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Protein

Tyrosine-protein phosphatase non-receptor type 23

Gene

PTPN23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1392Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cellular response to cytokine stimulus Source: Reactome
  • cilium assembly Source: UniProtKB
  • early endosome to late endosome transport Source: FlyBase
  • endocytic recycling Source: FlyBase
  • negative regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of adherens junction organization Source: UniProtKB
  • positive regulation of early endosome to late endosome transport Source: UniProtKB
  • positive regulation of homophilic cell adhesion Source: UniProtKB
  • positive regulation of Wnt protein secretion Source: FlyBase
  • protein transport Source: UniProtKB-KW
  • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-9008059 Interleukin-37 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
Alternative name(s):
His domain-containing protein tyrosine phosphatase
Short name:
HD-PTP
Protein tyrosine phosphatase TD14
Short name:
PTP-TD14
Gene namesi
Name:PTPN23
Synonyms:KIAA1471
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000076201.14
HGNCiHGNC:14406 PTPN23
MIMi606584 gene
neXtProtiNX_Q9H3S7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi202L → D: Nearly abolishes interaction with CHMP4B. Abolishes interaction with CHMP4B; when associated with D-206. 1 Publication1
Mutagenesisi206I → D: Abolishes interaction with CHMP4B; when associated with D-202. 1 Publication1
Mutagenesisi678F → D: Abolishes interaction with UBAP1. 1 Publication1

Organism-specific databases

DisGeNETi25930
OpenTargetsiENSG00000076201
PharmGKBiPA33996

Polymorphism and mutation databases

BioMutaiPTPN23
DMDMi68053318

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947771 – 1636Tyrosine-protein phosphatase non-receptor type 23Add BLAST1636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei733PhosphoserineCombined sources1
Modified residuei950Omega-N-methylarginineCombined sources1
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1123PhosphoserineCombined sources1
Modified residuei1131PhosphothreonineCombined sources1
Modified residuei1615Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9H3S7
MaxQBiQ9H3S7
PaxDbiQ9H3S7
PeptideAtlasiQ9H3S7
PRIDEiQ9H3S7
ProteomicsDBi80750

PTM databases

DEPODiQ9H3S7
iPTMnetiQ9H3S7
PhosphoSitePlusiQ9H3S7

Expressioni

Gene expression databases

BgeeiENSG00000076201
CleanExiHS_PTPN23
ExpressionAtlasiQ9H3S7 baseline and differential
GenevisibleiQ9H3S7 HS

Organism-specific databases

HPAiHPA016845

Interactioni

Subunit structurei

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117430, 46 interactors
DIPiDIP-29923N
IntActiQ9H3S7, 37 interactors
MINTiQ9H3S7
STRINGi9606.ENSP00000265562

Structurei

Secondary structure

11636
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 20Combined sources4
Helixi22 – 33Combined sources12
Turni38 – 41Combined sources4
Helixi42 – 56Combined sources15
Helixi62 – 81Combined sources20
Beta strandi94 – 97Combined sources4
Turni99 – 101Combined sources3
Beta strandi104 – 108Combined sources5
Helixi110 – 131Combined sources22
Helixi137 – 160Combined sources24
Helixi167 – 169Combined sources3
Helixi171 – 195Combined sources25
Helixi200 – 221Combined sources22
Helixi224 – 230Combined sources7
Helixi232 – 262Combined sources31
Helixi266 – 286Combined sources21
Turni287 – 289Combined sources3
Helixi292 – 318Combined sources27
Helixi327 – 329Combined sources3
Helixi349 – 352Combined sources4
Turni356 – 359Combined sources4
Helixi365 – 370Combined sources6
Helixi373 – 400Combined sources28
Helixi412 – 415Combined sources4
Helixi419 – 429Combined sources11
Helixi434 – 475Combined sources42
Helixi490 – 529Combined sources40
Helixi533 – 539Combined sources7
Helixi547 – 583Combined sources37
Turni588 – 591Combined sources4
Helixi601 – 605Combined sources5
Helixi606 – 609Combined sources4
Helixi610 – 621Combined sources12
Helixi623 – 635Combined sources13
Helixi638 – 703Combined sources66
Turni704 – 707Combined sources4

