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Protein

SPARC-related modular calcium-binding protein 2

Gene

SMOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi360 – 3711PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi397 – 4082PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SPARC-related modular calcium-binding protein 2
Alternative name(s):
Secreted modular calcium-binding protein 2
Short name:
SMOC-2
Smooth muscle-associated protein 2
Short name:
SMAP-2
Gene namesi
Name:SMOC2
Synonyms:SMAP2
ORF Names:MSTP117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112562.18
HGNCiHGNC:20323 SMOC2
MIMi607223 gene
neXtProtiNX_Q9H3U7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Dentin dysplasia 1 (DTDP1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent.
See also OMIM:125400

Organism-specific databases

DisGeNETi64094
MalaCardsiSMOC2
MIMi125400 phenotype
OpenTargetsiENSG00000112562
Orphaneti314721 Atypical dentin dysplasia due to SMOC2 deficiency
PharmGKBiPA134934590

Polymorphism and mutation databases

BioMutaiSMOC2
DMDMi38258648

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002031822 – 446SPARC-related modular calcium-binding protein 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 71PROSITE-ProRule annotation
Disulfide bondi44 ↔ 64PROSITE-ProRule annotation
Disulfide bondi53 ↔ 84PROSITE-ProRule annotation
Disulfide bondi90 ↔ 113By similarity
Disulfide bondi124 ↔ 131By similarity
Disulfide bondi133 ↔ 153By similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 240By similarity
Disulfide bondi251 ↔ 258By similarity
Disulfide bondi260 ↔ 281By similarity
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H3U7
MaxQBiQ9H3U7
PaxDbiQ9H3U7
PeptideAtlasiQ9H3U7
PRIDEiQ9H3U7
ProteomicsDBi80763
80764 [Q9H3U7-2]

PTM databases

iPTMnetiQ9H3U7
PhosphoSitePlusiQ9H3U7

Expressioni

Gene expression databases

BgeeiENSG00000112562 Expressed in 186 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_SMAP2
ExpressionAtlasiQ9H3U7 baseline and differential
GenevisibleiQ9H3U7 HS

Organism-specific databases

HPAiCAB033979

Interactioni

Subunit structurei

Binds various proteins from the extracellular matrix.By similarity

Protein-protein interaction databases

BioGridi122056, 2 interactors
IntActiQ9H3U7, 1 interactor
STRINGi9606.ENSP00000346537

Structurei

3D structure databases

ProteinModelPortaliQ9H3U7
SMRiQ9H3U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 86Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini87 – 153Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini213 – 281Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
Domaini347 – 382EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini384 – 419EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4578 Eukaryota
ENOG410YP7C LUCA
GeneTreeiENSGT00390000018436
HOVERGENiHBG058558
InParanoidiQ9H3U7
OMAiPRCPGSI
OrthoDBiEOG091G083O
PhylomeDBiQ9H3U7
TreeFamiTF320666

Family and domain databases

CDDicd16241 EFh_SPARC_SMOC2, 1 hit
cd00191 TY, 2 hits
Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR037640 SMOC2_EC
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 2 hits
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3U7-1) [UniParc]FASTAAdd to basket
Also known as: Smap2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLPQLCWLP LLAGLLPPVP AQKFSALTFL RVDQDKDKDC SLDCAGSPQK
60 70 80 90 100
PLCASDGRTF LSRCEFQRAK CKDPQLEIAY RGNCKDVSRC VAERKYTQEQ
110 120 130 140 150
ARKEFQQVFI PECNDDGTYS QVQCHSYTGY CWCVTPNGRP ISGTAVAHKT
160 170 180 190 200
PRCPGSVNEK LPQREGTGKT DDAAAPALET QPQGDEEDIA SRYPTLWTEQ
210 220 230 240 250
VKSRQNKTNK NSVSSCDQEH QSALEEAKQP KNDNVVIPEC AHGGLYKPVQ
260 270 280 290 300
CHPSTGYCWC VLVDTGRPIP GTSTRYEQPK CDNTARAHPA KARDLYKGRQ
310 320 330 340 350
LQGCPGAKKH EFLTSVLDAL STDMVHAASD PSSSSGRLSE PDPSHTLEER
360 370 380 390 400
VVHWYFKLLD KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDVNN
410 420 430 440
DKSISVQELM GCLGVAKEDG KADTKKRHTP RGHAESTSNR QPRKQG
Length:446
Mass (Da):49,674
Last modified:October 31, 2003 - v2
Checksum:iCF0D92A71C9E1006
GO
Isoform 2 (identifier: Q9H3U7-2) [UniParc]FASTAAdd to basket
Also known as: Smap2b

The sequence of this isoform differs from the canonical sequence as follows:
     170-170: T → TVSLQIFSVLNS

Show »
Length:457
Mass (Da):50,863
Checksum:iD20AE3BB82785925
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5I1H0Y5I1_HUMAN
SPARC-related modular calcium-bindi...
SMOC2
84Annotation score:
H0Y3J4H0Y3J4_HUMAN
SPARC-related modular calcium-bindi...
SMOC2
67Annotation score:
A0A087WTM0A0A087WTM0_HUMAN
SPARC-related modular calcium-bindi...
SMOC2
136Annotation score:

