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Entry version 174 (02 Jun 2021)
Sequence version 2 (31 Oct 2003)
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Protein

SPARC-related modular calcium-binding protein 2

Gene

SMOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes matrix assembly and cell adhesiveness (By similarity).

Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.

By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi360 – 3711PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi397 – 4082PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H3U7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPARC-related modular calcium-binding protein 2
Alternative name(s):
Secreted modular calcium-binding protein 2
Short name:
SMOC-2
Smooth muscle-associated protein 2
Short name:
SMAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMOC2
Synonyms:SMAP2
ORF Names:MSTP117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20323, SMOC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607223, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3U7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000112562.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dentin dysplasia 1 (DTDP1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
64094

MalaCards human disease database

More...
MalaCardsi
SMOC2
MIMi125400, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112562

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
314721, Atypical dentin dysplasia due to SMOC2 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934590

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H3U7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMOC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258648

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002031822 – 446SPARC-related modular calcium-binding protein 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 71PROSITE-ProRule annotation
Disulfide bondi44 ↔ 64PROSITE-ProRule annotation
Disulfide bondi53 ↔ 84PROSITE-ProRule annotation
Disulfide bondi90 ↔ 113By similarity
Disulfide bondi124 ↔ 131By similarity
Disulfide bondi133 ↔ 153By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 240By similarity
Disulfide bondi251 ↔ 258By similarity
Disulfide bondi260 ↔ 281By similarity
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H3U7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H3U7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3U7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3U7

PeptideAtlas

More...
PeptideAtlasi
Q9H3U7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3U7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80763 [Q9H3U7-1]
80764 [Q9H3U7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H3U7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3U7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3U7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112562, Expressed in descending thoracic aorta and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3U7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3U7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112562, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds various proteins from the extracellular matrix.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122056, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H3U7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346537

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H3U7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3U7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 86Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini87 – 153Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini213 – 281Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
Domaini347 – 382EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini384 – 419EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni147 – 228DisorderedSequence analysisAdd BLAST82
Regioni416 – 446DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi196 – 220Polar residuesSequence analysisAdd BLAST25
Compositional biasi418 – 438Basic and acidic residuesSequence analysisAdd BLAST21

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4578, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018436

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023483_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H3U7

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHYKSRH

Database of Orthologous Groups

More...
OrthoDBi
1057719at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3U7

TreeFam database of animal gene trees

More...
TreeFami
TF320666

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16241, EFh_SPARC_SMOC2, 1 hit
cd00191, TY, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.800.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR037640, SMOC2_EC
IPR019577, SPARC/Testican_Ca-bd-dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648, Kazal_2, 1 hit
PF10591, SPARC_Ca_bdg, 1 hit
PF00086, Thyroglobulin_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00280, KAZAL, 1 hit
SM00211, TY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF57610, SSF57610, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51465, KAZAL_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 2 hits
PS51162, THYROGLOBULIN_1_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3U7-1) [UniParc]FASTAAdd to basket
Also known as: Smap2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPQLCWLP LLAGLLPPVP AQKFSALTFL RVDQDKDKDC SLDCAGSPQK
60 70 80 90 100
PLCASDGRTF LSRCEFQRAK CKDPQLEIAY RGNCKDVSRC VAERKYTQEQ
110 120 130 140 150
ARKEFQQVFI PECNDDGTYS QVQCHSYTGY CWCVTPNGRP ISGTAVAHKT
160 170 180 190 200
PRCPGSVNEK LPQREGTGKT DDAAAPALET QPQGDEEDIA SRYPTLWTEQ
210 220 230 240 250
VKSRQNKTNK NSVSSCDQEH QSALEEAKQP KNDNVVIPEC AHGGLYKPVQ
260 270 280 290 300
CHPSTGYCWC VLVDTGRPIP GTSTRYEQPK CDNTARAHPA KARDLYKGRQ
310 320 330 340 350
LQGCPGAKKH EFLTSVLDAL STDMVHAASD PSSSSGRLSE PDPSHTLEER
360 370 380 390 400
VVHWYFKLLD KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDVNN
410 420 430 440
DKSISVQELM GCLGVAKEDG KADTKKRHTP RGHAESTSNR QPRKQG
Length:446
Mass (Da):49,674
Last modified:October 31, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF0D92A71C9E1006
GO
Isoform 2 (identifier: Q9H3U7-2) [UniParc]FASTAAdd to basket
Also known as: Smap2b

The sequence of this isoform differs from the canonical sequence as follows:
     170-170: T → TVSLQIFSVLNS

