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Protein

Golgi resident protein GCP60

Gene

ACBD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356).By similarity2 Publications
(Microbial infection) Sensitizes PI4KB activation by Kobuviral (Aichi) 3A protein.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fatty-acyl-CoA binding Source: InterPro
  • protein kinase A regulatory subunit binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432722 Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi resident protein GCP60
Alternative name(s):
Acyl-CoA-binding domain-containing protein 3
Golgi complex-associated protein 1
Short name:
GOCAP1
Golgi phosphoprotein 1
Short name:
GOLPH1
PBR- and PKA-associated protein 7
Peripheral benzodiazepine receptor-associated protein PAP7
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACBD3
Synonyms:GCP60, GOCAP1, GOLPH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000182827.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15453 ACBD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606809 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3P7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi243K → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi244Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi245Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi246I → A: Partial loss of PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi253Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi254T → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi256 – 258VQF → AAA: Loss of PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi257Q → A: Partial loss of PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi258 – 259FQ → AA: Loss of interaction with PI4KB. 1 Publication2
Mutagenesisi258F → A: Differential effect on PI4KB- and TBC1D22B-binding, with PI4KB-binding being much more affected than TBC1D22B-binding. 2 Publications1
Mutagenesisi259Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi260Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi261Y → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi264 – 266QQY → AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi266Y → A: No loss of interaction with PI4KB. 1 Publication1
Mutagenesisi267 – 269PGN → AAA: Loss of PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi275I → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi276L → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi282 – 285EQHY → AAAA: Loss of PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication4
Mutagenesisi284H → A: Almost complete loss of PI4KB- and TBC1D22B-binding. 2 Publications1
Mutagenesisi285Y → A: Differential loss of PI4KB- and TBC1D22B-binding, with PI4KB-binding being much more affected than TBC1D22B-binding. 2 Publications1
Mutagenesisi286Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi287Q → A: No effect on PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi288Y → A: Almost complete loss of PI4KB- and TBC1D22B-binding. 2 Publications1
Mutagenesisi344 – 345SS → AA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication2
Mutagenesisi380 – 381IK → AE: No effect on interaction with PI4KB but loss of interaction with Kobuviral (Aichi) 3A protein. Loss of ability to sensitize PI4KB activation by Kobuviral (Aichi) 3A protein. 1 Publication2
Mutagenesisi414 – 416SYL → AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi417 – 420FWEF → AAAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication4
Mutagenesisi433 – 435FEW → AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi494 – 496GSH → AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi511 – 513SYS → AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding. 1 Publication3
Mutagenesisi511S → A: Partial loss of PI4KB- and TBC1D22B-binding. 1 Publication1
Mutagenesisi525Y → A: No effect on interaction with PI4KB but loss of interaction with Kobuviral (Aichi) 3A protein. Loss of ability to sensitize PI4KB activation by Kobuviral (Aichi) 3A protein. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64746

Open Targets

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OpenTargetsi
ENSG00000182827

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28803

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACBD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316096

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004364491 – 528Golgi resident protein GCP60Add BLAST528
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00002140292 – 528Golgi resident protein GCP60, N-terminally processedAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine; in Golgi resident protein GCP60, N-terminally processedCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei18PhosphothreonineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H3P7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H3P7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H3P7

PeptideAtlas

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PeptideAtlasi
Q9H3P7

PRoteomics IDEntifications database

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PRIDEi
Q9H3P7

ProteomicsDB human proteome resource

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ProteomicsDBi
80738

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H3P7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H3P7

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9H3P7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous, with highest expression in testis and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182827 Expressed in 242 organ(s), highest expression level in epithelium of mammary gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACBD3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H3P7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H3P7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015594

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1 (PubMed:11590181). Interacts with PBR and PKA regulatory subunit RI-alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity). Interacts with PI4KB, TBC1D22A AND TBC1D22B; interactions with PI4KB and with TBC1D22A and TBC1D22B are mutually exclusive (PubMed:23572552, PubMed:27009356, PubMed:27989622). Interacts with C10ORF76 and RAB11B (PubMed:23572552).By similarity4 Publications
(Microbial infection) Interacts with 3A proteins from various picornaviruses, including hepatitis A virus, human parechovirus 1, and human klassevirus. Kobuviral (Aichi) 3A protein binding may compete the physiological interaction with TBC1D22A, while enteroviral (poliovirus) 3A protein does not seem to interfere (PubMed:23572552). Interacts (via GOLD domain) with Kobuviral (Aichi) 3A protein (PubMed:27989622, PubMed:23572552).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122262, 35 interactors

Database of interacting proteins

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DIPi
DIP-40673N

Protein interaction database and analysis system

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IntActi
Q9H3P7, 25 interactors

Molecular INTeraction database

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MINTi
Q9H3P7

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355777

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9H3P7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H3P7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H3P7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 174ACBPROSITE-ProRule annotationAdd BLAST92
Domaini384 – 526GOLDPROSITE-ProRule annotationAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni241 – 308Interaction with PI4KB1 PublicationAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili174 – 257Sequence analysisAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 60Pro-richAdd BLAST40
Compositional biasi182 – 240Glu-richAdd BLAST59
Compositional biasi196 – 238Arg-richAdd BLAST43
Compositional biasi241 – 308Gln-richAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GOLD domain is essential for giantin binding.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3878 Eukaryota
ENOG410XS5V LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063651

