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UniProtKB - Q9H410 (DSN1_HUMAN)

Entry version 168 (02 Jun 2021)
Sequence version 2 (01 Oct 2001)
Previous versions | rss
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Protein

Kinetochore-associated protein DSN1 homolog

Gene

DSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H410

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6798695, Neutrophil degranulation
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H410

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinetochore-associated protein DSN1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSN1
Synonyms:C20orf172, MIS13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16165, DSN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609175, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H410

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149636.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79980

Open Targets

More...OpenTargetsi		ENSG00000149636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162384106

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H410, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DSN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		28201793

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794811 – 356Kinetochore-associated protein DSN1 homologAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H410

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H410

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H410

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H410

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H410

PeptideAtlas

More...PeptideAtlasi		Q9H410

PRoteomics IDEntifications database

More...PRIDEi		Q9H410

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5379
80777 [Q9H410-1]
80778 [Q9H410-2]
80779 [Q9H410-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H410

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H410

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H410

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149636, Expressed in ventricular zone and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H410, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H410, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149636, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1.

Also interacts with KNL1, CBX3 and CBX5.

Interacts with KNSTRN.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123045, 63 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5643, Kinetochore MIS12 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H410

Protein interaction database and analysis system

More...IntActi		Q9H410, 63 interactors

Molecular INTeraction database

More...MINTi		Q9H410

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000389810

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H410, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H410

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni73 – 93DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S0JV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011347

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_042801_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H410

Identification of Orthologs from Complete Genome Data

More...OMAi		FDYMELV

Database of Orthologous Groups

More...OrthoDBi		922920at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H410

TreeFam database of animal gene trees

More...TreeFami		TF335504

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013218, Dsn1/Mis13

The PANTHER Classification System

More...PANTHERi		PTHR14778, PTHR14778, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08202, MIS13, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSVTRSEII DEKGPVMSKT HDHQLESSLS PVEVFAKTSA SLEMNQGVSE 
        60         70         80         90        100
ERIHLGSSPK KGGNCDLSHQ ERLQSKSLHL SPQEQSASYQ DRRQSWRRAS 
       110        120        130        140        150
MKETNRRKSL HPIHQGITEL SRSISVDLAE SKRLGCLLLS SFQFSIQKLE 
       160        170        180        190        200
PFLRDTKGFS LESFRAKASS LSEELKHFAD GLETDGTLQK CFEDSNGKAS 
       210        220        230        240        250
DFSLEASVAE MKEYITKFSL ERQTWDQLLL HYQQEAKEIL SRGSTEAKIT 
       260        270        280        290        300
EVKVEPMTYL GSSQNEVLNT KPDYQKILQN QSKVFDCMEL VMDELQGSVK 
       310        320        330        340        350
QLQAFMDEST QCFQKVSVQL GKRSMQQLDP SPARKLLKLQ LQNPPAIHGS 

GSGSCQ
Length:356
Mass (Da):40,067
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC75E113BE2A82A8B
GO
Isoform 2 (identifier: Q9H410-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MTSVTRSEII...SKSLHLSPQE → MIINWNQVSVLWKCLLK

Show »
Length:289
Mass (Da):32,928
Checksum:iDF1BDBB113760B93
GO
Isoform 4 (identifier: Q9H410-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:340
Mass (Da):38,323
Checksum:i2C2F449A8449F506
GO
Isoform 3 (identifier: Q9H410-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-118: Missing.

Show »
Length:249
Mass (Da):27,998
Checksum:i9D49E8D25B012B6B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW53Q5JW53_HUMAN
Kinetochore-associated protein DSN1...
DSN1
241Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW54Q5JW54_HUMAN
Kinetochore-associated protein DSN1...
DSN1
284Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW57Q5JW57_HUMAN
Kinetochore-associated protein DSN1...
DSN1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14564 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142F → S in BAC04024 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0038261 – 84MTSVT…LSPQE → MIINWNQVSVLWKCLLK in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_0442811 – 16Missing in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04320412 – 118Missing in isoform 3. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093031 mRNA Translation: BAC04024.1
AK023408 mRNA Translation: BAB14564.1 Frameshift.
AK301671 mRNA Translation: BAG63144.1
AK301840 mRNA Translation: BAG63283.1
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76101.1
CH471077 Genomic DNA Translation: EAW76102.1
CH471077 Genomic DNA Translation: EAW76104.1
CH471077 Genomic DNA Translation: EAW76106.1
BC058899 mRNA Translation: AAH58899.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13286.1 [Q9H410-1]
CCDS46596.1 [Q9H410-3]
CCDS46597.1 [Q9H410-4]

NCBI Reference Sequences

More...RefSeqi		NP_001138787.1, NM_001145315.1 [Q9H410-1]
NP_001138788.1, NM_001145316.1 [Q9H410-1]
NP_001138789.1, NM_001145317.1 [Q9H410-3]
NP_001138790.1, NM_001145318.1 [Q9H410-4]
NP_079194.3, NM_024918.3 [Q9H410-1]
XP_006723939.1, XM_006723876.2 [Q9H410-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3]
ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1]
ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1]
ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79980

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79980

UCSC genome browser

More...UCSCi		uc002xga.4, human [Q9H410-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093031 mRNA Translation: BAC04024.1
AK023408 mRNA Translation: BAB14564.1 Frameshift.
AK301671 mRNA Translation: BAG63144.1
AK301840 mRNA Translation: BAG63283.1
AL132768 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76101.1
CH471077 Genomic DNA Translation: EAW76102.1
CH471077 Genomic DNA Translation: EAW76104.1
CH471077 Genomic DNA Translation: EAW76106.1
BC058899 mRNA Translation: AAH58899.1
CCDSiCCDS13286.1 [Q9H410-1]
CCDS46596.1 [Q9H410-3]
CCDS46597.1 [Q9H410-4]
RefSeqiNP_001138787.1, NM_001145315.1 [Q9H410-1]
NP_001138788.1, NM_001145316.1 [Q9H410-1]
NP_001138789.1, NM_001145317.1 [Q9H410-3]
NP_001138790.1, NM_001145318.1 [Q9H410-4]
NP_079194.3, NM_024918.3 [Q9H410-1]
XP_006723939.1, XM_006723876.2 [Q9H410-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LSIX-ray2.00D68-200[»]
5LSJX-ray3.25D/F186-356[»]
5LSKX-ray3.50D68-356[»]
SMRiQ9H410
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123045, 63 interactors
ComplexPortaliCPX-5643, Kinetochore MIS12 complex
CORUMiQ9H410
IntActiQ9H410, 63 interactors
MINTiQ9H410
STRINGi9606.ENSP00000389810

PTM databases

iPTMnetiQ9H410
MetOSiteiQ9H410
PhosphoSitePlusiQ9H410

Genetic variation databases

BioMutaiDSN1
DMDMi28201793

Proteomic databases

EPDiQ9H410
jPOSTiQ9H410
MassIVEiQ9H410
MaxQBiQ9H410
PaxDbiQ9H410
PeptideAtlasiQ9H410
PRIDEiQ9H410
ProteomicsDBi5379
80777 [Q9H410-1]
80778 [Q9H410-2]
80779 [Q9H410-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1232, 181 antibodies

The DNASU plasmid repository

More...DNASUi		79980

Genome annotation databases

EnsembliENST00000373734; ENSP00000362839; ENSG00000149636 [Q9H410-3]
ENST00000373750; ENSP00000362855; ENSG00000149636 [Q9H410-1]
ENST00000426836; ENSP00000389810; ENSG00000149636 [Q9H410-1]
ENST00000448110; ENSP00000404463; ENSG00000149636 [Q9H410-4]
GeneIDi79980
KEGGihsa:79980
UCSCiuc002xga.4, human [Q9H410-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79980
DisGeNETi79980

GeneCards: human genes, protein and diseases

More...GeneCardsi		DSN1
HGNCiHGNC:16165, DSN1
HPAiENSG00000149636, Low tissue specificity
MIMi609175, gene
neXtProtiNX_Q9H410
OpenTargetsiENSG00000149636
PharmGKBiPA162384106
VEuPathDBiHostDB:ENSG00000149636.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S0JV, Eukaryota
GeneTreeiENSGT00390000011347
HOGENOMiCLU_042801_0_0_1
InParanoidiQ9H410
OMAiFDYMELV
OrthoDBi922920at2759
PhylomeDBiQ9H410
TreeFamiTF335504

Enzyme and pathway databases

PathwayCommonsiQ9H410
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6798695, Neutrophil degranulation
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SIGNORiQ9H410

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79980, 662 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DSN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DSN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79980
PharosiQ9H410, Tbio

Protein Ontology

More...PROi		PR:Q9H410
RNActiQ9H410, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149636, Expressed in ventricular zone and 184 other tissues
ExpressionAtlasiQ9H410, baseline and differential
GenevisibleiQ9H410, HS

Family and domain databases

InterProiView protein in InterPro
IPR013218, Dsn1/Mis13
PANTHERiPTHR14778, PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202, MIS13, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H410
Secondary accession number(s): B4DWT2
, E1P5U9, Q5JW55, Q5JW56, Q9H8P4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2001
Last modified: June 2, 2021
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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