CHMP4B

Functionⁱ

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).5 Publications

(Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.4 Publications

Miscellaneous

Its overexpression strongly inhibits HIV-1 release.

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18209100
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 14519844

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 24095276
endosomal transport Source: Reactome
exit from mitosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26040712
macroautophagy
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 20588296
maintenance of lens transparency
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17701905
membrane fission
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21310966
midbody abscission
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
mitotic cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21310966
mitotic metaphase plate congression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
multivesicular body assembly
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 20588296
negative regulation of autophagosome assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21975012
negative regulation of cell death
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
negative regulation of neuron death
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21975012
nuclear envelope reassembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26040712
nucleus organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
positive regulation of viral release from host cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14505570
posttranslational protein targeting to endoplasmic reticulum membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21975012
protein homooligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 18209100
regulation of centrosome duplication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
regulation of mitotic spindle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
regulation of viral process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14505570
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22547407
vacuolar transport Source: InterPro
viral budding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17701905
viral budding via host ESCRT complex
Source: UniProtKB
Inferred from direct assayⁱ
- 24878737
viral life cycle Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-1632852 Macroautophagy R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-1632852 Macroautophagy
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Charged multivesicular body protein 4b Alternative name(s): Chromatin-modifying protein 4b Short name: CHMP4b SNF7 homolog associated with Alix 1 SNF7-2 Short name: hSnf7-2 Vacuolar protein sorting-associated protein 32-2 Short name: Vps32-2 Short name: hVps32-2
Gene namesⁱ	Name:CHMP4B Synonyms:C20orf178, SHAX1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101421.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16171 CHMP4B
MIMⁱ	610897 gene
neXtProtⁱ	NX_Q9H444

Keywords - Cellular componentⁱ

Cytoplasm, Endosome, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cataract 31, multiple types (CTRCT31)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT31 includes posterior polar, progressive posterior subcapsular, nuclear, and anterior subcapsular cataracts.

Keywords - Diseaseⁱ

Cataract, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	128866
MalaCards human disease database More...MalaCardsⁱ	CHMP4B
MIMⁱ	605387 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000101421
Orphanetⁱ	98993 Early-onset posterior polar cataract 441447 Early-onset posterior subcapsular cataract
PharmGKBⁱ	PA25721

Polymorphism and mutation databases

BioMutaⁱ	CHMP4B
DMDMⁱ	24636296

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000211489	2 – 224	Charged multivesicular body protein 4bAdd BLAST		223

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	6	N6-acetyllysineCombined sources	1
Modified residueⁱ	114	N6-acetyllysineCombined sources	1
Modified residueⁱ	184	PhosphoserineCombined sources	1
Modified residueⁱ	223	PhosphoserineCombined sources	1

Post-translational modificationⁱ

ISGylated. Isgylation weakens its interaction with VPS4A.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9H444
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H444
PaxDbⁱ	Q9H444
PeptideAtlas More...PeptideAtlasⁱ	Q9H444
PRIDEⁱ	Q9H444
ProteomicsDBⁱ	80785

PTM databases

iPTMnetⁱ	Q9H444
PhosphoSitePlusⁱ	Q9H444

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000101421 Expressed in 197 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	HS_CHMP4B
Genevisibleⁱ	Q9H444 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041401 HPA051751

HPAⁱ

HPA041401
HPA051751

Interactionⁱ

Subunit structureⁱ

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP6 and CHMP4C. Interacts with PDCD6IP; the interaction is direct. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP7. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts with PTPN23.14 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		7	EBI-749627,EBI-749627
BROX	Q5VW32	5	EBI-749627,EBI-6286053
CC2D1A	Q6P1N0	3	EBI-749627,EBI-7112364
CHMP2A	O43633	3	EBI-749627,EBI-2692789
CHMP2B	Q9UQN3	2	EBI-749627,EBI-718324
CHMP3	Q9Y3E7	5	EBI-749627,EBI-2118119
CHMP4A	Q9BY43	4	EBI-749627,EBI-747981
CHMP5	Q9NZZ3	4	EBI-749627,EBI-751303
CHMP7	Q8WUX9	3	EBI-749627,EBI-749253
PDCD6IP	Q8WUM4	6	EBI-749627,EBI-310624
Pdcd6ip	Q9WU78-1	2	EBI-749627,EBI-15788421	From a different organism.
PTPN23	Q9H3S7	4	EBI-749627,EBI-724478
STAMBP	O95630	3	EBI-749627,EBI-396676
UBE2I	P63279	3	EBI-749627,EBI-80168

