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UniProtKB - Q9H400 (LIME1_HUMAN)

Entry version 148 (10 Feb 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Lck-interacting transmembrane adapter 1

Gene

LIME1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H400

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lck-interacting transmembrane adapter 1
Short name:
Lck-interacting membrane protein
Alternative name(s):
Lck-interacting molecule
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIME1
Synonyms:LIME
ORF Names:LP8067
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26016, LIME1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609809, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H400

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000203896.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6ExtracellularSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini28 – 295CytoplasmicSequence analysisAdd BLAST268

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi145Y → F: No change in binding to LCK, CSK or FYN. 1 Publication1
Mutagenesisi167Y → F: Abolishes binding to CSK. 1 Publication1
Mutagenesisi200Y → F: Reduces binding to CSK. 1 Publication1
Mutagenesisi235Y → F: No change in binding to LCK, CSK or FYN. 1 Publication1
Mutagenesisi254Y → F: Abolishes binding to LCK and reduces binding to FYN. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54923

Open Targets

More...OpenTargetsi		ENSG00000203896

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671551

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H400, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LIME1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752630

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000833321 – 295Lck-interacting transmembrane adapter 1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi28S-palmitoyl cysteine1 Publication1
Lipidationi31S-palmitoyl cysteine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei145PhosphotyrosineBy similarity1
Modified residuei167Phosphotyrosine1 Publication1
Modified residuei200Phosphotyrosine1 Publication1
Modified residuei235PhosphotyrosineBy similarity1
Modified residuei254Phosphotyrosine; by LCK1 Publication1
Modified residuei256PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylation of Cys-28 and Cys-31 is required for raft targeting.1 Publication
Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H400

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H400

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H400

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H400

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H400

PeptideAtlas

More...PeptideAtlasi		Q9H400

PRoteomics IDEntifications database

More...PRIDEi		Q9H400

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80775 [Q9H400-1]
80776 [Q9H400-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H400

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H400

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H400

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000203896, Expressed in right lobe of liver and 112 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H400, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H400, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000203896, Group enriched (blood, liver, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

When phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2, and GRB2 (By similarity). When phosphorylated in response to TCR stimulation and/or CD4 co-stimulation, interacts with LCK, CSK, FYN, PTPN11/SHP2, GRB2, PIK3R1 and GRAP2.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9H400
With#Exp.IntAct
AGR3 [Q8TD06]3EBI-2830566,EBI-3925742
AIG1 - isoform 1 [Q9NVV5-2]3EBI-2830566,EBI-11957045
AQP1 [P29972]3EBI-2830566,EBI-745213
ARFGAP3 [Q9NP61]3EBI-2830566,EBI-2875816
BNIP2 [Q12982]3EBI-2830566,EBI-752094
CALN1 [Q9BXU9]3EBI-2830566,EBI-12187137
CIAO2A [Q9H5X1]3EBI-2830566,EBI-752069
CLN6 [Q9NWW5]3EBI-2830566,EBI-6165897
EMD [P50402]3EBI-2830566,EBI-489887
FRMD8 [Q9BZ67]3EBI-2830566,EBI-5773072
GAD2 [Q05329]3EBI-2830566,EBI-9304251
GOSR2 [O14653]3EBI-2830566,EBI-4401517
LHFPL5 [Q8TAF8]3EBI-2830566,EBI-2820517
LPAR3 [Q9UBY5]3EBI-2830566,EBI-12033434
MAN2B2 [Q9Y2E5]3EBI-2830566,EBI-12243024
MEST [Q5EB52]3EBI-2830566,EBI-1050204
MIEF2 - isoform 3 [Q96C03-3]3EBI-2830566,EBI-11988931
NDRG4 - isoform 2 [Q9ULP0-2]3EBI-2830566,EBI-11978907
NINJ1 [Q92982]3EBI-2830566,EBI-2802124
NRAC [Q8N912]3EBI-2830566,EBI-12051377
PBX3 [Q96AL5]3EBI-2830566,EBI-741171
PKMYT1 - isoform 2 [Q99640-2]3EBI-2830566,EBI-12257782
PNPO [Q9NVS9]3EBI-2830566,EBI-11030787
PTPN9 [P43378]3EBI-2830566,EBI-742898
RTP2 [Q5QGT7]3EBI-2830566,EBI-10244780
SEC22C [Q9BRL7]3EBI-2830566,EBI-10297029
SLC41A2 [Q96JW4]3EBI-2830566,EBI-10290130
SNAP47 [Q5SQN1]3EBI-2830566,EBI-10244848
SNX1 [Q13596]3EBI-2830566,EBI-2822329
STX6 [O43752]3EBI-2830566,EBI-2695795
STX7 [O15400]3EBI-2830566,EBI-3221827
TBRG4 [Q969Z0]3EBI-2830566,EBI-702328
TMBIM6 [P55061]3EBI-2830566,EBI-1045825
TMEM143 [Q96AN5]3EBI-2830566,EBI-13342951
TMEM243 [Q9BU79]3EBI-2830566,EBI-12887458
TMEM74 [Q96NL1]3EBI-2830566,EBI-10292091
TMEM86B [Q8N661]3EBI-2830566,EBI-2548832
TMEM97 [Q5BJF2]3EBI-2830566,EBI-12111910
TRAF3IP3 [Q9Y228]3EBI-2830566,EBI-765817
UNC93B1 [Q9H1C4]3EBI-2830566,EBI-4401271
UPK2 [O00526]3EBI-2830566,EBI-10179682
ZFPL1 [O95159]3EBI-2830566,EBI-718439

