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Entry version 159 (10 Apr 2019)
Sequence version 4 (17 Oct 2006)
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Protein

Semaphorin-6B

Gene

SEMA6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in both peripheral and central nervous system development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Semaphorin-6B
Alternative name(s):
Semaphorin-Z
Short name:
Sema Z
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEMA6B
Synonyms:SEMAN, SEMAZ
ORF Names:UNQ1907/PRO4353
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167680.15

Human Gene Nomenclature Database

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HGNCi
HGNC:10739 SEMA6B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608873 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3T3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 603ExtracellularSequence analysisAdd BLAST578
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 888CytoplasmicSequence analysisAdd BLAST264

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10501

Open Targets

More...
OpenTargetsi
ENSG00000167680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35661

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEMA6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242786

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003234126 – 888Semaphorin-6BAdd BLAST863

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi116 ↔ 126PROSITE-ProRule annotation
Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi267 ↔ 378PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi292 ↔ 337PROSITE-ProRule annotation
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi486 ↔ 517PROSITE-ProRule annotation
Disulfide bondi526 ↔ 544PROSITE-ProRule annotation
Disulfide bondi532 ↔ 578PROSITE-ProRule annotation
Disulfide bondi536 ↔ 552PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei665Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H3T3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H3T3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H3T3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3T3

PeptideAtlas

More...
PeptideAtlasi
Q9H3T3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3T3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80754

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3T3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3T3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167680 Expressed in 132 organ(s), highest expression level in dorsolateral prefrontal cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H3T3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025157
HPA055778
HPA058523

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000467290

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H3T3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3T3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 523SemaPROSITE-ProRule annotationAdd BLAST493

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi661 – 674Poly-GlyAdd BLAST14
Compositional biasi750 – 753Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3611 Eukaryota
ENOG410XQZC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159170

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232047

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG072910

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H3T3

KEGG Orthology (KO)

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KOi
K06842

Identification of Orthologs from Complete Genome Data

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OMAi
CWIMSHR

Database of Orthologous Groups

More...
OrthoDBi
119118at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3T3

TreeFam database of animal gene trees

More...
TreeFami
TF316102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002165 Plexin_repeat
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11036 PTHR11036, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H3T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQTPRASPPR PALLLLLLLL GGAHGLFPEE PPPLSVAPRD YLNHYPVFVG
60 70 80 90 100
SGPGRLTPAE GADDLNIQRV LRVNRTLFIG DRDNLYRVEL EPPTSTELRY
110 120 130 140 150
QRKLTWRSNP SDINVCRMKG KQEGECRNFV KVLLLRDEST LFVCGSNAFN
160 170 180 190 200
PVCANYSIDT LQPVGDNISG MARCPYDPKH ANVALFSDGM LFTATVTDFL
210 220 230 240 250
AIDAVIYRSL GDRPTLRTVK HDSKWFKEPY FVHAVEWGSH VYFFFREIAM
260 270 280 290 300
EFNYLEKVVV SRVARVCKND VGGSPRVLEK QWTSFLKARL NCSVPGDSHF
310 320 330 340 350
YFNVLQAVTG VVSLGGRPVV LAVFSTPSNS IPGSAVCAFD LTQVAAVFEG
360 370 380 390 400
RFREQKSPES IWTPVPEDQV PRPRPGCCAA PGMQYNASSA LPDDILNFVK
410 420 430 440 450
THPLMDEAVP SLGHAPWILR TLMRHQLTRV AVDVGAGPWG NQTVVFLGSE
460 470 480 490 500
AGTVLKFLVR PNASTSGTSG LSVFLEEFET YRPDRCGRPG GGETGQRLLS
510 520 530 540 550
LELDAASGGL LAAFPRCVVR VPVARCQQYS GCMKNCIGSQ DPYCGWAPDG
560 570 580 590 600
SCIFLSPGTR AAFEQDVSGA STSGLGDCTG LLRASLSEDR AGLVSVNLLV
610 620 630 640 650
TSSVAAFVVG AVVSGFSVGW FVGLRERREL ARRKDKEAIL AHGAGEAVLS
660 670 680 690 700
VSRLGERRAQ GPGGRGGGGG GGAGVPPEAL LAPLMQNGWA KATLLQGGPH
710 720 730 740 750
DLDSGLLPTP EQTPLPQKRL PTPHPHPHAL GPRAWDHGHP LLPASASSSL
760 770 780 790 800
LLLAPARAPE QPPAPGEPTP DGRLYAARPG RASHGDFPLT PHASPDRRRV
810 820 830 840 850
VSAPTGPLDP ASAADGLPRP WSPPPTGSLR RPLGPHAPPA ATLRRTHTFN
860 870 880
SGEARPGDRH RGCHARPGTD LAHLLPYGGA DRTAPPVP
Length:888
Mass (Da):95,285
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF34843A4A7A4E1C
GO
Isoform 2 (identifier: Q9H3T3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     620-677: WFVGLRERRE...GGGGGAGVPP → VCVRASEGCC...RGSPRCRLGV
     678-888: Missing.

