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Entry version 175 (22 Apr 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Protein unc-45 homolog A

Gene

UNC45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).By similarityCurated2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-45 homolog A
Short name:
Unc-45A
Alternative name(s):
GCUNC-45
Smooth muscle cell-associated protein 1
Short name:
SMAP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UNC45A
Synonyms:SMAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30594 UNC45A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611219 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3U1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33K → E: Abolishes interaction with HSP90AB1; when associated with D-40. No effect on interaction with PGR. 1 Publication1
Mutagenesisi40A → D: Abolishes interaction with HSP90AB1; when associated with E-33. No effect on interaction with PGR. 1 Publication1
Mutagenesisi70K → E: Abolishes interaction with HSP90AB1; when associated with D-77. No effect on interaction with PGR. 1 Publication1
Mutagenesisi77A → D: Abolishes interaction with HSP90AB1; when associated with E-70. No effect on interaction with PGR. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55898

Open Targets

More...
OpenTargetsi
ENSG00000140553

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670638

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H3U1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UNC45A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761419

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002498881 – 944Protein unc-45 homolog AAdd BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphothreonineCombined sources1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei483N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H3U1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H3U1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H3U1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3U1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H3U1

PeptideAtlas

More...
PeptideAtlasi
Q9H3U1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3U1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80756 [Q9H3U1-1]
80757 [Q9H3U1-2]
80758 [Q9H3U1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3U1

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9H3U1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H3U1

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9H3U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140553 Expressed in lower esophagus and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H3U1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3U1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140553 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120986, 98 interactors

Protein interaction database and analysis system

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IntActi
Q9H3U1, 72 interactors

Molecular INTeraction database

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MINTi
Q9H3U1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000407487

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H3U1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1944
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H3U1

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H3U1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati21 – 54TPR 1Add BLAST34
Repeati58 – 91TPR 2Add BLAST34
Repeati92 – 125TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4151 Eukaryota
ENOG410XQNT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159320

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_007331_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H3U1

KEGG Orthology (KO)

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KOi
K21991

Identification of Orthologs from Complete Genome Data

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OMAi
CMCNMAM

Database of Orthologous Groups

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OrthoDBi
1059433at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3U1

TreeFam database of animal gene trees

More...
TreeFami
TF314096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 1 hit
PF11701 UNC45-central, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H3U1-1) [UniParc]FASTAAdd to basket
Also known as: 2, SMAP-1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVSGPGTPE PRPATPGASS VEQLRKEGNE LFKCGDYGGA LAAYTQALGL
60 70 80 90 100
DATPQDQAVL HRNRAACHLK LEDYDKAETE ASKAIEKDGG DVKALYRRSQ
110 120 130 140 150
ALEKLGRLDQ AVLDLQRCVS LEPKNKVFQE ALRNIGGQIQ EKVRYMSSTD
160 170 180 190 200
AKVEQMFQIL LDPEEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL
210 220 230 240 250
QRLLDMGETD LMLAALRTLV GICSEHQSRT VATLSILGTR RVVSILGVES
260 270 280 290 300
QAVSLAACHL LQVMFDALKE GVKKGFRGKE GAIIVDPARE LKVLISNLLD
310 320 330 340 350
LLTEVGVSGQ GRDNALTLLI KAVPRKSLKD PNNSLTLWVI DQGLKKILEV
360 370 380 390 400
GGSLQDPPGE LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIK
410 420 430 440 450
SWFEGQGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASEQ
460 470 480 490 500
EEEQLVAVEA LIHAAGKAKR ASFITANGVS LLKDLYKCSE KDSIRIRALV
510 520 530 540 550
GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID AGTRRWAVEG
560 570 580 590 600
LAYLTFDADV KEEFVEDAAA LKALFQLSRL EERSVLFAVA SALVNCTNSY
610 620 630 640 650
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMVC
660 670 680 690 700
MVKTESPVLT SSCRELLSRV FLALVEEVED RGTVVAQGGG RALIPLALEG
710 720 730 740 750
TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLNCSGLQN
760 770 780 790 800
FEALMALTNL AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC
810 820 830 840 850
NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLQRAAAG GLAMLTSMRP
860 870 880 890 900
TLCSRIPQVT THWLEILQAL LLSSNQELQH RGAVVVLNMV EASREIASTL
910 920 930 940
MESEMMEILS VLAKGDHSPV TRAAAACLDK AVEYGLIQPN QDGE
Length:944
Mass (Da):103,077
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i398707D0FF2A703D
GO
Isoform 2 (identifier: Q9H3U1-2) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTVSGPGTPEPRPATPG → MT

Show »
Length:929
Mass (Da):101,675
Checksum:iE5008C816362B094
GO
Isoform 3 (identifier: Q9H3U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-722: Missing.

