UniProtKB - Q9H3Z7 (ABHGB_HUMAN)
Protein
Protein ABHD16B
Gene
ABHD16B
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 247 | Charge relay systemBy similarity | 1 | |
Active sitei | 322 | Charge relay systemBy similarity | 1 | |
Active sitei | 418 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- acylglycerol lipase activity Source: GO_Central
- palmitoyl-(protein) hydrolase activity Source: GO_Central
- phospholipase activity Source: GO_Central
GO - Biological processi
- monoacylglycerol catabolic process Source: GO_Central
- phosphatidylserine catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q9H3Z7 |
SignaLinki | Q9H3Z7 |
Protein family/group databases
ESTHERi | human-ABHD16B, ABHD16 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein ABHD16BCurated (EC:3.-.-.-)Alternative name(s): Alpha/beta hydrolase domain-containing protein 16BCurated Short name: Abhydrolase domain-containing protein 16BImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183260.7 |
HGNCi | HGNC:16128, ABHD16B |
neXtProti | NX_Q9H3Z7 |
Subcellular locationi
Other locations
- membrane Source: GO_Central
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA25677 |
Miscellaneous databases
Pharosi | Q9H3Z7, Tdark |
Polymorphism and mutation databases
BioMutai | ABHD16B |
DMDMi | 23813959 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079463 | 1 – 469 | Protein ABHD16BAdd BLAST | 469 |
Proteomic databases
MassIVEi | Q9H3Z7 |
PaxDbi | Q9H3Z7 |
PeptideAtlasi | Q9H3Z7 |
PRIDEi | Q9H3Z7 |
ProteomicsDBi | 80774 |
TopDownProteomicsi | Q9H3Z7 |
PTM databases
iPTMneti | Q9H3Z7 |
PhosphoSitePlusi | Q9H3Z7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183260, Expressed in testis and 68 other tissues |
Genevisiblei | Q9H3Z7, HS |
Organism-specific databases
HPAi | ENSG00000183260, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126662, 2 interactors |
STRINGi | 9606.ENSP00000358932 |
Miscellaneous databases
RNActi | Q9H3Z7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 174 – 298 | AB hydrolase-1Sequence analysisAdd BLAST | 125 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 57 | Poly-Ala | 5 | |
Compositional biasi | 433 – 437 | Poly-Arg | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1553, Eukaryota |
GeneTreei | ENSGT00940000162803 |
HOGENOMi | CLU_040705_2_0_1 |
InParanoidi | Q9H3Z7 |
OMAi | YPGSMFL |
OrthoDBi | 580247at2759 |
PhylomeDBi | Q9H3Z7 |
TreeFami | TF314267 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H3Z7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCVICFVKAL VRVFKIYLTA SYTYPFRGWP VAFRWDDVRA VGRSSSHRAL
60 70 80 90 100
TCAAAAAGVW LLRDETLGGD ALGRPPRGAR SQAQCLLQQL RELPGQLASY
110 120 130 140 150
ALAHSLGRWL VYPGSVSLMT RALLPLLQQG QERLVERYHG RRAKLVACDG
160 170 180 190 200
NEIDTMFMDR RQHPGSHVHG PRLVICCEGN AGFYEMGCLS APLEAGYSVL
210 220 230 240 250
GWNHPGFGSS TGVPFPQHDA NAMDVVVEYA LHRLHFPPAH LVVYGWSVGG
260 270 280 290 300
FTATWATMTY PELGALVLDA TFDDLVPLAL KVMPHSWKGL VVRTVREHFN
310 320 330 340 350
LNVAEQLCCY PGPVLLLRRT QDDVVSTSGR LRPLSPGDVE GNRGNELLLR
360 370 380 390 400
LLEHRYPVVM AREGRAVVTR WLRAGSLAQE AAFYARYRVD EDWCLALLRS
410 420 430 440 450
YRARCEEELE GEEALGPHGP AFPWLVGQGL SSRRRRRLAL FLARKHLKNV
460
EATHFSPLEP EEFQLPWRL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050920 | 10 | L → Q. Corresponds to variant dbSNP:rs2281534Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL118506 Genomic DNA No translation available. |
CCDSi | CCDS13539.1 |
RefSeqi | NP_542189.1, NM_080622.3 |
Genome annotation databases
Ensembli | ENST00000369916; ENSP00000358932; ENSG00000183260 |
GeneIDi | 140701 |
KEGGi | hsa:140701 |
UCSCi | uc002ygx.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL118506 Genomic DNA No translation available. |
CCDSi | CCDS13539.1 |
RefSeqi | NP_542189.1, NM_080622.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126662, 2 interactors |
STRINGi | 9606.ENSP00000358932 |
Protein family/group databases
ESTHERi | human-ABHD16B, ABHD16 |
PTM databases
iPTMneti | Q9H3Z7 |
PhosphoSitePlusi | Q9H3Z7 |
Polymorphism and mutation databases
BioMutai | ABHD16B |
DMDMi | 23813959 |
Proteomic databases
MassIVEi | Q9H3Z7 |
PaxDbi | Q9H3Z7 |
PeptideAtlasi | Q9H3Z7 |
PRIDEi | Q9H3Z7 |
ProteomicsDBi | 80774 |
TopDownProteomicsi | Q9H3Z7 |
Protocols and materials databases
Antibodypediai | 70808, 8 antibodies |
DNASUi | 140701 |
Genome annotation databases
Ensembli | ENST00000369916; ENSP00000358932; ENSG00000183260 |
GeneIDi | 140701 |
KEGGi | hsa:140701 |
UCSCi | uc002ygx.2, human |
Organism-specific databases
CTDi | 140701 |
EuPathDBi | HostDB:ENSG00000183260.7 |
GeneCardsi | ABHD16B |
HGNCi | HGNC:16128, ABHD16B |
HPAi | ENSG00000183260, Low tissue specificity |
neXtProti | NX_Q9H3Z7 |
PharmGKBi | PA25677 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1553, Eukaryota |
GeneTreei | ENSGT00940000162803 |
HOGENOMi | CLU_040705_2_0_1 |
InParanoidi | Q9H3Z7 |
OMAi | YPGSMFL |
OrthoDBi | 580247at2759 |
PhylomeDBi | Q9H3Z7 |
TreeFami | TF314267 |
Enzyme and pathway databases
PathwayCommonsi | Q9H3Z7 |
SignaLinki | Q9H3Z7 |
Miscellaneous databases
BioGRID-ORCSi | 140701, 4 hits in 836 CRISPR screens |
ChiTaRSi | ABHD16B, human |
GenomeRNAii | 140701 |
Pharosi | Q9H3Z7, Tdark |
PROi | PR:Q9H3Z7 |
RNActi | Q9H3Z7, protein |
Gene expression databases
Bgeei | ENSG00000183260, Expressed in testis and 68 other tissues |
Genevisiblei | Q9H3Z7, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABHGB_HUMAN | |
Accessioni | Q9H3Z7Primary (citable) accession number: Q9H3Z7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations