Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin-related transmembrane protein 1

Gene

TMX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

GO - Molecular functioni

  • disulfide oxidoreductase activity Source: UniProtKB
  • protein disulfide isomerase activity Source: GO_Central

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • protein folding Source: GO_Central
  • response to endoplasmic reticulum stress Source: UniProtKB

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 1
Alternative name(s):
Thioredoxin domain-containing protein 1
Transmembrane Trx-related protein
Gene namesi
Name:TMX1
Synonyms:TMX, TXNDC, TXNDC1
ORF Names:PSEC0085, UNQ235/PRO268
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139921.12
HGNCiHGNC:15487 TMX1
MIMi610527 gene
neXtProtiNX_Q9H3N1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 180ExtracellularSequence analysisAdd BLAST154
Transmembranei181 – 203HelicalSequence analysisAdd BLAST23
Topological domaini204 – 280CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56C → S: Loss of reductase activity; when associated with S-59. 1 Publication1
Mutagenesisi59C → S: Loss of reductase activity; when associated with S-56. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000139921
PharmGKBiPA37968

Polymorphism and mutation databases

BioMutaiTMX1
DMDMi47117631

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003415327 – 280Thioredoxin-related transmembrane protein 1Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation1 Publication
Modified residuei228PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9H3N1
MaxQBiQ9H3N1
PaxDbiQ9H3N1
PeptideAtlasiQ9H3N1
PRIDEiQ9H3N1
ProteomicsDBi80733
TopDownProteomicsiQ9H3N1

PTM databases

iPTMnetiQ9H3N1
PhosphoSitePlusiQ9H3N1
SwissPalmiQ9H3N1

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in kidney, liver, placenta and lung.

Gene expression databases

BgeeiENSG00000139921
CleanExiHS_TXNDC1
ExpressionAtlasiQ9H3N1 baseline and differential
GenevisibleiQ9H3N1 HS

Organism-specific databases

HPAiHPA003085

Interactioni

Protein-protein interaction databases

BioGridi123510, 61 interactors
IntActiQ9H3N1, 37 interactors
MINTiQ9H3N1
STRINGi9606.ENSP00000393316

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 33Combined sources4
Turni36 – 38Combined sources3
Helixi39 – 42Combined sources4
Beta strandi44 – 52Combined sources9
Helixi57 – 73Combined sources17
Helixi74 – 76Combined sources3
Beta strandi79 – 84Combined sources6
Turni85 – 87Combined sources3
Helixi89 – 94Combined sources6
Beta strandi99 – 107Combined sources9
Beta strandi110 – 113Combined sources4
Helixi120 – 128Combined sources9
Helixi131 – 134Combined sources4

3D structure databases

ProteinModelPortaliQ9H3N1
SMRiQ9H3N1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H3N1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 132ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ9H3N1
OMAiCHNYFIE
OrthoDBiEOG091G0MRE
PhylomeDBiQ9H3N1
TreeFamiTF106376

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSGSLAVP LAVLVLLLWG APWTHGRRSN VRVITDENWR ELLEGDWMIE
60 70 80 90 100
FYAPWCPACQ NLQPEWESFA EWGEDLEVNI AKVDVTEQPG LSGRFIITAL
110 120 130 140 150
PTIYHCKDGE FRRYQGPRTK KDFINFISDK EWKSIEPVSS WFGPGSVLMS
160 170 180 190 200
SMSALFQLSM WIRTCHNYFI EDLGLPVWGS YTVFALATLF SGLLLGLCMI
210 220 230 240 250
FVADCLCPSK RRRPQPYPYP SKKLLSESAQ PLKKVEEEQE ADEEDVSEEE
260 270 280
AESKEGTNKD FPQNAIRQRS LGPSLATDKS
Length:280
Mass (Da):31,791
Last modified:March 1, 2001 - v1
Checksum:iA57E222481A997DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 16LVL → MVP in AAH36460 (PubMed:15489334).Curated3
Sequence conflicti98T → N in AAH36460 (PubMed:15489334).Curated1
Sequence conflicti177V → A in BAC11593 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048246 mRNA Translation: BAB20629.1
AY358640 mRNA Translation: AAQ89003.1
AK075395 mRNA Translation: BAC11593.1
AK312905 mRNA Translation: BAG35751.1
AL080080 mRNA Translation: CAB45700.2
AL591807 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65678.1
BC036460 mRNA Translation: AAH36460.1
BC056874 mRNA Translation: AAH56874.2
CCDSiCCDS41953.1
PIRiT12471
RefSeqiNP_110382.3, NM_030755.4
UniGeneiHs.125221

Genome annotation databases

EnsembliENST00000457354; ENSP00000393316; ENSG00000139921
GeneIDi81542
KEGGihsa:81542
UCSCiuc001wza.5 human

Similar proteinsi

Entry informationi

Entry nameiTMX1_HUMAN
AccessioniPrimary (citable) accession number: Q9H3N1
Secondary accession number(s): B2R7A4
, Q8N487, Q8NBN5, Q9Y4T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health