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Protein

Leucine-rich repeat neuronal protein 3

Gene

LRRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 3
Alternative name(s):
Neuronal leucine-rich repeat protein 3
Short name:
NLRR-3
Gene namesi
Name:LRRN3
ORF Names:Nbla10363, UNQ194/PRO220
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000173114.12
HGNCiHGNC:17200 LRRN3
neXtProtiNX_Q9H3W5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 628ExtracellularSequence analysisAdd BLAST606
Transmembranei629 – 649HelicalSequence analysisAdd BLAST21
Topological domaini650 – 708CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54674
OpenTargetsiENSG00000173114
PharmGKBiPA30468

Polymorphism and mutation databases

BioMutaiLRRN3
DMDMi74761421

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004582323 – 708Leucine-rich repeat neuronal protein 3Add BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi444 ↔ 496PROSITE-ProRule annotation
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi579N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9H3W5
PaxDbiQ9H3W5
PeptideAtlasiQ9H3W5
PRIDEiQ9H3W5
ProteomicsDBi80766

PTM databases

PhosphoSitePlusiQ9H3W5

Expressioni

Gene expression databases

BgeeiENSG00000173114
CleanExiHS_LRRN3
ExpressionAtlasiQ9H3W5 baseline and differential
GenevisibleiQ9H3W5 HS

Organism-specific databases

HPAiHPA043820
HPA046792

Interactioni

Protein-protein interaction databases

BioGridi120095, 3 interactors
STRINGi9606.ENSP00000312001

Structurei

3D structure databases

ProteinModelPortaliQ9H3W5
SMRiQ9H3W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69LRRNTAdd BLAST47
Repeati70 – 91LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 138LRR 3Add BLAST22
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati189 – 210LRR 6Add BLAST22
Repeati213 – 234LRR 7Add BLAST22
Repeati237 – 258LRR 8Add BLAST22
Repeati261 – 282LRR 9Add BLAST22
Repeati285 – 304LRR 10Add BLAST20
Repeati310 – 332LRR 11Add BLAST23
Repeati335 – 358LRR 12Add BLAST24
Domaini368 – 421LRRCTAdd BLAST54
Domaini421 – 514Ig-like C2-typeAdd BLAST94
Domaini523 – 617Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
OMAiPQLCTCE
OrthoDBiEOG091G066E
PhylomeDBiQ9H3W5
TreeFamiTF334360

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA
60 70 80 90 100
STVDCNDLGL LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS
110 120 130 140 150
QNNLSSVTNI NVKKMPQLLS VYLEENKLTE LPEKCLSELS NLQELYINHN
160 170 180 190 200
LLSTISPGAF IGLHNLLRLH LNSNRLQMIN SKWFDALPNL EILMIGENPI
210 220 230 240 250
IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES ISFYDNRLIK
260 270 280 290 300
VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
310 320 330 340 350
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY
360 370 380 390 400
HGTIESLPNL KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP
410 420 430 440 450
EFQGQNVRQV HFRDMMEICL PLIAPESFPS NLNVEAGSYV SFHCRATAEP
460 470 480 490 500
QPEIYWITPS GQKLLPNTLT DKFYVHSEGT LDINGVTPKE GGLYTCIATN
510 520 530 540 550
LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS WKASSKILKS
560 570 580 590 600
SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
610 620 630 640 650
KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS
660 670 680 690 700
PEMNCDGGHS YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV

IGLPTNMS
Length:708
Mass (Da):79,424
Last modified:March 1, 2001 - v1
Checksum:i24710478D6B124D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96G → S in AAH35133 (PubMed:15489334).Curated1
Sequence conflicti533Q → H in AAH35133 (PubMed:15489334).Curated1
Sequence conflicti541W → R in CAG33678 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04990124D → G. Corresponds to variant dbSNP:rs9942557Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134481 mRNA Translation: AAP97258.1
AB060967 mRNA Translation: BAB47184.1
AY358280 mRNA Translation: AAQ88647.1
CR457397 mRNA Translation: CAG33678.1
AL442092 mRNA Translation: CAC09450.1
BC035133 mRNA Translation: AAH35133.1
CCDSiCCDS5754.1
RefSeqiNP_001093128.1, NM_001099658.1
NP_001093130.1, NM_001099660.1
NP_060804.3, NM_018334.4
UniGeneiHs.3781

Genome annotation databases

EnsembliENST00000308478; ENSP00000312001; ENSG00000173114
ENST00000422987; ENSP00000412417; ENSG00000173114
ENST00000451085; ENSP00000397312; ENSG00000173114
GeneIDi54674
KEGGihsa:54674
UCSCiuc003vfs.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRRN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H3W5
Secondary accession number(s): O43377, Q6I9V8, Q8IYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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