Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidase inhibitor R3HDML

Gene

R3HDML

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative serine protease inhibitor.By similarity

Caution

Despite its name, it does not contain a R3H domain.Curated

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase inhibitor R3HDML
Alternative name(s):
Cysteine-rich secretory protein R3HDML
Gene namesi
Name:R3HDML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101074.3
HGNCiHGNC:16249 R3HDML
neXtProtiNX_Q9H3Y0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi140902
OpenTargetsiENSG00000101074
PharmGKBiPA34099

Polymorphism and mutation databases

DMDMi74752628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000028763525 – 56By similarityAdd BLAST32
ChainiPRO_000028763657 – 253Peptidase inhibitor R3HDMLAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H3Y0
PRIDEiQ9H3Y0
ProteomicsDBi80767

Expressioni

Gene expression databases

BgeeiENSG00000101074 Expressed in 13 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_R3HDML
GenevisibleiQ9H3Y0 HS

Organism-specific databases

HPAiHPA070264

Interactioni

Protein-protein interaction databases

BioGridi126761, 3 interactors
IntActiQ9H3Y0, 2 interactors
STRINGi9606.ENSP00000217043

Structurei

3D structure databases

ProteinModelPortaliQ9H3Y0
SMRiQ9H3Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 207SCPAdd BLAST141

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000111978
HOVERGENiHBG079090
InParanoidiQ9H3Y0
OMAiHIRASVH
OrthoDBiEOG091G048D
PhylomeDBiQ9H3Y0
TreeFamiTF316148

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR014044 CAP_domain
IPR035940 CAP_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3Y0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLPSTVGL AGLLFWAGQA VNALIMPNAT PAPAQPESTA MRLLSGLEVP
60 70 80 90 100
RYRRKRHISV RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW
110 120 130 140 150
ATQCIWAHGP SQLMRYVGQN LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP
160 170 180 190 200
RDCNPHCPWR CDGPTCSHYT QMVWASSNRL GCAIHTCSSI SVWGNTWHRA
210 220 230 240 250
AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM CFKGLKSNKF

TWF
Length:253
Mass (Da):28,605
Last modified:March 1, 2001 - v1
Checksum:i28976C6F32E3887E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03233915F → C. Corresponds to variant dbSNP:rs11699901Ensembl.1
Natural variantiVAR_04883468D → N. Corresponds to variant dbSNP:rs36117710Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA No translation available.
BC107048 mRNA Translation: AAI07049.1
CCDSiCCDS13329.1
RefSeqiNP_848586.1, NM_178491.3
UniGeneiHs.580807

Genome annotation databases

EnsembliENST00000217043; ENSP00000217043; ENSG00000101074
GeneIDi140902
KEGGihsa:140902
UCSCiuc002xls.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA No translation available.
BC107048 mRNA Translation: AAI07049.1
CCDSiCCDS13329.1
RefSeqiNP_848586.1, NM_178491.3
UniGeneiHs.580807

3D structure databases

ProteinModelPortaliQ9H3Y0
SMRiQ9H3Y0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126761, 3 interactors
IntActiQ9H3Y0, 2 interactors
STRINGi9606.ENSP00000217043

Polymorphism and mutation databases

DMDMi74752628

Proteomic databases

PaxDbiQ9H3Y0
PRIDEiQ9H3Y0
ProteomicsDBi80767

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217043; ENSP00000217043; ENSG00000101074
GeneIDi140902
KEGGihsa:140902
UCSCiuc002xls.3 human

Organism-specific databases

CTDi140902
DisGeNETi140902
EuPathDBiHostDB:ENSG00000101074.3
GeneCardsiR3HDML
HGNCiHGNC:16249 R3HDML
HPAiHPA070264
neXtProtiNX_Q9H3Y0
OpenTargetsiENSG00000101074
PharmGKBiPA34099
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000111978
HOVERGENiHBG079090
InParanoidiQ9H3Y0
OMAiHIRASVH
OrthoDBiEOG091G048D
PhylomeDBiQ9H3Y0
TreeFamiTF316148

Miscellaneous databases

ChiTaRSiR3HDML human
GenomeRNAii140902
PROiPR:Q9H3Y0

Gene expression databases

BgeeiENSG00000101074 Expressed in 13 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_R3HDML
GenevisibleiQ9H3Y0 HS

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR014044 CAP_domain
IPR035940 CAP_sf
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRSPL_HUMAN
AccessioniPrimary (citable) accession number: Q9H3Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again