3D structure databases

ProteinModelPortaliQ9H3S7
SMRiQ9H3S7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H3S7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 394BRO1PROSITE-ProRule annotationAdd BLAST387
Repeati250 – 283TPR 1Add BLAST34
Repeati374 – 407TPR 2Add BLAST34
Repeati953 – 95412
Repeati955 – 95622
Repeati957 – 95832
Repeati959 – 96042
Repeati961 – 96252
Repeati963 – 96462
Domaini1192 – 1452Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni770 – 1130HisAdd BLAST361
Regioni953 – 9646 X 2 AA approximate tandem repeats of P-QAdd BLAST12

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili550 – 623Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi716 – 1108Pro-richAdd BLAST393
Compositional biasi1509 – 1573Pro-richAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
KOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00780000121909
HOVERGENiHBG082231
InParanoidiQ9H3S7
KOiK18040
OMAiMKMACTH
OrthoDBiEOG091G02XV
PhylomeDBiQ9H3S7
TreeFamiTF323502

Family and domain databases

Gene3Di1.25.40.280, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR025304 ALIX_V_dom
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR028770 PTPN23
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR19134:SF333 PTHR19134:SF333, 1 hit
PfamiView protein in Pfam
PF13949 ALIX_LYPXL_bnd, 1 hit
PF03097 BRO1, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H3S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVPRMPMI WLDLKEAGDF HFQPAVKKFV LKNYGENPEA YNEELKKLEL
60 70 80 90 100
LRQNAVRVPR DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVPVTWTEIF
110 120 130 140 150
SGKSVAHEDI KYEQACILYN LGALHSMLGA MDKRVSEEGM KVSCTHFQCA
160 170 180 190 200
AGAFAYLREH FPQAYSVDMS RQILTLNVNL MLGQAQECLL EKSMLDNRKS
210 220 230 240 250
FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL VQMKIYYFAA
260 270 280 290 300
VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF
310 320 330 340 350
TMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA
360 370 380 390 400
VTGPDIFAKL VPMAAHEASS LYSEEKAKLL REMMAKIEDK NEVLDQFMDS
410 420 430 440 450
MQLDPETVDN LDAYSHIPPQ LMEKCAALSV RPDTVRNLVQ SMQVLSGVFT
460 470 480 490 500
DVEASLKDIR DLLEEDELLE QKFQEAVGQA GAISITSKAE LAEVRREWAK
510 520 530 540 550
YMEVHEKASF TNSELHRAMN LHVGNLRLLS GPLDQVRAAL PTPALSPEDK
560 570 580 590 600
AVLQNLKRIL AKVQEMRDQR VSLEQQLREL IQKDDITASL VTTDHSEMKK
610 620 630 640 650
LFEEQLKKYD QLKVYLEQNL AAQDRVLCAL TEANVQYAAV RRVLSDLDQK
660 670 680 690 700
WNSTLQTLVA SYEAYEDLMK KSQEGRDFYA DLESKVAALL ERTQSTCQAR
710 720 730 740 750
EAARQQLLDR ELKKKPPPRP TAPKPLLPRR EESEAVEAGD PPEELRSLPP
760 770 780 790 800
DMVAGPRLPD TFLGSATPLH FPPSPFPSST GPGPHYLSGP LPPGTYSGPT
810 820 830 840 850
QLIQPRAPGP HAMPVAPGPA LYPAPAYTPE LGLVPRSSPQ HGVVSSPYVG
860 870 880 890 900
VGPAPPVAGL PSAPPPQFSG PELAMAVRPA TTTVDSIQAP IPSHTAPRPN
910 920 930 940 950
PTPAPPPPCF PVPPPQPLPT PYTYPAGAKQ PIPAQHHFSS GIPAGFPAPR
960 970 980 990 1000
IGPQPQPHPQ PHPSQAFGPQ PPQQPLPLQH PHLFPPQAPG LLPPQSPYPY
1010 1020 1030 1040 1050
APQPGVLGQP PPPLHTQLYP GPAQDPLPAH SGALPFPSPG PPQPPHPPLA
1060 1070 1080 1090 1100
YGPAPSTRPM GPQAAPLTIR GPSSAGQSTP SPHLVPSPAP SPGPGPVPPR
1110 1120 1130 1140 1150
PPAAEPPPCL RRGAAAADLL SSSPESQHGG TQSPGGGQPL LQPTKVDAAE
1160 1170 1180 1190 1200
GRRPQALRLI ERDPYEHPER LRQLQQELEA FRGQLGDVGA LDTVWRELQD
1210 1220 1230 1240 1250
AQEHDARGRS IAIARCYSLK NRHQDVMPYD SNRVVLRSGK DDYINASCVE
1260 1270 1280 1290 1300
GLSPYCPPLV ATQAPLPGTA ADFWLMVHEQ KVSVIVMLVS EAEMEKQKVA
1310 1320 1330 1340 1350
RYFPTERGQP MVHGALSLAL SSVRSTETHV ERVLSLQFRD QSLKRSLVHL
1360 1370 1380 1390 1400
HFPTWPELGL PDSPSNLLRF IQEVHAHYLH QRPLHTPIIV HCSSGVGRTG
1410 1420 1430 1440 1450
AFALLYAAVQ EVEAGNGIPE LPQLVRRMRQ QRKHMLQEKL HLRFCYEAVV
1460 1470 1480 1490 1500
RHVEQVLQRH GVPPPCKPLA SASISQKNHL PQDSQDLVLG GDVPISSIQA
1510 1520 1530 1540 1550
TIAKLSIRPP GGLESPVASL PGPAEPPGLP PASLPESTPI PSSSPPPLSS
1560 1570 1580 1590 1600
PLPEAPQPKE EPPVPEAPSS GPPSSSLELL ASLTPEAFSL DSSLRGKQRM
1610 1620 1630
SKHNFLQAHN GQGLRATRPS DDPLSLLDPL WTLNKT
Length:1,636
Mass (Da):178,974
Last modified:March 1, 2001 - v1
Checksum:i536BDDF9D3DC95C0
GO