Sequence cautioni

The sequence AAQ13639 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169 – 170KT → TR in CAC10353 (PubMed:12741954).Curated2
Sequence conflicti212S → P in BAB20267 (PubMed:12031507).Curated1
Sequence conflicti434A → V in AAH47583 (PubMed:15489334).Curated1
Sequence conflicti439N → Y in CAC10353 (PubMed:12741954).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008722170T → TVSLQIFSVLNS in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014730 mRNA Translation: BAB20267.1
AB014737 mRNA Translation: BAB20274.1
AK056700 mRNA Translation: BAG51789.1
AL832303 mRNA Translation: CAI46175.1
AL109940 Genomic DNA No translation available.
AL136099 Genomic DNA No translation available.
AL138918 Genomic DNA No translation available.
AL442124 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47462.1
BC028420 mRNA Translation: AAH28420.1
BC047583 mRNA Translation: AAH47583.1
AF173892 mRNA Translation: AAQ13639.1 Different initiation.
AJ249902 mRNA Translation: CAC10353.1
CCDSiCCDS5307.1 [Q9H3U7-2]
CCDS55076.1 [Q9H3U7-1]
RefSeqiNP_001159884.1, NM_001166412.1 [Q9H3U7-1]
NP_071421.1, NM_022138.2 [Q9H3U7-2]
UniGeneiHs.487200

Genome annotation databases

EnsembliENST00000354536; ENSP00000346537; ENSG00000112562 [Q9H3U7-2]
ENST00000356284; ENSP00000348630; ENSG00000112562 [Q9H3U7-1]
GeneIDi64094
KEGGihsa:64094
UCSCiuc003qwr.2 human [Q9H3U7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014730 mRNA Translation: BAB20267.1
AB014737 mRNA Translation: BAB20274.1
AK056700 mRNA Translation: BAG51789.1
AL832303 mRNA Translation: CAI46175.1
AL109940 Genomic DNA No translation available.
AL136099 Genomic DNA No translation available.
AL138918 Genomic DNA No translation available.
AL442124 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47462.1
BC028420 mRNA Translation: AAH28420.1
BC047583 mRNA Translation: AAH47583.1
AF173892 mRNA Translation: AAQ13639.1 Different initiation.
AJ249902 mRNA Translation: CAC10353.1
CCDSiCCDS5307.1 [Q9H3U7-2]
CCDS55076.1 [Q9H3U7-1]
RefSeqiNP_001159884.1, NM_001166412.1 [Q9H3U7-1]
NP_071421.1, NM_022138.2 [Q9H3U7-2]
UniGeneiHs.487200

3D structure databases

ProteinModelPortaliQ9H3U7
SMRiQ9H3U7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122056, 2 interactors
IntActiQ9H3U7, 1 interactor
STRINGi9606.ENSP00000346537

PTM databases

iPTMnetiQ9H3U7
PhosphoSitePlusiQ9H3U7

Polymorphism and mutation databases

BioMutaiSMOC2
DMDMi38258648

Proteomic databases

EPDiQ9H3U7
MaxQBiQ9H3U7
PaxDbiQ9H3U7
PeptideAtlasiQ9H3U7
PRIDEiQ9H3U7
ProteomicsDBi80763
80764 [Q9H3U7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354536; ENSP00000346537; ENSG00000112562 [Q9H3U7-2]
ENST00000356284; ENSP00000348630; ENSG00000112562 [Q9H3U7-1]
GeneIDi64094
KEGGihsa:64094
UCSCiuc003qwr.2 human [Q9H3U7-1]

Organism-specific databases

CTDi64094
DisGeNETi64094
EuPathDBiHostDB:ENSG00000112562.18
GeneCardsiSMOC2
HGNCiHGNC:20323 SMOC2
HPAiCAB033979
MalaCardsiSMOC2
MIMi125400 phenotype
607223 gene
neXtProtiNX_Q9H3U7
OpenTargetsiENSG00000112562
Orphaneti314721 Atypical dentin dysplasia due to SMOC2 deficiency
PharmGKBiPA134934590
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4578 Eukaryota
ENOG410YP7C LUCA
GeneTreeiENSGT00390000018436
HOVERGENiHBG058558
InParanoidiQ9H3U7
OMAiPRCPGSI
OrthoDBiEOG091G083O
PhylomeDBiQ9H3U7
TreeFamiTF320666

Miscellaneous databases

ChiTaRSiSMOC2 human
GeneWikiiSMOC2
GenomeRNAii64094
PROiPR:Q9H3U7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112562 Expressed in 186 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_SMAP2
ExpressionAtlasiQ9H3U7 baseline and differential
GenevisibleiQ9H3U7 HS

Family and domain databases

CDDicd16241 EFh_SPARC_SMOC2, 1 hit
cd00191 TY, 2 hits
Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR037640 SMOC2_EC
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 2 hits
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSMOC2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3U7
Secondary accession number(s): B3KPS7
, Q4G169, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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