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Protein

Kinetochore-associated protein DSN1 homolog

Gene

DSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: GO_Central
  • neutrophil degranulation Source: Reactome

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6798695 Neutrophil degranulation
R-HSA-68877 Mitotic Prometaphase
SIGNORiQ9H410

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore-associated protein DSN1 homolog
Gene namesi
Name:DSN1
Synonyms:C20orf172, MIS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149636.15
HGNCiHGNC:16165 DSN1
MIMi609175 gene
neXtProtiNX_Q9H410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79980
OpenTargetsiENSG00000149636
PharmGKBiPA162384106

Polymorphism and mutation databases

BioMutaiDSN1
DMDMi28201793

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794811 – 356Kinetochore-associated protein DSN1 homologAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H410
MaxQBiQ9H410
PaxDbiQ9H410
PeptideAtlasiQ9H410
PRIDEiQ9H410
ProteomicsDBi80777
80778 [Q9H410-2]
80779 [Q9H410-3]

PTM databases

iPTMnetiQ9H410
PhosphoSitePlusiQ9H410

Expressioni

Gene expression databases

BgeeiENSG00000149636 Expressed in 170 organ(s), highest expression level in right testis
CleanExiHS_DSN1
ExpressionAtlasiQ9H410 baseline and differential
GenevisibleiQ9H410 HS

Organism-specific databases

HPAiHPA002813
HPA030627

Interactioni

Subunit structurei

Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN.3 Publications

Protein-protein interaction databases

BioGridi123045, 58 interactors
CORUMiQ9H410
IntActiQ9H410, 37 interactors
MINTiQ9H410
STRINGi9606.ENSP00000362850

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H410
SMRiQ9H410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHC2 Eukaryota
ENOG410YXFH LUCA
GeneTreeiENSGT00390000011347
HOGENOMiHOG000231275
HOVERGENiHBG051208
InParanoidiQ9H410
KOiK11544
OMAiTHDHQLE
OrthoDBiEOG091G08B4
PhylomeDBiQ9H410
TreeFamiTF335504

Family and domain databases

InterProiView protein in InterPro
IPR013218 Dsn1/Mis13
PANTHERiPTHR14778 PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202 MIS13, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSVTRSEII DEKGPVMSKT HDHQLESSLS PVEVFAKTSA SLEMNQGVSE
60 70 80 90 100
ERIHLGSSPK KGGNCDLSHQ ERLQSKSLHL SPQEQSASYQ DRRQSWRRAS
110 120 130 140 150
MKETNRRKSL HPIHQGITEL SRSISVDLAE SKRLGCLLLS SFQFSIQKLE
160 170 180 190 200
PFLRDTKGFS LESFRAKASS LSEELKHFAD GLETDGTLQK CFEDSNGKAS
210 220 230 240 250
DFSLEASVAE MKEYITKFSL ERQTWDQLLL HYQQEAKEIL SRGSTEAKIT
260 270 280 290 300
EVKVEPMTYL GSSQNEVLNT KPDYQKILQN QSKVFDCMEL VMDELQGSVK
310 320 330 340 350
QLQAFMDEST QCFQKVSVQL GKRSMQQLDP SPARKLLKLQ LQNPPAIHGS

GSGSCQ
Length:356
Mass (Da):40,067
Last modified:October 1, 2001 - v2
Checksum:iC75E113BE2A82A8B
GO
Isoform 2 (identifier: Q9H410-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MTSVTRSEII...SKSLHLSPQE → MIINWNQVSVLWKCLLK

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):32,928
Checksum:iDF1BDBB113760B93
GO
Isoform 4 (identifier: Q9H410-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:340
Mass (Da):38,323
Checksum:i2C2F449A8449F506
GO
Isoform 3 (identifier: Q9H410-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-118: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):27,998
Checksum:i9D49E8D25B012B6B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW53Q5JW53_HUMAN
Kinetochore-associated protein DSN1...
DSN1
241Annotation score:
Q5JW54Q5JW54_HUMAN
Kinetochore-associated protein DSN1...
DSN1
284Annotation score:
Q5JW57Q5JW57_HUMAN
Kinetochore-associated protein DSN1...
DSN1
141Annotation score:

