HRH4

Functionⁱ

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).1 Publication

Miscellaneous

Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R^--alpha-methylhistamine > S⁺-alpha-methylhistamine. Both N-alpha-methylhistamine > R^--alpha-methylhistamine behave as full agonists.

GO - Molecular functionⁱ

G protein-coupled acetylcholine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histamine receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10973974
- 11118334
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration Source: InterPro
regulation of MAPK cascade Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390650 Histamine receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390650 Histamine receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histamine H4 receptor Short name: H4R Short name: HH4R Alternative name(s): AXOR35 G-protein coupled receptor 105 GPRv53 Pfi-013 SP9144
Gene namesⁱ	Name:HRH4 Synonyms:GPCR105
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134489.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17383 HRH4
MIMⁱ	606792 gene
neXtProtⁱ	NX_Q9H3N8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 19	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	20 – 40	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	41 – 52	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	53 – 73	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	74 – 87	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	88 – 108	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	109 – 131	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	132 – 152	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	153 – 172	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	173 – 193	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	194 – 304	CytoplasmicSequence analysisAdd BLAST	111
Transmembraneⁱ	305 – 325	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	326 – 341	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	342 – 362	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	363 – 390	CytoplasmicSequence analysisAdd BLAST	28

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	59340
Open Targets More...OpenTargetsⁱ	ENSG00000134489
PharmGKBⁱ	PA134982275

Chemistry databases

ChEMBLⁱ	CHEMBL3759
Drug and drug target database More...DrugBankⁱ	DB00321 Amitriptyline DB00543 Amoxapine DB00477 Chlorpromazine DB00363 Clozapine DB01142 Doxepin DB05381 Histamine DB00408 Loxapine DB06148 Mianserin DB00334 Olanzapine DB05032 REV131
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	265

Polymorphism and mutation databases

BioMutaⁱ	HRH4
DMDMⁱ	14194819

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069693	1 – 390	Histamine H4 receptorAdd BLAST		390

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	9	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	87 ↔ 164	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9H3N8
PeptideAtlas More...PeptideAtlasⁱ	Q9H3N8
PRIDEⁱ	Q9H3N8
ProteomicsDBⁱ	80734 80735 [Q9H3N8-2]

PTM databases

iPTMnetⁱ	Q9H3N8
PhosphoSitePlusⁱ	Q9H3N8

Expressionⁱ

Tissue specificityⁱ

Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.1 Publication

Inductionⁱ

Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL10/interleukin-10 or IL13/interleukin-13.

Gene expression databases

Bgeeⁱ	ENSG00000134489 Expressed in 29 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_HRH4
Genevisibleⁱ	Q9H3N8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035009

HPAⁱ

HPA035009

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000256906

STRINGⁱ

9606.ENSP00000256906

Chemistry databases

BindingDBⁱ

Q9H3N8

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H3N8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000048707
HOVERGENⁱ	HBG102132
InParanoidⁱ	Q9H3N8
KEGG Orthology (KO) More...KOⁱ	K04152
OMAⁱ	LMVAVWV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G097A
PhylomeDBⁱ	Q9H3N8
TreeFamⁱ	TF351747

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008102 Histamine_H4_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01726 HISTAMINEH4R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9H3N8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS 
        60         70         80         90        100
SYFFLNLAIS DFFVGVISIP LYIPHTLFEW DFGKEICVFW LTTDYLLCTA 
       110        120        130        140        150
SVYNIVLISY DRYLSVSNAV SYRTQHTGVL KIVTLMVAVW VLAFLVNGPM 
       160        170        180        190        200
ILVSESWKDE GSECEPGFFS EWYILAITSF LEFVIPVILV AYFNMNIYWS 
       210        220        230        240        250
LWKRDHLSRC QSHPGLTAVS SNICGHSFRG RLSSRRSLSA STEVPASFHS 
       260        270        280        290        300
ERQRRKSSLM FSSRTKMNSN TIASKMGSFS QSDSVALHQR EHVELLRARR 
       310        320        330        340        350
LAKSLAILLG VFAVCWAPYS LFTIVLSFYS SATGPKSVWY RIAFWLQWFN 
       360        370        380        390
SFVNPLLYPL CHKRFQKAFL KIFCIKKQPL PSQHSRSVSS

Length:390

Mass (Da):44,496

Last modified:June 1, 2001 - v2

Checksum:ⁱC986B8AE7FF912C3

GO

Isoform 2 (identifier: Q9H3N8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
65-152: Missing.