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18209100
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 14519844

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126170, 124 interactors
ComplexPortalⁱ	CPX-329 ESCRT-III complex
CORUMⁱ	Q9H444
Database of interacting proteins More...DIPⁱ	DIP-29924N
IntActⁱ	Q9H444, 119 interactors
Molecular INTeraction database More...MINTⁱ	Q9H444
STRINGⁱ	9606.ENSP00000217402

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	23 – 57	Combined sources	35
Helixⁱ	62 – 96	Combined sources	35
Helixⁱ	209 – 212	Combined sources	4
Helixⁱ	213 – 221	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H444
SMRⁱ	Q9H444
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H444

EvolutionaryTraceⁱ

Q9H444

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	23 – 183	Sequence analysisAdd BLAST		161

Domainⁱ

The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.

Sequence similaritiesⁱ

Belongs to the SNF7 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1656 Eukaryota ENOG410YE9I LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005006
HOGENOMⁱ	HOG000209960
HOVERGENⁱ	HBG050928
InParanoidⁱ	Q9H444
KEGG Orthology (KO) More...KOⁱ	K12194
OMAⁱ	MQVNTLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0V7X
PhylomeDBⁱ	Q9H444
TreeFamⁱ	TF314269

Family and domain databases

InterProⁱ	View protein in InterPro IPR005024 Snf7_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03357 Snf7, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9H444-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVFGKLFGA GGGKAGKGGP TPQEAIQRLR DTEEMLSKKQ EFLEKKIEQE 
        60         70         80         90        100
LTAAKKHGTK NKRAALQALK RKKRYEKQLA QIDGTLSTIE FQREALENAN 
       110        120        130        140        150
TNTEVLKNMG YAAKAMKAAH DNMDIDKVDE LMQDIADQQE LAEEISTAIS 
       160        170        180        190        200
KPVGFGEEFD EDELMAELEE LEQEELDKNL LEISGPETVP LPNVPSIALP 
       210        220 
SKPAKKKEEE DDDMKELENW AGSM

Length:224

Mass (Da):24,950

Last modified:March 1, 2001 - v1

Checksum:ⁱDB1D79DD3803CB2F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037579	129	D → V in CTRCT31. 1 PublicationCorresponds to variant dbSNP:rs118203965EnsemblClinVar.		1
Natural variantⁱVAR_037580	161	E → K in CTRCT31. 1 PublicationCorresponds to variant dbSNP:rs118203966EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB100261 mRNA Translation: BAC79375.1 AY329085 mRNA Translation: AAQ91194.1 AL050349 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76293.1 CH471077 Genomic DNA Translation: EAW76294.1 BC033859 mRNA Translation: AAH33859.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13228.1
NCBI Reference Sequences More...RefSeqⁱ	NP_789782.1, NM_176812.4
UniGeneⁱ	Hs.472471

Genome annotation databases

Ensemblⁱ	ENST00000217402; ENSP00000217402; ENSG00000101421
GeneIDⁱ	128866
KEGGⁱ	hsa:128866
UCSC genome browser More...UCSCⁱ	uc002xaa.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H444	Chromatin modifying protein 4B		PANTR		279	UniRef100_Q9H444
Charged multivesicular body protein 4B		CALJA		224
Charged multivesicular body protein 4B		MACMU		224
Uncharacterized protein		PROCO		224
Uncharacterized protein		COLAP		224
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9H444	Charged multivesicular body protein 4b		CHICK		227	UniRef90_Q9H444
Charged multivesicular body protein 4b		MOUSE		224
Chromatin modifying protein 4B		PANTR		279
Charged multivesicular body protein 4B		CALJA		224
Charged multivesicular body protein 4B		MACMU		224
+102

