MUC13

Functionⁱ

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11278439

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

maintenance of gastrointestinal epithelium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17058067
O-glycan processing Source: Reactome
stimulatory C-type lectin receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5621480 Dectin-2 family R-HSA-913709 O-linked glycosylation of mucins R-HSA-977068 Termination of O-glycan biosynthesis

Reactomeⁱ

R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mucin-13 Short name: MUC-13 Alternative name(s): Down-regulated in colon cancer 1
Gene namesⁱ	Name:MUC13 Synonyms:DRCC1, RECC ORF Names:UNQ6194/PRO20221
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173702.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7511 MUC13
MIMⁱ	612181 gene
neXtProtⁱ	NX_Q9H3R2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 421	ExtracellularSequence analysisAdd BLAST	403
Transmembraneⁱ	422 – 442	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	443 – 512	CytoplasmicSequence analysisAdd BLAST	70

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56667
Open Targets More...OpenTargetsⁱ	ENSG00000173702
PharmGKBⁱ	PA31312

Polymorphism and mutation databases

BioMutaⁱ	MUC13
DMDMⁱ	296438300

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000019284	19 – 512	Mucin-13Add BLAST		494

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	151	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	169	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	177 ↔ 188	PROSITE-ProRule annotation
Disulfide bondⁱ	182 ↔ 197	PROSITE-ProRule annotation
Glycosylationⁱ	193	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	199 ↔ 210	PROSITE-ProRule annotation
Glycosylationⁱ	206	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	284	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	326 ↔ 338	PROSITE-ProRule annotation
Disulfide bondⁱ	331 ↔ 344	PROSITE-ProRule annotation
Glycosylationⁱ	332	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	346 ↔ 360	PROSITE-ProRule annotation
Disulfide bondⁱ	367 ↔ 378	PROSITE-ProRule annotation
Disulfide bondⁱ	371 ↔ 389	PROSITE-ProRule annotation
Disulfide bondⁱ	391 ↔ 403	PROSITE-ProRule annotation

Post-translational modificationⁱ

Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.

Highly N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H3R2
PaxDbⁱ	Q9H3R2
PeptideAtlas More...PeptideAtlasⁱ	Q9H3R2
PRIDEⁱ	Q9H3R2
ProteomicsDBⁱ	80744

PTM databases

iPTMnetⁱ	Q9H3R2
PhosphoSitePlusⁱ	Q9H3R2

Expressionⁱ

Tissue specificityⁱ

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000173702
CleanExⁱ	HS_MUC13
ExpressionAtlasⁱ	Q9H3R2 baseline and differential
Genevisibleⁱ	Q9H3R2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045163

HPAⁱ

HPA045163

Interactionⁱ

Subunit structureⁱ

Homodimer of beta subunits.1 Publication

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11278439

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121177, 17 interactors
IntActⁱ	Q9H3R2, 15 interactors
STRINGⁱ	9606.ENSP00000312235

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H3R2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	173 – 211	EGF-like 1PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	212 – 336	SEAPROSITE-ProRule annotationAdd BLAST	125
Domainⁱ	322 – 361	EGF-like 2PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	363 – 404	EGF-like 3PROSITE-ProRule annotationAdd BLAST	42

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	29 – 171	Thr-richAdd BLAST		143

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXVD Eukaryota ENOG410XXX6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106845
HOGENOMⁱ	HOG000168414
HOVERGENⁱ	HBG052532
InParanoidⁱ	Q9H3R2
KEGG Orthology (KO) More...KOⁱ	K17298
OMAⁱ	RCDYYGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GHV
TreeFamⁱ	TF335941

Family and domain databases

InterProⁱ	View protein in InterPro IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR009030 Growth_fac_rcpt_cys_sf IPR000082 SEA_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01390 SEA, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 3 hits
SUPFAMⁱ	SSF57184 SSF57184, 2 hits
PROSITEⁱ	View protein in PROSITE PS01186 EGF_2, 2 hits PS50026 EGF_3, 1 hit PS50024 SEA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9H3R2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKAIIHLTLL ALLSVNTATN QGNSADAVTT TETATSGPTV AAADTTETNF 
        60         70         80         90        100
PETASTTANT PSFPTATSPA PPIISTHSSS TIPTPAPPII STHSSSTIPI 
       110        120        130        140        150
PTAADSESTT NVNSLATSDI ITASSPNDGL ITMVPSETQS NNEMSPTTED 
       160        170        180        190        200
NQSSGPPTGT ALLETSTLNS TGPSNPCQDD PCADNSLCVK LHNTSFCLCL 
       210        220        230        240        250
EGYYYNSSTC KKGKVFPGKI SVTVSETFDP EEKHSMAYQD LHSEITSLFK 
       260        270        280        290        300
DVFGTSVYGQ TVILTVSTSL SPRSEMRADD KFVNVTIVTI LAETTSDNEK 
       310        320        330        340        350
TVTEKINKAI RSSSSNFLNY DLTLRCDYYG CNQTADDCLN GLACDCKSDL 
       360        370        380        390        400
QRPNPQSPFC VASSLKCPDA CNAQHKQCLI KKSGGAPECA CVPGYQEDAN 
       410        420        430        440        450
GNCQKCAFGY SGLDCKDKFQ LILTIVGTIA GIVILSMIIA LIVTARSNNK 
       460        470        480        490        500
TKHIEEENLI DEDFQNLKLR STGFTNLGAE GSVFPKVRIT ASRDSQMQNP 
       510 
YSRHSSMPRP DY