Show »
Length:222
Mass (Da):24,689
Checksum:iF4A24767BC104FE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PNX8A0A1W2PNX8_HUMAN
Protein unc-45 homolog A
UNC45A
1,084Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZI17A0A5F9ZI17_HUMAN
Protein unc-45 homolog A
UNC45A
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZI32A0A5F9ZI32_HUMAN
Protein unc-45 homolog A
UNC45A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti921T → R in CAB93429 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052629796T → M. Corresponds to variant dbSNP:rs8041035Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0205841 – 722Missing in isoform 3. 1 PublicationAdd BLAST722
Alternative sequenceiVSP_0205851 – 17MTVSG…PATPG → MT in isoform 2. 4 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014729 mRNA Translation: BAB20266.1
AB014736 mRNA Translation: BAB20273.1
AL357537 mRNA Translation: CAB93428.1
AL357538 mRNA Translation: CAB93429.1
AK291622 mRNA Translation: BAF84311.1
AK125721 mRNA Translation: BAG54239.1
CH471101 Genomic DNA Translation: EAX02127.1
BC006214 mRNA Translation: AAH06214.1
BC010995 mRNA Translation: AAH10995.2
BC037992 mRNA Translation: AAH37992.1
BC045635 mRNA Translation: AAH45635.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10367.1 [Q9H3U1-1]
CCDS42082.1 [Q9H3U1-2]

NCBI Reference Sequences

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RefSeqi
NP_001034764.1, NM_001039675.1 [Q9H3U1-2]
NP_001310548.1, NM_001323619.1 [Q9H3U1-1]
NP_001310550.1, NM_001323621.1 [Q9H3U1-2]
NP_061141.2, NM_018671.4 [Q9H3U1-1]
XP_011520081.1, XM_011521779.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000394275; ENSP00000377816; ENSG00000140553 [Q9H3U1-2]
ENST00000418476; ENSP00000407487; ENSG00000140553 [Q9H3U1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55898

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55898

UCSC genome browser

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UCSCi
uc002bqd.3 human [Q9H3U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014729 mRNA Translation: BAB20266.1
AB014736 mRNA Translation: BAB20273.1
AL357537 mRNA Translation: CAB93428.1
AL357538 mRNA Translation: CAB93429.1
AK291622 mRNA Translation: BAF84311.1
AK125721 mRNA Translation: BAG54239.1
CH471101 Genomic DNA Translation: EAX02127.1
BC006214 mRNA Translation: AAH06214.1
BC010995 mRNA Translation: AAH10995.2
BC037992 mRNA Translation: AAH37992.1
BC045635 mRNA Translation: AAH45635.1
CCDSiCCDS10367.1 [Q9H3U1-1]
CCDS42082.1 [Q9H3U1-2]
RefSeqiNP_001034764.1, NM_001039675.1 [Q9H3U1-2]
NP_001310548.1, NM_001323619.1 [Q9H3U1-1]
NP_001310550.1, NM_001323621.1 [Q9H3U1-2]
NP_061141.2, NM_018671.4 [Q9H3U1-1]
XP_011520081.1, XM_011521779.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBANMR-A1-135[»]
SMRiQ9H3U1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120986, 98 interactors
IntActiQ9H3U1, 72 interactors
MINTiQ9H3U1
STRINGi9606.ENSP00000407487

PTM databases

iPTMnetiQ9H3U1
MetOSiteiQ9H3U1
PhosphoSitePlusiQ9H3U1
SwissPalmiQ9H3U1

Polymorphism and mutation databases

BioMutaiUNC45A
DMDMi74761419

Proteomic databases

EPDiQ9H3U1
jPOSTiQ9H3U1
MassIVEiQ9H3U1
MaxQBiQ9H3U1
PaxDbiQ9H3U1
PeptideAtlasiQ9H3U1
PRIDEiQ9H3U1
ProteomicsDBi80756 [Q9H3U1-1]
80757 [Q9H3U1-2]
80758 [Q9H3U1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28924 109 antibodies

The DNASU plasmid repository

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DNASUi
55898

Genome annotation databases

EnsembliENST00000394275; ENSP00000377816; ENSG00000140553 [Q9H3U1-2]
ENST00000418476; ENSP00000407487; ENSG00000140553 [Q9H3U1-1]
GeneIDi55898
KEGGihsa:55898
UCSCiuc002bqd.3 human [Q9H3U1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55898
DisGeNETi55898

GeneCards: human genes, protein and diseases

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GeneCardsi
UNC45A
HGNCiHGNC:30594 UNC45A
HPAiENSG00000140553 Low tissue specificity
MIMi611219 gene
neXtProtiNX_Q9H3U1
OpenTargetsiENSG00000140553
PharmGKBiPA142670638

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00940000159320
HOGENOMiCLU_007331_0_0_1
InParanoidiQ9H3U1
KOiK21991
OMAiCMCNMAM
OrthoDBi1059433at2759
PhylomeDBiQ9H3U1
TreeFamiTF314096

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UNC45A human
EvolutionaryTraceiQ9H3U1

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
UNC45A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55898
PharosiQ9H3U1 Tbio

Protein Ontology

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PROi
PR:Q9H3U1
RNActiQ9H3U1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140553 Expressed in lower esophagus and 211 other tissues
ExpressionAtlasiQ9H3U1 baseline and differential
GenevisibleiQ9H3U1 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN45A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3U1
Secondary accession number(s): A8K6F7
, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2001
Last modified: April 22, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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