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Protein

Protein unc-45 homolog A

Gene

UNC45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).By similarityCurated2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog A
Short name:
Unc-45A
Alternative name(s):
GCUNC-45
Smooth muscle cell-associated protein 1
Short name:
SMAP-1
Gene namesi
Name:UNC45A
Synonyms:SMAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140553.16
HGNCiHGNC:30594 UNC45A
MIMi611219 gene
neXtProtiNX_Q9H3U1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33K → E: Abolishes interaction with HSP90AB1; when associated with D-40. No effect on interaction with PGR. 1 Publication1
Mutagenesisi40A → D: Abolishes interaction with HSP90AB1; when associated with E-33. No effect on interaction with PGR. 1 Publication1
Mutagenesisi70K → E: Abolishes interaction with HSP90AB1; when associated with D-77. No effect on interaction with PGR. 1 Publication1
Mutagenesisi77A → D: Abolishes interaction with HSP90AB1; when associated with E-70. No effect on interaction with PGR. 1 Publication1

Organism-specific databases

DisGeNETi55898
OpenTargetsiENSG00000140553
PharmGKBiPA142670638

Polymorphism and mutation databases

BioMutaiUNC45A
DMDMi74761419

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498881 – 944Protein unc-45 homolog AAdd BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineCombined sources1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei483N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H3U1
MaxQBiQ9H3U1
PaxDbiQ9H3U1
PeptideAtlasiQ9H3U1
PRIDEiQ9H3U1
ProteomicsDBi80756
80757 [Q9H3U1-2]
80758 [Q9H3U1-3]

PTM databases

iPTMnetiQ9H3U1
PhosphoSitePlusiQ9H3U1
SwissPalmiQ9H3U1

Expressioni

Tissue specificityi

Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach.1 Publication

Gene expression databases

BgeeiENSG00000140553
CleanExiHS_SMAP1
HS_UNC45A
ExpressionAtlasiQ9H3U1 baseline and differential
GenevisibleiQ9H3U1 HS

Organism-specific databases

HPAiHPA039228

Interactioni

Subunit structurei

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120986, 88 interactors
IntActiQ9H3U1, 67 interactors
MINTiQ9H3U1
STRINGi9606.ENSP00000407487

Structurei

Secondary structure

1944
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 32Combined sources12
Turni33 – 35Combined sources3
Helixi37 – 48Combined sources12
Helixi54 – 70Combined sources17
Helixi74 – 87Combined sources14
Helixi92 – 105Combined sources14
Helixi108 – 121Combined sources14
Helixi126 – 135Combined sources10

3D structure databases

ProteinModelPortaliQ9H3U1
SMRiQ9H3U1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H3U1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 54TPR 1Add BLAST34
Repeati58 – 91TPR 2Add BLAST34
Repeati92 – 125TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000285994
HOVERGENiHBG057344
InParanoidiQ9H3U1
KOiK21991
OMAiDQGLKKI
OrthoDBiEOG091G02FM
PhylomeDBiQ9H3U1
TreeFamiTF314096