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120264, 46 interactors

Protein interaction database and analysis system

More...IntActi		Q9H400, 46 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309521

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H400, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni145 – 148Interaction with GRB2By similarity4
Regioni167 – 170Interaction with CSK1 Publication4
Regioni200 – 203Interaction with CSK1 Publication4
Regioni235 – 238Interaction with LCK and PIK3R1By similarity4
Regioni254 – 257Interaction with LCK, PLCG2 and PIK3R1By similarity4

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RGRF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000050080

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H400

Identification of Orthologs from Complete Genome Data

More...OMAi		HQELPWA

Database of Orthologous Groups

More...OrthoDBi		931070at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H400

TreeFam database of animal gene trees

More...TreeFami		TF337416

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026072, Lime1

The PANTHER Classification System

More...PANTHERi		PTHR47740, PTHR47740, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15332, LIME1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLPVSWAPP ALWVLGCCAL LLSLWALCTA CRRPEDAVAP RKRARRQRAR 
        60         70         80         90        100
LQGSATAAEA SLLRRTHLCS LSKSDTRLHE LHRGPRSSRA LRPASMDLLR 
       110        120        130        140        150
PHWLEVSRDI TGPQAAPSAF PHQELPRALP AAAATAGCAG LEATYSNVGL 
       160        170        180        190        200
AALPGVSLAA SPVVAEYARV QKRKGTHRSP QEPQQGKTEV TPAAQVDVLY 
       210        220        230        240        250
SRVCKPKRRD PGPTTDPLDP KGQGAILALA GDLAYQTLPL RALDVDSGPL 
       260        270        280        290 
ENVYESIREL GDPAGRSSTC GAGTPPASSC PSLGRGWRPL PASLP
Length:295
Mass (Da):31,288
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD85ACE978F2DC99E
GO
Isoform 2 (identifier: Q9H400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:200
Mass (Da):20,841
Checksum:i44A69D6E2379BCB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZP9A0A087WZP9_HUMAN
Lck-interacting transmembrane adapt...
LIME1
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUJ1A0A087WUJ1_HUMAN
Lck-interacting transmembrane adapt...
LIME1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT39A0A087WT39_HUMAN
Lck-interacting transmembrane adapt...
LIME1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYI1V9GYI1_HUMAN
Lck-interacting transmembrane adapt...
LIME1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RKG5X6RKG5_HUMAN
Lck-interacting transmembrane adapt...
LIME1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246D → G in BAA91148 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053918211P → L. Corresponds to variant dbSNP:rs1151625Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0166421 – 95Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY203957 mRNA Translation: AAP34480.1
AK000413 mRNA Translation: BAA91148.1
AL121845 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75213.1
CH471077 Genomic DNA Translation: EAW75214.1
CH471077 Genomic DNA Translation: EAW75215.1
CH471077 Genomic DNA Translation: EAW75216.1
CH471077 Genomic DNA Translation: EAW75217.1
CH471077 Genomic DNA Translation: EAW75218.1
BC017016 mRNA Translation: AAH17016.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13536.1 [Q9H400-1]

