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UniProtKB - Q9H3K2 (GHITM_HUMAN)

Entry version 156 (11 Dec 2019)
Sequence version 2 (14 Aug 2001)
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Protein

Growth hormone-inducible transmembrane protein

Gene

GHITM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth hormone-inducible transmembrane protein
Alternative name(s):
Dermal papilla-derived protein 2
Mitochondrial morphology and cristae structure 1
Short name:
MICS1
Transmembrane BAX inhibitor motif-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GHITM
Synonyms:DERP2, MICS1, TMBIM5
ORF Names:My021, UNQ244/PRO281
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000165678.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:17281 GHITM

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H3K2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini46 – 82Mitochondrial matrixSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 125Mitochondrial intermembraneSequence analysisAdd BLAST22
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 159Mitochondrial matrixSequence analysisAdd BLAST13
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 190Mitochondrial intermembraneSequence analysis10
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213Mitochondrial matrixSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 244Mitochondrial intermembraneSequence analysis10
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 271Mitochondrial matrixSequence analysis6
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 345Mitochondrial intermembraneSequence analysisAdd BLAST53

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000165678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28673

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H3K2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GHITM

Domain mapping of disease mutations (DMDM)

More...DMDMi		15213977

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000017911946 – 345Growth hormone-inducible transmembrane proteinAdd BLAST300

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H3K2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H3K2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H3K2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H3K2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H3K2

PeptideAtlas

More...PeptideAtlasi		Q9H3K2

PRoteomics IDEntifications database

More...PRIDEi		Q9H3K2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80725

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9H3K2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H3K2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H3K2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H3K2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165678 Expressed in 238 organ(s), highest expression level in sperm

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H3K2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA016464
HPA061664

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q6PDS32EBI-2868909,EBI-6117196From Mus musculus.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117980, 59 interactors

Protein interaction database and analysis system

More...IntActi		Q9H3K2, 54 interactors

Molecular INTeraction database

More...MINTi		Q9H3K2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361207

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H3K2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H3K2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BI1 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1630 Eukaryota
ENOG410XPHY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00980000198543

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013204

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H3K2

KEGG Orthology (KO)

More...KOi		K21890

Identification of Orthologs from Complete Genome Data

More...OMAi		DMINIFI

Database of Orthologous Groups

More...OrthoDBi		1228054at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H3K2

TreeFam database of animal gene trees

More...TreeFami		TF314017

Family and domain databases

Conserved Domains Database

More...CDDi		cd10431 GHITM, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006214 Bax_inhibitor_1-related
IPR035871 GHITM

The PANTHER Classification System

More...PANTHERi		PTHR23291 PTHR23291, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01027 Bax1-I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAARLVCLR TLPSRVFHPA FTKASPVVKN SITKNQWLLT PSREYATKTR 
        60         70         80         90        100
IGIRRGRTGQ ELKEAALEPS MEKIFKIDQM GRWFVAGGAA VGLGALCYYG 
       110        120        130        140        150
LGLSNEIGAI EKAVIWPQYV KDRIHSTYMY LAGSIGLTAL SAIAISRTPV 
       160        170        180        190        200
LMNFMMRGSW VTIGVTFAAM VGAGMLVRSI PYDQSPGPKH LAWLLHSGVM 
       210        220        230        240        250
GAVVAPLTIL GGPLLIRAAW YTAGIVGGLS TVAMCAPSEK FLNMGAPLGV 
       260        270        280        290        300
GLGLVFVSSL GSMFLPPTTV AGATLYSVAM YGGLVLFSMF LLYDTQKVIK 
       310        320        330        340 
RAEVSPMYGV QKYDPINSML SIYMDTLNIF MRVATMLATG GNRKK
Length:345
Mass (Da):37,205
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i808FAED86A9CD98E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4A → V in CAB66648 (PubMed:11230166).Curated1
Sequence conflicti64E → G in AAG43135 (Ref. 3) Curated1
Sequence conflicti74I → M in CAB66648 (PubMed:11230166).Curated1
Sequence conflicti118Q → R in CAB66648 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB009685 mRNA Translation: BAA93049.1
AF131820 mRNA Translation: AAD20052.1
AF060923 mRNA Translation: AAG43135.1
AL136713 mRNA Translation: CAB66648.1
AY358824 mRNA Translation: AAQ89183.1
AK292864 mRNA Translation: BAF85553.1
AC022389 Genomic DNA No translation available.
AL603756 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80367.1
CH471142 Genomic DNA Translation: EAW80368.1
CH471142 Genomic DNA Translation: EAW80369.1
BC010354 mRNA Translation: AAH10354.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41542.1

NCBI Reference Sequences

More...RefSeqi		NP_055209.2, NM_014394.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372134; ENSP00000361207; ENSG00000165678

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27069

UCSC genome browser

More...UCSCi		uc001kcs.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009685 mRNA Translation: BAA93049.1
AF131820 mRNA Translation: AAD20052.1
AF060923 mRNA Translation: AAG43135.1
AL136713 mRNA Translation: CAB66648.1
AY358824 mRNA Translation: AAQ89183.1
AK292864 mRNA Translation: BAF85553.1
AC022389 Genomic DNA No translation available.
AL603756 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80367.1
CH471142 Genomic DNA Translation: EAW80368.1
CH471142 Genomic DNA Translation: EAW80369.1
BC010354 mRNA Translation: AAH10354.1
CCDSiCCDS41542.1
RefSeqiNP_055209.2, NM_014394.2

3D structure databases

SMRiQ9H3K2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117980, 59 interactors
IntActiQ9H3K2, 54 interactors
MINTiQ9H3K2
STRINGi9606.ENSP00000361207

PTM databases

iPTMnetiQ9H3K2
PhosphoSitePlusiQ9H3K2
SwissPalmiQ9H3K2

Polymorphism and mutation databases

BioMutaiGHITM
DMDMi15213977

Proteomic databases

EPDiQ9H3K2
jPOSTiQ9H3K2
MassIVEiQ9H3K2
MaxQBiQ9H3K2
PaxDbiQ9H3K2
PeptideAtlasiQ9H3K2
PRIDEiQ9H3K2
ProteomicsDBi80725
TopDownProteomicsiQ9H3K2

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		27069

Genome annotation databases

EnsembliENST00000372134; ENSP00000361207; ENSG00000165678
GeneIDi27069
KEGGihsa:27069
UCSCiuc001kcs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27069
EuPathDBiHostDB:ENSG00000165678.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		GHITM
HGNCiHGNC:17281 GHITM
HPAiHPA016464
HPA061664
neXtProtiNX_Q9H3K2
OpenTargetsiENSG00000165678
PharmGKBiPA28673

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1630 Eukaryota
ENOG410XPHY LUCA
GeneTreeiENSGT00980000198543
HOGENOMiHOG000013204
InParanoidiQ9H3K2
KOiK21890
OMAiDMINIFI
OrthoDBi1228054at2759
PhylomeDBiQ9H3K2
TreeFamiTF314017

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GHITM human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GHITM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27069
PharosiQ9H3K2 Tbio

Protein Ontology

More...PROi		PR:Q9H3K2
RNActiQ9H3K2 protein

Gene expression databases

BgeeiENSG00000165678 Expressed in 238 organ(s), highest expression level in sperm
GenevisibleiQ9H3K2 HS

Family and domain databases

CDDicd10431 GHITM, 1 hit
InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
IPR035871 GHITM
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGHITM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H3K2
Secondary accession number(s): A8K9Z9
, D3DWE0, O95894, Q5VT95, Q9H0P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: December 11, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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