DSN1

Functionⁱ

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.2 Publications

GO - Biological processⁱ

cell division Source: UniProtKB-KW
mitotic sister chromatid segregation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil degranulation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Chromosome partition, Mitosis

Biological process

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6798695 Neutrophil degranulation R-HSA-68877 Mitotic Prometaphase
SIGNORⁱ	Q9H410

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinetochore-associated protein DSN1 homolog
Gene namesⁱ	Name:DSN1 Synonyms:C20orf172, MIS13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149636.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16165 DSN1
MIMⁱ	609175 gene
neXtProtⁱ	NX_Q9H410

Keywords - Cellular componentⁱ

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79980
Open Targets More...OpenTargetsⁱ	ENSG00000149636
PharmGKBⁱ	PA162384106

Polymorphism and mutation databases

BioMutaⁱ	DSN1
DMDMⁱ	28201793

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079481	1 – 356	Kinetochore-associated protein DSN1 homologAdd BLAST		356

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	28	PhosphoserineCombined sources	1
Modified residueⁱ	30	PhosphoserineCombined sources	1
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	77	PhosphoserineCombined sources	1
Modified residueⁱ	81	PhosphoserineCombined sources	1
Modified residueⁱ	109	PhosphoserineCombined sources	1
Modified residueⁱ	125	PhosphoserineCombined sources	1
Cross-linkⁱ	253	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	331	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9H410
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H410
PaxDbⁱ	Q9H410
PeptideAtlas More...PeptideAtlasⁱ	Q9H410
PRIDEⁱ	Q9H410
ProteomicsDBⁱ	80777 80778 [Q9H410-2] 80779 [Q9H410-3]

PTM databases

iPTMnetⁱ	Q9H410
PhosphoSitePlusⁱ	Q9H410

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000149636 Expressed in 170 organ(s), highest expression level in right testis
CleanExⁱ	HS_DSN1
ExpressionAtlasⁱ	Q9H410 baseline and differential
Genevisibleⁱ	Q9H410 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002813 HPA030627

HPAⁱ

HPA002813
HPA030627

Interactionⁱ

Subunit structureⁱ

Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN.3 Publications

Protein-protein interaction databases

BioGridⁱ	123045, 58 interactors
CORUMⁱ	Q9H410
IntActⁱ	Q9H410, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q9H410
STRINGⁱ	9606.ENSP00000362850

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	119 – 122	Combined sources	4
Helixⁱ	130 – 149	Combined sources	20
Helixⁱ	150 – 152	Combined sources	3
Helixⁱ	161 – 184	Combined sources	24
Helixⁱ	189 – 192	Combined sources	4
Helixⁱ	204 – 242	Combined sources	39
Helixⁱ	265 – 269	Combined sources	5
Helixⁱ	274 – 314	Combined sources	41

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H410
SMRⁱ	Q9H410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IHC2 Eukaryota ENOG410YXFH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011347
HOGENOMⁱ	HOG000231275
HOVERGENⁱ	HBG051208
InParanoidⁱ	Q9H410
KEGG Orthology (KO) More...KOⁱ	K11544
OMAⁱ	THDHQLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08B4
PhylomeDBⁱ	Q9H410
TreeFamⁱ	TF335504

Family and domain databases

InterProⁱ	View protein in InterPro IPR013218 Dsn1/Mis13
PANTHERⁱ	PTHR14778 PTHR14778, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08202 MIS13, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H410-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSVTRSEII DEKGPVMSKT HDHQLESSLS PVEVFAKTSA SLEMNQGVSE 
        60         70         80         90        100
ERIHLGSSPK KGGNCDLSHQ ERLQSKSLHL SPQEQSASYQ DRRQSWRRAS 
       110        120        130        140        150
MKETNRRKSL HPIHQGITEL SRSISVDLAE SKRLGCLLLS SFQFSIQKLE 
       160        170        180        190        200
PFLRDTKGFS LESFRAKASS LSEELKHFAD GLETDGTLQK CFEDSNGKAS 
       210        220        230        240        250
DFSLEASVAE MKEYITKFSL ERQTWDQLLL HYQQEAKEIL SRGSTEAKIT 
       260        270        280        290        300
EVKVEPMTYL GSSQNEVLNT KPDYQKILQN QSKVFDCMEL VMDELQGSVK 
       310        320        330        340        350
QLQAFMDEST QCFQKVSVQL GKRSMQQLDP SPARKLLKLQ LQNPPAIHGS 

