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Entry version 152 (13 Feb 2019)
Sequence version 2 (01 Oct 2001)
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Protein

Kinetochore-associated protein DSN1 homolog

Gene

DSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: GO_Central
  • neutrophil degranulation Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6798695 Neutrophil degranulation
R-HSA-68877 Mitotic Prometaphase

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H410

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinetochore-associated protein DSN1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSN1
Synonyms:C20orf172, MIS13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149636.15

Human Gene Nomenclature Database

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HGNCi
HGNC:16165 DSN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609175 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79980

Open Targets

More...
OpenTargetsi
ENSG00000149636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162384106

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DSN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
28201793

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794811 – 356Kinetochore-associated protein DSN1 homologAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H410

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H410

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H410

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H410

PeptideAtlas

More...
PeptideAtlasi
Q9H410

PRoteomics IDEntifications database

More...
PRIDEi
Q9H410

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80777
80778 [Q9H410-2]
80779 [Q9H410-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H410

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H410

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000149636 Expressed in 170 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H410 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H410 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002813
HPA030627

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123045, 61 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H410

Protein interaction database and analysis system

More...
IntActi
Q9H410, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9H410

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LSIX-ray2.00D68-200[»]
5LSJX-ray3.25D/F186-356[»]
5LSKX-ray3.50D68-356[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H410

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H410

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHC2 Eukaryota
ENOG410YXFH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011347

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231275

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051208

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H410

KEGG Orthology (KO)

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KOi
K11544

Identification of Orthologs from Complete Genome Data

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OMAi
THDHQLE

Database of Orthologous Groups

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OrthoDBi
922920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H410

TreeFam database of animal gene trees

More...
TreeFami
TF335504

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013218 Dsn1/Mis13

The PANTHER Classification System

More...
PANTHERi
PTHR14778 PTHR14778, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08202 MIS13, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSVTRSEII DEKGPVMSKT HDHQLESSLS PVEVFAKTSA SLEMNQGVSE
60 70 80 90 100
ERIHLGSSPK KGGNCDLSHQ ERLQSKSLHL SPQEQSASYQ DRRQSWRRAS
110 120 130 140 150
MKETNRRKSL HPIHQGITEL SRSISVDLAE SKRLGCLLLS SFQFSIQKLE
160 170 180 190 200
PFLRDTKGFS LESFRAKASS LSEELKHFAD GLETDGTLQK CFEDSNGKAS
210 220 230 240 250
DFSLEASVAE MKEYITKFSL ERQTWDQLLL HYQQEAKEIL SRGSTEAKIT
260 270 280 290 300
EVKVEPMTYL GSSQNEVLNT KPDYQKILQN QSKVFDCMEL VMDELQGSVK
310 320 330 340 350
QLQAFMDEST QCFQKVSVQL GKRSMQQLDP SPARKLLKLQ LQNPPAIHGS

GSGSCQ
Length:356
Mass (Da):40,067
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC75E113BE2A82A8B
GO
Isoform 2 (identifier: Q9H410-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MTSVTRSEII...SKSLHLSPQE → MIINWNQVSVLWKCLLK

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):32,928
Checksum:iDF1BDBB113760B93
GO
Isoform 4 (identifier: Q9H410-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:340
Mass (Da):38,323
Checksum:i2C2F449A8449F506
GO
Isoform 3 (identifier: Q9H410-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-118: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):27,998
Checksum:i9D49E8D25B012B6B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW53Q5JW53_HUMAN
Kinetochore-associated protein DSN1...
DSN1
241Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW54Q5JW54_HUMAN
Kinetochore-associated protein DSN1...
DSN1
284Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW57Q5JW57_HUMAN
Kinetochore-associated protein DSN1...
DSN1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14564 differs from that shown. Reason: Frameshift at position 277.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142F → S in BAC04024 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0038261 – 84MTSVT…LSPQE → MIINWNQVSVLWKCLLK in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_0442811 – 16Missing in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04320412 – 118Missing in isoform 3. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093031 mRNA Translation: BAC04024.1
AK023408 mRNA Translation: BAB14564.1 Frameshift.
AK301671 mRNA Translation: BAG63144.1
AK301840 mRNA Translation: BAG63283.1
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76101.1
CH471077 Genomic DNA Translation: EAW76102.1
CH471077 Genomic DNA Translation: EAW76104.1
CH471077 Genomic DNA Translation: EAW76106.1
BC058899 mRNA Translation: AAH58899.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13286.1 [Q9H410-1]
CCDS46596.1 [Q9H410-3]
CCDS46597.1 [Q9H410-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001138787.1, NM_001145315.1 [Q9H410-1]
NP_001138788.1, NM_001145316.1 [Q9H410-1]
NP_001138789.1, NM_001145317.1 [Q9H410-3]
NP_001138790.1, NM_001145318.1 [Q9H410-4]
NP_079194.3, NM_024918.3 [Q9H410-1]
XP_006723939.1, XM_006723876.2 [Q9H410-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632268

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3]
ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1]
ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1]
ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79980

UCSC genome browser

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UCSCi
uc002xga.4 human [Q9H410-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093031 mRNA Translation: BAC04024.1
AK023408 mRNA Translation: BAB14564.1 Frameshift.
AK301671 mRNA Translation: BAG63144.1
AK301840 mRNA Translation: BAG63283.1
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76101.1
CH471077 Genomic DNA Translation: EAW76102.1
CH471077 Genomic DNA Translation: EAW76104.1
CH471077 Genomic DNA Translation: EAW76106.1
BC058899 mRNA Translation: AAH58899.1
CCDSiCCDS13286.1 [Q9H410-1]
CCDS46596.1 [Q9H410-3]
CCDS46597.1 [Q9H410-4]
RefSeqiNP_001138787.1, NM_001145315.1 [Q9H410-1]
NP_001138788.1, NM_001145316.1 [Q9H410-1]
NP_001138789.1, NM_001145317.1 [Q9H410-3]
NP_001138790.1, NM_001145318.1 [Q9H410-4]
NP_079194.3, NM_024918.3 [Q9H410-1]
XP_006723939.1, XM_006723876.2 [Q9H410-3]
UniGeneiHs.632268

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LSIX-ray2.00D68-200[»]
5LSJX-ray3.25D/F186-356[»]
5LSKX-ray3.50D68-356[»]
ProteinModelPortaliQ9H410
SMRiQ9H410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123045, 61 interactors
CORUMiQ9H410
IntActiQ9H410, 37 interactors
MINTiQ9H410
STRINGi9606.ENSP00000362850

PTM databases

iPTMnetiQ9H410
PhosphoSitePlusiQ9H410

Polymorphism and mutation databases

BioMutaiDSN1
DMDMi28201793

Proteomic databases

EPDiQ9H410
jPOSTiQ9H410
MaxQBiQ9H410
PaxDbiQ9H410
PeptideAtlasiQ9H410
PRIDEiQ9H410
ProteomicsDBi80777
80778 [Q9H410-2]
80779 [Q9H410-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79980
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3]
ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1]
ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1]
ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]
GeneIDi79980
KEGGihsa:79980
UCSCiuc002xga.4 human [Q9H410-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79980
DisGeNETi79980
EuPathDBiHostDB:ENSG00000149636.15

GeneCards: human genes, protein and diseases

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GeneCardsi
DSN1
HGNCiHGNC:16165 DSN1
HPAiHPA002813
HPA030627
MIMi609175 gene
neXtProtiNX_Q9H410
OpenTargetsiENSG00000149636
PharmGKBiPA162384106

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHC2 Eukaryota
ENOG410YXFH LUCA
GeneTreeiENSGT00390000011347
HOGENOMiHOG000231275
HOVERGENiHBG051208
InParanoidiQ9H410
KOiK11544
OMAiTHDHQLE
OrthoDBi922920at2759
PhylomeDBiQ9H410
TreeFamiTF335504

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6798695 Neutrophil degranulation
R-HSA-68877 Mitotic Prometaphase
SIGNORiQ9H410

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DSN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79980

Protein Ontology

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PROi
PR:Q9H410

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149636 Expressed in 170 organ(s), highest expression level in right testis
ExpressionAtlasiQ9H410 baseline and differential
GenevisibleiQ9H410 HS

Family and domain databases

InterProiView protein in InterPro
IPR013218 Dsn1/Mis13
PANTHERiPTHR14778 PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202 MIS13, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H410
Secondary accession number(s): B4DWT2
, E1P5U9, Q5JW55, Q5JW56, Q9H8P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2001
Last modified: February 13, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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