« Hide

        10         20         30         40         50
MPDTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS 
        60         70         80         90        100
SYFFLNLAIS DFFVVSESWK DEGSECEPGF FSEWYILAIT SFLEFVIPVI 
       110        120        130        140        150
LVAYFNMNIY WSLWKRDHLS RCQSHPGLTA VSSNICGHSF RGRLSSRRSL 
       160        170        180        190        200
SASTEVPASF HSERQRRKSS LMFSSRTKMN SNTIASKMGS FSQSDSVALH 
       210        220        230        240        250
QREHVELLRA RRLAKSLAIL LGVFAVCWAP YSLFTIVLSF YSSATGPKSV 
       260        270        280        290        300
WYRIAFWLQW FNSFVNPLLY PLCHKRFQKA FLKIFCIKKQ PLPSQHSRSV 

SS

Note: No experimental confirmation available.

Show »

Length:302

Mass (Da):34,497

Checksum:ⁱ9B67B07543663052

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	253	Q → R in BAB13698 (PubMed:10973974).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033477	138	A → V1 PublicationCorresponds to variant dbSNP:rs11665084Ensembl.		1
Natural variantⁱVAR_033478	206	H → R1 PublicationCorresponds to variant dbSNP:rs11662595Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042737	65 – 152	Missing in isoform 2. 1 PublicationAdd BLAST		88

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB044934 mRNA Translation: BAB13698.1 AB045370 mRNA Translation: BAB20091.1 AF307973 mRNA Translation: AAG32052.1 AF312230 mRNA Translation: AAK12081.1 AF329449 mRNA Translation: AAK43542.1 AF325356 mRNA Translation: AAL01684.1 AJ298292 mRNA Translation: CAC83493.1 DQ835186 mRNA Translation: ABI54174.1 AY136745 mRNA Translation: AAN01271.1 EF444982 Genomic DNA Translation: ACA05997.1 AC007922 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01189.1 BC069136 mRNA Translation: AAH69136.1 BC112348 mRNA Translation: AAI12349.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11887.1 [Q9H3N8-1] CCDS45841.1 [Q9H3N8-2]
PIRⁱ	JC7566
NCBI Reference Sequences More...RefSeqⁱ	NP_001137300.1, NM_001143828.1 [Q9H3N8-2] NP_001153638.1, NM_001160166.1 NP_067637.2, NM_021624.3 [Q9H3N8-1]
UniGeneⁱ	Hs.287388

Genome annotation databases

Ensemblⁱ	ENST00000256906; ENSP00000256906; ENSG00000134489 [Q9H3N8-1] ENST00000426880; ENSP00000402526; ENSG00000134489 [Q9H3N8-2]
GeneIDⁱ	59340
KEGGⁱ	hsa:59340
UCSC genome browser More...UCSCⁱ	uc002kvi.3 human [Q9H3N8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H3N8	Histamine receptor H4		HUMAN		390	UniRef90_Q9H3N8
HRH4 isoform 1		PANTR		390
Histamine H4 receptor		MACFA		390
HRH4 isoform 1		PONAB		390
Histamine H4 receptor		MACMU		390
+23
Q9H3N8-2	HRH4 isoform 2		PANTR		302	UniRef90_Q9H3N8-2
Uncharacterized protein		MACMU		302
Uncharacterized protein		COLAP		302
HRH4 isoform 2		PONAB		302
Uncharacterized protein		CERAT		302
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9H3N8	Histamine H4 receptor		MACFA		390	UniRef50_Q9H3N8
Uncharacterized protein		PANPA		390
HRH4 isoform 1		PANTR		390
HRH4 isoform 1		PONAB		390
Uncharacterized protein		COLAP		390
+73
Q9H3N8-2	Uncharacterized protein		MACFA		302	UniRef50_Q9H3N8-2
Uncharacterized protein		CERAT		302
HRH4 isoform 2		PONAB		302
Uncharacterized protein		PAPAN		302
Uncharacterized protein		MANLE		302
+40