GSGSCQ

Length:356

Mass (Da):40,067

Last modified:October 1, 2001 - v2

Checksum:ⁱC75E113BE2A82A8B

GO

Isoform 2 (identifier: Q9H410-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-84: MTSVTRSEII...SKSLHLSPQE → MIINWNQVSVLWKCLLK

« Hide

        10         20         30         40         50
MIINWNQVSV LWKCLLKQSA SYQDRRQSWR RASMKETNRR KSLHPIHQGI 
        60         70         80         90        100
TELSRSISVD LAESKRLGCL LLSSFQFSIQ KLEPFLRDTK GFSLESFRAK 
       110        120        130        140        150
ASSLSEELKH FADGLETDGT LQKCFEDSNG KASDFSLEAS VAEMKEYITK 
       160        170        180        190        200
FSLERQTWDQ LLLHYQQEAK EILSRGSTEA KITEVKVEPM TYLGSSQNEV 
       210        220        230        240        250
LNTKPDYQKI LQNQSKVFDC MELVMDELQG SVKQLQAFMD ESTQCFQKVS 
       260        270        280 
VQLGKRSMQQ LDPSPARKLL KLQLQNPPAI HGSGSGSCQ

Note: No experimental confirmation available.

Show »

Length:289

Mass (Da):32,928

Checksum:ⁱDF1BDBB113760B93

GO

Isoform 4 (identifier: Q9H410-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-16: Missing.

« Hide

        10         20         30         40         50
MSKTHDHQLE SSLSPVEVFA KTSASLEMNQ GVSEERIHLG SSPKKGGNCD 
        60         70         80         90        100
LSHQERLQSK SLHLSPQEQS ASYQDRRQSW RRASMKETNR RKSLHPIHQG 
       110        120        130        140        150
ITELSRSISV DLAESKRLGC LLLSSFQFSI QKLEPFLRDT KGFSLESFRA 
       160        170        180        190        200
KASSLSEELK HFADGLETDG TLQKCFEDSN GKASDFSLEA SVAEMKEYIT 
       210        220        230        240        250
KFSLERQTWD QLLLHYQQEA KEILSRGSTE AKITEVKVEP MTYLGSSQNE 
       260        270        280        290        300
VLNTKPDYQK ILQNQSKVFD CMELVMDELQ GSVKQLQAFM DESTQCFQKV 
       310        320        330        340
SVQLGKRSMQ QLDPSPARKL LKLQLQNPPA IHGSGSGSCQ

Show »

Length:340

Mass (Da):38,323

Checksum:ⁱ2C2F449A8449F506

GO

Isoform 3 (identifier: Q9H410-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
12-118: Missing.

« Hide

        10         20         30         40         50
MTSVTRSEII DELSRSISVD LAESKRLGCL LLSSFQFSIQ KLEPFLRDTK 
        60         70         80         90        100
GFSLESFRAK ASSLSEELKH FADGLETDGT LQKCFEDSNG KASDFSLEAS 
       110        120        130        140        150
VAEMKEYITK FSLERQTWDQ LLLHYQQEAK EILSRGSTEA KITEVKVEPM 
       160        170        180        190        200
TYLGSSQNEV LNTKPDYQKI LQNQSKVFDC MELVMDELQG SVKQLQAFMD 
       210        220        230        240 
ESTQCFQKVS VQLGKRSMQQ LDPSPARKLL KLQLQNPPAI HGSGSGSCQ

Note: No experimental confirmation available.

Show »

Length:249

Mass (Da):27,998

Checksum:ⁱ9D49E8D25B012B6B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5JW53	Q5JW53_HUMAN	Kinetochore-associated protein DSN1... Kinetochore-associated protein DSN1 homolog	DSN1	241	Annotation score:
Q5JW54	Q5JW54_HUMAN	Kinetochore-associated protein DSN1... Kinetochore-associated protein DSN1 homolog	DSN1	284	Annotation score:
Q5JW57	Q5JW57_HUMAN	Kinetochore-associated protein DSN1... Kinetochore-associated protein DSN1 homolog	DSN1	141	Annotation score:

