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UniProtKB - Q9H3Y6 (SRMS_HUMAN)
Protein
Tyrosine-protein kinase Srms
Gene
SRMS
Organism
Homo sapiens (Human)
Status
Functioni
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091).
Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907).
Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).
2 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation2 PublicationsEC:2.7.10.2PROSITE-ProRule annotation2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 258 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 350 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 236 – 244 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB
- signaling receptor binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: GO_Central
- innate immune response Source: GO_Central
- negative regulation of signal transduction Source: Reactome
- peptidyl-tyrosine autophosphorylation Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H3Y6 |
Reactomei | R-HSA-8849472, PTK6 Down-Regulation |
SignaLinki | Q9H3Y6 |
SIGNORi | Q9H3Y6 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SRMS Synonyms:C20orf148 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11298, SRMS |
MIMi | 617797, gene |
neXtProti | NX_Q9H3Y6 |
VEuPathDBi | HostDB:ENSG00000125508 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Note: Localizes to punctate cytoplasmic structures.2 Publications
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 223 | W → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 258 | K → M: Loss of kinase activity. Exhibits a diffused cytoplasmic localization. No effect on interaction with KHDRBS1 or VIM but abolishes tyrosine phosphorylation of both substrates. 2 Publications | 1 | |
Mutagenesisi | 380 | Y → F: Significant reduction in phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6725 |
OpenTargetsi | ENSG00000125508 |
PharmGKBi | PA36122 |
Miscellaneous databases
Pharosi | Q9H3Y6, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5703 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9H3Y6 |
Genetic variation databases
BioMutai | SRMS |
DMDMi | 27805732 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088160 | 1 – 488 | Tyrosine-protein kinase SrmsAdd BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 380 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q9H3Y6 |
MaxQBi | Q9H3Y6 |
PaxDbi | Q9H3Y6 |
PeptideAtlasi | Q9H3Y6 |
PRIDEi | Q9H3Y6 |
ProteomicsDBi | 80768 |
PTM databases
iPTMneti | Q9H3Y6 |
PhosphoSitePlusi | Q9H3Y6 |
Expressioni
Tissue specificityi
Highly expressed in most breast cancers (at protein level).
Gene expression databases
Bgeei | ENSG00000125508, Expressed in cerebellar hemisphere and 73 other tissues |
Genevisiblei | Q9H3Y6, HS |
Organism-specific databases
HPAi | ENSG00000125508, Tissue enhanced (stomach) |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112603, 28 interactors |
IntActi | Q9H3Y6, 3 interactors |
MINTi | Q9H3Y6 |
STRINGi | 9606.ENSP00000217188 |
Chemistry databases
BindingDBi | Q9H3Y6 |
Miscellaneous databases
RNActi | Q9H3Y6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 112 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 120 – 212 | SH2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 230 – 488 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 |
Domaini
The N-terminal region regulates its kinase activity.1 Publication
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000161518 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | Q9H3Y6 |
OMAi | RAQAKVC |
OrthoDBi | 539311at2759 |
PhylomeDBi | Q9H3Y6 |
TreeFami | TF351634 |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H3Y6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPFLRRRLA FLSFFWDKIW PAGGEPDHGT PGSLDPNTDP VPTLPAEPCS
60 70 80 90 100
PFPQLFLALY DFTARCGGEL SVRRGDRLCA LEEGGGYIFA RRLSGQPSAG
110 120 130 140 150
LVPITHVAKA SPETLSDQPW YFSGVSRTQA QQLLLSPPNE PGAFLIRPSE
160 170 180 190 200
SSLGGYSLSV RAQAKVCHYR VSMAADGSLY LQKGRLFPGL EELLTYYKAN
210 220 230 240 250
WKLIQNPLLQ PCMPQKAPRQ DVWERPHSEF ALGRKLGEGY FGEVWEGLWL
260 270 280 290 300
GSLPVAIKVI KSANMKLTDL AKEIQTLKGL RHERLIRLHA VCSGGEPVYI
310 320 330 340 350
VTELMRKGNL QAFLGTPEGR ALRLPPLLGF ACQVAEGMSY LEEQRVVHRD
