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Protein

Centromere protein H

Gene

CENPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.3 Publications

GO - Molecular functioni

  • kinetochore binding Source: UniProtKB

GO - Biological processi

  • CENP-A containing nucleosome assembly Source: Reactome
  • kinetochore assembly Source: InterPro
  • kinetochore organization Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein H
Short name:
CENP-H
Alternative name(s):
Interphase centromere complex protein 35
Gene namesi
Name:CENPHImported
Synonyms:ICEN35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153044.9
HGNCiHGNC:17268 CENPH
MIMi605607 gene
neXtProtiNX_Q9H3R5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64946
OpenTargetsiENSG00000153044
PharmGKBiPA26402

Polymorphism and mutation databases

BioMutaiCENPH
DMDMi74733576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894781 – 247Centromere protein HAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei68PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H3R5
MaxQBiQ9H3R5
PaxDbiQ9H3R5
PeptideAtlasiQ9H3R5
PRIDEiQ9H3R5
ProteomicsDBi80745

PTM databases

iPTMnetiQ9H3R5
PhosphoSitePlusiQ9H3R5

Expressioni

Gene expression databases

BgeeiENSG00000153044 Expressed in 138 organ(s), highest expression level in testis
CleanExiHS_CENPH
ExpressionAtlasiQ9H3R5 baseline and differential
GenevisibleiQ9H3R5 HS

Organism-specific databases

HPAiHPA036494

Interactioni

Subunit structurei

Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi122355, 40 interactors
CORUMiQ9H3R5
IntActiQ9H3R5, 35 interactors
MINTiQ9H3R5
STRINGi9606.ENSP00000283006

Structurei

3D structure databases

ProteinModelPortaliQ9H3R5
SMRiQ9H3R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 192Sequence analysisAdd BLAST146

Sequence similaritiesi

Belongs to the CENP-H/MCM16 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9S Eukaryota
ENOG410Y6WK LUCA
GeneTreeiENSGT00390000009578
HOGENOMiHOG000013068
HOVERGENiHBG081083
InParanoidiQ9H3R5
KOiK11500
OMAiKSMIDAN
OrthoDBiEOG091G1AJR
PhylomeDBiQ9H3R5
TreeFamiTF101134

Family and domain databases

InterProiView protein in InterPro
IPR040034 CENP-H
IPR008426 CENP-H_C
PANTHERiPTHR28662 PTHR28662, 1 hit
PfamiView protein in Pfam
PF05837 CENP-H, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H3R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEQPQMQDA DEPADSGGEG RAGGPPQVAG AQAACSEDRM TLLLRLRAQT
60 70 80 90 100
KQQLLEYKSM VDASEEKTPE QIMQEKQIEA KIEDLENEIE EVKVAFEIKK
110 120 130 140 150
LALDRMRLST ALKKNLEKIS RQSSVLMDNM KHLLELNKLI MKSQQESWDL
160 170 180 190 200
EEKLLDIRKK RLQLKQASES KLLEIQTEKN KQKIDLDSME NSERIKIIRQ
210 220 230 240
NLQMEIKITT VIQHVFQNLI LGSKVNWAED PALKEIVLQL EKNVDMM
Length:247
Mass (Da):28,481
Last modified:March 1, 2001 - v1
Checksum:iE1BCD4022710168F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KVZ3B3KVZ3_HUMAN
Centromere protein H, isoform CRA_b
CENPH hCG_27171
228Annotation score:
H0Y9E6H0Y9E6_HUMAN
Centromere protein H
CENPH
187Annotation score:
D6RBJ6D6RBJ6_HUMAN
Centromere protein H isoform 2
CENPH
98Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0361672E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs777698677Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035124 mRNA Translation: BAB18635.1
AK290746 mRNA Translation: BAF83435.1
CH471137 Genomic DNA Translation: EAW51304.1
BC015355 mRNA Translation: AAH15355.1
BC012024 mRNA Translation: AAH12024.1
CCDSiCCDS3998.1
RefSeqiNP_075060.1, NM_022909.3
UniGeneiHs.631967

Genome annotation databases

EnsembliENST00000283006; ENSP00000283006; ENSG00000153044
GeneIDi64946
KEGGihsa:64946
UCSCiuc003jvp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035124 mRNA Translation: BAB18635.1
AK290746 mRNA Translation: BAF83435.1
CH471137 Genomic DNA Translation: EAW51304.1
BC015355 mRNA Translation: AAH15355.1
BC012024 mRNA Translation: AAH12024.1
CCDSiCCDS3998.1
RefSeqiNP_075060.1, NM_022909.3
UniGeneiHs.631967

3D structure databases

ProteinModelPortaliQ9H3R5
SMRiQ9H3R5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122355, 40 interactors
CORUMiQ9H3R5
IntActiQ9H3R5, 35 interactors
MINTiQ9H3R5
STRINGi9606.ENSP00000283006

PTM databases

iPTMnetiQ9H3R5
PhosphoSitePlusiQ9H3R5

Polymorphism and mutation databases

BioMutaiCENPH
DMDMi74733576

Proteomic databases

EPDiQ9H3R5
MaxQBiQ9H3R5
PaxDbiQ9H3R5
PeptideAtlasiQ9H3R5
PRIDEiQ9H3R5
ProteomicsDBi80745

Protocols and materials databases

DNASUi64946
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283006; ENSP00000283006; ENSG00000153044
GeneIDi64946
KEGGihsa:64946
UCSCiuc003jvp.3 human

Organism-specific databases

CTDi64946
DisGeNETi64946
EuPathDBiHostDB:ENSG00000153044.9
GeneCardsiCENPH
HGNCiHGNC:17268 CENPH
HPAiHPA036494
MIMi605607 gene
neXtProtiNX_Q9H3R5
OpenTargetsiENSG00000153044
PharmGKBiPA26402
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9S Eukaryota
ENOG410Y6WK LUCA
GeneTreeiENSGT00390000009578
HOGENOMiHOG000013068
HOVERGENiHBG081083
InParanoidiQ9H3R5
KOiK11500
OMAiKSMIDAN
OrthoDBiEOG091G1AJR
PhylomeDBiQ9H3R5
TreeFamiTF101134

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiCENPH human
GeneWikiiCENPH
GenomeRNAii64946
PROiPR:Q9H3R5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153044 Expressed in 138 organ(s), highest expression level in testis
CleanExiHS_CENPH
ExpressionAtlasiQ9H3R5 baseline and differential
GenevisibleiQ9H3R5 HS

Family and domain databases

InterProiView protein in InterPro
IPR040034 CENP-H
IPR008426 CENP-H_C
PANTHERiPTHR28662 PTHR28662, 1 hit
PfamiView protein in Pfam
PF05837 CENP-H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPH_HUMAN
AccessioniPrimary (citable) accession number: Q9H3R5
Secondary accession number(s): A8K3Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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