Sequence cautionⁱ

The sequence BAB14564 differs from that shown. Reason: Frameshift at position 277.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	142	F → S in BAC04024 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_003826	1 – 84	MTSVT…LSPQE → MIINWNQVSVLWKCLLK in isoform 2. 1 PublicationAdd BLAST	84
Alternative sequenceⁱVSP_044281	1 – 16	Missing in isoform 4. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_043204	12 – 118	Missing in isoform 3. 1 PublicationAdd BLAST	107

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093031 mRNA Translation: BAC04024.1 AK023408 mRNA Translation: BAB14564.1 Frameshift. AK301671 mRNA Translation: BAG63144.1 AK301840 mRNA Translation: BAG63283.1 AL132768 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76101.1 CH471077 Genomic DNA Translation: EAW76102.1 CH471077 Genomic DNA Translation: EAW76104.1 CH471077 Genomic DNA Translation: EAW76106.1 BC058899 mRNA Translation: AAH58899.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13286.1 [Q9H410-1] CCDS46596.1 [Q9H410-3] CCDS46597.1 [Q9H410-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138787.1, NM_001145315.1 [Q9H410-1] NP_001138788.1, NM_001145316.1 [Q9H410-1] NP_001138789.1, NM_001145317.1 [Q9H410-3] NP_001138790.1, NM_001145318.1 [Q9H410-4] NP_079194.3, NM_024918.3 [Q9H410-1] XP_006723939.1, XM_006723876.2 [Q9H410-3]
UniGeneⁱ	Hs.632268

Genome annotation databases

Ensemblⁱ	ENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3] ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1] ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1] ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]
GeneIDⁱ	79980
KEGGⁱ	hsa:79980
UCSC genome browser More...UCSCⁱ	uc002xga.4 human [Q9H410-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H410	Isoform 4 of Kinetochore-associated protein DSN1 homolog		HUMAN		340	UniRef100_Q9H410
DSN1 isoform 6 (Fragment)		PANTR		141
Kinetochore-associated protein DSN1 homolog (Fragment)		HUMAN		141
Kinetochore-associated protein DSN1 homolog (Fragment)		HUMAN		241
DSN1 isoform 3 (Fragment)		PANTR		241

Protein	Similar proteins		Species	Score	Length	Source
Q9H410	Isoform 4 of Kinetochore-associated protein DSN1 homolog		HUMAN		340	UniRef90_Q9H410
DSN1 isoform 6 (Fragment)		PANTR		141
DSN1 isoform 1		PONAB		356
Uncharacterized protein		PANPA		356
Uncharacterized protein		NOMLE		356
+52
Q9H410-2	Kinetochore-associated protein DSN1 homolog		HUMAN		284	UniRef90_Q9H410-2
DSN1 isoform 6		PONAB		284
DSN1 isoform 10		PANTR		284
Uncharacterized protein		PANPA		249
Uncharacterized protein		NOMLE		249
+17
Q9H410-3	Isoform 2 of Kinetochore-associated protein DSN1 homolog		HUMAN		289	UniRef90_Q9H410-2
DSN1 isoform 6		PONAB		284
DSN1 isoform 10		PANTR		284
Uncharacterized protein		PANPA		249
Uncharacterized protein		NOMLE		249
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9H410	Kinetochore-associated protein DSN1 homolog		MOUSE		348	UniRef50_Q9H410
Isoform 4 of Kinetochore-associated protein DSN1 homolog		HUMAN		340
DSN1 isoform 6 (Fragment)		PANTR		141
DSN1 homolog, MIS12 kinetochore complex component		GORGO		356
Uncharacterized protein		NOMLE		356
+167
Q9H410-2	Kinetochore-associated protein DSN1 homolog		HUMAN		284	UniRef50_Q9H410-2
DSN1 isoform 6		PONAB		284
DSN1 isoform 10		PANTR		284
Uncharacterized protein		PANPA		249
Uncharacterized protein		NOMLE		249
+23
Q9H410-3	Isoform 2 of Kinetochore-associated protein DSN1 homolog		HUMAN		289	UniRef50_Q9H410-2
DSN1 isoform 6		PONAB		284
DSN1 isoform 10		PANTR		284
Uncharacterized protein		PANPA		249
Uncharacterized protein		NOMLE		249
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093031 mRNA Translation: BAC04024.1 AK023408 mRNA Translation: BAB14564.1 Frameshift. AK301671 mRNA Translation: BAG63144.1 AK301840 mRNA Translation: BAG63283.1 AL132768 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76101.1 CH471077 Genomic DNA Translation: EAW76102.1 CH471077 Genomic DNA Translation: EAW76104.1 CH471077 Genomic DNA Translation: EAW76106.1 BC058899 mRNA Translation: AAH58899.1
CCDSⁱ	CCDS13286.1 [Q9H410-1] CCDS46596.1 [Q9H410-3] CCDS46597.1 [Q9H410-4]
RefSeqⁱ	NP_001138787.1, NM_001145315.1 [Q9H410-1] NP_001138788.1, NM_001145316.1 [Q9H410-1] NP_001138789.1, NM_001145317.1 [Q9H410-3] NP_001138790.1, NM_001145318.1 [Q9H410-4] NP_079194.3, NM_024918.3 [Q9H410-1] XP_006723939.1, XM_006723876.2 [Q9H410-3]
UniGeneⁱ	Hs.632268