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051712

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H3P7

Identification of Orthologs from Complete Genome Data

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OMAi
GSHSYPG

Database of Orthologous Groups

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OrthoDBi
EOG091G0KJD

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H3P7

TreeFam database of animal gene trees

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TreeFami
TF321667

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00887 ACBP, 1 hit
PF13897 GOLD_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101576 SSF101576, 1 hit
SSF47027 SSF47027, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit
PS50866 GOLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVLNAERL EVSVDGLTLS PDPEERPGAE GAPLLPPPLP PPSPPGSGRG
60 70 80 90 100
PGASGEQPEP GEAAAGGAAE EARRLEQRWG FGLEELYGLA LRFFKEKDGK
110 120 130 140 150
AFHPTYEEKL KLVALHKQVL MGPYNPDTCP EVGFFDVLGN DRRREWAALG
160 170 180 190 200
NMSKEDAMVE FVKLLNRCCH LFSTYVASHK IEKEEQEKKR KEEEERRRRE
210 220 230 240 250
EEERERLQKE EEKRRREEEE RLRREEEERR RIEEERLRLE QQKQQIMAAL
260 270 280 290 300
NSQTAVQFQQ YAAQQYPGNY EQQQILIRQL QEQHYQQYMQ QLYQVQLAQQ
310 320 330 340 350
QAALQKQQEV VVAGSSLPTS SKVNATVPSN MMSVNGQAKT HTDSSEKELE
360 370 380 390 400
PEAAEEALEN GPKESLPVIA APSMWTRPQI KDFKEKIQQD ADSVITVGRG
410 420 430 440 450
EVVTVRVPTH EEGSYLFWEF ATDNYDIGFG VYFEWTDSPN TAVSVHVSES
460 470 480 490 500
SDDDEEEEEN IGCEEKAKKN ANKPLLDEIV PVYRRDCHEE VYAGSHQYPG
510 520
RGVYLLKFDN SYSLWRSKSV YYRVYYTR
Length:528
Mass (Da):60,593
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB36EC550F8268FC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93F → L in AAN60219 (Ref. 2) Curated1
Sequence conflicti230R → I in AAN60219 (Ref. 2) Curated1
Sequence conflicti265Q → R in AAN60219 (Ref. 2) Curated1
Sequence conflicti333S → P in AAN60219 (Ref. 2) Curated1
Sequence conflicti384 – 397KEKIQ…SVITV → QREDSAGCRFRDYS (Ref. 2) CuratedAdd BLAST14
Sequence conflicti425Y → C in AAN60219 (Ref. 2) Curated1
Sequence conflicti473K → R in AAH60792 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019615187E → D2 PublicationsCorresponds to variant dbSNP:rs2306120Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB043587 mRNA Translation: BAB20592.2
AY150218 mRNA Translation: AAN60219.1
AK025520 mRNA Translation: BAB15159.1
AK314468 mRNA Translation: BAG37076.1
AL592045 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69775.1
BC034563 mRNA Translation: AAH34563.2
BC045533 mRNA Translation: AAH45533.1
BC060792 mRNA Translation: AAH60792.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1551.1

NCBI Reference Sequences

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RefSeqi
NP_073572.2, NM_022735.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.520207

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000366812; ENSP00000355777; ENSG00000182827

Database of genes from NCBI RefSeq genomes

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GeneIDi
64746

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64746

UCSC genome browser

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UCSCi
uc001hpy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043587 mRNA Translation: BAB20592.2
AY150218 mRNA Translation: AAN60219.1
AK025520 mRNA Translation: BAB15159.1
AK314468 mRNA Translation: BAG37076.1
AL592045 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69775.1
BC034563 mRNA Translation: AAH34563.2
BC045533 mRNA Translation: AAH45533.1
BC060792 mRNA Translation: AAH60792.1
CCDSiCCDS1551.1
RefSeqiNP_073572.2, NM_022735.3
UniGeneiHs.520207

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N72NMR-A241-308[»]
2N73NMR-A241-308[»]
5LZ1X-ray2.00A364-528[»]
5LZ3X-ray3.00A364-528[»]
5LZ6X-ray2.60A364-528[»]
5TDQX-ray2.49A367-528[»]
ProteinModelPortaliQ9H3P7
SMRiQ9H3P7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122262, 35 interactors
DIPiDIP-40673N
IntActiQ9H3P7, 25 interactors
MINTiQ9H3P7
STRINGi9606.ENSP00000355777

Chemistry databases

BindingDBiQ9H3P7

PTM databases

iPTMnetiQ9H3P7
PhosphoSitePlusiQ9H3P7
SwissPalmiQ9H3P7

Polymorphism and mutation databases

BioMutaiACBD3
DMDMi51316096

Proteomic databases

EPDiQ9H3P7
MaxQBiQ9H3P7
PaxDbiQ9H3P7
PeptideAtlasiQ9H3P7
PRIDEiQ9H3P7
ProteomicsDBi80738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366812; ENSP00000355777; ENSG00000182827
GeneIDi64746
KEGGihsa:64746
UCSCiuc001hpy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64746
DisGeNETi64746
EuPathDBiHostDB:ENSG00000182827.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACBD3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0159664
HGNCiHGNC:15453 ACBD3
HPAiHPA015594
MIMi606809 gene
neXtProtiNX_Q9H3P7
OpenTargetsiENSG00000182827
PharmGKBiPA28803

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3878 Eukaryota
ENOG410XS5V LUCA
GeneTreeiENSGT00530000063651
HOVERGENiHBG051712
InParanoidiQ9H3P7
OMAiGSHSYPG
OrthoDBiEOG091G0KJD
PhylomeDBiQ9H3P7
TreeFamiTF321667

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACBD3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ACBD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64746

Protein Ontology

More...
PROi
PR:Q9H3P7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182827 Expressed in 242 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_ACBD3
ExpressionAtlasiQ9H3P7 baseline and differential
GenevisibleiQ9H3P7 HS

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PF13897 GOLD_2, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit
PS50866 GOLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP60_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3P7
Secondary accession number(s): B2RB29
, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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