Length:512

Mass (Da):54,604

Last modified:May 14, 2014 - v3

Checksum:ⁱ17D34E17B1637581

GO

Sequence cautionⁱ

The sequence BAA90925 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	196	F → I in BAA90925 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_056589	18	A → V. Corresponds to variant dbSNP:rs4679394Ensembl.	1
Natural variantⁱVAR_063124	100	I → T. Corresponds to variant dbSNP:rs4679392Ensembl.	1
Natural variantⁱVAR_056590	364	S → G. Corresponds to variant dbSNP:rs16836185Ensembl.	1
Natural variantⁱVAR_056591	503	R → S1 PublicationCorresponds to variant dbSNP:rs1127233Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035807 mRNA Translation: BAB19651.1 AF286113 mRNA Translation: AAK56861.1 AY358831 mRNA Translation: AAQ89190.1 AC026342 Genomic DNA No translation available. AK000070 mRNA Translation: BAA90925.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33839.2
NCBI Reference Sequences More...RefSeqⁱ	NP_149038.3, NM_033049.3
UniGeneⁱ	Hs.5940

Genome annotation databases

Ensemblⁱ	ENST00000616727; ENSP00000485028; ENSG00000173702
GeneIDⁱ	56667
KEGGⁱ	hsa:56667
UCSC genome browser More...UCSCⁱ	uc032sai.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9H3R2	Mucin 13, cell surface associated		GORGO		512
MUC13 isoform 1		PANTR		496
Mucin 13, cell surface associated		PANPA		496

Protein	Similar proteins		Species	Score	Length
Q9H3R2	Mucin 13, cell surface associated		GORGO		512
MUC13 isoform 1		PANTR		496
Mucin 13, cell surface associated		PANPA		496
Mucin 13, cell surface associated		AOTNA		493
Mucin 13B (Fragment)		PIG		409
+16

Cross-referencesⁱ

Web resourcesⁱ

Mucin database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035807 mRNA Translation: BAB19651.1 AF286113 mRNA Translation: AAK56861.1 AY358831 mRNA Translation: AAQ89190.1 AC026342 Genomic DNA No translation available. AK000070 mRNA Translation: BAA90925.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33839.2
NCBI Reference Sequences More...RefSeqⁱ	NP_149038.3, NM_033049.3
UniGeneⁱ	Hs.5940

3D structure databases

ProteinModelPortalⁱ	Q9H3R2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121177, 17 interactors
IntActⁱ	Q9H3R2, 15 interactors
STRINGⁱ	9606.ENSP00000312235

PTM databases

iPTMnetⁱ	Q9H3R2
PhosphoSitePlusⁱ	Q9H3R2

Polymorphism and mutation databases

BioMutaⁱ	MUC13
DMDMⁱ	296438300

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H3R2
PaxDbⁱ	Q9H3R2
PeptideAtlas More...PeptideAtlasⁱ	Q9H3R2
PRIDEⁱ	Q9H3R2
ProteomicsDBⁱ	80744

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000616727; ENSP00000485028; ENSG00000173702
GeneIDⁱ	56667
KEGGⁱ	hsa:56667
UCSC genome browser More...UCSCⁱ	uc032sai.1 human

Organism-specific databases

CTDⁱ	56667
DisGeNET More...DisGeNETⁱ	56667
EuPathDBⁱ	HostDB:ENSG00000173702.7
GeneCardsⁱ	MUC13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7511 MUC13
Human Protein Atlas More...HPAⁱ	HPA045163
MIMⁱ	612181 gene
neXtProtⁱ	NX_Q9H3R2
Open Targets More...OpenTargetsⁱ	ENSG00000173702
PharmGKBⁱ	PA31312
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXVD Eukaryota ENOG410XXX6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106845
HOGENOMⁱ	HOG000168414
HOVERGENⁱ	HBG052532
InParanoidⁱ	Q9H3R2
KEGG Orthology (KO) More...KOⁱ	K17298
OMAⁱ	RCDYYGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GHV
TreeFamⁱ	TF335941

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5621480 Dectin-2 family R-HSA-913709 O-linked glycosylation of mucins R-HSA-977068 Termination of O-glycan biosynthesis

Reactomeⁱ

R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRSⁱ	MUC13 human
GenomeRNAiⁱ	56667
Protein Ontology More...PROⁱ	PR:Q9H3R2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173702
CleanExⁱ	HS_MUC13
ExpressionAtlasⁱ	Q9H3R2 baseline and differential
Genevisibleⁱ	Q9H3R2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR009030 Growth_fac_rcpt_cys_sf IPR000082 SEA_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01390 SEA, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 3 hits
SUPFAMⁱ	SSF57184 SSF57184, 2 hits
PROSITEⁱ	View protein in PROSITE PS01186 EGF_2, 2 hits PS50026 EGF_3, 1 hit PS50024 SEA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MUC13_HUMAN
Accessionⁱ	Q9H3R2Primary (citable) accession number: Q9H3R2 Secondary accession number(s): Q6UWD9, Q9NXT5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	May 14, 2014
	Last modified:	June 20, 2018
	This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9H3R2 (MUC13_HUMAN)

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Mucin-13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Cytosol

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