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Protein

Growth hormone-inducible transmembrane protein

Gene

GHITM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth hormone-inducible transmembrane protein
Alternative name(s):
Dermal papilla-derived protein 2
Mitochondrial morphology and cristae structure 1
Short name:
MICS1
Transmembrane BAX inhibitor motif-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GHITM
Synonyms:DERP2, MICS1, TMBIM5
ORF Names:My021, UNQ244/PRO281
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165678.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17281 GHITM

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H3K2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini46 – 82Mitochondrial matrixSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 125Mitochondrial intermembraneSequence analysisAdd BLAST22
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 159Mitochondrial matrixSequence analysisAdd BLAST13
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 190Mitochondrial intermembraneSequence analysis10
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213Mitochondrial matrixSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 244Mitochondrial intermembraneSequence analysis10
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 271Mitochondrial matrixSequence analysis6
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 345Mitochondrial intermembraneSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27069

Open Targets

More...
OpenTargetsi
ENSG00000165678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28673

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GHITM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
15213977

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000017911946 – 345Growth hormone-inducible transmembrane proteinAdd BLAST300

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H3K2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H3K2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H3K2

PeptideAtlas

More...
PeptideAtlasi
Q9H3K2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H3K2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80725

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9H3K2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H3K2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H3K2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H3K2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165678 Expressed in 238 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_GHITM

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H3K2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016464
HPA061664

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Sarm1Q6PDS32EBI-2868909,EBI-6117196From Mus musculus.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117980, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H3K2, 10 interactors

Molecular INTeraction database

More...
MINTi
Q9H3K2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361207

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H3K2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H3K2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BI1 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1630 Eukaryota
ENOG410XPHY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008960

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013204

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051731

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H3K2

KEGG Orthology (KO)

More...
KOi
K21890

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMINIFI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0DVQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H3K2

TreeFam database of animal gene trees

More...
TreeFami
TF314017

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10431 GHITM, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006214 Bax_inhibitor_1-related
IPR035871 GHITM

The PANTHER Classification System

More...
PANTHERi
PTHR23291 PTHR23291, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01027 Bax1-I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAARLVCLR TLPSRVFHPA FTKASPVVKN SITKNQWLLT PSREYATKTR
60 70 80 90 100
IGIRRGRTGQ ELKEAALEPS MEKIFKIDQM GRWFVAGGAA VGLGALCYYG
110 120 130 140 150
LGLSNEIGAI EKAVIWPQYV KDRIHSTYMY LAGSIGLTAL SAIAISRTPV
160 170 180 190 200
LMNFMMRGSW VTIGVTFAAM VGAGMLVRSI PYDQSPGPKH LAWLLHSGVM
210 220 230 240 250
GAVVAPLTIL GGPLLIRAAW YTAGIVGGLS TVAMCAPSEK FLNMGAPLGV
260 270 280 290 300
GLGLVFVSSL GSMFLPPTTV AGATLYSVAM YGGLVLFSMF LLYDTQKVIK
310 320 330 340
RAEVSPMYGV QKYDPINSML SIYMDTLNIF MRVATMLATG GNRKK
Length:345
Mass (Da):37,205
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i808FAED86A9CD98E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4A → V in CAB66648 (PubMed:11230166).Curated1
Sequence conflicti64E → G in AAG43135 (Ref. 3) Curated1
Sequence conflicti74I → M in CAB66648 (PubMed:11230166).Curated1
Sequence conflicti118Q → R in CAB66648 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB009685 mRNA Translation: BAA93049.1
AF131820 mRNA Translation: AAD20052.1
AF060923 mRNA Translation: AAG43135.1
AL136713 mRNA Translation: CAB66648.1
AY358824 mRNA Translation: AAQ89183.1
AK292864 mRNA Translation: BAF85553.1
AC022389 Genomic DNA No translation available.
AL603756 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80367.1
CH471142 Genomic DNA Translation: EAW80368.1
CH471142 Genomic DNA Translation: EAW80369.1
BC010354 mRNA Translation: AAH10354.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41542.1

NCBI Reference Sequences

More...
RefSeqi
NP_055209.2, NM_014394.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.352656

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372134; ENSP00000361207; ENSG00000165678

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27069

UCSC genome browser

More...
UCSCi
uc001kcs.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009685 mRNA Translation: BAA93049.1
AF131820 mRNA Translation: AAD20052.1
AF060923 mRNA Translation: AAG43135.1
AL136713 mRNA Translation: CAB66648.1
AY358824 mRNA Translation: AAQ89183.1
AK292864 mRNA Translation: BAF85553.1
AC022389 Genomic DNA No translation available.
AL603756 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80367.1
CH471142 Genomic DNA Translation: EAW80368.1
CH471142 Genomic DNA Translation: EAW80369.1
BC010354 mRNA Translation: AAH10354.1
CCDSiCCDS41542.1
RefSeqiNP_055209.2, NM_014394.2
UniGeneiHs.352656

3D structure databases

ProteinModelPortaliQ9H3K2
SMRiQ9H3K2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117980, 58 interactors
IntActiQ9H3K2, 10 interactors
MINTiQ9H3K2
STRINGi9606.ENSP00000361207

PTM databases

iPTMnetiQ9H3K2
PhosphoSitePlusiQ9H3K2
SwissPalmiQ9H3K2

Polymorphism and mutation databases

BioMutaiGHITM
DMDMi15213977

Proteomic databases

EPDiQ9H3K2
MaxQBiQ9H3K2
PaxDbiQ9H3K2
PeptideAtlasiQ9H3K2
PRIDEiQ9H3K2
ProteomicsDBi80725
TopDownProteomicsiQ9H3K2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27069
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372134; ENSP00000361207; ENSG00000165678
GeneIDi27069
KEGGihsa:27069
UCSCiuc001kcs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27069
DisGeNETi27069
EuPathDBiHostDB:ENSG00000165678.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GHITM
HGNCiHGNC:17281 GHITM
HPAiHPA016464
HPA061664
neXtProtiNX_Q9H3K2
OpenTargetsiENSG00000165678
PharmGKBiPA28673

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1630 Eukaryota
ENOG410XPHY LUCA
GeneTreeiENSGT00390000008960
HOGENOMiHOG000013204
HOVERGENiHBG051731
InParanoidiQ9H3K2
KOiK21890
OMAiDMINIFI
OrthoDBiEOG091G0DVQ
PhylomeDBiQ9H3K2
TreeFamiTF314017

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GHITM human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GHITM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27069

Protein Ontology

More...
PROi
PR:Q9H3K2

Gene expression databases

BgeeiENSG00000165678 Expressed in 238 organ(s), highest expression level in sperm
CleanExiHS_GHITM
GenevisibleiQ9H3K2 HS

Family and domain databases

CDDicd10431 GHITM, 1 hit
InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
IPR035871 GHITM
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGHITM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3K2
Secondary accession number(s): A8K9Z9
, D3DWE0, O95894, Q5VT95, Q9H0P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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