Protein	Similar proteins		Species	Score	Length	Source
Q9H444	Charged multivesicular body protein 4b		CHICK		227	UniRef50_Q9H444
Charged multivesicular body protein 4b		MOUSE		224
Chromatin modifying protein 4B		PANTR		279
Charged multivesicular body protein 4B		CALJA		224
Charged multivesicular body protein 4B		MACMU		224
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB100261 mRNA Translation: BAC79375.1 AY329085 mRNA Translation: AAQ91194.1 AL050349 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76293.1 CH471077 Genomic DNA Translation: EAW76294.1 BC033859 mRNA Translation: AAH33859.1
CCDSⁱ	CCDS13228.1
RefSeqⁱ	NP_789782.1, NM_176812.4
UniGeneⁱ	Hs.472471

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3C3Q	X-ray	2.10	B	207-224	[»]
	3UM3	X-ray	3.80	B	121-224	[»]
	4ABM	X-ray	1.80	A/B/C/D	23-97	[»]
	5MK2	X-ray	1.70	C	205-224	[»]
ProteinModelPortalⁱ	Q9H444
SMRⁱ	Q9H444
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126170, 124 interactors
ComplexPortalⁱ	CPX-329 ESCRT-III complex
CORUMⁱ	Q9H444
DIPⁱ	DIP-29924N
IntActⁱ	Q9H444, 119 interactors
MINTⁱ	Q9H444
STRINGⁱ	9606.ENSP00000217402

PTM databases

iPTMnetⁱ	Q9H444
PhosphoSitePlusⁱ	Q9H444

Polymorphism and mutation databases

BioMutaⁱ	CHMP4B
DMDMⁱ	24636296

Proteomic databases

EPDⁱ	Q9H444
MaxQBⁱ	Q9H444
PaxDbⁱ	Q9H444
PeptideAtlasⁱ	Q9H444
PRIDEⁱ	Q9H444
ProteomicsDBⁱ	80785

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000217402; ENSP00000217402; ENSG00000101421
GeneIDⁱ	128866
KEGGⁱ	hsa:128866
UCSCⁱ	uc002xaa.4 human

Organism-specific databases

CTDⁱ	128866
DisGeNETⁱ	128866
EuPathDBⁱ	HostDB:ENSG00000101421.3
GeneCardsⁱ	CHMP4B
HGNCⁱ	HGNC:16171 CHMP4B
HPAⁱ	HPA041401 HPA051751
MalaCardsⁱ	CHMP4B
MIMⁱ	605387 phenotype 610897 gene
neXtProtⁱ	NX_Q9H444
OpenTargetsⁱ	ENSG00000101421
Orphanetⁱ	98993 Early-onset posterior polar cataract 441447 Early-onset posterior subcapsular cataract
PharmGKBⁱ	PA25721
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1656 Eukaryota ENOG410YE9I LUCA
GeneTreeⁱ	ENSGT00390000005006
HOGENOMⁱ	HOG000209960
HOVERGENⁱ	HBG050928
InParanoidⁱ	Q9H444
KOⁱ	K12194
OMAⁱ	MQVNTLE
OrthoDBⁱ	EOG091G0V7X
PhylomeDBⁱ	Q9H444
TreeFamⁱ	TF314269

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-1632852 Macroautophagy R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-1632852 Macroautophagy
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

ChiTaRSⁱ	CHMP4B human
EvolutionaryTraceⁱ	Q9H444
GeneWikiⁱ	CHMP4B
GenomeRNAiⁱ	128866
Protein Ontology More...PROⁱ	PR:Q9H444
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101421 Expressed in 197 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	HS_CHMP4B
Genevisibleⁱ	Q9H444 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005024 Snf7_fam
Pfamⁱ	View protein in Pfam PF03357 Snf7, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CHM4B_HUMAN
Accessionⁱ	Q9H444Primary (citable) accession number: Q9H444 Secondary accession number(s): E1P5N4, Q53ZD6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9H444 (CHM4B_HUMAN)

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Charged multivesicular body protein 4b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Nucleus

Cytosol

Other locations

Cytosol

Endosome

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