360 370 380 390 400
LAARNVLVDD GLACKVADFG LARLLKDDIY SPSSSSKIPV KWTAPEAANY
410 420 430 440 450
RVFSQKSDVW SFGVLLHEVF TYGQCPYEGM TNHETLQQIM RGYRLPRPAA
460 470 480
CPAEVYVLML ECWRSSPEER PSFATLREKL HAIHRCHP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041831 | 73 | R → C1 PublicationCorresponds to variant dbSNP:rs56053583Ensembl. | 1 | |
Natural variantiVAR_041832 | 75 | G → R1 PublicationCorresponds to variant dbSNP:rs55863722Ensembl. | 1 | |
Natural variantiVAR_041833 | 88 | I → V1 PublicationCorresponds to variant dbSNP:rs35558836Ensembl. | 1 | |
Natural variantiVAR_051700 | 218 | P → L. Corresponds to variant dbSNP:rs378483Ensembl. | 1 | |
Natural variantiVAR_051701 | 255 | V → M. Corresponds to variant dbSNP:rs34969822Ensembl. | 1 | |
Natural variantiVAR_041834 | 301 | V → L1 PublicationCorresponds to variant dbSNP:rs310657Ensembl. | 1 | |
Natural variantiVAR_051702 | 325 | P → L. Corresponds to variant dbSNP:rs8122355Ensembl. | 1 | |
Natural variantiVAR_041835 | 377 | D → E1 PublicationCorresponds to variant dbSNP:rs55838540Ensembl. | 1 | |
Natural variantiVAR_041836 | 397 | A → V1 PublicationCorresponds to variant dbSNP:rs6011889Ensembl. | 1 | |
Natural variantiVAR_041837 | 452 | P → L1 PublicationCorresponds to variant dbSNP:rs8120713Ensembl. | 1 | |
Natural variantiVAR_041838 | 453 | A → T1 PublicationCorresponds to variant dbSNP:rs310655Ensembl. | 1 | |
Natural variantiVAR_041839 | 457 | V → L1 PublicationCorresponds to variant dbSNP:rs310654Ensembl. | 1 | |
Natural variantiVAR_041840 | 465 | S → T1 PublicationCorresponds to variant dbSNP:rs33933649Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121829 Genomic DNA No translation available. |
CCDSi | CCDS13525.1 |
RefSeqi | NP_543013.1, NM_080823.3 |
Genome annotation databases
Ensembli | ENST00000217188; ENSP00000217188; ENSG00000125508 |
GeneIDi | 6725 |
KEGGi | hsa:6725 |
MANE-Selecti | ENST00000217188.2; ENSP00000217188.1; NM_080823.4; NP_543013.1 |
UCSCi | uc002yfi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121829 Genomic DNA No translation available. |
CCDSi | CCDS13525.1 |
RefSeqi | NP_543013.1, NM_080823.3 |
3D structure databases
SMRi | Q9H3Y6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112603, 28 interactors |
IntActi | Q9H3Y6, 3 interactors |
MINTi | Q9H3Y6 |
STRINGi | 9606.ENSP00000217188 |
Chemistry databases
BindingDBi | Q9H3Y6 |
ChEMBLi | CHEMBL5703 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9H3Y6 |
PTM databases
iPTMneti | Q9H3Y6 |
PhosphoSitePlusi | Q9H3Y6 |
Genetic variation databases
BioMutai | SRMS |
DMDMi | 27805732 |
Proteomic databases
MassIVEi | Q9H3Y6 |
MaxQBi | Q9H3Y6 |
PaxDbi | Q9H3Y6 |
PeptideAtlasi | Q9H3Y6 |
PRIDEi | Q9H3Y6 |
ProteomicsDBi | 80768 |
Protocols and materials databases
Antibodypediai | 29781, 194 antibodies from 26 providers |
DNASUi | 6725 |
Genome annotation databases
Ensembli | ENST00000217188; ENSP00000217188; ENSG00000125508 |
GeneIDi | 6725 |
KEGGi | hsa:6725 |
MANE-Selecti | ENST00000217188.2; ENSP00000217188.1; NM_080823.4; NP_543013.1 |
UCSCi | uc002yfi.3, human |
Organism-specific databases
CTDi | 6725 |
DisGeNETi | 6725 |
GeneCardsi | SRMS |
HGNCi | HGNC:11298, SRMS |
HPAi | ENSG00000125508, Tissue enhanced (stomach) |
MIMi | 617797, gene |
neXtProti | NX_Q9H3Y6 |
OpenTargetsi | ENSG00000125508 |
PharmGKBi | PA36122 |
VEuPathDBi | HostDB:ENSG00000125508 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000161518 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | Q9H3Y6 |
OMAi | RAQAKVC |
OrthoDBi | 539311at2759 |
PhylomeDBi | Q9H3Y6 |
TreeFami | TF351634 |
Enzyme and pathway databases
PathwayCommonsi | Q9H3Y6 |
Reactomei | R-HSA-8849472, PTK6 Down-Regulation |
SignaLinki | Q9H3Y6 |
SIGNORi | Q9H3Y6 |
Miscellaneous databases
BioGRID-ORCSi | 6725, 8 hits in 1069 CRISPR screens |
GenomeRNAii | 6725 |
Pharosi | Q9H3Y6, Tchem |
PROi | PR:Q9H3Y6 |
RNActi | Q9H3Y6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125508, Expressed in cerebellar hemisphere and 73 other tissues |
Genevisiblei | Q9H3Y6, HS |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SRMS_HUMAN | |
Accessioni | Q9H3Y6Primary (citable) accession number: Q9H3Y6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families