NCBI Reference Sequences

More...RefSeqi		NP_001292583.1, NM_001305654.1
NP_001292584.1, NM_001305655.1
NP_060276.2, NM_017806.3 [Q9H400-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309546; ENSP00000309521; ENSG00000203896 [Q9H400-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54923

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54923

UCSC genome browser

More...UCSCi		uc002ygp.5, human [Q9H400-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY203957 mRNA Translation: AAP34480.1
AK000413 mRNA Translation: BAA91148.1
AL121845 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75213.1
CH471077 Genomic DNA Translation: EAW75214.1
CH471077 Genomic DNA Translation: EAW75215.1
CH471077 Genomic DNA Translation: EAW75216.1
CH471077 Genomic DNA Translation: EAW75217.1
CH471077 Genomic DNA Translation: EAW75218.1
BC017016 mRNA Translation: AAH17016.1
CCDSiCCDS13536.1 [Q9H400-1]
RefSeqiNP_001292583.1, NM_001305654.1
NP_001292584.1, NM_001305655.1
NP_060276.2, NM_017806.3 [Q9H400-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120264, 46 interactors
IntActiQ9H400, 46 interactors
STRINGi9606.ENSP00000309521

PTM databases

iPTMnetiQ9H400
PhosphoSitePlusiQ9H400
SwissPalmiQ9H400

Genetic variation databases

BioMutaiLIME1
DMDMi74752630

Proteomic databases

EPDiQ9H400
jPOSTiQ9H400
MassIVEiQ9H400
MaxQBiQ9H400
PaxDbiQ9H400
PeptideAtlasiQ9H400
PRIDEiQ9H400
ProteomicsDBi80775 [Q9H400-1]
80776 [Q9H400-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4202, 344 antibodies

The CPTC Antibody Portal

More...CPTCi		Q9H400, 1 antibody

Genome annotation databases

EnsembliENST00000309546; ENSP00000309521; ENSG00000203896 [Q9H400-1]
GeneIDi54923
KEGGihsa:54923
UCSCiuc002ygp.5, human [Q9H400-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54923
DisGeNETi54923

GeneCards: human genes, protein and diseases

More...GeneCardsi		LIME1
HGNCiHGNC:26016, LIME1
HPAiENSG00000203896, Group enriched (blood, liver, lymphoid tissue)
MIMi609809, gene
neXtProtiNX_Q9H400
OpenTargetsiENSG00000203896
PharmGKBiPA142671551
VEuPathDBiHostDB:ENSG00000203896.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RGRF, Eukaryota
GeneTreeiENSGT00510000050080
InParanoidiQ9H400
OMAiHQELPWA
OrthoDBi931070at2759
PhylomeDBiQ9H400
TreeFamiTF337416

Enzyme and pathway databases

PathwayCommonsiQ9H400

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54923, 3 hits in 854 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LIME1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54923
PharosiQ9H400, Tdark

Protein Ontology

More...PROi		PR:Q9H400
RNActiQ9H400, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000203896, Expressed in right lobe of liver and 112 other tissues
ExpressionAtlasiQ9H400, baseline and differential
GenevisibleiQ9H400, HS

Family and domain databases

InterProiView protein in InterPro
IPR026072, Lime1
PANTHERiPTHR47740, PTHR47740, 1 hit
PfamiView protein in Pfam
PF15332, LIME1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIME1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H400
Secondary accession number(s): E1P5K5
, E1P5K6, Q5JWJ2, Q6XYB3, Q9NX69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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