Show »
Length:677
Mass (Da):73,952
Checksum:i99B68C53C88E80C2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF87661 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30E → D in BAB20669 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047625620 – 677WFVGL…AGVPP → VCVRASEGCCGRVCQVGHAC RVCVHERRSWWPQRPGRWLS RRWGFQKARGSPRCRLGV in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_047626678 – 888Missing in isoform 2. 1 PublicationAdd BLAST211

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB022433 mRNA Translation: BAB20669.1
AF216389 mRNA Translation: AAF87661.1 Sequence problems.
FR839673 mRNA Translation: CCA61013.1
AY358939 mRNA Translation: AAQ89298.1
AC011498 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69208.1
BC142617 mRNA Translation: AAI42618.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12131.1 [Q9H3T3-1]

NCBI Reference Sequences

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RefSeqi
NP_115484.2, NM_032108.3 [Q9H3T3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.465642

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000586582; ENSP00000467290; ENSG00000167680 [Q9H3T3-1]
ENST00000586965; ENSP00000465722; ENSG00000167680 [Q9H3T3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10501

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10501

UCSC genome browser

More...
UCSCi
uc010dud.3 human [Q9H3T3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022433 mRNA Translation: BAB20669.1
AF216389 mRNA Translation: AAF87661.1 Sequence problems.
FR839673 mRNA Translation: CCA61013.1
AY358939 mRNA Translation: AAQ89298.1
AC011498 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69208.1
BC142617 mRNA Translation: AAI42618.1
CCDSiCCDS12131.1 [Q9H3T3-1]
RefSeqiNP_115484.2, NM_032108.3 [Q9H3T3-1]
UniGeneiHs.465642

3D structure databases

ProteinModelPortaliQ9H3T3
SMRiQ9H3T3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000467290

PTM databases

iPTMnetiQ9H3T3
PhosphoSitePlusiQ9H3T3

Polymorphism and mutation databases

BioMutaiSEMA6B
DMDMi116242786

Proteomic databases

EPDiQ9H3T3
jPOSTiQ9H3T3
MaxQBiQ9H3T3
PaxDbiQ9H3T3
PeptideAtlasiQ9H3T3
PRIDEiQ9H3T3
ProteomicsDBi80754

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000586582; ENSP00000467290; ENSG00000167680 [Q9H3T3-1]
ENST00000586965; ENSP00000465722; ENSG00000167680 [Q9H3T3-3]
GeneIDi10501
KEGGihsa:10501
UCSCiuc010dud.3 human [Q9H3T3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10501
DisGeNETi10501
EuPathDBiHostDB:ENSG00000167680.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SEMA6B
HGNCiHGNC:10739 SEMA6B
HPAiCAB025157
HPA055778
HPA058523
MIMi608873 gene
neXtProtiNX_Q9H3T3
OpenTargetsiENSG00000167680
PharmGKBiPA35661

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00940000159170
HOGENOMiHOG000232047
HOVERGENiHBG072910
InParanoidiQ9H3T3
KOiK06842
OMAiCWIMSHR
OrthoDBi119118at2759
PhylomeDBiQ9H3T3
TreeFamiTF316102

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10501

Protein Ontology

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PROi
PR:Q9H3T3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167680 Expressed in 132 organ(s), highest expression level in dorsolateral prefrontal cortex
GenevisibleiQ9H3T3 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEM6B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3T3
Secondary accession number(s): A5PKU4, F6IB19, Q9NRK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: April 10, 2019
This is version 159 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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