Sequence cautioni

The sequence BAA95995 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti647L → G in CAB53676 (PubMed:17974005).Curated1
Sequence conflicti1087S → P in CAB53676 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022682944A → T2 PublicationsCorresponds to variant dbSNP:rs6780013Ensembl.1
Natural variantiVAR_0226831099P → S in a lung cancer cell line; may be a common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs149563514Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025194 mRNA Translation: BAB19280.1
AF290614 mRNA Translation: AAK28025.1
AK289502 mRNA Translation: BAF82191.1
CH471055 Genomic DNA Translation: EAW64823.1
BC004881 mRNA Translation: AAH04881.2
BC027711 mRNA Translation: AAH27711.2
BC089042 mRNA Translation: AAH89042.1
AB040904 mRNA Translation: BAA95995.2 Different initiation.
AL110210 mRNA Translation: CAB53676.1
BT009758 mRNA Translation: AAP88760.1
AF169350 mRNA Translation: AAD50276.1
CCDSiCCDS2754.1
PIRiT14756
RefSeqiNP_001291411.1, NM_001304482.1
NP_056281.1, NM_015466.3
UniGeneiHs.25524

Genome annotation databases

EnsembliENST00000265562; ENSP00000265562; ENSG00000076201
GeneIDi25930
KEGGihsa:25930
UCSCiuc003crf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTN23_HUMAN
AccessioniPrimary (citable) accession number: Q9H3S7
Secondary accession number(s): A8K0D7
, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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