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5LSI	X-ray	2.00	D	68-200	[»]
	5LSJ	X-ray	3.25	D/F	186-356	[»]
	5LSK	X-ray	3.50	D	68-356	[»]
ProteinModelPortalⁱ	Q9H410
SMRⁱ	Q9H410
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123045, 58 interactors
CORUMⁱ	Q9H410
IntActⁱ	Q9H410, 37 interactors
MINTⁱ	Q9H410
STRINGⁱ	9606.ENSP00000362850

PTM databases

iPTMnetⁱ	Q9H410
PhosphoSitePlusⁱ	Q9H410

Polymorphism and mutation databases

BioMutaⁱ	DSN1
DMDMⁱ	28201793

Proteomic databases

EPDⁱ	Q9H410
MaxQBⁱ	Q9H410
PaxDbⁱ	Q9H410
PeptideAtlasⁱ	Q9H410
PRIDEⁱ	Q9H410
ProteomicsDBⁱ	80777 80778 [Q9H410-2] 80779 [Q9H410-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79980
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3] ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1] ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1] ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]
GeneIDⁱ	79980
KEGGⁱ	hsa:79980
UCSCⁱ	uc002xga.4 human [Q9H410-1]

Organism-specific databases

CTDⁱ	79980
DisGeNETⁱ	79980
EuPathDBⁱ	HostDB:ENSG00000149636.15
GeneCardsⁱ	DSN1
HGNCⁱ	HGNC:16165 DSN1
HPAⁱ	HPA002813 HPA030627
MIMⁱ	609175 gene
neXtProtⁱ	NX_Q9H410
OpenTargetsⁱ	ENSG00000149636
PharmGKBⁱ	PA162384106
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHC2 Eukaryota ENOG410YXFH LUCA
GeneTreeⁱ	ENSGT00390000011347
HOGENOMⁱ	HOG000231275
HOVERGENⁱ	HBG051208
InParanoidⁱ	Q9H410
KOⁱ	K11544
OMAⁱ	THDHQLE
OrthoDBⁱ	EOG091G08B4
PhylomeDBⁱ	Q9H410
TreeFamⁱ	TF335504

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6798695 Neutrophil degranulation R-HSA-68877 Mitotic Prometaphase
SIGNORⁱ	Q9H410

Miscellaneous databases

GeneWikiⁱ	DSN1
GenomeRNAiⁱ	79980
Protein Ontology More...PROⁱ	PR:Q9H410
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149636 Expressed in 170 organ(s), highest expression level in right testis
CleanExⁱ	HS_DSN1
ExpressionAtlasⁱ	Q9H410 baseline and differential
Genevisibleⁱ	Q9H410 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013218 Dsn1/Mis13
PANTHERⁱ	PTHR14778 PTHR14778, 1 hit
Pfamⁱ	View protein in Pfam PF08202 MIS13, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DSN1_HUMAN
Accessionⁱ	Q9H410Primary (citable) accession number: Q9H410 Secondary accession number(s): B4DWT2 , E1P5U9, Q5JW55, Q5JW56, Q9H8P4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	October 1, 2001
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H410 (DSN1_HUMAN)

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Kinetochore-associated protein DSN1 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Lysosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