Sequence cautioni

The sequence BAB14564 differs from that shown. Reason: Frameshift at position 277.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142F → S in BAC04024 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0038261 – 84MTSVT…LSPQE → MIINWNQVSVLWKCLLK in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_0442811 – 16Missing in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04320412 – 118Missing in isoform 3. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093031 mRNA Translation: BAC04024.1
AK023408 mRNA Translation: BAB14564.1 Frameshift.
AK301671 mRNA Translation: BAG63144.1
AK301840 mRNA Translation: BAG63283.1
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76101.1
CH471077 Genomic DNA Translation: EAW76102.1
CH471077 Genomic DNA Translation: EAW76104.1
CH471077 Genomic DNA Translation: EAW76106.1
BC058899 mRNA Translation: AAH58899.1
CCDSiCCDS13286.1 [Q9H410-1]
CCDS46596.1 [Q9H410-3]
CCDS46597.1 [Q9H410-4]
RefSeqiNP_001138787.1, NM_001145315.1 [Q9H410-1]
NP_001138788.1, NM_001145316.1 [Q9H410-1]
NP_001138789.1, NM_001145317.1 [Q9H410-3]
NP_001138790.1, NM_001145318.1 [Q9H410-4]
NP_079194.3, NM_024918.3 [Q9H410-1]
XP_006723939.1, XM_006723876.2 [Q9H410-3]
UniGeneiHs.632268

Genome annotation databases

EnsembliENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3]
ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1]
ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1]
ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]
GeneIDi79980
KEGGihsa:79980
UCSCiuc002xga.4 human [Q9H410-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093031 mRNA Translation: BAC04024.1
AK023408 mRNA Translation: BAB14564.1 Frameshift.
AK301671 mRNA Translation: BAG63144.1
AK301840 mRNA Translation: BAG63283.1
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76101.1
CH471077 Genomic DNA Translation: EAW76102.1
CH471077 Genomic DNA Translation: EAW76104.1
CH471077 Genomic DNA Translation: EAW76106.1
BC058899 mRNA Translation: AAH58899.1
CCDSiCCDS13286.1 [Q9H410-1]
CCDS46596.1 [Q9H410-3]
CCDS46597.1 [Q9H410-4]
RefSeqiNP_001138787.1, NM_001145315.1 [Q9H410-1]
NP_001138788.1, NM_001145316.1 [Q9H410-1]
NP_001138789.1, NM_001145317.1 [Q9H410-3]
NP_001138790.1, NM_001145318.1 [Q9H410-4]
NP_079194.3, NM_024918.3 [Q9H410-1]
XP_006723939.1, XM_006723876.2 [Q9H410-3]
UniGeneiHs.632268

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LSIX-ray2.00D68-200[»]
5LSJX-ray3.25D/F186-356[»]
5LSKX-ray3.50D68-356[»]
ProteinModelPortaliQ9H410
SMRiQ9H410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123045, 58 interactors
CORUMiQ9H410
IntActiQ9H410, 37 interactors
MINTiQ9H410
STRINGi9606.ENSP00000362850

PTM databases

iPTMnetiQ9H410
PhosphoSitePlusiQ9H410

Polymorphism and mutation databases

BioMutaiDSN1
DMDMi28201793

Proteomic databases

EPDiQ9H410
MaxQBiQ9H410
PaxDbiQ9H410
PeptideAtlasiQ9H410
PRIDEiQ9H410
ProteomicsDBi80777
80778 [Q9H410-2]
80779 [Q9H410-3]

Protocols and materials databases

DNASUi79980
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3]
ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1]
ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1]
ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]
GeneIDi79980
KEGGihsa:79980
UCSCiuc002xga.4 human [Q9H410-1]

Organism-specific databases

CTDi79980
DisGeNETi79980
EuPathDBiHostDB:ENSG00000149636.15
GeneCardsiDSN1
HGNCiHGNC:16165 DSN1
HPAiHPA002813
HPA030627
MIMi609175 gene
neXtProtiNX_Q9H410
OpenTargetsiENSG00000149636
PharmGKBiPA162384106
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHC2 Eukaryota
ENOG410YXFH LUCA
GeneTreeiENSGT00390000011347
HOGENOMiHOG000231275
HOVERGENiHBG051208
InParanoidiQ9H410
KOiK11544
OMAiTHDHQLE
OrthoDBiEOG091G08B4
PhylomeDBiQ9H410
TreeFamiTF335504

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6798695 Neutrophil degranulation
R-HSA-68877 Mitotic Prometaphase
SIGNORiQ9H410

Miscellaneous databases

GeneWikiiDSN1
GenomeRNAii79980
PROiPR:Q9H410
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149636 Expressed in 170 organ(s), highest expression level in right testis
CleanExiHS_DSN1
ExpressionAtlasiQ9H410 baseline and differential
GenevisibleiQ9H410 HS

Family and domain databases

InterProiView protein in InterPro
IPR013218 Dsn1/Mis13
PANTHERiPTHR14778 PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202 MIS13, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDSN1_HUMAN
AccessioniPrimary (citable) accession number: Q9H410
Secondary accession number(s): B4DWT2
, E1P5U9, Q5JW55, Q5JW56, Q9H8P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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