Show »
Length:457
Mass (Da):50,863
Checksum:iD20AE3BB82785925
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5I1H0Y5I1_HUMAN
SPARC-related modular calcium-bindi...
SMOC2
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3J4H0Y3J4_HUMAN
SPARC-related modular calcium-bindi...
SMOC2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTM0A0A087WTM0_HUMAN
SPARC-related modular calcium-bindi...
SMOC2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ13639 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169 – 170KT → TR in CAC10353 (PubMed:12741954).Curated2
Sequence conflicti212S → P in BAB20267 (PubMed:12031507).Curated1
Sequence conflicti434A → V in AAH47583 (PubMed:15489334).Curated1
Sequence conflicti439N → Y in CAC10353 (PubMed:12741954).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008722170T → TVSLQIFSVLNS in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014730 mRNA Translation: BAB20267.1
AB014737 mRNA Translation: BAB20274.1
AK056700 mRNA Translation: BAG51789.1
AL832303 mRNA Translation: CAI46175.1
AL109940 Genomic DNA No translation available.
AL136099 Genomic DNA No translation available.
AL138918 Genomic DNA No translation available.
AL442124 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47462.1
BC028420 mRNA Translation: AAH28420.1
BC047583 mRNA Translation: AAH47583.1
AF173892 mRNA Translation: AAQ13639.1 Different initiation.
AJ249902 mRNA Translation: CAC10353.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5307.1 [Q9H3U7-2]
CCDS55076.1 [Q9H3U7-1]

NCBI Reference Sequences

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RefSeqi
NP_001159884.1, NM_001166412.1 [Q9H3U7-1]
NP_071421.1, NM_022138.2 [Q9H3U7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354536; ENSP00000346537; ENSG00000112562 [Q9H3U7-2]
ENST00000356284; ENSP00000348630; ENSG00000112562 [Q9H3U7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64094

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64094

UCSC genome browser

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UCSCi
uc003qwr.2, human [Q9H3U7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014730 mRNA Translation: BAB20267.1
AB014737 mRNA Translation: BAB20274.1
AK056700 mRNA Translation: BAG51789.1
AL832303 mRNA Translation: CAI46175.1
AL109940 Genomic DNA No translation available.
AL136099 Genomic DNA No translation available.
AL138918 Genomic DNA No translation available.
AL442124 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47462.1
BC028420 mRNA Translation: AAH28420.1
BC047583 mRNA Translation: AAH47583.1
AF173892 mRNA Translation: AAQ13639.1 Different initiation.
AJ249902 mRNA Translation: CAC10353.1
CCDSiCCDS5307.1 [Q9H3U7-2]
CCDS55076.1 [Q9H3U7-1]
RefSeqiNP_001159884.1, NM_001166412.1 [Q9H3U7-1]
NP_071421.1, NM_022138.2 [Q9H3U7-2]

3D structure databases

SMRiQ9H3U7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122056, 4 interactors
IntActiQ9H3U7, 1 interactor
STRINGi9606.ENSP00000346537

PTM databases

GlyGeniQ9H3U7, 2 sites
iPTMnetiQ9H3U7
PhosphoSitePlusiQ9H3U7

Genetic variation databases

BioMutaiSMOC2
DMDMi38258648

Proteomic databases

jPOSTiQ9H3U7
MassIVEiQ9H3U7
MaxQBiQ9H3U7
PaxDbiQ9H3U7
PeptideAtlasiQ9H3U7
PRIDEiQ9H3U7
ProteomicsDBi80763 [Q9H3U7-1]
80764 [Q9H3U7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33562, 136 antibodies

The DNASU plasmid repository

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DNASUi
64094

Genome annotation databases

EnsembliENST00000354536; ENSP00000346537; ENSG00000112562 [Q9H3U7-2]
ENST00000356284; ENSP00000348630; ENSG00000112562 [Q9H3U7-1]
GeneIDi64094
KEGGihsa:64094
UCSCiuc003qwr.2, human [Q9H3U7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64094
DisGeNETi64094

GeneCards: human genes, protein and diseases

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GeneCardsi
SMOC2
HGNCiHGNC:20323, SMOC2
HPAiENSG00000112562, Low tissue specificity
MalaCardsiSMOC2
MIMi125400, phenotype
607223, gene
neXtProtiNX_Q9H3U7
OpenTargetsiENSG00000112562
Orphaneti314721, Atypical dentin dysplasia due to SMOC2 deficiency
PharmGKBiPA134934590
VEuPathDBiHostDB:ENSG00000112562.18

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4578, Eukaryota
GeneTreeiENSGT00390000018436
HOGENOMiCLU_023483_0_0_1
InParanoidiQ9H3U7
OMAiDHYKSRH
OrthoDBi1057719at2759
PhylomeDBiQ9H3U7
TreeFamiTF320666

Enzyme and pathway databases

PathwayCommonsiQ9H3U7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64094, 3 hits in 982 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SMOC2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SMOC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64094
PharosiQ9H3U7, Tbio

Protein Ontology

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PROi
PR:Q9H3U7
RNActiQ9H3U7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112562, Expressed in descending thoracic aorta and 202 other tissues
ExpressionAtlasiQ9H3U7, baseline and differential
GenevisibleiQ9H3U7, HS

Family and domain databases

CDDicd16241, EFh_SPARC_SMOC2, 1 hit
cd00191, TY, 2 hits
Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR037640, SMOC2_EC
IPR019577, SPARC/Testican_Ca-bd-dom
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
PF10591, SPARC_Ca_bdg, 1 hit
PF00086, Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00280, KAZAL, 1 hit
SM00211, TY, 2 hits
SUPFAMiSSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF57610, SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51465, KAZAL_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 2 hits
PS51162, THYROGLOBULIN_1_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMOC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3U7
Secondary accession number(s): B3KPS7
, Q4G169, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: June 2, 2021
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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