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3U1-1) [UniParc]FASTAAdd to basket
Also known as: 2, SMAP-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVSGPGTPE PRPATPGASS VEQLRKEGNE LFKCGDYGGA LAAYTQALGL
60 70 80 90 100
DATPQDQAVL HRNRAACHLK LEDYDKAETE ASKAIEKDGG DVKALYRRSQ
110 120 130 140 150
ALEKLGRLDQ AVLDLQRCVS LEPKNKVFQE ALRNIGGQIQ EKVRYMSSTD
160 170 180 190 200
AKVEQMFQIL LDPEEKGTEK KQKASQNLVV LAREDAGAEK IFRSNGVQLL
210 220 230 240 250
QRLLDMGETD LMLAALRTLV GICSEHQSRT VATLSILGTR RVVSILGVES
260 270 280 290 300
QAVSLAACHL LQVMFDALKE GVKKGFRGKE GAIIVDPARE LKVLISNLLD
310 320 330 340 350
LLTEVGVSGQ GRDNALTLLI KAVPRKSLKD PNNSLTLWVI DQGLKKILEV
360 370 380 390 400
GGSLQDPPGE LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIK
410 420 430 440 450
SWFEGQGLAG KLRAIQTVSC LLQGPCDAGN RALELSGVME SVIALCASEQ
460 470 480 490 500
EEEQLVAVEA LIHAAGKAKR ASFITANGVS LLKDLYKCSE KDSIRIRALV
510 520 530 540 550
GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID AGTRRWAVEG
560 570 580 590 600
LAYLTFDADV KEEFVEDAAA LKALFQLSRL EERSVLFAVA SALVNCTNSY
610 620 630 640 650
DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMVC
660 670 680 690 700
MVKTESPVLT SSCRELLSRV FLALVEEVED RGTVVAQGGG RALIPLALEG
710 720 730 740 750
TDVGQTKAAQ ALAKLTITSN PEMTFPGERI YEVVRPLVSL LHLNCSGLQN
760 770 780 790 800
FEALMALTNL AGISERLRQK ILKEKAVPMI EGYMFEEHEM IRRAATECMC
810 820 830 840 850
NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLQRAAAG GLAMLTSMRP
860 870 880 890 900
TLCSRIPQVT THWLEILQAL LLSSNQELQH RGAVVVLNMV EASREIASTL
910 920 930 940
MESEMMEILS VLAKGDHSPV TRAAAACLDK AVEYGLIQPN QDGE
Length:944
Mass (Da):103,077
Last modified:March 1, 2001 - v1
Checksum:i398707D0FF2A703D
GO
Isoform 2 (identifier: Q9H3U1-2) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTVSGPGTPEPRPATPG → MT

Show »
Length:929
Mass (Da):101,675
Checksum:iE5008C816362B094
GO
Isoform 3 (identifier: Q9H3U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-722: Missing.

Show »
Length:222
Mass (Da):24,689
Checksum:iF4A24767BC104FE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti921T → R in CAB93429 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052629796T → M. Corresponds to variant dbSNP:rs8041035Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0205841 – 722Missing in isoform 3. 1 PublicationAdd BLAST722
Alternative sequenceiVSP_0205851 – 17MTVSG…PATPG → MT in isoform 2. 4 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014729 mRNA Translation: BAB20266.1
AB014736 mRNA Translation: BAB20273.1
AL357537 mRNA Translation: CAB93428.1
AL357538 mRNA Translation: CAB93429.1
AK291622 mRNA Translation: BAF84311.1
AK125721 mRNA Translation: BAG54239.1
CH471101 Genomic DNA Translation: EAX02127.1
BC006214 mRNA Translation: AAH06214.1
BC010995 mRNA Translation: AAH10995.2
BC037992 mRNA Translation: AAH37992.1
BC045635 mRNA Translation: AAH45635.1
CCDSiCCDS10367.1 [Q9H3U1-1]
CCDS42082.1 [Q9H3U1-2]
RefSeqiNP_001034764.1, NM_001039675.1 [Q9H3U1-2]
NP_001310548.1, NM_001323619.1 [Q9H3U1-1]
NP_001310550.1, NM_001323621.1 [Q9H3U1-2]
NP_061141.2, NM_018671.4 [Q9H3U1-1]
XP_011520081.1, XM_011521779.2 [Q9H3U1-1]
UniGeneiHs.389461

Genome annotation databases

EnsembliENST00000394275; ENSP00000377816; ENSG00000140553 [Q9H3U1-2]
ENST00000418476; ENSP00000407487; ENSG00000140553 [Q9H3U1-1]
GeneIDi55898
KEGGihsa:55898
UCSCiuc002bqd.3 human [Q9H3U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUN45A_HUMAN
AccessioniPrimary (citable) accession number: Q9H3U1
Secondary accession number(s): A8K6F7
, Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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