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Entry version 151 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Leucine-rich repeat neuronal protein 3

Gene

LRRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 3
Alternative name(s):
Neuronal leucine-rich repeat protein 3
Short name:
NLRR-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRN3
ORF Names:Nbla10363, UNQ194/PRO220
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17200 LRRN3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3W5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 628ExtracellularSequence analysisAdd BLAST606
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei629 – 649HelicalSequence analysisAdd BLAST21
Topological domaini650 – 708CytoplasmicSequence analysisAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54674

Open Targets

More...
OpenTargetsi
ENSG00000173114

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30468

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761421

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004582323 – 708Leucine-rich repeat neuronal protein 3Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi444 ↔ 496PROSITE-ProRule annotation
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi579N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H3W5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3W5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3W5

PeptideAtlas

More...
PeptideAtlasi
Q9H3W5

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3W5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80766

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3W5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173114 Expressed in 206 organ(s), highest expression level in neocortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3W5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3W5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043820
HPA046792

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120095, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397312

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3W5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 69LRRNTAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati70 – 91LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 138LRR 3Add BLAST22
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati189 – 210LRR 6Add BLAST22
Repeati213 – 234LRR 7Add BLAST22
Repeati237 – 258LRR 8Add BLAST22
Repeati261 – 282LRR 9Add BLAST22
Repeati285 – 304LRR 10Add BLAST20
Repeati310 – 332LRR 11Add BLAST23
Repeati335 – 358LRR 12Add BLAST24
Domaini368 – 421LRRCTAdd BLAST54
Domaini421 – 514Ig-like C2-typeAdd BLAST94
Domaini523 – 617Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252914

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQLCTCE

Database of Orthologous Groups

More...
OrthoDBi
998247at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3W5

TreeFam database of animal gene trees

More...
TreeFami
TF334360

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H3W5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA
60 70 80 90 100
STVDCNDLGL LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS
110 120 130 140 150
QNNLSSVTNI NVKKMPQLLS VYLEENKLTE LPEKCLSELS NLQELYINHN
160 170 180 190 200
LLSTISPGAF IGLHNLLRLH LNSNRLQMIN SKWFDALPNL EILMIGENPI
210 220 230 240 250
IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES ISFYDNRLIK
260 270 280 290 300
VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
310 320 330 340 350
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY
360 370 380 390 400
HGTIESLPNL KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP
410 420 430 440 450
EFQGQNVRQV HFRDMMEICL PLIAPESFPS NLNVEAGSYV SFHCRATAEP
460 470 480 490 500
QPEIYWITPS GQKLLPNTLT DKFYVHSEGT LDINGVTPKE GGLYTCIATN
510 520 530 540 550
LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS WKASSKILKS
560 570 580 590 600
SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
610 620 630 640 650
KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS
660 670 680 690 700
PEMNCDGGHS YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV

IGLPTNMS
Length:708
Mass (Da):79,424
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24710478D6B124D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW58E7EW58_HUMAN
Leucine-rich repeat neuronal protei...
LRRN3
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96G → S in AAH35133 (PubMed:15489334).Curated1
Sequence conflicti533Q → H in AAH35133 (PubMed:15489334).Curated1
Sequence conflicti541W → R in CAG33678 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04990124D → G. Corresponds to variant dbSNP:rs9942557Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF134481 mRNA Translation: AAP97258.1
AB060967 mRNA Translation: BAB47184.1
AY358280 mRNA Translation: AAQ88647.1
CR457397 mRNA Translation: CAG33678.1
AL442092 mRNA Translation: CAC09450.1
BC035133 mRNA Translation: AAH35133.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5754.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093128.1, NM_001099658.1
NP_001093130.1, NM_001099660.1
NP_060804.3, NM_018334.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308478; ENSP00000312001; ENSG00000173114
ENST00000422987; ENSP00000412417; ENSG00000173114
ENST00000451085; ENSP00000397312; ENSG00000173114

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54674

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54674

UCSC genome browser

More...
UCSCi
uc003vfs.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134481 mRNA Translation: AAP97258.1
AB060967 mRNA Translation: BAB47184.1
AY358280 mRNA Translation: AAQ88647.1
CR457397 mRNA Translation: CAG33678.1
AL442092 mRNA Translation: CAC09450.1
BC035133 mRNA Translation: AAH35133.1
CCDSiCCDS5754.1
RefSeqiNP_001093128.1, NM_001099658.1
NP_001093130.1, NM_001099660.1
NP_060804.3, NM_018334.4

3D structure databases

SMRiQ9H3W5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120095, 3 interactors
STRINGi9606.ENSP00000397312

PTM databases

PhosphoSitePlusiQ9H3W5

Polymorphism and mutation databases

BioMutaiLRRN3
DMDMi74761421

Proteomic databases

jPOSTiQ9H3W5
MaxQBiQ9H3W5
PaxDbiQ9H3W5
PeptideAtlasiQ9H3W5
PRIDEiQ9H3W5
ProteomicsDBi80766

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54674
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308478; ENSP00000312001; ENSG00000173114
ENST00000422987; ENSP00000412417; ENSG00000173114
ENST00000451085; ENSP00000397312; ENSG00000173114
GeneIDi54674
KEGGihsa:54674
UCSCiuc003vfs.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54674
DisGeNETi54674

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRN3
HGNCiHGNC:17200 LRRN3
HPAiHPA043820
HPA046792
neXtProtiNX_Q9H3W5
OpenTargetsiENSG00000173114
PharmGKBiPA30468

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000160513
HOGENOMiHOG000252914
OMAiPQLCTCE
OrthoDBi998247at2759
PhylomeDBiQ9H3W5
TreeFamiTF334360

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LRRN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54674

Protein Ontology

More...
PROi
PR:Q9H3W5

Gene expression databases

BgeeiENSG00000173114 Expressed in 206 organ(s), highest expression level in neocortex
ExpressionAtlasiQ9H3W5 baseline and differential
GenevisibleiQ9H3W5 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3W5
Secondary accession number(s): O43377, Q6I9V8, Q8IYQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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