
Beta strandi20 – 25Combined sources6
Beta strandi28 – 30Combined sources3
Beta strandi32 – 35Combined sources4
Beta strandi49 – 55Combined sources7
Turni60 – 62Combined sources3
Beta strandi66 – 74Combined sources9
Helixi77 – 94Combined sources18
Helixi100 – 117Combined sources18
Helixi118 – 120Combined sources3

3D structure databases

ProteinModelPortaliQ9H446
SMRiQ9H446
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H446

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 114RWDPROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 197Interaction with DRG2By similarityAdd BLAST56

Sequence similaritiesi

Belongs to the RWDD1/GIR2 family.Curated

Phylogenomic databases

eggNOGiKOG4018 Eukaryota
ENOG410XT0M LUCA
GeneTreeiENSGT00390000009168
HOGENOMiHOG000237961
HOVERGENiHBG060864
InParanoidiQ9H446
OMAiIYCGELE
OrthoDBiEOG091G0ODA
PhylomeDBiQ9H446
TreeFamiTF313662

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR032378 ZC3H15/TMA46_C
PfamiView protein in Pfam
PF16543 DFRP_C, 1 hit
PF05773 RWD, 1 hit
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H446-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT
60 70 80 90 100
TLKFTYSEKY PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI
110 120 130 140 150
FTLVTAVQEK LNEIVDQIKT RREEEKKQKE KEAEEAEKQL FHGTPVTIEN
160 170 180 190 200
FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK LSGKQLFETD HNLDTSDIQF
210 220 230 240
LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD SAD
Length:243
Mass (Da):27,940
Last modified:March 1, 2001 - v1
Checksum:iA7AABD457136B4DA
GO
Isoform 2 (identifier: Q9H446-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:147
Mass (Da):17,082
Checksum:iA2927D314AE84CE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 130TRREEEKKQKE → LEERRKNKR in AAD27733 (PubMed:10810093).CuratedAdd BLAST11
Sequence conflicti139Q → R in AAD40376 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445001 – 96Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132958 mRNA Translation: AAD27733.1
AF092134 mRNA Translation: AAD40376.1
AK290727 mRNA Translation: BAF83416.1
AK301089 mRNA Translation: BAG62691.1
AL121953 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48221.1
CH471051 Genomic DNA Translation: EAW48222.1
BC015802 mRNA Translation: AAH15802.1
CCDSiCCDS34520.1 [Q9H446-1]
CCDS43496.1 [Q9H446-2]
RefSeqiNP_001007465.1, NM_001007464.2 [Q9H446-2]
NP_057036.2, NM_015952.3 [Q9H446-1]
NP_057188.2, NM_016104.3 [Q9H446-2]
UniGeneiHs.532164

Genome annotation databases

EnsembliENST00000466444; ENSP00000420357; ENSG00000111832 [Q9H446-1]
ENST00000487832; ENSP00000428778; ENSG00000111832 [Q9H446-2]
GeneIDi51389
KEGGihsa:51389
UCSCiuc003pxc.5 human [Q9H446-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRWDD1_HUMAN
AccessioniPrimary (citable) accession number: Q9H446
Secondary accession number(s): A8K3W2
, A8MT24, Q9Y313, Q9Y6B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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