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB044934 mRNA Translation: BAB13698.1 AB045370 mRNA Translation: BAB20091.1 AF307973 mRNA Translation: AAG32052.1 AF312230 mRNA Translation: AAK12081.1 AF329449 mRNA Translation: AAK43542.1 AF325356 mRNA Translation: AAL01684.1 AJ298292 mRNA Translation: CAC83493.1 DQ835186 mRNA Translation: ABI54174.1 AY136745 mRNA Translation: AAN01271.1 EF444982 Genomic DNA Translation: ACA05997.1 AC007922 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01189.1 BC069136 mRNA Translation: AAH69136.1 BC112348 mRNA Translation: AAI12349.1
CCDSⁱ	CCDS11887.1 [Q9H3N8-1] CCDS45841.1 [Q9H3N8-2]
PIRⁱ	JC7566
RefSeqⁱ	NP_001137300.1, NM_001143828.1 [Q9H3N8-2] NP_001153638.1, NM_001160166.1 NP_067637.2, NM_021624.3 [Q9H3N8-1]
UniGeneⁱ	Hs.287388

3D structure databases

ProteinModelPortalⁱ	Q9H3N8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000256906

STRINGⁱ

9606.ENSP00000256906

Chemistry databases

BindingDBⁱ	Q9H3N8
ChEMBLⁱ	CHEMBL3759
DrugBankⁱ	DB00321 Amitriptyline DB00543 Amoxapine DB00477 Chlorpromazine DB00363 Clozapine DB01142 Doxepin DB05381 Histamine DB00408 Loxapine DB06148 Mianserin DB00334 Olanzapine DB05032 REV131
GuidetoPHARMACOLOGYⁱ	265

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q9H3N8
PhosphoSitePlusⁱ	Q9H3N8

Polymorphism and mutation databases

BioMutaⁱ	HRH4
DMDMⁱ	14194819

Proteomic databases

PaxDbⁱ	Q9H3N8
PeptideAtlasⁱ	Q9H3N8
PRIDEⁱ	Q9H3N8
ProteomicsDBⁱ	80734 80735 [Q9H3N8-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000256906; ENSP00000256906; ENSG00000134489 [Q9H3N8-1] ENST00000426880; ENSP00000402526; ENSG00000134489 [Q9H3N8-2]
GeneIDⁱ	59340
KEGGⁱ	hsa:59340
UCSCⁱ	uc002kvi.3 human [Q9H3N8-1]

Organism-specific databases

CTDⁱ	59340
DisGeNETⁱ	59340
EuPathDBⁱ	HostDB:ENSG00000134489.6
GeneCardsⁱ	HRH4
HGNCⁱ	HGNC:17383 HRH4
HPAⁱ	HPA035009
MIMⁱ	606792 gene
neXtProtⁱ	NX_Q9H3N8
OpenTargetsⁱ	ENSG00000134489
PharmGKBⁱ	PA134982275
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000048707
HOVERGENⁱ	HBG102132
InParanoidⁱ	Q9H3N8
KOⁱ	K04152
OMAⁱ	LMVAVWV
OrthoDBⁱ	EOG091G097A
PhylomeDBⁱ	Q9H3N8
TreeFamⁱ	TF351747

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390650 Histamine receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390650 Histamine receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiⁱ	Histamine_H4_receptor
GenomeRNAiⁱ	59340
Protein Ontology More...PROⁱ	PR:Q9H3N8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134489 Expressed in 29 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_HRH4
Genevisibleⁱ	Q9H3N8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR008102 Histamine_H4_rcpt
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01726 HISTAMINEH4R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HRH4_HUMAN
Accessionⁱ	Q9H3N8Primary (citable) accession number: Q9H3N8 Secondary accession number(s): B0YJ19 , B2KJ48, Q4G0I6, Q9GZQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q9H3N8 (HRH4_HUMAN)

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Histamine H4 receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